The role of connective tissue metabolic processes in the development of pathological processes at inflammation of different intensity in parodontium

The objective. To study metabolic processes in connective tissue (CT) at different intensity of inflammation in parodontium. Materials and methods. The research is conducted on the sample of oxyproline, which is one of the indicators in the study of metabolic processes in the CT. This amino-acid presents in the blood in the free state, reflects the processes of collagen degradation in the form of protein-binding oxyproline and has no unambiguous interpretation. Results. At low intensity of the imflammation in the periodontium (stomatitis and alveolitis), the synthesis and collagen degradation are in relative equilibrium, and an increase in its intensity (gingivitis and especially periodontitis) leads to its violation. Conclusions. It has been established that the CT plays an important role in the development of pathological processes in periodontal tissues. The concentration of free and peptide-linked oxyproline in serum is higher in the groups of patients with more severe periodontal inflammation (periodontitis and gingivitis)

Erythrocytes and their value in pathogenesis of parodontium inflammatory diseases

Cheremisina V. F., Bereznyakova A. I. Erythrocytes and their value in pathogenesis of parodontium inflammatory diseases. Journal of Education, Health and Sport. 2019;9(4):611-617. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3240160 http://ojs.ukw.edu.pl/index.php/johs/article/view/7005 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.04.2019. Revised: 15.04.2019. Accepted: 29.04.2019. ERYTHROCYTES AND THEIR VALUE IN PATHOGENESIS OF PARODONTIUM INFLAMMATORY DISEASES V. F. Cheremisina, A. I. Bereznyakova National University of Pharmacy, Kharkiv, Ukraine; [email protected] Abstract The value of experimental animals (white rats) erythrocytes in pathogenesis of parodontium inflammatory disease was searched. The dynamics of Hb changes, erythrocytes number and hematocrit were surveyed. Periodontitis was moulded by special diet. When periodontitis developed oxidative stress and enhanced generation of reactive oxygen species were observed as well as changes in the number of erythrocytes, hemoglobin and erythrocyte indices. The latter were caused by membrane destructive processes in erythrocytes, decrease in their absolute number due to hemolysis, and changes in hematocrit due to blood redistribution. Key words: erythrocytes, hemoglobin, hematocrit, periodontitis

Role of calcium-phosphorus metabolism in periodontal tissue resorption in rats

In the article presented the results of the study of calcium-phosphorus metabolism in rats with alveolitis. The analysis of biochemical markers of bone turnover in the blood and urine of the animals revealed significant shifts calcium-phosphorus metabolism in rats with alveolitis and soft tissues involved in periodontal resorption. The content of calcitonin is not critical in the mechanisms of resorption of the periodontal soft tissues. A negative correlation relationship between the level of the ionized calcium content in blood serum calcitonin in rats with alveolitis

Thermodynamic Model of Ion-Exchange Process as Exemplified by Cerium Sorption from Multisalt Solutions

A complex heterogeneous process of ion exchange can be defined with an isotherm-isobar equation of the chemical reaction, which describes differential affinity between the process and its effect – the law of mass action. Ion exchange includes processes accompanied by changes in the charge of ions and functional groups caused by the passing of ionic bond into covalent one. Hence isotherm equations of ion exchange for such processes must differ from conventional stoichiometric equations, but they can be obtained by classical study approaches to ion exchange equilibrium. The paper describes a new thermodynamic model, based on linearization of mass action law, modified for the ion exchange equation. The application of this model allows to define stoichiometry of ion exchange and the shape of ions adsorbed by the solid phase of ion-exchange resins, as well as to estimate equilibrium constant and Gibbs free energy of the process. Comparative analysis has been carried out for the thermodynamic model of cerium sorption in the form of anionic complex with Trilon B from a multisalt solution with ionic strength of 1 mol/kg (NaNO3) under рН = 3 and temperature 298 K on a test sample of weak-base anion-exchange resin Cybber EV009. Experimental isotherm of the sorption has been obtained. Calculations of thermodynamic parameters have been performed using Langmuir, Freundlich, Dubinin – Radushkevich, Temkin and Flory – Huggins models, as well as thermodynamic model of linearized mass action law, proposed by the authors. Calculated values of the equilibrium constant and Gibbs energy – K = 9.0±0.5 and ΔrG0298 = –5.54±0.27 kJ/mol – characterize the sorption of EDTA cerate ions by ion-exchange resin. The shape of adsorbed ions has been defined in Stern-Helmholtz layer of CeTr, and total capacity of anion resin EV009 for EDTA cerate ions has been estimated as q∞ = 2.0±0.1 mol/kg

Sorption of rare earth coordination compounds

Rare earth elements (REEs) are valuable and strategically important in many high-technology areas, such as laser technology, pharmacy and metallurgy. The main methods of REE recovery are precipitation, extraction and sorption, in particular ion exchange using various sorbents, which allow to perform selective recovery and removal of associated components, as well as to separate rare earth metals with similar chemical properties. The paper examines recovery of ytterbium in the form of coordination compounds with Trilon B on weakly basic anion exchange resin D-403 from nitrate solutions. In order to estimate thermodynamic sorption parameters of ytterbium anionic complexes, ion exchange process was carried out from model solutions under constant ionic strength specified by NaNO3, optimal liquid to solid ratio, pH level, temperatures 298 and 343 K by variable concentrations method. Description of thermodynamic equilibrium was made using mass action law formulated for ion exchange equation and mathematically converted to linear form. Values of equilibrium constants, Gibbs free energy, enthalpy and entropy of the sorption process have been calculated. Basing on calculated values of Gibbs energy, a sorption series of complex REE ions with Trilon B was obtained over anion exchange resin D-403 from nitrate solutions at temperature 298 K. Sorption characteristics of anion exchange resin have been estimated: total capacity, limiting sorption of complex ions, total dynamic capacity and breakthrough dynamic capacity

O narzędziach i wynikach badań = About the tools and the results of the research

Mrozkowiak M., Bereznyakova A. I., Cheremisina V. F., Zukow W. O narzędziach i wynikach badań = About the tools and the results of the research. Journal of Education, Health and Sport. 2015;5(11):245-260. ISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.33965http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2811%29%3A245-260https://pbn.nauka.gov.pl/works/670087Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja.Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 25.09.2015. Revised 25.10.2015. Accepted: 10.11.2015. O narzędziach i wynikach badańAbout the tools and the results of the research M. Mrozkowiak1, А. И. Березнякова2, В. Ф. Черемисина2, W. Zukow1M. Mrozkowiak1, A. I. Bereznyakova2, V. F. Cheremisina2, W. Zukow1 1Uniwersytet Kazimierza Wielkiego, Bydgoszcz1Kazimierz Wielki University, Bydgoszcz2Национальный фармацевтический университет, г. Харьков2National University of Pharmacy, Kharkiv  Słowa kluczowe: postawa ciała, cechy krwi, narzędzia badawcze, wyniki badań.Keywords: posture, blood, research tools, the results of the research. Streszczenie Pomimo wielu opracowanych koncepcji oceny postawy ciała, prześwietlenie promieniami Roentgena jest nadal metodą najbardziej popularną. Ortopedzi, porównując różne metody leczenia, mają tendencję do formułowania wniosków tylko na podstawie zdjęcia rtg. Należy zauważyć, że badanie z wykorzystaniem mory projekcyjnej nie zastępuje diagnostyki postawy rtg. Bowiem oparta jest na innej zasadzie działania, wykorzystuje między innymi analizę układu kostnego, a zalecana pozycja podczas zdjęcia nie rejestruje postawy habitualnej.Problemy podobnej natury występują także w pomiarze wielkości cech krwi. Dla zachowania wysokiej standaryzacji pobrań i analizy materiału należy zadbać aby: pobór krwi nastąpił przez tą samą osobę i w tych samych warunkach socjalnych, z tego samego odcinka żyły, w tym samym ustawieniem kończyny górnej o rozluźniony mięśniach, strzykawką tej samej firmy, zastosowano te same warunki i metodę analizy krwi. Nie bez znaczenia jest także czas po jakim nastąpiła analiza cech krwi, stosowana procedura analizy i producent stosowanych odczynników. W związku z tym, w ocenie wielkości cech krwi należy brać pod uwagę podawane przez laboratorium analityczne obowiązujące wielkości referencyjne. Abstract Despite the many developed the concept of evaluation of the body posture, overexposure x-ray is still the most popular method. Orthopedists, comparing the various methods of treatment, they tend to formulate proposals on the basis of x-ray pictures. It should be noted that a study using projection moire does not replace diagnostic x-ray attitude. Because it is based on a different principle, inter alia, an analysis of the skeletal system, and recommended items during the photos does not record the attitude of habitual.            Problems of a similar nature occur also in measuring the size of blood characteristics. To preserve the high standardisation of donations and material analysis, care should be taken to: collection of blood followed by the same person and the same social conditions, with the same section of the vein at the same setting of the upper extremity of relaxed muscles, inject the same company, the same conditions and method of analysis of the blood. Not without significance is also the time that there had been an analysis of the characteristics of the blood analysis procedure used and the manufacturer used reagents. Therefore, in assessing the size of the blood characteristics have to be taken into account given by the analytical laboratory, the existing benchmarks

Magnetic Resonance (MR) rectography in diagnostics of small-size rectal neoplasms

Purpose was the assessment of diagnostic efficiency of MR-rectography in diagnostics of small-size rectal neoplasms. 12 patients with polyps and small tumors of a rectum are examined, the size of detected neoplasms varied in the range 3-18 mm. Native MRI and MRI with retrograde contrasting by ultrasonic gel was carried out. Results of MRI are compared with results of videocolonoscopy. Sensitivity of native MRT was 24%, MR- rectography was 88%. MR-rectography can be used in diagnostics of small-size rectal neoplasms

A criterion of colorectal cancer diagnosis using exosome fluorescence-lifetime imaging

This study was aimed to investigate the applicability of the exosome fluorescence-lifetime imaging microscopy (FLIM) for colorectal cancer (CRC) diagnosis. Differential ultra-centrifugation was used to extract exosomes from the blood plasma of 11 patients with colon polyps (CPs) and 13 patients with CRC at the T2-4, N0-3, and M0-1 stages. Analysis was performed using a two-photon FLIM device. In total, 165 and 195 FLIM images were recorded for the CP and CCR patient groups, respectively. Two classes of exosomes differentiated by autofluorescence average lifetime tm were discovered in the samples. The first class of exosomes with tm = (0.21 0.06) ns was mostly found in samples from CRC patients. The second class with tm = (0.43 0.19) ns was mostly found in samples from CP patients. The relative number of “CRC-associated” exosomes Nch in the FLIM dataset was shown to be very small for the CP patient group and large for the CRC patient group. This difference was statistically significant. Therefore, the suggested CRS diagnostics criterion can be as follows. If Nch > 0.5, the probability of CRC is high. If Nch < 0.3, the probability of CRC is low

Оценка уровня жизни населения Тамбовской области

Purpose of the study. To assess the standard of living of the population of the Tambov region through statistical methods.Materials and methods. The study used the methods of analysis of the composition and structure, the calculation of absolute and relative indicators of dynamics, average values, comparative analysis, graphical method of analysis, as well as the general theoretical method of analysis of Russian and foreign literary sources. The main information sources for the study were the data from the official website of the Federal State Statistics Service, its territorial office in the Tambov region, as well as the data from the Unified Interdepartmental Statistical Information System. In addition, the works of such authors as R. Zhukov, M. Malkina, N. Zotkina, S. Ignatova, E. Sadovaya, V. Sautkina and others were analyzed.Results. The main results of the study include the following:– Over 6 years (from 2012 to 2017) in the Tambov region, the largest share of the population, namely 23.0% in 2012 and 27.1% in 2017, had an average per capita cash income of 15 to 25 thousand rubles; – In 2012, the average per capita income of a resident of the studied region was most often met for 16,381.5 rubles (fashion value), and in 2017 – 18,561.0 rubles;– In the Tambov region from 2012 to 2017, the average absolute deviation of the studied indicator from the average in Russia is 5434.1 rubles;– The purchasing power of money incomes of the population has decreased for almost all food and non-food products; – The main sources of monetary incomes of the population of the Tambov region in 2017 are the wages of employees and receipts from social benefits (their share in the income structure is more than 20%);– The structure of the budget expenditures of the population of the Tambov region in 2017 is as follows: the purchase of goods and payment for services amounted to 77.5; mandatory payments and fees - 7.7%; real estate purchase - 1.9%; growth of financial assets - 12.9%;– The size of the average per capita monetary income of the population is inversely related to the unemployment rate of the region.Conclusion. In general, summing up the study, we can draw the following conclusion. For a number of indicators characterizing the standard of living of the population of the Tambov region, there is a positive trend, for example, an increase in the average per capita cash income of the population. Another positive trend was found: an inverse relationship between the unemployment rate and average per capita income. However, despite this, in our region it is lower than the average in Russia. Half of the population has incomes less than 17,730 rubles, and the most common income is in the amount of 18,561 rubles, which is significantly lower than the average for the Tambov region.Цель исследования. Дать оценку уровню жизни населения Тамбовской области посредством статистических методов.Материалы и методы. В исследовании были использованы методы анализа состава и структуры, расчет абсолютных и относительных показателей динамики, средних величин, сравнительный анализ, графический метод анализа, а также общетеоретический метод анализа российских и зарубежных литературных источников. Основными информационными источниками для проведения исследования стали данные официального сайта Федеральной службы государственной статистики, ее территориального органа по Тамбовской области, а также данные Единой межведомственной информационно-статистической системы. Кроме того, были проанализированы труды таких авторов, как Жуков Р.А., Малкина М.Ю., Зоткина Н.С., Игнатова С.В., Садовая Е.С., Сауткина В.А. и др.Результаты. Основными результатами исследования можно назвать следующие:– На протяжении 6 лет (с 2012 по 2017 годы) в Тамбовской области наибольшая доля населения, а именно 23,0% в 2012 году и 27,1% в 2017 году, имели среднедушевой денежный доход в размере от 15 до 25 тыс. руб.– В 2012 году чаще всего встречался среднедушевой доход жителя исследуемого региона в размере 16381,5 руб. (значение моды), а в 2017 году – 18561,0 руб.– В Тамбовской области с 2012 по 2017 годы среднее абсолютное отклонение исследуемого показателя от среднего по России составляет – 5434,1 руб.– Покупательная способность денежных доходов населения снизилась практически на все продукты питания и непродовольственные товары.– Основные источники денежных доходов населения Тамбовской области в 2017 – это заработная плата наемных работников и поступления за счет социальных выплат (их доля в структуре доходов более 20%).– Структура расходной части бюджета населения Тамбовской области в 2017 году имеет следующий вид: приобретение товаров и оплата услуг составило 77,5; обязательные платежи и взносы – 7,7%; приобретение недвижимости – 1,9%; прирост финансовых активов – 12,9%.– Размер среднедушевого денежного дохода населения находится в обратной зависимости от уровня безработицы региона.Заключение. В целом, подводя итог исследованию, можно сделать следующий вывод. По ряду показателей, характеризующих уровень жизни населения Тамбовской области, наблюдается положительная тенденция, например, рост среднедушевых денежных доходов населения. Была обнаружена еще одна положительная тенденция: обратная зависимость уровня безработицы и доходов в среднем на душу населения. Но, не смотря на это, в нашем регионе он ниже, чем в среднем по России. Половина населения имеет доходы меньше 17730 руб., а также наиболее распространен доход в размере 18561 руб., что значительно ниже среднего по Тамбовской области