AXIAL DISPERSION OF LIQUID IN MOBILE-BED CONTACTING

Axial dispersion of liquid in Mobile-Bed Contacting (MBC) was investigated employing transient-response technique with impulse input of NaCI tracer. Experiments were performed in a 0.195 m ID column. Three different packing diameters (15, 19.5 and 32 mm) and three different static bed heights (0.1, 0.195 and 0.3 m) were used. Gas flow rate was varied between 3.02 and 4.05 kg/m2/s and liquid flow rate from 2.4 to 10.4 kg/m2/s. Transfer function analysis of data yielded that Peclet number was practically independent of liquid and gas flow rates and static bed height but depended on packing size only. A simple correlation for Peclet number was developedPublisher's Versio

Life Cycle Assessment in the Olive Oil sector

The olive oil industry is a significant productive sector in the European Union and the related production process is characterised by a variety of different practices and techniques for the agricultural production of olives and for their processing into olive oil. Depending on these different procedures, olive oil production is associated with several adverse effects on the environment, both in the agricultural and in the olive oil production phase. As a consequence, tools such as LCA are becoming increasingly important for this type of industry. Following an overview of the characteristics of the olive oil supply chain and its main environmental problems, the authors of this chapter provide a description of the international state of the art of LCA implementation in this specific sector, as well as briefly describing other life cycle thinking methodologies and tools (such as simplified LCA, footprint labels and Environmental Product Declarations). Then, the methodological problems connected with the application of LCA in the olive oil production sector are analysed in depth, starting from a critical comparative analysis of the applicative LCA case studies in the olive oil production supply chain. Finally, guidelines for the application of LCA in the olive oil production sector are proposed

Ephrin-B2 reverse signaling regulates progression and lymph node metastasis of oral squamous cell carcinoma.

Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck and frequently metastasizes to cervical lymph nodes. Aggressive local invasion and metastasis of OSCC are significant factors for poor prognosis. In this study, we investigated whether ephrin-B2 expressed in OSCC contributed to tumor progression and lymph node metastasis. Clinical specimens from patients with OSCC had robust ephrin-B2-positive tumor cells and ephrin-B2 protein level was associated with clinical stage, lymph node metastasis, and poor survival outcomes. We also determined that ephrin-B2 protein level was increased in OSCC cell lines compared to normal human oral keratinocytes and that its levels were associated with the migratory and invasive potential of OSCC cell lines. Transfection of an EFNB2-specific small interfering RNA (siRNA) into SAS-L1 cells significantly reduced proliferation, attachment, migration, and invasion through phosphorylation of the epidermal growth factor receptor, FAK, ERK1/2, p38, AKT, and JNK1/2 pathways. Furthermore, knockdown of EFNB2 significantly suppressed adhesion and transmigration of SAS-L1 cells toward human lymphatic endothelial cells. In addition, the growth rate of tumor xenografts and cervical lymph node metastases of OSCC were suppressed by local injection of EFNB2 siRNA. These results suggest that ephrin-B2 overexpression and activation of the ephrin-B2 reverse signaling pathway in tumor microenvironment in OSCC facilitates progression and lymph node metastasis via enhancement of malignant potential and interaction with surrounding cells