Design and Implementation of Yingjisha County Hospital Information System

随着社会的发展，人们对健康越来越关注，医院的业务不断增长，处理越来越复杂，简单的人工经营管理，已无法满足医院的需要，成为医院发展的瓶颈。传统的手工操作模式，病人帐目繁杂，病人查帐困难，病区和药房的药品浪费现象严重且无法追踪，人工传送各种记帐单容易漏、错帐，人工划价收费差错难以避免。因此，如何提高服务水平、提高工作效率，成为迫待解决的问题。医院管理信息化不仅能提高医务人员的工作效率和医疗水平，而且能提高医院的服务质量和管理水平,医院对管理信息系统有着强烈的需求。开发英吉沙县人民医院管理信息系统(HIS)的目标就是立足医院应用实际，着眼医院未来发展，以强化医院管理，提高医疗质量，方便患者就医和查询...With the development of the society, health has become an ever more important issue. Hospital business is growing increasingly complex, so simple manual operation and management, as a bottleneck, has been unable to meet the needs of the hospital. The problematic traditional manual operation mode includes difficulties in checking patient accounts, untraceable waste in ward and pharmacy medicines, p...学位：工程硕士院系专业：软件学院_工程硕士(软件工程)学号：X201023047

关联企业认定的国际比较与借鉴

关联企业认定，是转让定价税制的起点，虽然在实践中各个国家的具体作法可能有所不同，但大都把认定企业间是否存在关联关系作为对关联企业业务往来进行调整的前提。《联合国范本》和《经合组织范本》都把管理、控制和资本作为认定关联企业的依据，在这两个范本的基础上，..

Characteristics of PCBs in a Capacitor Storage Site and an Industrial Brownfield

研究了四川资阳机车厂废弃电力电容器封存点与旧工业场地土壤与降尘中28种多氯联苯(PCbS)的污染水平与组成特征.电容器封存山洞未封闭洞口处土壤中PCbS含量最高,28种PCbS的总含量(ΣPCbS)达227 502 ng.g-1,铸铁车间窗台降尘中也有高残留的PCbS,ΣPCbS在10μg.g-1以上,封存点和铸铁车间样品中PCbS单体含量之间均存在显著的正相关关系(P<0.01).高污染样品中PCbS的同族体分布均以四氯代PCbS为最高,其次为三氯代PCbS和五氯代PCbS.与封存点土壤相比,铸铁车间样品中高氯代PCbS的贡献更大.12种类二英PCbS的毒性当量(TEQ)介于75.43~24 027 Pg.g-1之间,远大于电子垃圾拆解区土壤,但普遍都以PCb126的毒性当量贡献占绝对优势.The levels and congener patterns of 28 PCBs compounds were investigated in soil and dust fallout collected in a capacitor storage site and an industrial brownfield,respectively in Sichuan Ziyang Locomotive Factory.The highest concentration of the total PCBs(PCBs=227 502 ng·g-1) was found in soil collected from the front gate(unsealed) of the capacitor storage tunnel.Very high levels of PCBs,exceed 10 μg·g-1,were also found in the dust collected from the window sill of an iron foundry.There were significant positive correlations(P<0.01) among PCB congener concentration in the storage site and the iron foundry samples.The major contribution to the total content of PCBs in the high contaminated samples was tetrachlorinated biphenyls,followed by tri-and penta-chlorinated biphenyls.Hexa-and higher chlorinated biphenyls contributed more to PCBs in the iron foundry than those in the storage site.The total toxicity equivalents(TEQ) of 12 dioxin-like congeners varied in the range of 75.43-24 027 pg·g-1 and were much higher than those in soils of e-waste recycling sites.However,PCB126 contribute the most to the TEQ in most cases.国家自然科学基金项目(40603020);福建省自然科学基金计划项目(2009J05106

Preparation and in vitro evaluation of chitosan microspheres containing matrine

目的:以壳聚糖为囊材制备苦参碱结肠靶向给药微球及评价其体外释药情况。方法:用乳化化学交联法制备微球,以微球的粒径分布百分数、载药量及包封率为优化指标对影响微球制备的主要因素用正交试验设计优化制备条件;并对最佳制备工艺制得的微球进行3种不同递质(人工胃液、人工肠液及大鼠结肠液)中的体外释放度评价。结果:制得的苦参碱壳聚糖微球在电镜下,球形表面圆整,粒径分布适宜,微球平均粒径为(68.3±2.7)μm,平均载药量为(16.0±0.5)%,平均包封率为(66.3±4.2)%。苦参碱壳聚糖微球在人工胃液中2h不释药;在人工肠液中4h内释放不到1%,96h释药不到10%;在含大鼠结肠内容物的磷酸盐缓冲液(pH6.8)中4h释放10%左右,36h释药近50%,此后释药趋于缓慢,96h释药近80%。结论:苦参碱壳聚糖微球几乎不在上消化道释药,而是在结肠靶向释药。OBJECTIVE To preparate the chitosan microspheres containing matrine for the colon-specific drug delivery and evaluate its release in vitro.METHODS The chitosan microspheres containing matrine were prepared by emulsion-chemical crosslink technique.The better preparation procedure with respect to particles size distribution,embedding rate and drug loading were optimized by the orthogonal experimental design.In-vitro drug release were carried out in the artificial gastric,artificial intestinal and the phosphate buffered saline(pH(6.8)) containing rat colon contents.RESULTS The chitosan microspheres containing matrine was shown to have good spherical geometry,a smooth surface and suitable size distribution under scanning electron micrographs.Average diameter of microspheres was((68.3)±(2.7))μm,drug loading was((16.0)±(0.5))%,embedding rate ((66.3)±(4.2))%.Little release and a little release of matrine from the microspheres were observed in the artificial gastric juice and in the artificial intestinal juice,respectively.However,the release of matrine was markedly increased in the phosphate buffered saline(pH(6.8)) containing rat colon contents,which was near to 10%,50% and 80% at 4 h,36 h and 96 h,respectively.CONCLUSION These findings suggest that the chitosan microspheres containing matrine may be useful a dosage form for colon-specific drug delivery.甘肃省自然科学基金(编号ZS0001-A23-073-Y

Uncertainty Analysis of Gas/Particle Partitioning of Atmospheric Polycyclic Aromatic Hydrocarbons

于2010年8月10~14日用双层石英膜和双层聚氨酯泡沫(Puf)的方法采集并分析了厦门大学海洋楼顶大气中气态和颗粒态多环芳烃(PAHS),并采用标准误差传递方法对气/粒分配系数(kP)的不确定度进行了分析.测量结果显示,低分子量PAHS如萘、苊、二氢苊和芴在Puf吸附体系中的穿透能力最强,穿透率接近50%;如考虑第一层石英滤膜对气态萘、苊和二氢苊的吸附影响,则校正后的kP值比校正前相应的kP值低1个数量级以上.采用标准误差传递方法得到PAHS气/粒分配系数kP的不确定度,介于28.14%~50.37%之间,且表现为易挥发和难挥发性PAHS的kP值皆具有较高的不确定度,而半挥发性PAHS的kP值的不确定度则较小.kP值的不确定度来源分析显示,气态PAHS浓度的不确定度的影响最大(方差贡献均值=77.9%),其次为颗粒态PAHS浓度的不确定度(方差贡献均值=22.0%),大气颗粒物浓度的不确定度影响最小(方差贡献均值=0.1%).因此,选择合适的采样系统以获取更加准确的气态PAHS的浓度,是提高PAHS气/粒分配系数准确度的关键.During the period from August 10,2010 through August 14,2010,particle and gas phase PAHs were collected and analyzed using double filters plus PUFs(Poly Urethane Foam) sampling system,and the uncertainties of gas/particle partitioning coefficients of PAHs were investigated using the propagation of errors formulas.The results showed that low-molecular weight PAHs such as naphthalene,acenaphthylene,acenaphthene and fluorene possessed the strong breakthrough capacity with the breakthrough rates close to 50% in double PUF cartridges.The corrected Kp values based on the sorption of PAHs to the primary filter were more than an order of magnitude higher than those without sorption correction for naphthalene,acenaphthylene and acenaphthene.The uncertainties for all the 19 PAHs ranged from 28.14% to 50.37% based on the standard error propagation formulas,with higher values for volatile and involatile PAHs and lower values for semi-volatile PAHs.The results also showed that the uncertainties of Kp were mainly contributed from the measurements of particle(average variance contribution was 77.9%) and gas(average variance contribution was 22.0%) phase PAHs while the contributions of total suspended particle were ignorable.Thus,getting more accurate data for gaseous PAHs using an appropriate sampling system is the key to increase the accuracy of gas/particle partitioning coefficients of PAHs.国家自然科学基金项目(40971257);环保公益性行业科研专项项目(201009004);国家海洋局近海海域生态环境重点实验室开放基金项目(200911

基于生物质谱技术的磷酰化修饰策略在多肽测序中的应用

该文建立了一种利用磷酰化修饰结合电喷雾质谱(ESI-Q-TOF)测定多肽氨基酸序列的有效方法。利用Atherton-Todd反应,以二丙基亚磷酰酯(DPP)为磷酰化试剂,应用生物质谱技术,对磷酰化修饰后的5种模型肽的磷酰化反应情况进行了系统研究,考察了磷酰化肽的二级质谱特征,并与未经磷酰化反应的肽的二级质谱特征对比。结果表明,经过磷酰化修饰后,肽的二级质谱中的a1离子信号强度明显增加,可以准确鉴定其N端氨基酸;b系列离子信息完整,信号强度增强,使得多肽C ID测序的谱图简单、清晰,有利于肽的氨基酸序列的测定;赖氨酸(K,128.10 u)和谷氨酰胺(Q,128.13 u)两种氨基酸质荷比相近,由于二者磷酰化修饰后的差异性,使其得到准确区分。经过5种已知氨基酸序列的模型肽的磷酰化后结合质谱技术进行氨基酸序列测定验证,结果表明该方法简单、快速、准确,提高了利用质谱技术进行多肽测序的准确度和灵敏度,可为蛋白质组学研究提供有效的技术手段

采用茂金属催化剂制备乙烯-1-辛烯共聚物及其性能研究

采用自制单茂金属催化剂MXC,经Al（i-Bu）3和[Ph3C]+[B（C6F5）4]-活化后对乙烯和1-辛烯进行了催化共聚,利用核磁共振碳谱(13C-NMR)、凝胶渗透色谱（GPC）、差示扫描量热法（DSC）考察了聚合条件对催化剂催化性能的影响,对比了共聚物样品以及进口韩国SK公司的聚烯烃弹性体（POE）产品。结果表明:共聚物样品与SK公司的POE产品在13C-NMR中有相似的吸收峰,组成及聚集态结构相近;随催化剂Al/Ti比（摩尔比,下同）减小,催化活性增加,共聚物的重均相对分子质量（■w）先减小后增大;聚合温度从90℃升高至130℃,催化活性降低,共聚物的相对分子质量减小,相对分子质量分布指数（PDI）变宽;当Al/Ti比为300时,共聚物■w由24.36×104降至9.87×104;当Al/Ti比为150,聚合温度为110℃时,催化活性达到11.77×106g/（mol·h）,共聚物■w,PDI,熔融温度、结晶度依次为10.05×104, 3.14, 76.95℃, 2.27%,1-辛烯插入率达到13.2%

厦门市某医院体检人群中有机氯农药暴露与胆石症发病的关联性研究

目的探讨厦门市第二医院体检人群中有机氯农药暴露与胆结石发生的关联及其发病危险因素。方法收集2015年2月-8月在医院健康体检人群中经B超确诊的新发胆囊结石患者100例,以同期参加体检的非胆囊结石者为对照,进行1∶2配比的病例对照研究。进行流行病学调查,采用气相色谱联用电子捕获器检测研究对象外周血中有机氯农药水平。应用多因素条件Logistic回归模型分析有机氯农药与胆囊结石发病的关系。结果病例组血清中α-HCH残留水平高于对照组,差异有统计学意义;Logistic回归分析非酒精性脂肪肝、2型糖尿病、血清α-HCH含量增高可能增加胆结石的患病危险,OR值及95%CI分别为5.134(1.952~13.502)、4.754(1.849~12.220)和1.357(1.094~1.854)。结论环境有机氯农药暴露可能是胆囊结石病发生的危险因素。厦门市科技计划项目(3502Z20163006)；厦门市集美区科技计划项目(20142C01)；厦门大学校长基金(20720152012)

ST段抬高型急性心肌梗死院前溶栓治疗中国专家共识

急性心肌梗死仍然严重威胁我国人民健康,在我国广大城乡地区,形势更为严峻[1,2]。及时救治急性心肌梗死患者,降低死亡率和保护心脏功能刻不容缓。鉴于我国的实际情况,院前溶栓治疗在大城市以外的城乡地区具有重要意义。为此,中国医师协会胸痛专业委员会及中国医学救援协会心血管急救分会专门组织有关专家制订了本共识,旨在帮助院前医疗急救人员对急性心肌梗死患者选择最佳