Bir köpeğin idrar yolu infeksiyonunda saptanan Acinetobacter baumannii ve Streptococcus canis

Nozokomiyal infeksiyonlar insan hastanelerinin ana problemlerinden birini oluşturmasına rağmen, son döneme kadar veteriner hekimliğinde fazla dikkat edilmemiştir. İstanbul Üniversitesi Veteriner Fakültesi İç Hastalıkları Anabilim Dalı’na 1 yaşlı Kangal ırkı köpek idrar yapmada zorlanma ve idrarda kan bulunması şikayetleri ile getirildi. Yapılan klinik muayene, kan, idrar tahlilleri ve idrardan yapılan bakteriyolojik kültür sonucunda Acinetobacter baumannii ve Streptococcus canis’in neden olduğu idrar yolu infeksiyonu teşhisi konuldu. Bu olgu sunumunun amacı, son dönemde veteriner hekimliğinde de görülmeye başlayan asinetobakterlerin idrar yolu infeksiyonlarında göz önünde tutulmasını sağlamaktır

Constitution and Validation of a New Symptom Assessment Tool for Overactive Bladder: Marmara Overactive Bladder Questionnaire (M-OBQ)

Objective The aim of this study is to constitute and validate a symptom questionnaire to be used in the diagnosis and follow up of patients with OAB that complies with the specific needs of the Turkish society and that allows the assessment of both disease symptoms and their effects on quality of life. Materials and Methods A total of 78 OAB patients and 90 control patients were included in this study between January 2007 and June 2007. All included patients underwent urine analysis/culture, blood creatinine levels, 3-day voiding dairy, urinary ultrasonography and plain abdominal graphy evaluations. Results Among 168 patients included 99 (58, 95) were males and 69 (41,1%) were females. Mean age was 47,3 (±17, 2) years. Cronbach alpha value which is a determinant of internal consistency was 0.92 for M-OAB questionnaire. The Spearman correlation co- efficient for total score was found to be 0.98 (p=0.001) in the test- retest analysis. The highest sensitivity (97%) and specificity (94%) values for the M-OAB questionnaire to make a diagnosis of OAB were obtained with a cut off value of 12.5 for the total score. Conclusion This study shows the development of a reliable and valid OAB specific symptom and quality of assessment tool that is short and easily applicable in the daily clinical practice. This questionnaire can provide the clinicians with practical comfort and a standardized quantification of the patient symptoms

The diagnostic value of protein carbonyl levels inAcute carbon monoxide intoxication

Amaç: Karbonmonoksit (CO) gelişmiş ülkelerde zehirlenme ile ilişkili mortalite ve morbiditenin ana nedenidir ve birçok ülkede ölümcül zehirlenmelerin yarısından fazlasından sorumlu tutulmaktadır. Bu çalışmada akut CO zehirlenmeli hastalarda meydana gelen hipoksi nedeniyle ortaya çıkan oksidatif strese bağlı olarak, iyi bir oksidatif stres markerı olan protein karbonilin (PC) tanısal değerini belirlemek amaçlanmıştır. Gereç ve Yöntem: Acil serviste CO zehirlenmesi tanısı alan 34 hasta ve sağlıklı 38 gönüllü çalışmaya alınmıştır. Hastaların başvuru anı ve tedavi sonrası PC seviyeleri, kontrol grubu ile karşılaştırılmıştır. Bulgular: Başvuru anında ortalama PC seviyeleri arasında hasta grubu ve kontrol grubu arasında istatistiksel olarak anlamlı fark tespit edilmemiştir, p 0.305 (hasta grubu 0.025 0.01, kontrol grup 0.026 0.01). Hasta grubunda tedavi sonrası PC seviyelerinde başvuru anına göre anlamlı bir düşüş tespit edilmiştir, p 0.006 (başvuru 0.025 0.01, tedavi sonrası 0.017 0.008). Hastalarda başvuru anında CO-Hb seviyeleri ile PC seviyeleri arasında istatistiksel olarak anlamlı bir korelasyon tespit edilmemiştir (Corelation coefficient -0.006, p 0.971). Sonuç: PC'nin CO zehirlenmeli hastalarda akut dönemde bir biyobelirteç olarak kullanılmasının uygun olmadığını düşünmekteyiz.Objective: Carbon monoxide (CO) is the main cause of intoxication-related mortality and morbidity in developed countries. It is responsible for more than half of fatal intoxications in many countries. The purpose of this study was to determine the diagnostic value of protein carbonyl (PC), a good marker of oxidative stress, in association with oxidative stress resulting from hypoxia emerging in patients with acute CO intoxication. Methods: Thirty-four patients diagnosed with acute CO intoxication at the Emergency Department and 38 healthy volunteers were included in the study. Patients' PC levels at time of admission and after treatment were compared with those of a control group. Results: No statistically significant difference was observed among PC levels at time of admission in the patient and control groups (p 0.305, patient group 0.025 ± 0.01, control group 0.026 ± 0.01). A significant decrease was determined in post-treatment PC levels in the patient group compared to those at time of admission (p 0.006, admission 0.025 ± 0.01, post-treatment 0.017 ± 0.008). No significant correlation was determined between patients' carboxyhemoglobin (CO-Hb) levels and PC levels at time of admission (Correlation coefficient -0.006, p 0.971). Conclusions: We think that PC is not suitable for use as a biomarker in the acute period in patients with CO intoxication

Clinical Characteristics and Outcome of Cardiovascular Implantable Electronic Device Infections in Turkey

Murat, Bektas/0000-0002-6564-7185; Yuksel, Murat/0000-0003-2636-5211WOS: 000377435200008PubMed: 25589093Infection is one of the most devastating outcomes of cardiovascular implantable electronic device (CIED) implantation and is related to significant morbidity and mortality. In our country, there is no evaluation about CIED infection. Therefore, our aim was to investigate clinical characteristics and outcome of patients who had infection related to CIED implantation or replacement. The study included 144 consecutive patients with CIED infection treated at 11 major hospitals in Turkey from 2005 to 2014 retrospectively. We analyzed the medical files of all patients hospitalized with the diagnosis of CIED infection. Inclusion criteria were definite infection related to CIED implantation, replacement, or revision. Generator pocket infection, with or without bacteremia, was the most common clinical presentation, followed by CIED-related endocarditis. Coagulase-negative staphylococci and Staphylococcus aureus were the leading causative agents of CIED infection. Multivariate analysis showed that infective endocarditis and ejection fraction were the strongest predictors of in-hospital mortality

The diagnostic value of protein carbonyl levels in acute carbon monoxide intoxication

Tatli, Ozgur/0000-0003-0263-7630WOS: 000419631500004Objective: Carbon monoxide (CO) is the main cause of intoxication-related mortality and morbidity in developed countries. It is responsible for more than half of fatal intoxications in many countries. The purpose of this study was to determine the diagnostic value of protein carbonyl (PC), a good marker of oxidative stress, in association with oxidative stress resulting from hypoxia emerging in patients with acute CO intoxication. Methods: Thirty-four patients diagnosed with acute CO intoxication at the Emergency Department and 38 healthy volunteers were included in the study. Patients' PC levels at time of admission and after treatment were compared with those of a control group. Results: No statistically significant difference was observed among PC levels at time of admission in the patient and control groups (p = 0.305, patient group 0.025 +/- 0.01, control group 0.026 +/- 0.01). A significant decrease was determined in post-treatment PC levels in the patient group compared to those at time of admission (p = 0.006, admission 0.025 +/- 0.01, post-treatment 0.017 +/- 0.008). No significant correlation was determined between patients' carboxyhemoglobin (CO-Hb) levels and PC levels at time of admission (Correlation coefficient = -0.006, p= 0.971). Conclusions: We think that PC is not suitable for use as a biomarker in the acute period in patients with CO intoxication