EFFECT OF CREATIVE DRAMA METHOD ON GEOMETRY TEACHING

Geometry holds an important place in the developmental process of mathematical thinking. When geometry is the subject in mathematics lessons, it is seen by students as an unlikeable and hard to understand. It is not easy to get students who come to school with this prejudice to like the lesson and explain it. Our aim in this research is to eliminate this prejudice using right teaching methods and make mathematics a lesson attended voluntarily and with pleasure by the students. With this aim in mind, the effect of creative drama method on students’ success for the 6th grade mathematics lesson, area of triangles subject has been researched. This study has been applied on 100 students enrolled in two different state secondary schools in Aegean Region in 2017-2018 teaching term. In this study, classes are divided into two groups as control group and experimental group and a success test designed by researchers on area of triangles subject is applied to students as pretest and final test. This test consists of 7 multiple choice and 3 open ended questions. Data obtained from the test is analyzed by statistical method. After the analysis, a meaningful difference in favor of experimental group has arisen. Based on the reviews made with the students, it is noticed that the interest of students to mathematics lesson has increased as a result of creative drama applications.  Article visualizations

Bipolar bozuklukta psikolojik dayanıklılık, algılanan sosyal destekle ilişkili midir?

Objective: Psychological resilience (PR) is a risk factor that is associated with onset of disease, quality of life, and prognosis in bipolar disorder (BD). There are variables that can affect PR positively and negatively; one of them is perceived social support (PSS). The aim of this study was to examine this relationship. Methods: The Multidimensional Scale of PSS, Adult PR Scale, and Data Collection Form were requested from 90 patients with bipolar I disorder in the euthymic stage and 30 controls who were matched for age, gender, marital status, and level of education. Results: PSS and PR scores were significantly lower in the bipolar group than in the control group. In the control group, only the family subscale of PSS was significantly correlated with PR, while both the family and friend subscales were significantly associated with PR in the bipolar group. In a regression analysis which considered PR as an independent variable, the family and friend subscales of PSS and age at onset were significant. Conclusion: Family therapy and peer support groups in addition to medical therapy in BD may contribute positively to prognosis. In addition, training modules to develop PR for BD patients with risk factors such as childhood trauma and early onset would improve prognosis.Amaç: Ruhsal dayanıklılık (RD), bipolar bozuklukta (BB) hastalık başlangıcı, yaşam kalitesi ve prognoz ile ilişkili bir risk etkenidir. RD’yi olumlu ve olumsuz yönde etkileyebilecek değişkenler vardır ve bunlardan biri algılanan sosyal destektir (ASD). Çalışmanın amacı BB hastalarında RD ile ASD arasındaki ilişkiyi incelemektir. Yöntem: Ötimik evredeki BB I hastası 90 kişi ile yaş, cinsiyet, medeni durum ve eğitim açısından eşleştirilmiş 30 kişiden oluşan kontrol grubuna çok boyutlu ASD Ölçeği, Yetişkin RD Ölçeği ile Veri Toplama Formu verilmiştir. Bulgular: ASD ve RD puanları BB grubunda kontrol grubuna göre anlamlı olarak düşüktü. Kontrol grubunda ASD ölçeğinin aile alt boyutu RD ile anlamlı korelasyon gösterirken, BB grubunda hem aile, hem de arkadaş alt ölçekleri anlamlı korelasyon gösterdi. RD'nin bağımsız değişken alındığı regresyon analizinde ASD'nin aile ve arkadaş alt ölçekleri, hastalık başlangıç yaşı ile geçmişte intihar girişimi öyküsü varlığı anlamlı bulundu. Sonuç: BB’de ilaç tedavisine ek olarak aile terapisi ve akran destek grupları prognoza olumlu katkıda bulunabilir. Ek olarak, çocukluk çağı travması. intihar girişimi öyküsü ve erken başlangıç gibi risk etkenleri olan BB hastaları için RD’yi geliştirmeye yönelik ruhsal eğitim modüllerinin prognoza olumlu katkıları olabilirQ1WOS:0004927249000052-s2.0-8507466629

Perception of Orthodontic Treatment Need Among Orthodontists, General Dentists and Lay People

Aim:The main objective of our study was to examine the possible differences in dental esthetic perceptions among dentists, orthodontists and laypeople.Subjects and Methods:The participants of the study consisted of 3 different groups as orthodontists, dentists who have at least 4 years clinical experience and laypeople. Thirty individuals were selected for each group. All the selected people were asked to complete the questionnaires. Assessment of treatment need was obtained by evaluating the Aesthetic Component (AC) of Index of Orthodontic Treatment Need (IOTN). This index contains a series of 10 black and white photographs of anterior teeth displaying varying degrees of malocclusion. The participants of this study were asked to rank each black and white photograph between 1 and 10 according to their perception of orthodontic treatment need.Results:There were only minor differences in perception of orthodontic treatment need. Differences were detected in photographs 1 and 9. In photograph 1, orthodontists and dentists gave similar scores but lay people scored higher than dental professionals.Conclusion:The present study aimed to investigate the possible differences in perception of orthodontic treatment need among orthodontists, general dentists and lay people and the results found only minor differences between the groups

GNSS station design for global climate change monitoring in Antarctica: ınstallation of TUR1 and TUR2 GNSS stations on Horseshoe Island in Antarctica During The 4th Turkish Antarctic Science Expedition

Son yıllarda uzay tabanlı konumlama sistemleri, GNSS Meteorolojisi ve GNSS Reflektometresi teknikleri kullanılarak gözlemlenen atmosferik su buharı, deniz, buz ve kar seviyeleri gibi önemli parametrelerle küresel iklim değişikliğinin izlenmesinde etkili bir destekleyici araç haline gelmiştir. Küresel ölçekte tüm bölgelerden daha hızlı ısınan Antarktika'da iklim değişikliğini incelemek, gelecekteki iklim değişikliğini daha doğru tahmin etmek için çok önemlidir. Dünya'nın iklim değişikliği etkilerinin izlenebilmesi amacıyla, 118Y322 No’lu TÜBİTAK projesi kapsamında GNSS Meteorolojisi ve GNSS Reflektometresi teknikleri ile 24 Şubat 2020 tarihinden itibaren Antarktika’da atmosferik su buharı değişimleri, kar derinliği ve buz kalınlığı değişimleri gözlemlenmektedir. Bu çalışmada, Troposfer ve Deniz Seviyesi Gözlem İstasyonu (TUR1) ile Troposfer ve Kar / Buz Seviyesi Gözlem İstasyonunun (TUR2) tasarım çalışmaları ve 4. Ulusal Antarktika Bilim Seferi’nde Antarktika Horseshoe Adası’na kurulum aşamaları anlatılmıştır. Bu çalışmalar, meteorolojik koşullar, şebekeden bağımsız ve batarya ile bütünleşik enerji sisteminin en sağlıklı şekilde güneş ve rüzgâr enerjisinden beslenmesi ve bölgede oluşabilecek buzul oluşumu ve kayaç parçalanması gibi jeolojik parametreler de göz önüne alınarak yapılmıştır.In recent years, space-based positioning systems have become an effective supporting tool for monitoring global climate change by important parameters such as atmospheric water vapor, sea, ice and snow levels observed by using GNSS Meteorology and GNSS Reflectometry techniques. Studying climate change in Antarctica, which is warming faster than all of the regions on a global scale, is very important to predict future climate change more accurately. In order to monitor climate change effects of the Earth, tropospheric water vapor variations, snow depth and ice thickness changes have been observing in Antarctica since 24 February 2020 by means of GNSS Meteorology and GNSS Reflectometry techniques within the scope of the TUBITAK Project No. 118Y322 In this study, designing studies of Troposphere and Sea Level Observation Station (TUR1) and Troposphere and Snow / Ice Level Observation Station (TUR2) and installation steps to Horseshoe Island in Antarctica during the 4th National Antarctic Science Expedition are explained. These studies was carried out by taking into account the meteorological conditions, the healthiest feeding of the off grid battery integrated energy system from solar and wind energy and geological parameters such as glacial formation and rock fragmentation that may occur in the region

Farklı Asetat Konsantrasyonlarında Phodobacter Capsulatus'un_Poly-Beta Hidroksi Bütirik asit ve hidrojen üretimi ve ilgili gen ifadelerinin incelenmesi.

Hydrogen, which is a clean energy source, is one of the alternatives for fossil fuels. Biological hydrogen production is one of the hydrogen production methods. Rhodobacter capsulatus is a photosynthetic bacterium that produces hydrogen via photofermentation. R. capsulatus can also synthesize some valuable by-products such as Poly-beta- hydroxy butyric acid (PHB), which is a biodegradable bioplastic. In a two stage biohydrogen production system, which is combination of dark fermentation and photofermentation, dark fermentor effluents are used for photofermentation by R.capsulatus. Dark fermentor effluents usually contain high amount of acetate. High amount of acetate may decrease the efficiency of hydrogen production by causing high amount of PHB production. Therefore, it is significant to determine optimum acetate concentration for photofermentation. In this study, the effects of acetate concentration on hydrogen and PHB production by R.capsulatus were investigated by growing bacteria at various acetate concentrations (10 mM-65 mM). In addition, gene expression analysis was performed to investigate the effects of acetate at transcriptional level. For this purpose, expression levels of the genes that encode nitrogenase which is the enzyme that catalyzes hydrogen production and PHB synthase, which is the key enzyme of the PHB synthesis pathway, are examined. Optimum acetate concentration for photofermentation with high hydrogen yield and low PHB amount was determined to be in the range 25 mM-50 mM. nifD expression was found to be high at optimum acetate concentrations and phaC expression was found to be the highest at 65 mM.M.S. - Master of Scienc

In Vitro Evaluation of a Solid Supersaturated Self Nanoemulsifying Drug Delivery System (Super-SNEDDS) of Aprepitant for Enhanced Solubility

Aprepitant (APR) belongs to Class II of the Biopharmaceutical Classification System (BCS) because of its low aqueous solubility. The objective of the current work is to develop self-nanoemulsifying drug delivery systems (SNEDDS) of APR to enhance its aqueous solubility. Preformulation studies involving screening of excipients for solubility and emulsification efficiency were carried out. Pseudo ternary phase diagrams were constructed with blends of oil (Imwitor® 988), cosolvent (Transcutol® P), and various surfactants (Kolliphor® RH40, Kolliphor® ELP, Kolliphor® HS15). The prepared SNEDDS were characterized for droplet size and nanoemulsion stability after dilution. Supersaturated SNEDDS (super-SNEDDS) were prepared to increase the quantity of loaded APR into the formulations. HPMC, PVP, PVP/VA, and Soluplus® were used as polymeric precipitation inhibitors (PPI). PPIs were added to the formulations at 5% and 10% by weight. The influence of the PPIs on drug precipitation was investigated. In vitro lipolysis test was carried out to simulate digestion of formulations in the gastrointestinal tract. Optimized super-SNEDDS were formulated into free-flowing granules by adsorption on the porous carriers such as Neusilin® US2. In vitro dissolution studies of solid super-SNEDDS formulation revealed an increased dissolution rate of the drug due to enhanced solubility. Consequently, a formulation to improve the solubility and potentially bioavailability of the drug was developed

Quetiapine Fumarate Extended-release Tablet Formulation Design Using Artificial Neural Networks

Objectives: This design study was implemented within the scope of the quality by design approach, which included the “International Conference on Harmonization” guidelines. We evaluated the quality of a modified-release tablet formulation of quetiapine fumarate, which was designed using artificial neural networks (ANN), and determined a new formulation that was similar to the reference product. Materials and Methods: Twelve different formulations were produced and tested. The reference product’s results and our experimental results were used as outputs for the training of the ANN programs of Intelligensys Ltd. Results: Dissolution tests were performed with the new formulation (F13) suggested by the INForm V.4 ANN program in three different pHs of the gastrointestinal system. The compliance of this formulation was confirmed by comparing the results with an f2 similarity test. Conclusion: Use of these programs supports research and development processes with multiple evaluation methods and alternative formulations may be determined faster and at lower cost