透明质酸修饰的聚(N‑异丙基丙烯酰胺‑丙烯酸)水凝胶及应用

本发明公开了一种透明质酸修饰的聚(N‑异丙基丙烯酰胺‑丙烯酸)水凝胶，首先采用RAFT聚合方法制备聚(N‑异丙基丙烯酰胺‑丙烯酸)水凝胶，然后将聚(N‑异丙基丙烯酰胺‑丙烯酸)水凝胶浸泡在水中，加入1‑(3‑二甲氨基丙基)‑3‑乙基碳二亚胺盐酸盐和N‑羟基丁二酰亚胺反应，最后加入带有肼基基团的透明质酸进行共价固定反应，得到具备较好细胞相容性的透明质酸修饰的聚(N‑异丙基丙烯酰胺‑丙烯酸)水凝胶，并公开该水凝胶在药物控制释放中的应用，本发明的产品在生物医用领域具有广泛的潜在应用前景

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies