Effect of the trans - theoretical model of behavior based WeChat health education on self - management among patients with maintenance hemodialysis

目的 探讨基于行为转变的微信干预模式对维持性血液透析患者自我管理的研究效果.方法 选取60例维持性血液透析患者实施微信健康教育,健康教育方案是基于行为转变理论制订,包括血液透析专业知识、自我管理、科学饮食等方面内容.实施干预12周后,对患者的生化指标、自我管理水平及自我效能感得分进行干预前后比较.结果 干预后患者自我管理得分较干预前有显著提升,表现在情绪处理和自我护理方面,差异有统计学意义（P＜0.01）.干预后患者的生化指标白蛋白、血钾、肌酐、尿素氮的差异有统计学意义（P＜0.01）.患者的自我效能感提升.结论 基于行为转变理论的微信健康教育可以改善维持性血液透析患者的生化指标,提高自我管理水平,帮助患者了解血液透析知识以及提升自信心,为今后改善血液透析患者自我管理提供一种新的干预模式.Objective To explore the effect of WeChat intervention model based on the trans-theoretical model of behavior（TTMB） on self-management of maintenance hemodialysis patients.Methods Sixty cases of maintenance hemodialysis patients were given WeChat health education,and the health education program was based on TTMB,ineluding hemodialysis expertise,self-management,scientific diet and so on.After 12 weeks＇intervention,the biochemical index,the self-management level and the self-efficacy score of patients were compared before and after intervention.Results The scores of self-management of patients after intervention were significantly higher than those before intervention,which were expressed in terms of emotional management and self-care,and the difference was statistically significant （P 〈 0.01）.After the intervention,the biochemical indexes diffences of albumin,serum potassium,creatinine and urea nitrogen of patients were statistically significant （P 〈 0.01）.The self-efficacy of patients were elevated.Conclusion The TTMB WeChat health education can improve the biochemical indexes and the level of self-management of maintenance hemodialysis patients,and it helps patients to understand hemodialysis knowledge as well as improve self-confident,to provide a new intervention model for improving self-management of hemodialysis patients in the future.国家自然科学基金（71403232

Separation and Enrichment of Melamine in Feed by a New Molecular Imprinting Solid-phase Extraction Column

[目的]研制一种新型的分子印迹固相萃取小柱,用于分离富集饲料中的三聚氰胺。[方法]采用本体聚合法制备了三聚氰胺分子印迹聚合物,以该聚合物为填料制作三聚氰胺分子印迹固相萃取(MIP-SPE)小柱,优化了固相萃取条件,应用高效液相色谱(HPlC)法测定浓缩液中的三聚氰胺含量。[结果]自制的MIP-SPE小柱可以从饲料中选择性地分离、富集三聚氰胺,有效地去除饲料中的复杂基质,加标回收率约为95%。MIP-SPE小柱与空白印迹固相萃取小柱(nMIP-SPE)的对比试验表明,前者的萃取效率明显高于后者。[结论]自制的新型三聚氰胺MIP-SPE小柱可用于饲料提取液中的三聚氰胺高选择性分离富集,使用简便,具有广阔的应用前景。[Objective] The research aimed to develop a new molecular imprinting solid-phase extraction column for the separation and enrichment of melamine in feed.[Method] The molecular imprinting polymer of melamine was prepared by noumenon polymeric method.This polymer was used as filler to prepare molecular imprinting polymer solid-phase extraction(MIP-SPE) column of melamine.The solid-phase extraction conditions were optimized and melamine content in concentrated solution was determined by using HPLC.[Result]Melamine could be separated selectively from feed and enriched by home-made MIP-SPE column.It could wipe off complex matrix from feed and the addition recovery rate was 95%.The contrast experiment between MIP-SPE column and NMIP-SPE(non-imprinted polymer-solid phase extraction) column showed that the extraction efficiency of the former was obviously higher than the latter.[Conclusion] The home-made MIP-SPE column could be used to separate and enrich melamine in feed efficiently,with a broad application prospect.厦门市科技计划项目(3502Z20110018

Testing System of Phosphor Excited by Blue LED Based on Integral Sphere

为尽可能反映荧光粉在实际工作条件下的发光性质,准确测量荧光粉的发光性能,提出了一种基于积分球的荧光粉发光性能测试系统。该系统采用蓝光lEd作为激发光源,配置有TEC控温系统对光源有效实施控温,可提供持续稳定的激发荧光粉发光。采用出光筒控制光源方向和积分球收集光线,能有效防止能量损失,提高测试的精确性。通过实验得到了不同强度蓝光激发下的荧光粉光谱功率分布以及发光效能、量子效率、光转换效率等参数的变化规律。随着驱动电流的增大,由于蓝光芯片内量子限制斯塔克效应,从而导致蓝光峰值波长出现小幅度的蓝移。三种效率在小电流下基本呈线性下降趋势,且在大电流下趋于平缓。实验结果表明,该系统及方法可以有效地评价实际lEd芯片工作状态下的荧光粉发光性能。A testing system for phosphor luminous characteristics based on integral sphere is proposed so as to show luminous characteristics of phosphor at actual operation circumstances and measure its luminous characteristics accurately.Blue LED is used as an excited source in the system.TEC temperature control system is used to control the temperature of the source effectively.And continuous and stable excited light is provided to excite phosphor illumining.Energy loss is prevented effectively and testing accuracy is enhanced for the direction of source controlled by a light tube and light ray collected by integral sphere.Based on experiments,spectrum power distributions of phosphor excited by blue light with difference light strength and variation rules of parameters such as luminous efficiency,quantum efficiency and light conversion efficiency are got.With the increasing of driving current,a small blue shift appears in blue light peak wavelength for quantum confined Stark effect in blue light chip.Three kinds of efficiency almost show linear decline trend at low current and then approach to constant at high current.Experimental results show that luminous characteristics of phosphor on real LED chip at operation state can be evaluated effectively by the system and method.国家自然科学基金项目(11104230); 福建省重点科技项目(2011H6025;2012H0039

The Difference of Luminous Performance Between Traditional Phosphor Packaging LED and Remote Phosphor LED

研究了传统白光lEd与蓝光激发的球冠形远程荧光粉白光lEd在不同电流、不同热沉温度下的发光性能,并对其机理差异展开了探讨。实验结果表明:随热沉温度和驱动电流的上升,传统白光lEd的量子效率和电光转换效率急剧下降,并导致其y/b比(yEllOW/bluE rATIO)下降,相关色温上升。而在远程荧光粉白光lEd中,其量子效率、光转换效率和相关色温在相同实验条件下变化幅度都较小。由光强空间分布和y/b比空间分布可知,远程荧光粉白光lEd的光强分布呈类似蝠翼分布,且y/b比空间均匀性远大于传统白光lEd。Under different drive current and heat sink temperature,luminous performances as well as physical mechanisms were studied for both traditional phosphor-dispensing packaging white LED and blue light-converting hemisphere remote phosphor LEDs.With the increase of the heat sink temperature and the drive currents,the quantum efficiency and light conversion efficiency in the traditional phosphor-dispensing packaging white LED drop rapidly,which is responsible for the decrease of Y/B ratio(Yellow/Blue Ratio) and the apparent increase of CCT(correlated color temperature).However,the parameters of quantum efficiency,light conversion efficiency and CCT in blue light-converting hemisphere remote-phosphor packaging LEDs have little change under the same experimental conditions.In addition,the remote phosphor LEDs exhibit a batwing spatial luminous intensity distribution and the spatial Y/B ratio distribution is much more homogeneous compared with the traditional phosphor-dispensing packaging white LED.国家自然科学基金(11104230;61102030); 福建省产学研重大科技项目(2011H6025;2013H6024); 福建省重点科技项目(2012H0039)资

Establishment and Characterization of a Targeting Tumor Vesseles System for Inducing Thrombosis

目的建立一种新型的靶向高效诱发肿瘤血管血栓栓塞体系磁流体-神经纤维网蛋白1抗体A6-链霉亲和素:生物素-短截型组织因子(Mf-A6-SA:b-TTf)。方法化学交联技术制备神经纤维网蛋白1抗体A6-链霉亲和素、磁流体-神经纤维网蛋白1抗体A6-链霉亲和素和生物素-短截型组织因子交联物,凝血因子X活化实验鉴定复合体系活化凝血因子X的活力,荧光显微镜技术和普鲁士蓝染色法同时观察施加外界磁场后复合体系的靶向作用,凝血实验直接观察复合体系引入链霉亲和素:生物素的生物放大效应,体内生物分布实验观察复合体系的安全性。结果成功制备磁流体-神经纤维网蛋白1抗体A6-链霉亲和素及生物素-短截型组织因子,磁流体-神经纤维网蛋白1抗体A6-链霉亲和素:生物素-短截型组织因子体系保留有高效激活凝血因子X的活性,与靶点的结合具有靶向性及高效富集性,体内实验证实能安全有效诱发肿瘤血管栓塞。结论成功制备的具有靶向诱发肿瘤血管血栓栓塞体系磁流体-神经纤维网蛋白1抗体A6-链霉亲和素:生物素-短截型组织因子为进一步探索肿瘤血管的靶向治疗奠定基础。OBJECTIVE To establish a novel targeting tumor vessels system MF-A6-SA:B-tTF for efficiently inducing thrombosis.METHODS Chemical cross-linking technique was used to prepare a cross-linking agent of the A6-Streptavidin( A6-SA),MFA6-SA and Biotein-tTF(B-tTF).FX coagulation assay was used to test MF-A6-SA:B-tTF system's FX activity.Fluorescence microscopy and prussian blue staining were used to simultaneously observe the targeting activity of MF-A6-SA:B-tTF with an external magnetic field.Hemagglutination was directly used to study the system' s biological amplification by SA /B.Biodistribution experiment was used to observe the toxicity of MF-A6-SA:B-tTF.RESULTS MF-A6-SA and B-tTF were successfully prepared.MF-A6-SA:B-tTF system could activate FX,inducing the blood coagulating cascade powerfully.MF-A6-SA:B-tTF could be accumulated to the desired target area with targeting and induce thrombosis in tumor blood vessels in vitro and in vivo.CONCLUSION The double targeting tumor vessels system MF-A6-SA:B-tTF maybe provide a basis for developing the tumor blood vessels targeting therapy.国家自然科学基金资助项目(30973485;81172970); 国家级大学生创新性实验项目(201210384134

第十八届美国理论与应用力学大会总结

1会议概况2018年6月5—9日,第18届美国理论与应用力学大会(18th U.S. National Congress of Theoretical and Applied Mechanics, USNCTAM2018)在美国芝加哥召开.本次大会由美国力学国家委员会和中国力学学会联合主办,旨在探讨和交流近四年世界范围内在理论和应用力学领域的基础研究、创新技术的最新进展,吸引了来自世界各地的近千名专家学

Ion exchange solid phase extraction Combined with HPLC to test melamine in milk

本文以混合型阳离子(MCX)固相萃取(SPE)小柱分离富集了牛奶提取液中的三聚氰胺,优化了固相萃取条件,复杂基质被有效去除,应用高效液相色谱(HPlC)法成功实现牛奶中三聚氰胺的检测,加标回收率接近90%。In this paper,MCX-SPE column was used to separate and enrich melamine from Milk,the situation of solid phase extraction was optimized,complex matrix was dislodged efficiently,Melamine in milk was detected successfully by the way of HPLC,recovery rate was about to90%.厦门市科技计划项目(3502Z20110018)资

Dynamic path planning of multi-rotor unmanned aerial vehicle in indoor complex environment

针对多旋翼无人机在室内复杂环境下的动态路径规划问题,提出了一种基于高度降维空间环境模型的无记忆回归A*算法.首先,提出了一种高度降维的空间环境建模方法,将三维空间降到二维,降低了环境模型的复杂度,提高了规划效率.在环境建模的基础上,提出了以全局路径规划结果为基础进行局部动态搜索的思路,并设计了无记忆回归A*算法,即首先使用传统A*算法进行全局路径规划,参考全局规划结果,利用无记忆回归A*算法对动态障碍物进行避障,避障完成后回归到全局规划路径上.最后利用仿真实验验证了所提方法的有效性.仿真结果表明,在指定环境下所提方法的路径规划时间和路径规划长度较无记忆A*算法更短,两项指标分别提升了13.8％和41.6％.</p

An Improved UAV Path Planning Environment Modeling Method

三维环境建模是无人机路径规划研究中的基础问题,传统栅格法在构建高精度环境时,栅格数会呈指数级增长,无法保证规划方法的实时性和有效性.针对传统栅格法存在的上述问题,提出一种高度降维的三维环境建模方法.首先采用传统栅格法分割三维空间;然后构建一个包含无人机起始点与目标终点的平面,对比该平面与障碍物的高度关系,忽略低于无人机飞行高度的障碍物;接着再次采用传统栅格法分割该平面,并将其作为无人机轨迹规划平面,实现对环境模型降维的目的;最后,在仿真实验中将A~*算法作为高度降维三维环境下的路径规划方法,并通过与传统栅格法对比分析,得出高度降维三建模方法既能够满足环境模型精度要求又可以提高规划算法的处理效率.</p