The association of adiponectin polymorphisms with food intake

Obesity has become one of the most common diseases in the world and represents a serious public-health problem. The aim of this cross-sectional study was to examine the influence of dietary factors on the association between two adiponectin SNPs and some biochemical parameters. Ninety-six, healthy nonsmoking adults aged 25-49 participated in this cross sectional study. Two single nucleotide polymorphisms (SNPs) at adiponectin (ADIPOQ) gene, +276G>T and +45T>G were genotyped in all participants. Additionally, the participants underwent standard anthropomorphological measurements of body composition, blood pressure measurements, dietary intake assessment and fasting serological measurements of glucose, insulin, triacylglycerol’s, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, and C-reactive protein. Based on measured biometrical parameters a statistical analysis was performed for assessing dietary intake. The SNP276G<T and SNP45T<G of the ADIPOQ gene are associated with different responses of total cholesterol, HDL cholesterol and C-reactive protein (CRP) to low or high intake of polyunsaturated fatty acid, saturated fatty acid and omega-3 fatty acid

Early warning signs for metabolic syndrome

Chemometrics is the field of science covering the development and application of mathematical and statistical methods to identify important chemical information. It is indispensable in the evaluation of experimental results and suitable for exploration of large data sets. Within the Trans2Care project we intend to apply chemometrics methods in several areas related to the problems explored by the Project partners. In particular we shall investigate transmembrane protein transport mechanism with data-driven modelling approach and also applying biomolecular simulations. We’ll combine our theoretical approach with experimental data provided by the Project partners, which will contribute to a better exploration of the available information in biomolecular systems studied, in the research of neurodegenerative diseases, in cardiovascular and pathohistological research. It will also intensify the collaboration, mobility of researchers and exchange of knowledge between partners

On the Elementary Mechanical Effects of the Space-Time-Symmetry Relativity

This paper is an addendum to the article “On the Evolution of Approaches to the Space- Time Symmetry”, Natural Science, Vol. 10, No. 3, pp. 81-84, 2018. The analysis is based on the Galileo’s postulate that all inertial reference frames are equal. The postulate results immediately in the absolute speed limit, which is identical for all bodies in all reference frames. Two kinds of elementary particles are admitted: unhurried and restless ones (ex-emplified, accordingly, with electrons and photons). Any particle may be treated as wave packet, the particle mass and momentum depending on the reference frame. Thus, space-time-symmetry is the natural background for the relativistic and quantum theories

Clinical and neurophysiological changes in patients with pineal region expansions [Kliničke i neurofiziološke značajke u bolesnika s ekspanzivnim tvorbama pinealne regije]

In the last 20 years neurological and neurosurgical follow up of our patients with pineal region expansions (118 patients) pointed to certain clinical and neurophysiological regularities. We performed retrospective study which included 84 patients with pineal region expansions in the period from 1992 to 2009. The study included 55 women and 29 men, mean age 30.08 +/- 13.93 years, with positive brain magnetic resonance imaging (MRI)--70 patients (83.4%) had simple pineal gland cysts, and 14 patients (16.67%) had expansive process in pineal region with compressive effect. All patients had headache, while 32 patients (38%) had epileptic phenomena--primary generalized seizures. Patients had common electroencephalography (EEG) pattern with paroxysmal discharges of 3Hz (or more than 3 Hz) spike-and-wave complexes. Operation with supracerebellar infratentorial approach was performed in 70 patients. In most of our patients indication for the operation was established based on the size of the cyst (15 mm or more), with the signs of compression on the quadrigeminal plate and compression of the surrounding veins, which could result in seizures and EEG changes verified in our group of patients. Pathohistological analysis revealed pineocytomas in 11 cases (15.71%), pinealoblastomas in 2 cases (2.86%), one case of teratoma (1.43%), while 56 patients had pineal gland cysts (80%). Following surgery clinical condition improved in all patients--patients became seizure-free and headaches significantly decreased. Other symptoms including diplopiae, nausea, vomiting, vertigo as well as blurred vision also disappeared. There were no complications after surgical procedures. This study points to often appearance of seizures that clinically and neurophysiologically present as primary generalized epilepsy in patients with pineal region expansions. Our hypotheses are that mass effect on the surrounding veins that affects normal perfusion, compressive effect on the quadrigeminal plate and the aqueduct of the midbrain, hemosiderin deposists, as well as secretion disturbances of anticonvulsive agent melatonin can be involved in the pathogenesis of seizures. We suggest to perform high resolution brain MRI with special demonstration of pineal region in all young patients that have seizures and specific EEG changes