聚胺基甲酸酯/二氧化鈦抗紫外線奈米混成材料之製備

[[notice]]補正完畢[[conferencetype]]國內[[conferencedate]]20060113~2006011

恶性血液病患者中性粒细胞减少期抗菌药物临床应用的回顾性分析

目的研究分析恶性血液病患者粒细胞减少期住院期间的抗菌药物使用情况,为抗菌药物临床应用决策提供参考。方法对我院2009~2010年83例恶性血液病患者中性粒细胞减少期使用的抗菌药物品种、病原学检查、抗菌药物费用、应用例次、应用时间、用药频度(dddS)、药物利用指数(duI)及抗菌药物联合用药等进行回顾性分析,分析其应用合理性。结果 83例恶性血液病患者中,54例患者出现感染,感染率为65.06%,病原学检查阳性15例;81例应用了抗菌药物,使用最多的抗菌药物是头孢吡肟。dddS排序前3位的药物主要包括注射用头孢吡肟、氟康唑注射液、亚胺培南西司他丁,duI≤1的有14个,duI>1的6个。结论本试验分析结果对恶性血液病患者中性粒细胞减少期的合理使用抗菌药物具有参考意义

周期反常性

除众所周知的氢在周期表中的位置不确定性、第二周期元素的性质的特殊性之外,本文将详细介绍d区元素的电子排布,第四周期非金属元素最高价态的不稳定性,惰性电子对效应,第五、六周期重过渡元素的相似性和次周期性以及第3族元素编排反常现象并作必要的探讨

非标准岩样岩石力学参数试验研究

通过对非标准岩样的室内试验来获取岩石力学参数是试验研究中必须处理的技术问题。对某矿4种不同岩石的非标准岩样进行单轴抗压实验和巴西劈裂实验,分析了岩样的强度分布特点,考虑尺寸效应和形状效应,对岩石强度试验结果进行了修正,获得了岩石的单轴抗压、抗拉强度、弹性模量、帕松比、粘聚力和内摩擦角等力学参数,并对所得参数进行了分析。所得力学参数为该矿山的岩石力学和地压研究提供了基础资料

Maroteaux-Lamy综合征的ARSB基因分析及新突变的致病性鉴定

【目的】对7家拟诊为Maroteaux_Lamy综合征(MPSⅥ)的患儿及其父母进行ARSB基因的突变检测和新突变的致病性鉴定,以揭示其分子发病机制,为将来的产前/植入前基因诊断等创造前提条件。【方法】在临床初诊及GAG尿检和MPS酶检的基础上,抽取患儿及其父母EDTA抗凝血,进行ARSB基因的PCR扩增和Sanger测序。对所发现的新突变,在经HGMD、1000G和ExAC等数据库核实排查后,首先用SWISS-MODEL软件分析、比对突变蛋白和正常蛋白的空间构象,然后用Clustal X软件分析跨物种氨基酸的保守性,用PROVEAN、SIFT、PolyPhen-2软件预测新突变的致病性,最后用ACMG标准对新突变的致病性进行综合分析鉴定。【结果】1)7个家系先证者的基因检测结果分别为:No1:c.574T> C,p.C192R纯合错义突变;No2:c.160G> A/p.D54N(来自其母)和c.1197C> G/p.F399L(来自其父)的复合杂合子;No3:仅检出c.1072G> A/p.V358M和IVS5 as(-27)A>C变异,但酶检和临床表型符合Ⅵ型;No4:为c.281C> T,p.S94L(新突变,来自其母)和IVS5 as(-27)A> C(来自其父)的复合杂合子;No5:为c.1197 C> G,p.F399L纯合错义突变;No6:为c.1197 C> G,p.F399L(来自其母)和c.1379 C> T,p.S460F(新突变,来自其父)的复合杂合子;No7:为c.499 G> A,p.G167R(来自其父)和c.1325C>T,p.T442M(来自其母)的复合杂合子。2)新突变鉴定结果:对正常ARSB酶蛋白和p.S94L突变酶蛋白的空间构象的预测比对结果显示,两者有明显区别;跨物种保守性分析结果显示,p.94突变点所在氨基酸(S)在物种进化过程中具有高度保守性;PROVEAN、SIFT和PolyPhen-2软件对p.S94L预测结果分别为:Deleterious、Damaging和Probably damaging。用上述方法对p.S460F的预测结果及ACMG的综合分析结果也显示该突变可能是致病性的。【结论】1)家系4的p.S94L和家系6的p.S460F新突变可能都是新的致病性突变,有可能都是引起患儿发病的内在原因之一。2)家系1,2,5,6,7可以确诊为MPS Ⅵ型,其基因型和表现型具有显著的相关性,家系3虽经酶检确诊,临床症状和尿检结果也都与MPS Ⅵ型符合,但却未能在DNA水平查到明确的突变类型,其表现型与基因型的相关性还有待进一步证实。国家自然科学基金(30772069);;闽粤合作科研基金(71010025和71020010

全喉切除术后无喉者的语言康复实践

喉癌患者行全喉切除后,由于丧失语言功能,严重影响了其生活、生存质量,积极帮助无喉者使其获得语言康复,既是医疗问题,也是社会问题,我们与香港新声会联合举办语言康复训练班,收到较好的效果,现报告如下.postprin

C_(60)离子束撞击固体表面坍塌沉积物的拉曼光谱研究

Ｃ６０离子束撞击固体表面坍塌沉积物的拉曼光谱研究唐紫超任斌黄荣彬田中群郑兰荪（固体表面物理化学国家重点实验室厦门大学化学系厦门３６１００５）ＣｏｌａｐｓｅｄＤｅｐｏｓｉｔｉｏｎｏｆＡｃｃｅｌａｔｅｄＣ６０ＢｅａｍｏｎＳｏｌｉｄＳｕｒｆａｃｅｓ——Ｃ..

负偏置沉积法可控制备CuO多孔纳米结构薄膜

由于具有低成本、无毒、铜源丰富等优点,以及在气敏传感器、太阳能电池、光催化等领域的潜在应用前景,CuO薄膜引起了人们的广泛关注.采用射频平衡磁控溅射镀膜系统,在薄膜沉积过程中通过施加不同衬底负偏压可控制备了CuO多孔纳米结构薄膜.研究发现,所得CuO薄膜具有灵活可调的孔隙度和纳米构筑单元形貌特征,并且它们与衬底负偏压的大小密切相关;薄膜沿衬底法线方向呈柱状生长且具有显著的（111）择优取向;禁带宽度在2.0.35 eV之间可调.很明显地,传统的溅射离子轰击、再溅射理论并不适合用来解释上述负偏压效应,因此在此基础上提出了一种负偏置沉积过程中材料原子或分子在薄膜表面选择性优先沉积机制.国家自然科学基金(51501018,11574255)；江苏省自然科学基金(BK20150267,BK20141169)；江西省教育厅科技项目(GJJ161197)；江西省自然科学基金(20132BAB212005)资助

中华双腔吸虫的生活史

本文首次报告中华双腔吸虫(Dicrocoelium chinensis)发展史各发育期的形态特征,通过生活史研究,首次阐明第一中间宿主是陆地蜗牛——同型阔纹蜗牛(Bradybaena similaris))(人工感染成功的厦门蜗牛)、枝小丽螺(Ganesella virgo)(黑龙江扎赉特旗,天然感染)及华蜗牛(Cathaicafasciola)(山西安泽,天然感染);第二中间宿主是蚂蚁:(Camponotuscompressus(山西安泽人工感染及天然感染)、Formica truncicola(黑龙江扎赉特旗,天然感染)及Formica gagates(吉林、乌兰浩特)。 比较了中华双腔吸虫和矛形双腔吸虫发育各期的主要特点,由此将长期来一直被混淆在矛形双腔吸虫中的这一重要虫种分别出来。 阐述了山西安泽中华双腔吸虫病流行区病原在自然界散布情况,包括羊只感染成虫状况及病原幼虫期在第二阶段的两个中间宿主(蜗牛和蚂蚁)感染情况

Controllable fabrication of Cu_2O porous nanostructured films by negative bias deposition method

由于具有低成本、无毒、铜源丰富等优点,以及在气敏传感器、太阳能电池、光催化等领域的潜在应用前景,; Cu_2O薄膜引起了人们的广泛关注.采用射频平衡磁控溅射镀膜系统,在薄膜沉积过程中通过施加不同衬底负偏压可控制备了Cu_2O多孔纳米结构薄膜.研; 究发现,所得Cu_2O薄膜具有灵活可调的孔隙度和纳米构筑单元形貌特征,并且它们与衬底负偏压的大小密切相关;薄膜沿衬底法线方向呈柱状生长且具有显著; 的(111)择优取向;禁带宽度在2.0~2.35; eV之间可调.很明显地,传统的溅射离子轰击、再溅射理论并不适合用来解释上述负偏压效应,因此在此基础上提出了一种负偏置沉积过程中材料原子或分子在薄; 膜表面选择性优先沉积机制.As one of the most common two kinds of copper oxides, cuprous oxide; (Cu_2O) is an important p-type transition metal oxide semiconductor; material. Due to the advantages of low-cost, non-toxicity and abundant; copper sources and the potential applications in the fields of gas; sensors, solar cells and photocatalysts, thin films of Cu_2O have; attracted great interest of researchers. To enhance the performances of; the above Cu_2O-based surface-sensitive devices and materials, the; researchers tend to prepare Cu_2O thin films of porous or even; nanoporous structures. However, there is still no effective method; available for the controllable fabrication of Cu_2O porous; nanostructured films (or porous nanostructure-films, short for PNFs),; which owns not only the common features of porous thin films but also; the unique properties of nanosize building units. By using a; radiofrequency balanced magnetron sputtering (MS) deposition system, in; this paper, Cu_2O PNFs were prepared on clean glass slides by applying; different negative bias voltage during film deposition. After the; preparation, a field-emission scanning electron microscope (FESEM), a; grazing-incidence X-ray diffractometer (GIXRD) and an; ultraviolet-visible (UV-Vis) spectrophotometer were applied subsequently; for the detailed characterizations of surface morphology, texture and; optical property respectively. It was observed that the as-prepared; Cu_2O PNFs exhibited flexible porosities and nanosize building units,; which were greatly dependent on the substrate negative bias voltage. In; particular, when the substrate bias voltage was kept at -50 or -150 V,; the as-prepared Cu_2O PNFs both demonstrated intriguing triangular; pyramid-like nanostructures with distinct edges and corners on the; porous film surface. Further, the side view FESEM images and the; out-of-plane GIXRD spectra demonstrated a columnar growth of the Cu_2O; PNFs with a notable preferential orientation of (111). The optical; testing results showed that the band gap of the Cu_2O PNFs obtained at; different negative bias voltages was tunable between 2.0 and 2.35 eV,; which demonstrated a little red or blue shift relative to that of bulk; Cu_2O (2.17 eV). It is expected that the traditional ion bombardment and; re-sputtering theories are not suitable for the explanation of the above; bias voltage effects. This is because the traditional ion bombardment; and re-sputtering theories were proposed to account for the bias; deposition in an unbalanced magnetron sputtering (MS) system rather than; the present balanced MS system. Further, the experimentally observed; non-linearly changed density or porosity of the Cu_2O PNFs with the bias; voltage at relatively low values and the common even surface at; relatively high values confirmed this viewpoint. Based on the above; findings and analysis, a selectively preferential deposition of material; atoms or molecules on the film surface during the negative bias; deposition was proposed. That is, when the substrate is negatively; biased, the tipcharging effect of electrons would occur on the nanoscale; rough surface of the substrate or the depositing film. The resulting; electric field near the substrate or film surface is non-uniform and; could be regarded as an assembly of many electric fields of particle or; tip charges.国家自然科学基金; 江苏省自然科学基金; 江西省教育厅科技项目; 江西省自然科学基