152 research outputs found
Design and Implementation of a university Campus Supermarket Management System
当前互联网在日常生活的各个领域面都有广泛的应用,基于互联网建立方便、便捷的生活平台也是现在广泛关注的话题。网上超市也就是通过互联网作为展示平台,线上订购,线下配送的一种商业运营模式。 本系统的整体平台根据我国大学校园的实际情况,在详细分析了系统需求的基础上进行开发和实现。该系统采用MVC三层架构,开发了一个B/S模式的基于校园的在线超市系统,系统由商品用户模块、商品订购模块、商铺管理模块、商品管理模块、权限管理模块和订单管理模块等组成。用户模块负责用户个人信息的维护;商品订购模块包括商品的展示、商品搜索、下单和支付等功能;商铺管理模块负责商铺管理;商品管理模块负责对店铺的商品进行管理;权限管...At present, the Internet has been widely used in all fields of daily life, based on the Internet to establish a convenient living platform is now widely concerned about the topic. Online supermarket is through the Internet as a display platform, online ordering offline distribution of a business model. Based on the actual situation of university campus in China and detailed analysis of the system...学位:工程硕士院系专业:软件学院_工程硕士(软件工程)学号:X201323090
Research on Purchase Risk Management Based on Hedging—Take A Company as An Example
近年来,随着经济全球化影响,世界范围内各国家之间的联系愈加密切,国外与国内市场的界限愈加模糊。国内市场上大宗原材料的价格受到国际市场影响的程度加深,导致价格大幅度波动,给我国制造业企业的正常经营带来了很大的风险。套期保值作为一种重要的风险管理手段,能够有效地转移企业因为原材料价格波动带来的风险,提高企业的经营效益。目前在国外,参与套期保值的公司越来越多。但是在国内,尤其是中小企业,由于经验的缺乏、意识不够等因素,参与套期保值的企业比例并不是很高。 本文以A公司为研究对象,重点研究A公司在原材料铜价格剧烈波动的背景下如何借助套期保值的工具来降低风险。首先,介绍A公司的套期保值现状,同时对A公司...In recent years, with the impact of economic globalization, the links of countries are more closely in the world, the boundaries of foreign and domestic markets become increasingly blurred. In the domestic market, the price of bulk raw materials more impact by the international market, resulting in significant fluctuations of price, brought a lot of risks to manufacturing enterprises' normal opera...学位:工程硕士院系专业:管理学院_工程硕士(物流工程)学号:1772014115104
金砖五国专利发展现状比较分析
本文对金砖五国的专利发展现状进行了比较分析。结果显示,中国在专利申请量、授权量以及专利产出效率方面具有绝对的领先优势,而在专利授权率以及有效专利比率上处于劣势地位;中国已成为金砖五国间最大的国际专利受理国;金砖国家能够形成技术领域的优势互补。最后,笔者针对我国专利事业的发展提出了建议
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中药是我国传统医学的重要组成部分,但部分中药存在成分复杂、水溶性差等问题,给临床前研究,尤其是体外药效学研究带来困扰。本文就目前体外药效学研究中难溶性中药或中药成分增溶方法或技术进行综述,探讨其可行性及对中药药效行为的影响。福建省自然科学基金项目(2015J01491
Spectrum-effect relationship of immunosuppressive activity of Leigongteng Duogan Tablet based on partial least squares regression analysis
目的初步探讨雷公藤多苷片免疫抑制作用及其HPlC指纹图谱间的相关性。方法采用HPlC建立7个厂家生产的雷公藤多苷片醋酸乙酯提取物的指纹图谱,选择刀豆蛋白A(COn A)刺激的小鼠脾淋巴细胞模型进行免疫抑制药效学研究,分别考察雷公藤多苷片对小鼠脾淋巴细胞增殖以及细胞因子γ干扰素(Ifn-γ)分泌的影响;采用偏最小二乘回归分析法分析谱效关系。结果建立了7个厂家生产的雷公藤多苷片的HPlC指纹图谱,从HPlC指纹图谱中提取出18个能够表征差异的特征峰。药效研究结果显示不同厂家生产的雷公藤多苷片均可显著抑制COn A诱导的小鼠脾淋巴细胞增殖和Ifn-γ的分泌(P<0.05)。偏最小二乘回归法分析结果显示,以抑制小鼠脾淋巴细胞增殖IC50值为药效指标时第1、2、6、7、17、18号峰为药效峰;以Ifn-γ分泌抑制率为指标时,第1、2、6、7、8、9、12、13号峰为药效峰。结论第1、2、6、7、8、9、12、13、17、18号峰所代表的化合物可能为雷公藤多苷片中发挥免疫抑制主要有效成分。Objective To investigate the immunosuppressive components in Leigongteng Duogan Tablet(LDT).Methods High performance liquid chromatography(HPLC) was applied to establish the fingerprint for LDT from seven manufactures.The immunosuppressive effect of LDT was observed on Con A-induced mice spleen cells, and the cell proliferation and contents of IFN-γ were recorded.Then the partial least squares regression(PLSR) analysis was used to investigate its spectrum-effect relationship.Results The HPLC fingerprint for LDT from seven manufactures was established, and 18 characteristic peaks were confirmed.The in vitro cell experimental results showed that the proliferation of mice spleen cells and secretion of IFN-γ were inhibited by all LDT significantly compared with the control group.According to the results of PLSR, No.1, 2, 6, 7, 17, and 18 peaks were strongly related to the proliferation inhibition of mice spleen cells and No.1, 2, 6, 7, 8, 9, 12, and 13 peaks were related to the secretion of IFN-γ.Conclusion The No.1, 2, 6, 7, 8, 9, 12, 13, 17, and 18 peaks are the principal immunosuppressive substances in LDT.福建省科技计划重大项目(2012I1001
Hypoglycemic action of acidic polysaccharide in leaf of Gynura divaricata and its effect on related indexes
与西药相比,传统中药及其提取物具有经济、安全的优点,同时还可避免西药的许多副作用[1]。中药材白子草又名白背三七,为菊科(COMPOSITAE)三七属(gynurA CASS.)植物白子菜〔gynurA dIVArICATA(lInn.)dC.〕的干燥叶,具有清热、舒筋、止血、祛痰等功效[2]。在民间,白子菜的茎和叶可药食两用,用于治疗高血压、糖尿病和高血脂症等[3],其化学成分复杂,目前已分离获得多糖类[3]、黄酮类[4-6]、生物碱[4,7-8]和脂肪酸[9]等成分。Gynura divaricata acidic polysaccharide( GDAP) was extracted and purified from dry leaf of Gynura divaricata( Linn.) DC.Effects of successive lavage GDAP for 0,7,14 and 21 d with daily dose of 15,37 and 60 mg·kg- 1on blood glucose content of diabetic model mice were analyzed,and differences in SOD activity and MDA content in serum and glycogen content in liver of mice were compared.The results show that with prolonging of successive administration time and increasing of GDAP daily dose,blood glucose content of diabetic model mice generally appears the decreasing trend.With successive administration for 14 and 21 d,blood glucose content of different GDAP treatment groups is generally lower than that of CK group( 0.9% Na Cl injection with daily dose of 10 m L·kg- 1) but higher than that of T1group( metformin with daily dose of 200 mg·kg- 1).In which,after successive administration GDAP for 21 d with daily dose of 37 and60 mg·kg- 1,blood glucose content of diabetic model mice is significantly or extremely significantly lower than that of CK group but significantly or extremely significantly higher than that of T1 group,while SOD activity in serum of diabetic model mice is significantly higher and its MDA content is significantly lower than those of CK group,but there is no significant difference with those of T1 group.Glycogen content in liver of diabetic model mice of different GDAP treatment groups is higher than that of CK group,but lower than that of T1 group.It is suggested that GDAP is the main hypoglycemic components in polysaccharide of G.divaricata leaf, and it has dose-effect relationship in hypoglycemic activity.Hypoglycemic mechanism of GDAP is probably related to improving antioxidant enzyme ability in the body,enhancing activity of scavenging oxygen free radicals,relieving liver damage,and increasing glycogen storage capacity.福建省自然科学基金资助项目(2012J01400
SARS-CoV-2 病毒感染对精子质量的影响
目的旨在探究已接种新冠疫苗的COVID-19感染后精液中SARS-CoV-2 RNA的检测情况,并分析感染恢复期不同阶段对精子质量的影响。方法于2023年1月至3月就诊安徽医科大学第一附属医院生殖医学中心既往已接种新冠疫苗且近期咽拭子(包括感染状态)SARS-CoV-2呈阳性的男性患者,留取精液样本,通过RT-qPCR方法检测精液SARS-CoV-2病毒RNA存在情况。回顾性分析COVID-19感染恢复期不同阶段对精子质量影响;通过横向比较COVID-19感染恢复<30 d与≥30 d患者精液体积、精子浓度、精子总数、前向运动百分率、畸形率、精子DFI等指标;并进一步纵向自身对照比较未感染COVID-19与感染COVID-19恢复阶段(<30 d与≥30 d)精液质量指标。结果在所有纳入研究的205名患者精液样本中均未检测到SARS CoV-2 RNA。此外,无论是横向比较COVID-19感染恢复期不同阶段还是纵向自身对照比较未感染COVID-19与感染COVID-19恢复阶段的精液体积、精子总数、精子畸形率、精子DFI及HDS,两组差异均无统计学意义(P>0.05),而精子前向运动百分率下降,两组差异具有统计学意义(P<0.05)。结论对于既往接种新冠疫苗COVID-19感染的患者,SARS-CoV-2病毒不会通过精子性传播,并且COVID-19感染恢复期30 d内弱精子症发生率可能增加,然而这种影响短期内是可逆的
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