246 research outputs found

    The Pragmatic Analysis of Presupposition in Police Interrogation

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    语用预设一直是哲学家和语言学家们关注的焦点之一。他们中有许多人已经对预设的一些方面进行了透彻的研究,但是很多都是关于政治访谈和广告语料的分析。本文旨在以警察讯问为切入点,通过语料分析来展示语用预设在警察讯问中的应用。 在理论建构部分,本文首先回顾了前人对警察讯问的研究。与此同时,作者介绍了预设理论在中西方的发展。接着,文章详细阐述了语用预设,包括其概念,特征及触发语。就语用预设的特征而言,作者选择了最具代表的共知性,隐蔽性和可取消性,并将它们运用到警察讯问中来。文章的重点着眼于研究讯问人员如何技巧地运用语用预设的三个特征以实现特定的讯问意图。这一理论为下一章的语料分析提供了理论框架。在本文的...Pragmatic presupposition has been a great interest of many philosophers and linguists. Many of them have done thorough research on some aspects of it, but mostly about political interviews and advertisements. Hence, this thesis will set out from pragmatic presupposition in police interrogation and demonstrate how pragmatic presupposition is well applied to police interrogation by data analysis. ...学位:文学硕士院系专业:外文学院外语教学部_语言学及应用语言学学号:X200711402

    中国法における独禁法に違反する契約の効力論

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    京都大学新制・課程博士博士(法学)甲第22942号法博第262号新制||法||172(附属図書館)京都大学大学院法学研究科法政理論専攻(主査)教授 潮見 佳男, 教授 横山 美夏, 教授 吉政 知広学位規則第4条第1項該当Doctor of LawsKyoto UniversityDGA

    Research on police reform and innovation during the period of social transformation(fujian)

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    当今时代,经济社会的快速发展给处在社会公共管理最前沿的公安工作带来很大压力。从世界各国警务发展趋势看,“新公共管理思潮”、“综合警务”、“一警多能”、“情报引领警务”、“公安行政管理社会化”是大多数国家(地区)警察机构都正在推行的警务改革模式。反观我国,长期以来警务运行一直是单一警务模式占主导,传统警务的运行模式已经无法适应当前社会对公安工作的要求。 从我国公安成立到现在,关于警务体制机构、运行机制以及配套措施等改革完善的研究探索不断,但至今都没有一种全国性的改革纲要和方向,基本上由各地公安试点创新,因此,在新形势下研究和推行现代警务改革,既存在着理论、政策上的研究价值,也十分符合公安实践的...Nowadays, the quick development of economics and society has brought great pressure to the police work, which is in the forefront of social and public management. In the view of the development trend of police service of various countries in the world, we can see that “New Public Management Ideological Trend” “Integrated Police” “A Policeman with Several Abilities” “Intelligence Guides Police Serv...学位:公共管理硕士院系专业:公共事务学院公共管理系_公共管理硕士(MPA)学号:X200813619

    空间回归方法在慢性病研究中的应用进展

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    随着社会经济的发展和人们生活方式的转变,慢性病发病率不断攀升,已成为严重困扰个人、家庭和社会的焦点问题。在世界范围内,2010年估计有3450万人死于慢性病,较20年前有明显的增加[1]。目前我国慢性病患者已超过2亿人,占总人口的20%以上,其中,2012年我国18岁及以上成人高血压、糖尿病、慢性阻塞性肺病患病率分别为25.3%、9.7%、9.9%,厦门市科技计划项目(350Z20143006

    顾客流失原因的分析

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    顾客流失直接影响商业企业的经济效益。企业对于老顾客或忠诚顾客的有效管理,日益成为管理人员面临的挑战,顾客流失行为导致的因素十分复杂,不能一概而论,分析顾客流失的原因是顾客保持中非常重要的一环

    基于机器学习的智能出租车预测系统

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    为了更合理地调度出租车资源,提出基于机器学习的智能出租车预测系统.首先,对波尔图出租车GPS数据集进行分割处理,并抽取其中的一部分作为研究对象;接着利用回声状态网络算法预测旅行目的地;最后利用随机森林算法在相同情况下预测出租车抵达时间.实验表明本系统能根据当前的波尔图出租车GPS数据集预测出实际出租车某段旅程的目的地和旅程所需要的时间,以达到减少出租车资源浪费的目的.福建省自然科学基金(2017J01739);;福建师范大学教学改革研究项目(I201602015)~

    Surface Activation of Amino Polystyrene Microbeads Using Bromoacetic Acid for Immobilization of Antibodies

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    E-mail:[email protected][中文文摘]分子固定化技术[1]是构造化学、生物敏感元件的重要内容。本文研究氨基聚苯乙烯微珠表面的溴乙酸活化及抗体固定化效率。在pH4.5 条件下,溴乙酸与氨基聚苯乙烯微珠混合反应,制备成表面溴乙酰化的微珠。然后活化的氨基微珠与抗体分子进行偶联。抗体微珠与荧光标记二抗作用后,在荧光显微镜下拍摄微珠的荧光图像,考察活化微珠连接抗体分子的效果。进一步工作将应用抗体微珠开展实际血清样品中的抗原检测。[英文文摘]In this work, surface activation of amino polystyrene microbeads using bromoacetic acid for immobilization of antibodies is presented. The activation efficiency was investigated via microscopic fluorescent imaging.论文工作得到了国家自然科学基金(No.20775065)、教育部高校博士点基金(No.20070384023)、 化学生物传感与计量学国家重点实验室(湖南大学)开放课题(No.2006021)、国家基础科学人才培 养基金(No.J0630429)项目资助

    Research and Development of a New Type of Walking Aids for Lower Limbs

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    目的设计一种新型助行器,要求能够分散受力点,减少上半身体部分局部受力以尽量避免腋部并发症与不适感,同时要求结构简单,制造方便。方法应用Solidwork软件进行结构设计:主体略呈长“T”形,主要包括腋托、手把、小腿支撑、拐杖脚等部分。主体及各主要部分受力情况采用ABAQUS软件进行有限元分析。结果采用普通304不锈钢管材制造的助行器符合强度要求。结论设计的新型助行器具有结构简单、使用方便、安全可靠、操作流程易懂的特点,可满足不同状态下的需求和不同高度人体的使用。研制出的新型下肢助行器,可为进一步通过基于下肢受力点设计出助行器提供相关参考。Objective To design a new type of walking aids, which can disperse force, decrease the stress on the upper exmnerty, reduce complications and discomfort of axilla, and has the advantages of simple structure and convenient manufacture. Methods The structure was design with Solidwork software: the main part looked a little like "T", including the axillary support part, handle part, leg support part, crutch feet part and so on. The force of the major structure and the main parts was analyzed by ABAQU--an engineering simulation finite element analysis software. Results The walking aids made of ordinary 304 stainless steel tube met the mechanical requirements. Conclusions The new type of designed walking aids has the features of simple structure, convenient use, safety and reliability, and easy operation process, which can meet the requirements in different states and the use by people with different heights. The new type of designed walking aids for lower limbs can further provide relevant reference for new kinds of walking aids to design on the basis of force points of lower limbs.厦门市科技局科技惠民计划项目(3502220154017

    FTIR-ATR Spectrometry of BSA Adsorption on Hydroxyapatite

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    采用傅里叶变换红外衰减全反射(FTIR-ATR)光谱法对牛血清白蛋白(BSA)在羟磷灰石(HA)[Ca_(10)(OH)_2(PO_4)_6]表面不同时间的相互吸附作用进行了表征。在BSA溶液作用下,羟磷灰石表面的Ca~(2+)、PO_4~(3-)和OH~-离子初始的溶解和再沉淀使得BSA与HA相互作用层层叠加,在HA表面形成从表层到次表层分子都包含有吸附的BSA的覆盖层,从而加深两者之间的相互作用。经红外差谱法处理过的相关ATR数据表明,BSA与HA之间的相互作用是快速的,并随时间变化进一步加强;来自HA上PO_4~(3-)的P=O基团对蛋白质肽键的酰胺Ⅱ带(-CNH)、多肽链的甲基(-CH_3)和亚甲基(-CH_2)上氢的吸附作用要比P-O快速而且强烈。Ca~(2+)在该吸附过程中起了极其重要的作用,其快速与蛋白质肽键的羰基氧发生作用,并诱导该蛋白质二级结构由β-折叠向α-螺旋和β-转角构象转变;伴随着这一构象变化,蛋白质多肽链上大多数肽键的-C=O和H-N-活性基团从链间氢键交联中释放出来,带动众多的氢分别参与同HA表面的Ca~(2+)、PO_4~(3-)和OH~-离子的相互吸附作用,并牢牢地结合于HA表面;这对硬组织的再生起着重要作用,促进了HA的生物矿化过程。The microcosmic process of bovine serum albumin(BSA) adsorbing onto hydroxyapatite(HA) for different time intervals was investigated by Fourier transform infrared attenuated total internal reflectance(FTIRATR) spectrometry.The initial dissolution and re-precipitation of PO_4~(3-),Ca~(2+),and OH~- ions from the HA coating led to the occurrence of the coating including adsorbed BSA on the HA from surface-to subsurface-molecular layers and to in-depth interaction between BSA and HA.The subtraction results gained in the adsorption regions of HA and BSA reveal that the binding of P=O,from the phosphate(PO_4~(3-)),to the hydrogen of amide Ⅱ,methyl and methene of the BSA appears to be considerably more rapid and stronger than that of the P—O group.In addition,it is very likely that Ca~(2+) plays an important role in the interaction of BSA with HA.It appears that the binding of Ca~(2+) to the carbonyl-oxygen of the peptide bond in BSA caused a significant,molecular,conformational rearrangement of polypeptide backbones from β-pleated sheet to helical circles of α-helix and β-turn.This change appears to have been followed by much hydrogen of polypeptides being driven to bind PO_4~(3-) and OH~-effectively and much-C=O and H-N- groups of the peptide bond being freed from inter-chain hydrogenbonding to act on Ca~(2+) and combine strongly with the HA surface.This might reasonably be expected to promote hard tissue regeneration.BSA seems to be activated by the inductive effect of Ca~(2+) via the molecular rearrangement of polypeptide backbones from pleated sheet to helical circles and in turn reacts strongly on the HA,resulting in profound effects on the course of biomineralization.国家自然科学基金(51571169)资助项目~

    Efficient and Practical Synthesis of α-Amino Amides through Gold-Catalyzed Intermolecular Oxidation of Ynamides

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    α-氨基酰胺作为一类重要的羰基化合物广泛存在于众多天然的和非天然的生物活性分子之中.本工作实现了芳胺nH对在水相体系中通过金催化的分子间氧化炔烃途径产生的α-羰基金卡宾的插入反应.这种通过非重氮方式产生α-羰基金属卡宾的策略为有效合成多种官能团化的α-氨基酰胺化合物提供了一种通用且实用的方法.α-Amino amides constitute an important category of carbonyl compounds which exist in a large number of bioactive natural and non natural molecules.In this paper, an efficient intermolecular reaction of gold carbene intermediates, generated through gold-catalyzed intermolecular oxidation of alkynes, with primary anilines has been realized in aqueous media.Importantly, this non-diazo approach provides a general and practical solution for the synthesis of various functionalized α-amino amides.国家自然科学基金(Nos.21102119;21272191); 教育部创新团队资助项目~
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