Cervical mucus test for pregnancy diagnosis in Akkaraman ewes and Angora goats

Bu çalışmanın amacı, koyun ve keçilerde gebelik tanı yöntemi olarak kullanılan servikal mukus kaynatma testinin saha koşullarında uygulanabilirliği ve doğruluk oranının araştırılmasıdır. Çalışmada 50 baş Akkaraman ırkı koyun ve 50 baş Ankara keçisi materyal olarak kullanıldı. Servikal mukus testi ile koyunlarda % 80 doğruluk oranı, %73.3 sensitivite, % 82.9 spesivite, % 64.7 pozitif tanımlama oranı ve % 87.9 negatif tanımlama oranı elde edildi. Keçilerde ise bu oranlar sırasıyla % 70, % 60, % 72.5, % 35.3 ve % 87.9 olarak bulundu. Ayrıca korpus luteum büyüklüğü ve progesteron değerleri arasındaki korelasyon araştırıldı. Gebe ve gebe olmayan tüm hayvanlar içinde sadece gebe olmayan koyunlarda korelasyonun önemli olduğu (r=0.58; p<0.05) tespit edildi. Bunlara ilaveten yapılan vaginal sitoloji değerlendirmesinde gebe ve gebe olmayan hayvanlar arasında hücre kompozisyonu bakımından ayırıcı bir farklılığın olmadığı saptandı. Sonuç olarak, koyun ve keçilerde yapılan bu çalışmada servikal mukus kaynatma testiyle koyunlarda gebeliğin tanısında keçilere göre daha yüksek oranlar elde edilebileceği ve bu yöntemin saha koşullarında uygulanabileceği kanısına varıldı.The aim of this study was to investigate practicability of cervical mucus test, which is used for diagnosis of pregnancy, in field conditions and accuracy rate in ewes and goats. This study was performed in 50 Akkaraman ewes and 50 Angora goats. In ewes, % 80 accuracy rate, % 73.3 sensitivity, % 82.9 specificity, % 64.7 predictive value of positive and % 87.9 predictive value of negative were found with cervical mucus test and these rates were % 70, % 60, % 72.5, % 35.3 and % 87.9 respectively in goats. In addition, correlation was investigated between the size of corpus luteum and progesterone levels. Correlation was found important only in non-pregnant ewes of all pregnant and non-pregnant animals (r=0.58; p&lt;0.05). Besides, an important difference was not determined between composition of cells in vaginal cytologic evaluation in pregnant and non-pregnant animals. As a result, cervical mucus test can be used in field conditions and the accuracy rates in ewes are higher than goats

Hidrometralı bir kedide adenom ve endometrial polipoid

Ankara Üniversitesi Veteriner Fakültesi Doğum ve Jinekoloji Anabilim Dalı Kliniğine l yaşlı bir kedi abort şüphesi ile getirildi. Tekrarlayan kanlı vaginal akıntıdan dolayı hasta gözetimimiz altına alındı. Ultrasonografide fötüs gözlenmediğinden ve uterusta anekojen bir alan olduğundan bu vakanın abortus olmadığı sonucuna varıldı. Kedide, ultrasonografı ile tespit edilen anekojenik alan büyük olduğundan medikal yolla tedavi edilemiyeceği kanısına varıldı. Vaginal akıntıya rağmen hastanın genel durumu operasyon için elverişliydi. Bu yüzden, ovariohisterektomi yapılmasına karar verildi. Uterusun histopatolojik incelemesinde endometrial polipler, adenom ve hidrometra tespit edildi.A 1 -year-old cat with a suspected abortion was brought to the clinic of the Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Ankara University. The cat was examined because of a reoccurrence of a bloody vaginal discharge. Failure to detect a foetus by ultrasonography and the presence of an anechoic zone in the uterus revealed that there had not an abortion. Since the anechoic zone was large, it was thought that a pharmacological approach would not be successful. Despite the vaginal discharge, the physical condition of the patient was suitable for surgery. Therefore, we decided to perform an ovariohysterectomy. Histopathological examination of the uterus revealed adenoma, hydrometra and proliferative polyps in the endometrium

Novel predictors of infarct-related artery patency for ST-segment elevation myocardial infarction: Platelet-to-lymphocyte ratio, uric acid, and neutrophil-to-lymphocyte ratio

BSTRACT Objective: the neutrophil/lymphocyte ratio (NLR), the platelet/lymphocyte ratio (PLR), and uric acid (UA) are inflammatory markers in cardiovascular disease. However, there are not enough data on infarct-related artery (IRA) patency in ST-segment elevation myocardial infarction (STEMI). We aimed to investigate the association of NLR, PLR, and UA with IRA patency before percutaneous coronary intervention (PCI) in STEMI. Methods: the study was designed as a retrospective study. Three hundred and twenty-four consecutive patients with STEMI were divided into two groups according to pre-PCI Thrombolysis in Myocardial Infarction flow grade (TIMI). Patients with a TIMI flow grade of into the spontaneous reperfusion (SR) group, while patients with TIMI flow grade of 0, 1 and 2 were placed into the non-SR group. the &#967;2 and independentsamples t-test, Mann-Whitney U test, multivariate logistic regression analysis, and receiver-operator characteristic (ROC) curve analysis were used for the statistical analysis. Results: PLR, NLR, and UA values in the SR group were lower than in the non-SR group (p&lt;0.004, p&lt;0.001, p&lt;0.001, respectively). in the multivariate analysis, serum UA level and PLR were found to be independent predictors of pre-PCI IRA patency. in the ROC curve analysis, PLR >190, UA>5.75 mg/dL, and NLR>4.2 predicted non-SR. the sensitivity and specificity of the association between low IRA TIMI flow grade and PLR were 88% and 84%, 72% and 66% for UA, and 74% and 44% for NLR, respectively. Conclusion: We determined that PLR and UA are novel predictors of IRA patency before PCI. We suggest that PLR and UA may be used in riskstratifying STEMI.

The effectiveness of combined preventive treatment with Ceftiofur, Oxytocin and PGF2α on fertility parameters in cows

The present study is aimed at evaluating the effectiveness of combined preventive treatment with Ceftiofur Hydrochloride (CHR), Oxytocin (OXT) andPGF2α on fertility parameters and puerperal disorder rates in postpartum (pp)dairy cows. A total of 191 Holstein-Friesian cows were divided into fourgroups. The cows in group I (GI; n=37) and II (GII; n=69) were treated on adaily basis with CHR and OXT for five and three days pp, respectively. GroupIII (GIII; n=52) was designed as the PGF2α group, and group IV (GIV; n=33)served as a control group. The animals in GI, GII, and GIII were given aPGF2α analogue on days 15 and 26 pp. Each group was further divided intosubgroups of normal parturition (np) and dystocia (d) when the study resultswere evaluated. It was found that the first service pregnancy rates for the subgroup of dystocia were significantly higher (P&lt;0.05 and P&lt;0.01) in subgroupGII (76.9%) than in GI (30.0%) and GIV (37.5%). Furthermore, the mediantime to first service and the median time to pregnancy were longer for cowsin subgroup GIVd as compared with subgroups GId, GIId, and GIIId(P&lt;0.001; P&lt;0.01). Group II was found to have the lowest endometritis ratesafter treatment of subgroups-d and -np. No statistically significant differencewas found between the groups with regard to cystic ovary rates after treatment (P&gt;0.05). As the treatment with CHR-OXT combined with PGF2α ondays 15 and 26 was associated to improved uterine involution patterns andreproductive performance, our results suggest that administration of this preventive treatment would be useful, especially for cases of dystocia.&nbsp;</p

Türkiye’de nonvalvüler atriyum fibrilasyonlu hastalarda vitamin K antagonisti ve yeni oral antikoagülan kullanımı uygulamalarını değerlendirmek için epidemiyolojik çalışma - AFTER*-2 çalışması dizaynı

Amaç: Atriyum fibrilasyonu (AF) önlenebilir iskemik inmenin en sık nedenlerinden biri olup artmış kardiyovasküler morbidite ve mortaliteyle ilişkilidir. Ülkemizde yeni oral antikoagülan kullanım sıklığı, vitamin K antagonisti kullanan hastalarda Uluslararası Düzeltme Oranı’nın (INR) etkin düzeyde kalma oranı ve AF tedavi yönetimi ile ilgili büyük bir çalışma mevcut değildir. Bu çok merkezli çalışmada amacımız nonvalvüler AF hastalarında epidemiyolojik verilerin analizi, takibi ve değerlendirilmesidir. Çalışma planı: Kırk iki merkezden elektrokardiyografisinde en az bir defa AF atağı tespit edilmiş ardışık 4100 erişkin hasta çalışmaya alınacaktır. Romatizmal mitral darlığı ve protez kapak hastalığı olan AF hastaları çalışmaya alınmayacaktır. Hastalar birinci yılın sonunda majör kardiyak sonlanım noktaları (ölüm, geçici iskemik atak, inme, sistemik tromboembolizm, majör kanama ve hastane yatışı) açısından değerlendirilecektir. Bulgular: İlk sonuçlar Haziran 2015 yılında bekleniyor. Majör kardiyak sonlanım noktaları açısından veriler Ocak 2016’da elde edilecektir. Sonuç: AFTER-2 çalışması ile ülkemizdeki non-valvüler AF hastalarının oral antikoagülan tedavi kullanım sıklığı ve çeşidi, varfarin alan hastalarda etkin INR düzeylerinde kalma oranı ve benimsenen tedavi yönetimi belirlenecektir. Ayrıca, ülkemizde AF’li hastalarda majör istenmeyen olay sıklığı ve bu olayların bağımsız belirteçleri de ortaya çıkarılacaktır (AFTER-2 Study ClinicalTrials.gov number, NCT02354456). Anahtar Kelimeler: Antikoagülan ilaç; atriyum fibrilasyonu/epidemiyoloji; ilaç kullanımı; elektrokardiyografi; uluslararası düzeltme oranı; varfarin.Objectives: Atrial fibrillation (AF) is one of the most common causes opreventable ischemic stroke and is related to increased cardiovasculamorbidity and mortality. There is a lack of data in Turkey on the use onew oral anticoagulants (NOACs), and time in therapeutic INR range (TTR) in vitamin K antagonist users and AF management modalityIn this multi-center trial, we aimed to analyze, follow and evaluate the epidemiological data in non-valvular AF patients. Study design: Four thousand one hundred consecutive adulpatients from 42 centers with at least one AF attack identified on electrocardiography will be included in the study. Patients with rheumatic mitral valve stenosis and prosthetic valve disease will be excluded from the study. At the end of one year, the patients will be evaluated in terms of major cardiac end points (death, transient ischemic attack, strokesystemic thromboembolism, major bleeding and hospitalization). Results: First results are expected in June 2015. Data about majocardiovascular end-points will be available in January 2016. Conclusion: The rates and kind of oral anticoagulant use, TTR in vitamin K antagonist users and main management modality applied in non-valvular AF patients will be determined by AFTER-2 studyIn addition, the rate of major adverse events (MACEs) and the independent predictors of these MACEs will be detected (AFTER-2 Study ClinicalTrials.gov number, NCT02354456.)