An investigation of the digital game addiction between high school students

The aim of this study was to investigate the digital game addiction levels of the high school students, according to some variables such as sports participation, gender, place of accommodation and level of income.The sample group comprises 931 high school students (508, %54,6 female and 423, %45,4 male) from several villages, districts and Kutahya city center (a town in the west part of Turkey with the population of 325.000). They participated to the study voluntarily. In addition to personal information from prepared by the researcher, the game addiction scale developed by Lemmens et al. (2009) and adapted to Turkish by Irmak and Erdogan (2015) was used as a data gathering tool. It is a five point Likert type scale and has one factor and seven items. In order to evaluate the results the descriptive statistical methods (percentage (%), frequency (f) and t-test, one-way ANOVA) were used.As a result, the significant difference was determined regarding digital game addiction [t (931)=-3,76; p=0,00]  between the students who participate to the sports activities and who do not. So, the non-participant students found more game addicted. According to the gender, male students were determined more addicted than females [t (931)=9,45; p=0,00]. No significant difference was determined in terms of the place where the students lived (p=0,56, p>0,05). Finally, the significant difference was determined in terms of the income levels, [f (931)=3,07; p=0,01] on behalf of  the students who had good income level. They found more addicted

A Real-Life Turkish Experience of Ruxolitinib in Polycythemia Vera

Introduction:Ruxolitinib is a small -molecule inhibitor of the JAK1/2 pathway. This study aimed to reveal the results and side-effect profile of the use of ruxolitinib as a treatment option in polycythemia vera (PV).Methods:A total of 34 patients with PV from 18 different centers were included in the study. The evaluation of the response under treatment with ruxolitinib was determined as a reduction in spleen volume (splenomegaly size: ≥35%) by imaging and control of hematocrit levels (≤45%) compared to baseline.Results:While the number of patients in which a reduction in spleen volume and hematocrit control was achieved was 19 (55.9%) at 3 months of treatment, it was 21 (61.8%) at 6 months. Additionally, while the number of side effects was negatively correlated with the reduction in spleen volume (Spearman’s rho: -0.365, p=0.034), a decrease in the hematocrit level was positively correlated (Spearman’s rho: 0.75, p=0.029). Those without a reduction in spleen volume experienced more constipation (chi-square: 5.988, Fisher’s exact test: p=0.033).Conclusion:This study shed light on the use of ruxolitinib in PV and the importance of splenomegaly on studies planned with larger patient groups

Synthesis of PbS: Mo (3%) thin film and investigation of its properties

Pure PbS and PbS:Mo(3%) thin films were synthesized on glass substrates at room temperature using the chemical bath deposition (CBD) method. The main purpose of this study is to examine the effect of the Mo additive metal on the crystallite size, optical energy band gap and photovoltaic properties of the PbS semiconductor thin film. Although the structure of PbS:Mo(3%) thin film was the same as the pure PbS, the crystallite size of PbS:Mo(3%) thin film (24.12 nm) was found to be lower than that of pure PbS (25.97 nm). The band gap values of PbS and PbS:Mo(3%) thin films were obtained as 1.89 eV and 1.91 eV, respectively. The possible reason for the increase in the energy band gap of PbS:Mo(3%) thin film is the incorporation of Mo6+ ions into the PbS lattice. Photovoltaic properties of PbS and PbS:Mo(3%) thin films synthesized on Zn2SnO4 coated on FTO conductive glasses via CBD technique were investigated using the IPCE and J–V measurements. The IPCE (%) values obtained at 400 nm for the pure PbS and PbS:Mo(3%) thin films were 35% and 41%, respectively. The power conversion efficiency (?) values were obtained as 2.02% and 2.11% for pure PbS and PbS:Mo(3%) thin films, respectively. Thus, it was observed that the doped metal has significantly improved the photovoltaic properties of PbS thin films

Sağlıklı ve İshalli Buzağılarda İndirekt Osilometrik Yöntemle Ölçülen Kan Basıncı Değerlerinin Karşılaştırılması

Kan basıncı, kardiyovasküler sistem fonksiyonunun değerlendirilmesi için ölçülmesi gereken önemli bir parametre-dir. Çiftlik hayvanı hekimliğinde kan basıncının ölçülmesi rutinde yaygın olarak kullanılmamaktadır. Oysaki ishal nedeniyle oluşan; periferal dolaşım bozukluğu, hipovolemi ve kollaps buzağıların kan basıncı değerlerinde anormalliklere sebep olabilir. Ayrıca, kan basıncı değerleri ishal ve çeşitli enfeksiyonlara bağlı olarak gelişen sepsis, SIRS ve septik şok gibi buzağılarda genel durum bozukluğuyla seyreden durumlarınteşhis ve prognozun tahmin edilmesinde yardımcı bir faktör olabilir. Bu araştırmada; indirekt osilometrik yöntem ile sağlıklı ve ishalli buzağılardan elde edilen kan basıncı [sistolik kan basıncı (SKB), diyastolik kan basıncı (DKB) ve ortalama arter basıncı (OAB)] değerlerinin karşılaştırılması amaçlandı. Bu amaçla, 20 sağlıklı ve 20 ishalli olmak üzere toplam 40 adet buzağının kan basıncı değerleri non-invaziv osilometrik kan basıncı cihazı ile 3 farklı bölgeden (sağ ön ekstremite, sol ön ekstremite ve kuyruk kökü) ölçüldü. İshalli buzağılardan sağ ön ekstremite, sol ön ekstremite ve kuyruk kökünden kan basıncı ölçümleri elde edildi [Sağ ön ekst-remite; SKB (mmHg) (87.07±27.32), DKB (mmHg) (100.33±26.55), OAB (mmHg) (95.07±21.02), Sol ön ekstremite; SKB (mmHg) (82.80±22.50), DKB (mmHg) (94.47±20.62), OAB (mmHg) (90.27±19.69), kuyruk; SKB (mmHg) (56.73±12.38), DKB (mmHg) (75.60±12.21), OAB (mmHg) (91.20±22.73)] değerleri elde edildi. Sonuç olarak, osilomet-rik kan basıncı ölçme işlemi klinik pratikte hızlı ve kullanışlı bir tekniktir. İshalli buzağıların sağ ön ekstremitelerinden ölçülen SKB (87.07±27.32 mmHg) ve OAB (95.07±21.02 mmHg) değerleri, sağlıklı buzağılardan (SKB; 158.80±13.12 mmHg, OAB; 123.67±21.70 mmHg) istatistiksel olarak anlamlı düzeyde düşük bulundu (P&lt;0.001). Bu araştırmadan elde edilen bulgular ishale bağlı olarak gelişen düşük arteriyel kan basıncı gibi hayati tehdit eden durumlarda kan ba-sıncını artırmaya yönelik terapötik ajanların tedavi stratejileri arasında yer alması gerektiğinin önemini göstermektedir.Blood pressure (BP) is an important parameter to be measured for the evaluation of cardiovascular system function. Measuring BP in farm animals does not require routine use of medicine. However, due to diarrhea peripheral circulatory disorders, hypovolemia and collapse may cause abnormalities in BP values of calves. In addition, BP values can be a helpful factor in diagnosing and predicting prognosis of conditions with poor general condition in calves, such as sepsis due to diarrhea and various infections, SIRS and septic shock. In this study; It was aimed to compare the BP [systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP)] values obtained from healthy calves with and diarrheic calves by indirect oscillometric method. For this purpose, a total of 40 calves, 20 di-arrheic calves with diarrhea and 20 calves with healthy). BP were measured from 3 different regions: right forelimb [SBP (mmHg) (87.07±27.32), DBP (mmHg) (100.33±26.55), MAP (mmHg) (95.07±21.02)], left forelimb [SBP (mmHg) (82.80±22.50), DBP (mmHg) (94.47±20.62), MAP (mmHg) (90.27±19.69)] and tail [SBP (mmHg) (56.73±12.38), DBP (mmHg) (75.60±12.21), MAP (mmHg) (91.20±22.73)]. In conclusion, indirect oscillometric BP measurement is a fast and useful technique in clinical practice. SBP (87.07±27.32 mmHg) and MAP (95.07±21.02 mmHg) values measured from the right forelimb of calves with diarrhea were statistically significantly lower than healthy calves (SBP; 158.80±13.12 mmHg, MAP; 123.67±21.70 mmHg) (P&lt;0.001). The findings of this study show the importance of inclu-ding the therapeutic agents to increase BP should be among the treatment strategies in life-threatening conditions such as low arterial BP due to diarrhea.</p

Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules

Here we determined the in vitro inhibitory effects of 5-(2-hydroxyethyl)-3,4-dimethylthiazolium iodide (1), 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride (2) and thiamine (3) on human erythrocyte carbonic anhydrase I, II isozymes (hCA I and hCA II) and secreted isoenzyme CA VI. K I values ranged from 0.38 to 2.27 mu M for hCA I, 0.085 to 0.784 mu M for hCA II and 0.062 to 0.593 mu M for hCA VI, respectively. The compounds displayed relatively strong actions on hCA II, in the same range as the clinically used sulfonamidesethoxzolamide, zonisamide and acetazolamide.WOS:0003145310000122-s2.0-84891458403PubMed: 2214567