Toward a Biblical View of Collective Responsibility for the Seventh-day Adventist Church in the Twenty-first Century

The notion of collective responsibility is an issue that is not very popular in the postmodern society. However, the idea of collective responsibility can be found in the Bible. This thesis examines philosophical, ethical, and biblical sources on the subject. The biblical evidence focuses on examining Josh 7 and Ezek 18, as well as some of the New Testament contributions to the topic. The relationship between collective responsibility, collective personality, and collective punishment is discussed. The thesis acknowledges collective responsibility as a valid biblical doctrine and proposes its application for church members, leaders, and the decision-making process in the Seventh-day Adventist church in the twenty-first century

Analysis and Design of Implementation of Websites

Import 05/08/2014Práce se zabývá analýzou, návrhem a implementací webových stránek pro obec Nový Hrozenkov. Zaměřuje se na požadavky stanovené legislativou České republiky, přístupnost webových stránek, WCAG pravidla a proces tvorby šablony pro WordPress.The bachelor´s thesis deals with analysis, proposal and implementation of web pages for the municipality Novy Hrozenkov. Focuses on legal restrictions given by the law of Czech republic, web accessibility, WCAG rules and process of creating template for WordPress.155 - Katedra aplikované informatikyvýborn

Overview of Clinical Cytogenetics in Mammalian Livestock

Whilst balanced chromosomal aberrations, often do not present phenotypically in carriers they are known to cause reduced fertility in livestock. Mammalian livestock are of vital economic importance with pigs and cattle providing over 50% of consumed meat globally. Furthermore, cattle are the main providers of a dairy industry worth over $750 billion. In an industry where a small population of high value males (boars/bulls/rams) are used in the vast majority of artificial insemination, the potential financial loss caused by a sub-fertile male could be considerable especially if aberrations are passed down to offspring. This thesis reports on recent data collected using novel Multiprobe® Fluorescent in situ Hybridisation (FISH) devices on porcine and bovine blood samples for robust systematic screening of chromosomal abnormalities. There is significant potential for widespread use of these devices as they offer a more sensitive and accurate approach than given with previous methods such as karyotyping. Using this method 775 pigs and 3 cattle were screened. We reported that 14.5% of screened pigs presented with 8 different types of abnormality which is a far higher prevalence then previously recorded by karyotyping. 2 of 3 cattle samples also presented with an abnormality. Our results showed that poor quality of many samples received in 2021-2022 due to delivery complications meant that translocations were undetectable using a standard karyotype. However, FISH works well even with sub-optimal sample quality meaning time and money would not be lost in the repeating of sample collection and delivery. Multiprobe® device analysis is a comprehensive, robust system in bovine and porcine samples therefore, there is potential for it to work in other livestock species. This thesis reports on the use of probes selected for the bovine Multiprobe® device to test the extend they will bind to ovine (sheep) chromosomes to potentially create a novel ovine Multiprobe® device

Уровень провоспалительных цитокинов внутриматочных смывов при гиперплазиях эндометрия

Проведено вивчення змін рівня прозапальних цитокінів ІЛ -1ß, ІЛ -6 та ФНП-α в маткових змивах у жінок з різними видами гіперплазій ендометрію. Встановлено, що формування гіперплазії ендометрію супроводжується активацією прозапальних цитокінів. Найбільш виражені зміни виявлені при комплексній гіперплазії ендометрію. Запальний процес в урогенітальної системі сприяє більш вираженому зростанню рівня цитокінів в маткових змивах. Оцінка вираженості змін в рівні цитокінів маткових змивів може використовуватися в якості додаткового критерію, що характеризує гіперплазії ендометрію, для оцінки формування запальних змін в ендометрії при його гіперплазії і для оцінки прогнозу перебігу гіперплазій.Levels of proinflammatory cytokines IL-1ß, IL-6 and TNF-α in uterine lavage fluid of women with different types of endometrial hyperplasia were studied. It is established that the formation of endometrial hyperplasia is associated with activation of proinflammatory cytokines. The most intensive changes were found in complex endometrial hyperplasia. Inflammation in the urogenital system leads to more intensive increase of cytokines level in the uterine washout. Investigation of changes in cytokines levels in uterine lavage fluid can be used as an additional criterion for characteristics of endometrial hyperplasia, to assess the formation of inflammatory changes in the endometrium and for prognosis of hyperplasia

Red Wine Polyphenols Prevent Endothelial Damage Induced by CCl 4 Administration

Summary It became evident in the present study that carbon tetrachloride (CCl 4 ), in addition to its known liver and renal toxicity, causes serious damage to endothelial cells. The preventive effect of red wine on cardiovascular diseases has been documented in a number of human population studies as well as in animal experimental models. In this study, the endothelium protective effect of polyphenolic compounds isolated from red wine was studied in rats administered 0.5 ml of CCl 4 /kg body weight intraperitoneally twice a week for 8 weeks. Endothelemia (endothelial cells/10 μl of plasma) was used as the marker of endothelial cell injury in vivo. Chronic CCl 4 treatment for 8 weeks lead to a 3-fold increase of free endothelial cells circulating in the blood when compared to the baseline values (2.5±0.3). Parallel oral administration of polyphenols 40 mg/kg/day significantly decreased the endothelemia. Polyphenolic compounds alone did not produce significant changes. Three weeks of spontaneous recovery after the 8-week treatment with CCl 4 did not lead to a marked decrease of endothelemia, but the administration of red wine polyphenols during the 3-week period significantly decreased free endothelial cells in the blood. It can be concluded that long-term administration of CCl 4 may serve as a useful experimental model of endothelial damage. The red wine polyphenolic compounds exert a powerful protective effect on endothelial cells from the injury caused by CCl 4 . This effect was documented by decreased endothelemia that corresponded to diminished endothelial cell swelling and detachment evaluated by histology of the vascular intima. The endothelium protective effect may be one of the key factors that contribute to the preventive action of red wine on cardiovascular diseases

Biplanar versus conventional two-dimensional ultrasound guidance for radial artery catheterisation

Background: Ultrasound guidance increases first-pass success rates and decreases the number of cannulation attempts and complications during radial artery catheterisation but it is debatable whether short-, long-, or oblique-axis imaging is superior for obtaining access. Three-dimensional (3D) biplanar ultrasound combines both short- and long-axis views with their respective benefits. This study aimed to determine whether biplanar imaging would improve the accuracy of radial artery catheterisation compared with conventional 2D imaging. Methods: This before-and-after trial included adult patients who required radial artery catheterisation for elective cardiothoracic surgery. The participating anaesthesiologists were experienced in 2D and biplanar ultrasound-guided vascular access. The primary endpoint was successful catheterisation in one skin break without withdrawals. Secondary endpoints were the numbers of punctures and withdrawals, scanning and procedure times, needle visibility, perceived mental effort of the operator, and posterior wall puncture or other mechanical complications. Results: From November 2021 until April 2022, 158 patients were included and analysed (2D=75, biplanar=83), with two failures to catheterise in each group. First-pass success without needle redirections was 58.7% in the 2D group and 60.2% in the biplanar group (difference=1.6%; 95% confidence interval [CI], –14.0%–17.1%; P=0.84), and first-pass success within one skin break was 77.3% in the 2D group vs 81.9% in the biplanar group (difference=4.6%; 95% CI, 8.1%–17.3%; P=0.473). None of the secondary endpoints differed significantly. Conclusions: Biplanar ultrasound guidance did not improve success rates nor other performance measures of radial artery catheterisation. The additional visual information acquired with biplanar imaging did not offer any benefit. Clinical trial registration: N9687 (Dutch Trial Register).</p