40 research outputs found
艾纳香油通过NF-κB非经典信号影响花生四烯酸代谢缓解LPS所致巨噬细胞的炎症反应
目的本文旨在探讨艾纳香油(BBO)通过核转录因子κB(NF-κB)非经典通路影响花生四烯酸(AA)代谢通路发挥抗炎作用。方法采用豚鼠离体回肠法检测BBO对慢反应物质(SRS-A)生成的影响,ELISA法检测BBO对脂多糖(LPS) 诱导巨噬细胞前列腺素E2(PGE2)及白三烯 B4(LTB4)产生的影响,qRT-PCR检测BBO对LPS诱导巨噬细胞COX-2、5-LOX、FLAP和RelB表达的影响,Western blot检测BBO对NF-κB非经典通路蛋白肿瘤坏死因子受体作用因子3(TRAF3)、肿瘤坏死因子受体作用因子2(TRAF2)、NF-κB 诱导激酶(NIK)、p100和RelB浓度的影响。结果在1mg·mL-1的BBO药物浓度下减弱了豚鼠回肠的收缩张力(P<0.001),对SRS-A的生成抑制率达到65.34%;与LPS模型组相比,BBO在40-80 μg· mL-1浓度下降低AA代谢通路中PGE2(P<0.05)和LTB4(P<0.05)的浓度,降低COX-2(P<0.05)、5-LOX(P<0.05)和FLAP(P<0.05)的表达;此外,40-80 μg· mL-1浓度下BBO还降低LPS导致的NF-κB非经典通路中TRAF3(P<0.05)、TRAF2(P<0.05)和NIK(P<0.05)的浓度,进一步抑制p100蛋白的磷酸化(P<0.05),同时抑制转录因子RelB的表达(P<0.05)和RelB蛋白的水平(P<0.05),而BBO自身不引起这些基因与蛋白的变化。结论BBO可能通过抑制NF-κB非经典信号中调节蛋白TRAF3和TRAF2,转录因子RelB的浓度,造成NIK蛋白的诱导激酶作用受到抑制,进一步抑制了p100蛋白的磷酸化及其与转录因子RelB的结合,从而影响到下游AA通路中重要限速酶COX-2、5-LOX和 FLAP的表达与炎症介质PGE2和LTB4的水平发挥抗炎作用
中更新世晚期以来塞尔维亚北部&lt;bold&gt;Titel&lt;/bold&gt;黄土&lt;bold&gt;-&lt;/bold&gt;古土壤序列的岩石磁学特征与机制
Physical health care monitoring for people with serious mental illness
Background
Current guidance suggests that we should monitor the physical health of people with serious mental illness and there has been a significant financial investment over recent years to provide this.
Objectives
To assess the effectiveness of physical health monitoring as a means of reducing morbidity, mortality and reduction in quality of life in people with serious mental illness.
Search methods
We searched the Cochrane Schizophrenia Group Trials Register (October 2009) which is based on regular searches of CINAHL, EMBASE, MEDLINE and PsycINFO.
Selection criteria
All randomised or quasi-randomised clinical trials focusing on physical health monitoring versus standard care or comparing i) self monitoring vs monitoring by health care professional; ii) simple vs complex monitoring; iii) specific vs non-specific checks iv) once only vs regular checks or v) comparison of different guidance.
Data collection and analysis
The authors (GT, AC, SM) independently screened search results and identified three studies as possibly fulfilling the review's criteria. On examination, however, all three were subsequently excluded.
Main results
We did not identify any randomised trials which assessed the effectiveness of physical health monitoring in people with serious mental illness.
Authors' conclusions
There is no evidence from randomised trials to support current guidance and practice. Guidance and practice are based on expert consensus, clinical experience and good intentions rather than high quality evidenc
西安蓝田S_4古土壤剖面中针铁矿富集层与土壤古水分研究
利用野外调查与观察、电镜观察和X-射线衍射法,对西安市蓝田县白鹿塬东端安村北约1km的第四纪黄土-古土壤剖面(34°17'N, 109°32'E)中第4层古土壤(S_4)的铁锰结核样品进行了实验分析。整个S_4古土壤风化剖面厚度为5.6m,粘化层的厚度为1.5m,在S_4古土壤层下部5.0?5.6m深度范围发现了具有指示当时土壤水分含量、地下水富集、水分循环等作用的针铁矿(a-FeO(OH))与铁锰结核富集层。针铁矿呈褐黄色薄膜分布于土体表面。含针铁矿的铁锰结核呈黑褐色球形,电镜下主要呈颗粒状、球形和呈菊花形等形态。针铁矿和铁锰结核呈层分布在同一层位,形成于当时的地下水位附近。在铁锰结核样品中,针铁矿含量为0.9%~3.3%,粘土矿物伊利石含量为6.0% ~ 15.5%,高岭石含量为2% -5%,石英含量为61.1%~66.6%, 斜长石含量10% ~ 16.4%, 钾长石含量3.8%-6.0%。针铁矿与铁锰结核的发育和迁移深度指示,在西安蓝田安村附近S_4古土壤发育时期,年降水量至少为900mm,且重力水分布深度达到了5.6m,5.6m深度范围内的含水量大于25%,在针铁矿和铁锰结核发育层位,含水量接近饱和。当时土壤水分含量很充足,土壤水分平衡为正,有较多水分补给地下水,适于茂盛森林植被发育。研究显示,组成铁锰结核的物质成分来自S_4古土壤粘化层中高价铁锰氧化物迁移,并随着地下水位的升降而发生还原和氧化聚集形成。</p
pn结及其制备方法
本发明公开了一种pn结及其制备方法,该pn结包括n型Si半导体层和位于所述n型Si半导体层中部区域的p型SnO半导体层,其中,所述n型Si半导体层上设置有第一电极;所述p型SnO半导体层上设置有第二电极。本发明的pn结有明显的整流效应,可应用于发光二极管、太阳能电池、光电探测器、气敏传感器等半导体器件,扩大了氧化亚锡的应用范围
(111)A InP衬底上MOCVD外延InGaAsP的表面形貌和光学特性
为了研究(111)衬底的特性以及实现等边三角形微腔激光器,利用金属有机化学气相淀积(MOCVD)研究了(111)A InP衬底上InGaAsP外延层的表面形貌和光学特性。考虑到(111)A InP衬底的悬挂键密度比较低,在生长过程中有意提高了V/III比。通过扫描电子显微镜(SEM)和光荧光(PL)谱分别研究了外延层的表面形貌和光学特性。实验发现,表面形貌和光学特性随V/III比和温度的变化非常大。最佳V/IlI比和温度分别为400和625℃
