Single p(a)lace, multiple narratives: The Topkapi Palace in Western travel accounts from the eighteenth to the twentieth century

[No abstract available

Introduction: Western travel writing and the city in the Muslim world

[No abstract available

Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis.

The successful completion of cytokinesis requires the coordinated activities of diverse cellular components including membranes, cytoskeletal elements and chromosomes that together form partly redundant pathways, depending on the cell type. The biochemical analysis of this process is challenging due to its dynamic and rapid nature. Here, we systematically compared monopolar and bipolar cytokinesis and demonstrated that monopolar cytokinesis is a good surrogate for cytokinesis and it is a well-suited system for global biochemical analysis in mammalian cells. Based on this, we established a phosphoproteomic signature of cytokinesis. More than 10,000 phosphorylation sites were systematically monitored; around 800 of those were up-regulated during cytokinesis. Reconstructing the kinase-substrate interaction network revealed 31 potentially active kinases during cytokinesis. The kinase-substrate network connects proteins between cytoskeleton, membrane and cell cycle machinery. We also found consensus motifs of phosphorylation sites that can serve as biochemical markers specific to cytokinesis. Beyond the kinase-substrate network, our reconstructed signaling network suggests that combination of sumoylation and phosphorylation may regulate monopolar cytokinesis specific signaling pathways. Our analysis provides a systematic approach to the comparison of different cytokinesis types to reveal alternative ways and a global overview, in which conserved genes work together and organize chromatin and cytoplasm during cytokinesis.EMBO (European Molecular Biology Organization) Installation Grant; Young Scientist Award Program BAGEP of the Science Academy (Turkey); TUBITAK-Marie Curie Co-funded Brain Circulation Schem

Effect of Music on Postoperative Pain and Physiologic Parameters of Patients after Open Heart Surgery

PubMedID: 23452523The aim of this study was to investigate the effect of listening to personal choice of music on self-report of pain intensity and the physiologic parameters in patients who have undergone open heart surgery. The study design was quasiexperimental. Patients were selected through convenience sampling in the Cardiovascular Surgery Intensive Care Unit at a university hospital. The study was conducted with a total of 87 patients who underwent open heart surgery: 44 in the music group, 43 in the control group, ages between 18 and 78 years. Through pretest-posttest design, postoperative first-day data were collected. First, physiologic parameters (blood pressure, heart rate, oxygen saturation, and respiratory rate) were recorded and a unidimensional verbal pain intensity scale applied to all participants. Later, the control group had a rest in their beds while the music group listened to their choice of music for 30 minutes. Physiologic data were then collected and the pain intensity scale applied once more. In the music group, there was a statistically significant increase in oxygen saturation (p = .001) and a lower pain score (p = .001) than in the control group. There was no difference between the groups in the other physiologic parameters. Results of this research provide evidence to support the use of music. Music might be a simple, safe, and effective method of reducing potentially harmful physiologic responses arising from pain in patients after open heart surgery. © 2013 American Society for Pain Management Nursing

The efficacy of Botulinum Toxin A in poststroke spasticity

To assess the efficacy of the Botulinum Toxin A (BTX-A) on spasticity, motor evaluation, function and quality of life in patients with spasticity of upper and lower extremity following hemiplegia. Spasticity was assessed with Modified Ashworth Scale (MAS), motor function of upper and lower extremities and hand of hemiplegic side were evaluated with Brunnstrom neurophysiologic evaluation, mobilization was assessed with Rivermead Motor Assessment (RMA), upper extremity function was evaluated with Fugl Meyer (FM), functional assesment was evaluated with Functional Independence Measure (FIM), quality of life was assessed with Short Form 36 (SF-36) at baseline and at week 6. Sixteen patients (4 right hemiplegia, 12 left hemiplegia) with mean age of 47.56±17.2 years were included. BTX-A was injected into the forearm flexors in 7 cases, pronators in 6 cases, wrist flexors in 6 cases, finger flexors in 10 cases, and ankle flexors in 8 cases with a total dose of 300 U for each case. Significant improvements were detected for MAS of all muscles which were BTX-A injected compared to pretreatment. Significant improvements were detected for Brunnstrom evaluation of hand, RMA, FM and FIM compared to pretreatment. While significant improvement was found for only role limitations due to physical problems subgroup of SF-36, there was no statistical difference for other subgroups. Botulinum toxin A is safe regarding side effects, and improves the functional capacity of patient in the treatment of spasticity

Seckel syndrome: Case report [Seckel sendromu]

Seckel syndrome, an autosomal recessive syndrome is characterised by microcephaly, dwarfism-prenatal onset growth deficiency, prominent nose, bird- like narrow face, micrognathia, severe mental retardation, chromosomal instability, pancytopenia. Incidence is 1:10000. Here an uncommon case with Seckel Syndrome was reported

Mental retardation and fragil X syndrome [Mental retardasyon ve frajil X sendromu]

Fragile X syndrome is a genetic disorder with a semidominance of X chromosome due to mutation in fragile X mental retardation-1 gen (familial mental retardation-1 or FMR-1) which is characterized by learning, linguistic and memory problems due to temporal lobe dysfunction. Fragile X syndrome is the second common cause of mental retardation after Down syndrome. Fragile X syndrome constitues 1/3-1/4 of X linked mental retardation. Its incidence is 1/4000 in male, 1/6000 in female children. There is no difference between ethnic groups

Down syndrome [Down sendromu]

Down syndrome is a genetic disorder with an excess genetic material on 21th chromosome, mild mental retardation and anomalies of multiple organ systems. Physical and neurophysicological findings such as mental retardation, linguistic and memory problems accompany this syndrome. Neuroanatomical origins of this cognitive dysfunctions are not clear yet. The risk of Down syndrome differs with respect to races, and ethnic groups, maternal age distribution, prenatal diagnosis and cytogenetic analysis

A newborn with klinefelter and trisomy 18 syndrome: Case report

Double trisomy may occur as autosomal with sex chromosome trisomy or double autosomal trisomy. This coincidence is very rare. Trisomy 18, that is first recognized as a specific entity in 1960 by discovery of the extra 18 chromosome, is characterized by intrauterine growth retardation, prominent occiput, micrognathia, rocker-bottom feet. Klinefelter's syndrome, that is described in 1942, is the most common single cause of hypogonadism and infertility. Paternal meiosis errors account for about one half of Klinefelter syndrome while remainder are mostly due to maternal meiosis errors. Here, we present a newborn with trisomy 18 with Klinefelter syndrome (48 XXY, 18+), showing the clinical features of trisomy 18. Copyright © 2012 by Türkiye Klinikleri

Predictive factors for latency period in viable pregnancies complicated by preterm premature rupture of the membranes [Preterm prematür membran rüptürü ile komplike viabl gebeliklerde latens süresini öngörü faktörleri]

Objective: In this study, we aimed to evaluate some laboratory and clinical factors in the prediction of latency period for pregnant patients complicated with preterm premature rupture of the membranes. Materials and Methods: Sixty-five pregnant patients between 24 and 34 weeks of gestation, who were admitted to University of Çukurova School of Medicine Hospital with the diagnosis of preterm premature rupture of the membranes (PPROM) between January 01, 2013 and December 31, 2013, were included in this study. Serum CRP, procalcitonin, sedimentation rate, leukocyte count and cervical length (measured with transvaginal ultrasound) of patients were analyzed for the correlation with the latency period. Results: None of the parameters were found to be correlated with the latency period. However, patients with cervical length of <25 mm were found to have shorter duration of latency. Conclusion: Although preterm premature rupture of the membranes is thought to be either an infection-based disease or a disease increasing the risk of infectious complications, major infection markers are not found to be helpful criteria for the prediction of latency period. Patients with a cervical length of <25 mm can be expected to deliver earlier and, therefore, can be referred to a tertiary center earlier. © 2015, Turkish Society of Obstetrics and Gynecology. All rights reserved