Maligniteyi taklit eden pulmoner arteriyovenöz malformasyon: Olgu sunumu

Pulmonary arteriovenous malformations (AVM) are congenital lesions and are often arise in the lower lobes due to abnormal capillary development. Forty-two years old male patient presented with hemoptysis and he was referred to our clinic with the suspicion of malignancy. Postero-anterior chest roentgenogram revealed homogenous opacity on the right perihilar zone. Computed tomography revealed a mass which was located at the right upper lobe. For the dia gnosis and staging 18F-FDG PET- CT was obtained. The mass was 6.5x5x4.5 cm and showed increased FDG uptake, 2,97. The lesion was considered as a large PAVM because of the linear density showing luminal contrast enhancement which was located between the lesion and right upper pulmonary vein. Dynamic contrast enhaced tomography revealed a solid mass with a suspicion of PAVM with thrombotic occlusion. Pulmonary angiography was free of AVM and fistulae. The patient underwent right upper lobectomy. Pathologic studies were consistent with pulmonary AVM. This case is presented because of upper lobe involvement, normal pulmonary angiography and the need of surgical operation as the only diagnostic tool

Au/n-Si Schottky Diyodların Kapasite-Frekans Karakteristiklerinden Arayüzey Hal Dağılım Eğrilerinin Belirlenmesi

A novel Differentially encoded Space-Time Spreading (DSTS) scheme using two transmit antennas and Sphere Packing (SP) is proposed, which we refer to as the DSTS-SP arrangement. The advocated SP-aided system outperforms DSTS dispensing with SP and requires no channel knowledge. We also demonstrate that the performance of DSTS-SP systems can be further improved by serially concatenated convolutional coding and by performing SP-symbol-to-bit demapping as well as channel decoding iteratively. Explicitly, the proposed turbo-detected DSTS-SP scheme exhibits an Eb/N0 gain of 17.8dB at a Bit Error Rate (BER) of 10?5 over an uncoded identical-throughput system and an Eb/N0 gain of 1.9dB over the equivalent 2 bits/symbol effective throughput QPSK-modulated turbo-detected DSTS scheme

Enzymatic synthesis of I-125/131 labeled 8-hydroxyquinoline glucuronide and in vitro/in vivo evaluation of biological influence

8-Hydroxyquinoline (8-OHQ) is a long-known molecule which due to its metal-complexation ability is frequently used for analysis. It is also called oxine. Oxine and derivatives have been investigated to process antitumor and antimicrobial activities. 8-Hydroxyquinolyl-glucuronide (8-OHQ-Glu) was enzymatically synthesized using microsome preparates separated from Hutu-80 cells, labeled with I-125 to perform a radionuclide labeled prodrug and investigated of its biological affinities on Hutu-80 (human duodenum intestinal adenocarcinoma), Caco-2 (human colorectal adenocarcinoma), Detroit 562 (human pharynx adenocarcinoma) cells and ACBRI 519 (primary human small intestine epithelial cells) in this work. UDP-glucuronyl transferase (UDPGT) rich microsome preparates, which are used for glucuronidation in enzymatic synthesis, were extracted from Hutu-80 cells

L-Carnitine Protection Against Cisplatin Nephrotoxicity In Rats: Comparison with Amifostin Using Quantitative Renal Tc 99m DMSA Uptake

Objective: In this study, we aimed to investigate the cytoprotective effect of L-carnitine against cisplatin-induced nephrotoxicity and to compare its efficacy with that of amifostin by quantitative renal Tc 99m DMSA uptake. Material and Methods: Male Wistar rats were randomly divided into six groups of six animals each. 1) Control (saline; 5 ml/kg intraperitoneally); 2) L-carnitine (CAR; 300 mg/kg intraperitoneally); 3) Amifostine (AMI; 200 mg /kg intraperitoneally); 4) Cisplatin (CIS;7 mg/kg intraperitoneally); 5) Cisplatin plus L-carnitine (CIS + CAR); 6) Cisplatin plus amifostine (CIS + AMI). L-carnitine and amifostine were injected 30 minutes before cisplatin in Group 5 and 6. Tc 99m DMSA, 7.4 MBq/0.2 ml, was injected through the tail vein 72 hours after the drug administration. Rats were killed and kidneys removed by dissection 2 hours after the injection of the radiopharmaceutical. The percentage of the injected dose per gram of kidney tissue (%ID/g) was calculated. Renal function was monitored by measuring BUN and plasma levels of creatinine. Lipid peroxidation and glutathione content were determined by measuring malondialdehyde (MDA) and reduced glutathione (GSH) in kidney tissue homogenates. Results: Tc 99m DMSA uptake per gram tissue of the kidney as %ID/g was 29.54±4.72, 29.86 ± 7.47 and 26.37 ± 4.54 in the control, CAR and AMI groups respectively. %ID/g was the lowest of all the groups, 11.60±3.59 (p<0.01), in the cisplatin group. Carnitine or amifostine administration 30 minutes before cisplatin injection resulted a significant increase in %ID/g, 21.28±7.73 and 18.97±3.24 respectively, compared to those of cisplatin-treated rats (p<0.002). A marked increase in plasma BUN and creatinine indicating nephrotoxicity and acute renal failure was observed in the cisplatin-treated group. MDA and GSH levels were concordant with cisplatin-induced oxidative stress in the kidney tissue. Conclusion: The results showed that L-carnitine significantly attenuates the cisplatin-induced nephrotoxicity as amifostin. (MIRT 2011; 20: 1-6