盾壳霉次生代谢活性成分研究进展

盾壳霉是世界性病原真菌核盘菌的主要拮抗真菌之一,具有控制温室和田间多种作物菌核病的潜力。本文对国内外盾壳霉次级代谢产物的结构类型及其活性以及相关生物合成研究进行综述,为进一步研究盾壳霉制剂提供依据。厦门市科技惠民计划基金项目(3502Z20154069

Evaluation technique of the loss of coastal ecosystem services caused by sea reclamation project with three methods

在分析填海工程对海洋环境影响的基础上,结合《海洋生态资本评估技术导则》(gb/T 28058-2011)综合构建了填海工程对海洋生态系统服务功能损耗评估指标体系。分别采用价值评估法、能值分析法和物种丰度经验公式法对生态损耗进行价值评估,以福鼎市塔下新建填海工程为分析对象进行了实证评估,生态系统服务价值总损失量分别为672.0万元·年–1、809.2万元·年–1和133.3万元·年–1。通过与国内相关研究成果进行比较,分析三种评估方法的可行性和适用性,以期在实际环境影响评价工作中将工程外部成本纳入项目经济损益分析,为海岸带经济可持续发展提供技术支撑。Based on the effects of marine environment caused by sea reclamation and Technical Directives for Marine Ecological Capital Assessment(GB/T 28058-2011), the indexes of the losses of coastal ecosystem services caused by sea reclamation were built.The lost value of sea reclamation was calculated with three methods including economic evaluation, emergy analysis and biodiversity experiential formula which were applied in the new sea reclamation in Taxia Fuding Fujian Province separately, and the total ecosystem lost value was 672.0×104yuan·a–1, 809.2×104yuan·a–1, and 133.3×104yuan·a–1 correspondingly.Compared with other relevant researches, the methods are expected to apply in EIA economic evaluation in order to consider external cost and to apply in coastal economic sustainable development.海洋渔业安全环境保障服务系统关键技术研究及示范应用(201205006

Dynamic Evolution of Regional Ecological Services Based on TM Remote Sensing

针对传统评估区域生态系统服务价值空间异质性的问题,本研究将TM遥感影像与价值评估法相结合,测算出针对研究区域的当量因子表,并建立了只需遥感影像数据即可快速并较为精准地动态计算区域生态系统服务价值的多元回归模型。文章以北京市永定河、厦门市和青海省不同尺度为例,对该方法评估区域生态系统服务价值的可行性和准确性进行了讨论,以期为生态综合管理提供定量化参考依据。This paper discussed the dynamic evaluating of regional ecological services with remote sensing technique,based on the comprehensive analysis the character of indexes method and currently equivalent method applying to regional ecological services.With the established method in the literature,it discussed the practical possibility for evaluation the temporal and special regional ecological services in Yongding River,Xiamen and Qinghai province.Compared with the traditional static indexes evaluation,our method discussed the possibility of dynamically evolutional evaluation,in order to provide reference of ecosystem management.北京市科学技术委员会“永定河生态修复目标体系研究”(D090409004009003);北京市生态学重点学科项

影响中晚期肝细胞肝癌手术切除预后的多因素分析

探讨影响中晚期肝细胞肝癌手术切除预后的因素。方法对130例中晚期大肝癌随访1～7年,采用单因素、多因素分析统计不同预后因素对患者生存率的影响。结果手术后1,3 ,5年生存率分别81.7%,24.3%,18.4%。单因素分析提示影响预后的因素为肝癌大小、是否早期复发、肝硬化情况、输血量;多因素分析提示肝癌大小、肿瘤早期复发是影响肝癌术后的预后因素。结论：中晚期肝癌手术切除预后仍不理想,重视围手术期处理,预防术后早期复发有望提高手术疗效 [英文摘要]Objective To study the prognostic factors in patients who received hepatectomy for large hepatocellular carcinoma(HCC). Methods 130 patients operated for large HCC were followed up for 1～7 years. Twenty possible factors were analyzed by Kaplan-Meier Log rank estimate. A multivariative survival analysis of these individal variable was undertaken using the cumulative survival rate by the computers COX proportional hazard. Result The overall cumulative survival rate at 1,3,5 years was 81.7%,24.3%,18.4% re..

Anti-resonance features of destructive quantum interference in single-molecule thiophene junctions achieved by electrochemical gating

基于单个有机分子来构筑电子器件为电子器件微型化提供潜在技术方案。本研究发展了可集成电化学门控的单分子电子器件测试芯片技术和科学仪器方法，在实验和理论两个层面对具有相消量子干涉效应的噻吩衍生物分子器件的电输运过程进行了电化学调控研究，从而首次在室温下实现了对单分子电子器件中量子干涉效应的反共振现象的直接观测和调控，为制备基于量子干涉效应的新型分子材料和器件提供了全新的设计思路和策略。该研究充分展示了电化学调控技术在信息材料和器件领域的重要应用潜力，也体现了我校固体表面物理化学国家重点实验室在电化学研究和科学仪器研发领域的技术积累，以及面向科学前沿开展交叉学科探索的研究特色。 该研究工作是在洪文晶教授、上海电力大学陈文博教授、英国兰卡斯特大学Colin Lambert教授指导下完成的。化学化工学院博士生白杰和李晓慧为论文的共同第一作者，刘俊扬副研究员、师佳副教授、研究生唐永翔、刘帅、黄晓娟、谭志冰和萨本栋微纳研究院的杨杨副教授等也参与了研究工作。田中群教授和毛秉伟教授为该工作提供了重要指导。【Abstract】Controlling the electrical conductance and in particular the occurrence of quantum interference in single-molecule junctions through gating effects, has potential for the realization of high-performance functional molecular devices. In this work, we used an electrochemically-gated, mechanically-controllable break junction technique to tune the electronic behaviour of thiophene-based molecular junctions that show destructive quantum interference (DQI) features. By varying the voltage applied to the electrochemical gate at room temperature, we reached a conductance minimum that provides direct evidence of charge transport controlled by an anti-resonance arising from DQI. Our molecular system enables conductance tuning close to two orders of magnitude within the non-faradaic potential region, which is significantly higher than that achieved with molecules not showing DQI. Our experimental results, interpreted using quantum transport theory, demonstrate that electrochemical gating is a promising strategy for obtaining improved in-situ control over the electrical performance of interference-based molecular devices.This research was supported by the National Key R&D Program of China (2017YFA0204902), National Natural Science Foundation of China (21722305, 21673195, 21503179, 21703188), the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, Natural Science Foundation of Shanghai (17ZR1447100), Science and Technology Commission of Shanghai Municipality (14DZ2261000), China Postdoctoral Science Foundation (2017M622060) for funding work in Xiamen. It was also supported by EU Horizon 2020 project QuIET under grant agreement no. 767187EC FP7 ITN ‘MOLESCO’ project no. 606728 and UK EPSRC grants EP/N017188/1 and EP/M014452/1 and Leverhulme Trust (Leverhulme Early Career Fellowships no. ECF-2017-186 and ECF-2018-375) for funding instrumentation used in Lancaster. It was also supported by Hungarian and Czech Academies of Sciences (P2015-107) and Hungarian Research Foundation (OTKA 112034) for funding instrumentation used in Hungary. The authors thank Z.-Q. Tian and B.-W. Mao, Xiamen University, for useful discussions. 该工作获得科技部国家重点研发计划课题（2017YFA0204902），国家自然科学基金委优秀青年科学基金等项目（21722305、21673195、21703188、21503179）以及中国博士后科学基金（2017M622060）等项目的资助，也得到了固体表面物理化学国家重点实验室、能源材料化学协同创新中心的支持

类泛素蛋白及其中文命名

泛素家族包括泛素及类泛素蛋白,约20种成员蛋白.近年来,泛素家族领域取得了迅猛发展,并已与生物学及医学研究的各个领域相互交叉.泛素家族介导的蛋白质降解和细胞自噬机制的发现分别于2004和2016年获得诺贝尔奖.但是,类泛素蛋白并没有统一规范的中文译名. 2018年4月9日在苏州召开的《泛素家族介导的蛋白质降解和细胞自噬》专著的编委会上,部分作者讨论了类泛素蛋白的中文命名问题,并在随后的\"泛素家族、自噬与疾病\"(Ubiquitinfamily,autophagy anddiseases)苏州会议上提出了类泛素蛋白中文翻译草案,此草案在参加该会议的国内学者及海外华人学者间取得了高度共识.冷泉港亚洲\"泛素家族、自噬与疾病\"苏州会议是由美国冷泉港实验室主办、两年一度、面向全球的英文会议.该会议在海内外华人学者中具有广泛影响,因此,参会华人学者的意见具有一定的代表性.本文介绍了10个类别的类泛素蛋白的中文命名,系统总结了它们的结构特点,并比较了参与各种类泛素化修饰的酶和它们的生物学功能.文章由45名从事该领域研究的专家合作撰写,其中包括中国工程院院士1名,相关学者4名,长江学者3名,国家杰出青年科学基金获得者18名和美国知名高校华人教授4名.他们绝大多数是参加编写即将由科学出版社出版的专著《泛素家族介导的蛋白质降解和细胞自噬》的专家