Safety and efficacy of transdermal fentanyl in patients with cancer pain: phase IV, Turkish oncology group trial

We have performed a prospective evaluation of the efficacy, safety and convenience of the transdermal therapeutic system - fentanyl (TTS-F) in Turkish cancer patients when it was newly available in Turkey. Ninety-nine patients with historically confirmed malignancy and pain entered the study; the mean age was 55.1 (16-58) years. The study duration was 28 days. Transdermal therapeutic system - fentanyl was used in opioid-naive or pre-treated patients. Most patients reported a decrease in pain severity. Use of rescue medication decreased from day 4 to day 28. The majority of patients rated patch convenience of use as excellent. A total of 22.2% of patients experienced adverse events that were either probably related or very likely to be related to the study drug. The majority of the adverse events mentioned were related to the digestive system. Eighteen serious adverse events were reported by 13 patients. Six events were doubtfully related, and 12 events were not related to the study drug. Four patients died during the trial. None of these deaths was attributed to the study drug. In conclusion, the trial showed that TTS-F is easily managed, effective and will help to enable the appropriate opioid administration to patients who are suffering from cancer pain in Turkey

TÜRKIYE'DEKI ARICILIK FAALIYETINE HUKUKI PERSPEKTIFTEN BAKIS

Turkey ranks as one of the countries with significant production potential in the world beekeeping sector. Our country, which ranks third place in the world in terms of honeybee colony numbers, ranks twenty-first place in honey exports and earns income much below the potential of this sector. In this respect, Turkey can respond to the needs for the production of honey in the domestic market, though it is far from being an important actor in exporting honey to international markets. Current legal regulations could be an important reason for this matter because beekeepers may not be able to satisfy the needs of the sector and enhance the productivity. As the standardization studies for bee products other than honey have not been completed in our country, legal legislation could not be established. The delay in the establishment of the necessary legal arrangements leads to serious dangers in terms of bee breeds and plant species in our country. We should prepare proper techniques, for the whole country, which is accessible and workable, transparent, and corresponds with the current legislation covering all stages of producing bee products and beekeeping, then Turkey will make significant strides in the beekeeping industry. The worth of brand values from products that have been legally audited result in an increase in price in the market. Copyright © 2019 Business Lawyer. All rights reserved.Scopu

BILECIK ILINDEN TOPLANAN ARI POLENLERININ BOTANIK ORIJINLERI ILE TOPLAM FENOLIK VE FLAVONOID IÇERIKLERININ BELIRLENMESI

Plant pollen is one of the main nutritional sources of honey bees, which has high protein content. Honey bees collect plant pollen during flower visits and bring it back to the hive. Due to its high nutritional content, bee pollen, which has many therapeutic effects, is also used as an important food supplement in human nutrition. Because of this, pollen traps are attached to the hive enterance and the pollen loads from honey bee legs are collected and provided for human consumption. The content of bee pollen varies mainly depending on botanical origin, climate, geographical characteristics, and type of bee collecting it. In this study, the total phenolic and flavonoid content of bee pollen samples, collected from 5 different regions of the Bilecik province, were determined and compared. As a result, it was found that bee pollen samples contained 19 families and 28 different plant taxa. The Fabaceae family was the most dominant, except for one region. Copyright © 2019 Business Lawyer. All rights reserved.Scopu

KARAÇALI (Paliurus spina-christi Mill.) BALININ KARAKTERISTIK ÖZELLIKLERI

In this study characteristic properties of Jerusalem thorn, Christ's thorn or Garland thorn honey (Paliurus spina-christi Mill.) were investigated that obtained from different locations of Marmara and Trakya regions of Turkey. Eighteen honey samples were collected from Bursa, Edirne and Kirklareli regions by experienced beekeepers in 2018. Melissopalynological analysis, physicochemical parameters, pH, moisture, color, conductivity and optical rotation values, chemical parameters, proline, sugar components, total phenolic, flavonoid, tannin amounts and phenolic profile analyzes were analyzed of the honey samples Antioxidant and antimicrobial activities were tested as biological activities. According to the results of the study, it was found that the honey has a highly monofloral properties ranged from 69.5% and 96%. Antimicrobial activity values of the honey were compared with standard antibiotics and two different Manuka honeys. It was found that the honeys were showed higher antimicrobial and antifungal activities against 10 different pathogenic than Manuka honeys. As a result, it is thought that Jerusalem thorn honey have high biological active potential as monofloral honey for apitherapy applications. Copyright © 2019 Business Lawyer. All rights reserved.Scopu

Analysis of grayanatoxin in Rhododendron honey and effect on antioxidant parameters in rats

Yonar, Muhammet Enis/0000-0001-9519-4247WOS: 000345734400020PubMed: 25193682Ethnopharmacological relevance: Rhododendron honey, locally known as "mad honey", contains gryanotoksin (GTX) and thus induces toxic effects when consumed in large amounts. But, it is still popularly used for treating medical conditions such as high blood pressure or gastro-intestinal disorders. The aim of this study was to evaluate the effect of GTX on antioxidant parameters measured from rats fed with Rhododendron honey. Material and methods: A total of sixty Sprague-Dawley female rats were divided into five groups of 12 rats each, one being the control group (Group 1) and the others being the experimental groups (Groups 2 to 5). Group 2 was treated with 0.015 mg/kg/bw of Grayanotoxin-III (GTX-III) standard preparation via intraperitoneal injection. Groups 3, 4 and 5 were respectively given Rhododendron honey (RH) at doses of 0.1, 0.5, and 2.5 g/kg/bw via oral gavage. After one hour, blood samples were collected from the rats. Glutathione peroxidase (GSh-Px), superoxide dismutase (SOD), catalase (CAT) activities and malondialdehyde (MDA) contents were examined in blood, heart, lungs, liver, kidney, testicles, epididiymis, spleen and brain specimens. Results: The data from the rats in Groups 2 (GTX) and 5 (RH at 2.5 g/kg/bw) showed negative effect on the antioxidants parameters in blood and all tissue samples examined at the specified doses and time period. Administration of GTX to rats at dose of 0.015 mg/kg/bw resulted in lipid peroxidation. (This part needs to be enhanced more). Conclusion: It has been observed that both Grayanotoxin and high dose Rhododendron honey treatments showed oxidant effect on blood plasma and organ tissues investigated. (C) 2014 Elsevier Ireland Ltd. All rights reserved.Scientific Research Projects Unit of Erciyes UniversityErciyes University [FBY-11-374]; Ethical Committee of Erciyes UniversityErciyes UniversityThe authors would like to acknowledge the approval of the project by the Ethical Committee of Erciyes University and would also like to thank Scientific Research Projects Unit of Erciyes University for their generous research support (Project no: FBY-11-374)