39 research outputs found

    Untraditional Solutions For The Usage Of Greenhouse Effect

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    The heat solar energy traditionally is used in greenhouses for ensuring optimal plant vegetation regime in our climatic conditions. Glass verandas built during last centuries at the south side of living houses and summer cottages are appreciated as original use of solar energy. Veranda as light and warm room was used for different household needs and also for social activities. Up-to-date materials and technologies proposes wide spectrum of innovative activities for greenhouses and conservatories. The variable amount of solar energy is possible to smooth out by using accumulation system. In the paper results from vegetable drying experiments are presented. In the research used products ā€“ carrots, dry matter of the product at the start 8.5%, chopped product ā€“ 9.9%, after desiccation ā€“ equilibrium moisture content 10 -11%. The experimental device placed in the room is simulating the processes, which would occur if we use greenhouse for product drying, accordingly making changes in the design of conventional greenhouses by separating drying section from growing section, supplying warm heated in the greenhouse upper layer air from the bottom by forcing it with axial ventilator, and accordingly choosing appropriate accumulation system for energy storage in case when outside air temperature drop occurs

    LASER DRILLING QUALITY OF VARIOUS MATERIALS DEPENDING ON THE LASER BEAM PARAMETERS

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    This research describes Nd:Yag laserbeam drilling in different material types. Experimental part was used to predict the effect of laser drilling parameters including laser beam power and defocusing. In this research was used two material types- aluminium and ceramic

    The right to claim for damages if one of the party located on the vessels: Jurisdiction and applicable law

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    The Masters thesis will resolve some important thesis for partiesā€™ rights to claim for damages if other party breach the contract or agreement. This work is divided into four main sections: first part International contracts sales of goods and its relation to contracts for the carriage of goods by sea; the second part the biggest emphasis will be to draw on the contracts for the carriage of goods by sea; and the third part will be concentrated to applicable law in disputes arising from loss or damage of cargo or delay; and the fourth applicable jurisdiction in disputes arising from international contracts for the carriage of goods by sea

    Population screening for hereditary and familial cancer syndromes in Valka district of Latvia

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    <p>Abstract</p> <p>Background</p> <p>The growing possibilities of cancer prevention and treatment as well as the increasing knowledge about hereditary cancers require proper identification of the persons at risk. The aim of this study was to test the outcome of population screening in the scientific and practical evaluation of hereditary cancer.</p> <p>Methods</p> <p>Population screening for hereditary cancer was carried out retrospectively in a geographic area of Latvia. Family cancer histories were collected from 18642 adults representing 76.6% of the population of this area. Hereditary cancer syndromes were diagnosed clinically. Molecular testing for <it>BRCA1 </it>founder mutations 300 T/G, 4153delA and 5382insC was conducted in 588 persons who reported at least one case of breast or ovary cancer among blood relatives.</p> <p>Results</p> <p>Clinically, 74 (0.40%; 95% confidence interval (CI): 0.32 - 0.50%) high-risk and 548 (2.94%, 95% CI: 2.71 - 3.19) moderate-risk hereditary cancer syndromes were detected covering wide cancer spectrum. All syndromes were characterised by high cancer frequency among blood relatives ranging 8.6 - 46.2% in contrast to spouse correlation of 2.5 - 3.6%. The mean age of cancer onset ranged 38.0 - 72.0 years in different syndromes. The <it>BRCA1 </it>gene mutations were identified in 10 (1.7%; 95% CI: 0.9 - 3.1%) probands. Families with established BRCA1 gene founder mutations were identified with the frequency 1:2663 clinically screened persons.</p> <p>Conclusions</p> <p>Population screening is a useful practical tool for the identification of persons belonging to families with high frequency of malignant tumours. The whole hereditary and familial cancer spectrum along with the age structure was identified adjusting follow-up guidelines. Another benefit of the population screening is the possibility to identify oncologically healthy persons belonging to hereditary and familial cancer families so that appropriate surveillance can be offered. Clinical diagnostics is appropriate for population screening purposes; molecular investigation provides additional information. In collaboration with family doctors, the screening is technically manageable as characterised by high compliance.</p

    Challenges in the management of a patient with Cowden syndrome: case report and literature review

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    We would like to present a patient with a classical phenotype of a rare disorder - Cowden syndrome, its diagnostics and management challenges. A breast surgeon has to be aware of this rare condition when treating a patient with breast manifestations of Cowden syndrome and has to refer the patient to a clinical geneticist for further evaluation. Sequencing of the PTEN gene showed the Asp24Gly mutation. According to the latest literature data, the lifetime risk of breast cancer for Cowden syndrome patients is 81% and surgery is a justified option to reduce the risk of breast cancer. Bilateral risk-reducing mastectomy with immediate reconstruction was performed to eliminate further risk of breast cancer. 3 years after the risk-reducing breast surgery the patient is satisfied with the outcome. This is to our best knowledge the first reported Cowden syndrome case with follow-up data after risk-reducing measures have been taken

    Canadian international economic relations

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    Diplomdarbā apskatÄ«ta Kanādas, kas ir augsti attÄ«stÄ«ta valsts, ekonomika, sākot ar ekonomikas vēsturi un beidzot ar mÅ«sdienu izaicinājumiem, kurus Eiropas SavienÄ«bas (ES) dalÄ«bvalstÄ«m un Kanādai rada 2016. gadā noslēgtais ES un Kanādas brÄ«vās tirdzniecÄ«bas lÄ«gums (CETA). Darba ievadā ir dots Kanādas raksturojums, tās teritoriālie aspekti, politiskā iekārta, dabas apstākļi un bagātÄ«gie resursi. UzmanÄ«ba veltÄ«ta arÄ« iedzÄ«votāju etniskajam sastāvam, vecuma grupām, nodarbinātÄ«bai, veselÄ«bas stāvoklim, nodarboÅ”anās veidiem un dzÄ«ves dārdzÄ«bai. Darbā ir analizēta arÄ« Kanādas ekonomikas vēsture, sākot ar 16. gadsimtu, kad Å”eit, ierodoties imigrantiem, sāka attÄ«stÄ«ties zvejniecÄ«ba un kažokādu ieguve un tirdzniecÄ«ba. Pēc tam Kanādas tālāko attÄ«stÄ«bu ietekmēja konfederācija un rÅ«pniecÄ«bas, kā arÄ« lauksaimniecÄ«bas attÄ«stÄ«ba un pilsētu izaugsme. Diplomdarbā Ä«paÅ”a uzmanÄ«ba pievērsta Centrālajai Kanādai, jo tai ir noteicoŔā vieta visas Kanādas ekonomikā gan vēsturiski, gan arÄ« mÅ«sdienās. Lielāko daļu diplomdarba aizņem Kanādas starptautiskās tirdzniecÄ«bas raksturojums, izvērtējot Kanādas valdÄ«bas lomu tirdzniecÄ«bas attÄ«stÄ«bā, tās tirdzniecÄ«bas partnerus, eksporta un importa preces. ÄŖpaÅ”a uzmanÄ«ba veltÄ«ta ES un Kanādas brÄ«vās tirdzniecÄ«bas lÄ«gumam (CETA), jo no tā ir atkarÄ«ga daudzu valstu, tostarp, arÄ« Latvijas ekonomikas attÄ«stÄ«ba nākotnē.Graduation work deals with Canada, which is a highly developed country, the economy, starting with the economic history and ending with the modern challenges that the European Union (EU) the Member States and Canada generate 2016 signed the EU-Canada Free Trade Agreement (CETA). Working in the introduction is given the characteristics of Canada, the territorial aspects of the political system, natural conditions and extensive resources. Attention is also paid to the ethnic composition of the population, age groups, jobs, state of health, type and cost of living. The paper also analysed the Canadian economic history, from the 16th century, when here, arriving immigrants, we began to develop fishing and fur trade and mining. After further development of the Canadian Confederation and affected industries, as well as the development of agriculture and urban growth. Graduation work focuses on the Central Canada because it is a key place for all of the Canadian economy, both historically and today. Most of the graduation work occupies Canadian international trade characteristics, evaluating the Canadian government's role in the development of trade, its trade partners, export and import goods. Particular attention is paid to the EU-Canada free trade agreement (CETA), because it depends on many countries, including the Latvian economic development in the future

    Windows game ā€œPocket Dungeonā€

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    Kvalifikācijas darbā ir aprakstÄ«ta daļējs Windows operētāj sistēmas spēles ā€“ā€œPocket Dungeonā€izpildÄ«jums un tā prasÄ«bu specifikācija. Å Ä« lietotne ir izstrādāta balstoties uz C# programmÄ“Å”anas valodas ar Unity3D ietvara palÄ«dzÄ«bu.Spēle sastāv no vairākām funkcionalitātēmā€“pretinieku, atribÅ«tu, inventāra un cīņas sistēmām kā arÄ« procesuālu mapju Ä£enerÄ“Å”anu ar lÄ«meņa atslēgas principu.Spēles progresu ir iespējams saglabāt un ielādēt no jauna.Spēlētājam ir iespēja izpētÄ«t mapes, savākt resursus, bÅ«vēt celtnes un cÄ«nÄ«ties pret dažādiem pretiniekiem, kamēr tas uzlabo savus atribÅ«tus,papildina inventāra saturu un apgÅ«st jaunas burvestÄ«bas.Sistēmas pamatdarbÄ«ba norisinās, kā darbvirsmas lietotne, tās datu uzglabāŔanai netiek pielietotas datu bāzes, bet tā vietā tika aizstātas ar sarealizētām objektu struktÅ«rām.The qualification work describes in-completed software of Windows operating systems game ā€“ā€œPocket Dungeonā€. This software is developed using C# programming language and Unity3D game engine.The system contains many different functionality ā€“procedural world generation, that uses seed-based system for its generation, enemy, inventory, equipment and fighting functionality.The progress of game is savable, meaning that player can continue the game from its last state. Player can explore generated maps, collect resources and use them to create buildings, collect loot from treasure chests to populates its inventory. Player can also fight with different types of monsters while collecting experience points and increasing both its level and attributes.The software primary works as desktop application and its data is stored in separate files that contains object serialized data

    Molecular Subtypes and Immunohistochemical Profiles in Breast Cancer. Summary of the Doctoral Thesis

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    Promocijas darbs izstrādāts RÄ«gas Stradiņa universitātē. AizstāvÄ“Å”ana: 2013. gada 10. jÅ«nijā plkst. 15.00 RÄ«gas Stradiņa universitātes ĶirurÄ£ijas promocijas padomes atklātā sēdē RÄ«gā, Dzirciema ielā 16, Hipokrāta auditorijā.Promocijas darbs ā€œKrÅ«ts vēža molekulāro apakÅ”tipu un imÅ«nhistoÄ·Ä«miskā profila raksturojumsā€ veltÄ«ts krÅ«ts vēža morfoloÄ£iskajai un imÅ«nhistoÄ·Ä«miskajai izpētei. KrÅ«ts vēzis ir viens no biežākajiem ļaundabÄ«gajiem audzējiem Rietumu valstu populācijās un visbiežākais ļaundabÄ«gais audzējs sievietēm. Tā izplatÄ«ba Latvijā saglabājas augsta. KrÅ«ts vēzim raksturÄ«gās heterogenitātes dēļ Pasaules VeselÄ«bas organizācijas apstiprinātā morfoloÄ£iskā klasifikācija nespēj atklāt visus audzēja parametrus, kas raksturo audzēja bioloÄ£isko potenciālu un ļauj izvēlēties personalizētu terapiju, tādēļ krÅ«ts audzēju raksturojumam izmantojama molekulārā klasifikācija. Molekulārie apakÅ”tipi sākotnēji tika noteikti, analizējot gēnu ekspresiju ar mikrokartÄ“Å”anas tehnoloÄ£iju. Å obrÄ«d imÅ«nhistoÄ·Ä«mija tiek pieņemta kā atbilstoŔākā aizvietojoŔā tehnoloÄ£ija. Promocijas darbā detalizēti raksturoti krÅ«ts vēža 5 molekulārie subtipi (lumināls A, lumināls B (HER2 negatÄ«vs), lumināls B (HER2 pozitÄ«vs), HER2 pozitÄ«vs un trÄ«skārÅ”i negatÄ«vs) atbilstoÅ”i St. Gallēnas klasifikācijai (2011), kas ir novatoriska pieeja arÄ« pasaules praksē, kā arÄ« veikti pētÄ«jumi jaunu prognostisku faktoru atklāŔanai, analizējot molekulas, kas nosaka audzēja galvenās bioloÄ£iskās Ä«paŔības ā€“ iesaistās Ŕūnu proliferācijā un Ŕūnu cikla kontrolē (ciklÄ«ns D1), ļauj audzēja Ŕūnām izvairÄ«ties no apoptozes (BCL2 onkoproteÄ«ns), saistÄ«ti ar mutācijām proto-onkogēnos (p53) un angioÄ£enēzi (ciklooksigenāze-2). PētÄ«juma teorētiskās bāzes izstrādei izmantoti 247 literatÅ«ras avoti. Promocijas darbā izvirzÄ«ts mērÄ·is klasificēt krÅ«ts vēža gadÄ«jumus pēc molekulāriem apakÅ”tipiem un izvērtēt minētos jaunos potenciālos prognostiskos faktorus krÅ«ts vēža audos. Izmantojot morfoloÄ£iskas, imÅ«nhistoÄ·Ä«miskās vizualizācijas un in situ hibridizācijas tehnoloÄ£ijas, izpētÄ«ti 383 secÄ«gi invazÄ«va krÅ«ts vēža gadÄ«jumi. PētÄ«juma rezultātā izveidotas 4 imÅ«nhistoÄ·Ä«miskās vizualizācijas tehnoloÄ£ijas p53 proteÄ«na, BCL2 proteÄ«na, ciklooksigenāzes-2 un ciklÄ«na D1 noteikÅ”anai, detalizēti raksturoti krÅ«ts vēža 5 molekulārie apakÅ”tipi, iegÅ«ts p53, BCL2, ciklooksigenāzes-2 un ciklÄ«nu D1 ekspresējoÅ”u krÅ«ts vēžu molekulārais portrets un noteikts Å”o faktoru sastopamÄ«bas biežums. Kompleksi izvērtējot daudzu parametru prognostisko nozÄ«mi, kā dzÄ«vildzi ietekmējoÅ”i faktori identificēti krÅ«ts vēža lokālā izplatÄ«ba (pT) un reÄ£ionālo limfmezglu metastātisks bojājums (pN), audzēja diferenciācijas pakāpe, molekulārais subtips, kā arÄ« p53 un BCL2 ekspresija.Promocijas darbs veikts ar Eiropas Sociālā Fonda projekta "Jaunas starpdisciplināras zinātniskās grupas izveide krÅ«ts vēža izpētei, terapijas efektivitātes un pacientu dzÄ«ves kvalitātes uzlaboÅ”anai" (vienoÅ”anās Nr. 2009/0230/1DP/1.1.1.2.0/09/APIA/VIAA/070) atbalst
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