Quality of life in adult patients with acne vulgaris before and after treatment

Objectives: To investigate effect of acne treatment on quality of life in patients with acne vulgaris.Materials and methods: The study was prospective and conducted in a university hospital, enrolling the previously untreated patients with acne vulgaris. Before treatment, dermatology life quality index (DLQI) was applied to all participants of both study and control group. After 3rd and 6th months of treatment administration, DLQI tool was applied to patients in the study group, and scores were compared.Results: The acne severity of patients in the study group was 17 (27.9%), 34 (55.7%) and 10 (16.4%) for mild, moderate and severe form, respectively. Mean scoring for DLQI in the study group and the control group was 8.74±5.07 and 2.21±2.44, respectively (p=0.0005). In the study, significant difference were observed in life quality scores between severe acne and mild acne patients, and between severe acne and moderate acne patients (p=0.003 and p=0.011, respectively), but not between mild and moderate acne patients (p=0.937). Effect of gender in acne vulgaris on quality of life was not significantly different (p=0.336). At stage of treatment at the end of 3rd and 6th month, improvements on quality of life was observed significant for overall and all classification of acne severity (mild, moderate and severe; p<0.001, p<0.001 and p<0.001, respectively).Conclusions: We concluded that acne vulgaris was one of the major skin diseases inversely affecting quality of life in patients and we observed that quality of life improved with treatment in patients

Erişkin akne vulgaris hastalarında tedavi öncesi ve sonrası hayat kalitesi

To investigate effect of acne treatment on quality of life in patients with acne vulgaris. Materials and methods: The study was prospective and conducted in a university hospital, enrolling the previously untreated patients with acne vulgaris. Before treatment, dermatology life quality index (DLQI) was applied to all participants of both study and control group. After 3rd and 6th months of treatment administration, DLQI tool was applied to patients in the study group, and scores were compared. Results: The acne severity of patients in the study group was 17 (27.9%), 34 (55.7%) and 10 (16.4%) for mild, moderate and severe form, respectively. Mean scoring for DLQI in the study group and the control group was 8.745.07 and 2.212.44, respectively (p0.0005). In the study, significant difference were observed in life quality scores between severe acne and mild acne patients, and between severe acne and moderate acne patients (p0.003 and p0.011, respectively), but not between mild and moderate acne patients (p0.937). Effect of gender in acne vulgaris on quality of life was not significantly different (p0.336). At stage of treatment at the end of 3rd and 6th month, improvements on quality of life was observed significant for overall and all classification of acne severity (mild, moderate and severe; p0.001, p0.001 and p0.001, respectively). Conclusions: We concluded that acne vulgaris was one of the major skin diseases inversely affecting quality of life in patients and we observed that quality of life improved with treatment in patients.Akne vulgaris hastalarında akne tedavisinin hayat kalitesi üzerine etkisinin incelenmesi amaçlanmıştır. Gereç ve yöntem: çalışma prospektif olarak tasarlandı. Daha öncesinde akne tedavisi almayan hastalar alındı ve çalışma bir üniversite hastanesinde yürütüldü. çalışma grubu ve kontrol grubu oluşturuldu. Tedavi öncesi hastalara ve kontrol grubuna Dermatolojik Yaşam Kalitesi İndeksi (DYKI) ölçeği uygulandı. Tedavi sonrası 3. ve 6. aylarda DYKI tekrar uygulandı. Tüm Skorlar karşılaştırıldı. Bulgular: çalışma grubunda bulunan akne olgularından 17 (%27,9) hasta hafif, 34 hasta orta (%55,7) ve 10 hasta (%16,4) ileri derece akne grubunda idi. çalışma grubu ve kontrol grubunun ortalama DYKI skoru sırası ile 8,74±5,07 ve 2,21±2,44 idi (p0,0005). çalışma grubunda ileri derece akne ile orta derece akne; ileri derece akne ile hafif dereceli akne arasında yaşam kalitesi skoru arasında anlamlı fark izlendi (p0,003, p0,011 sırası ile), fakat hafif ve orta derece akne arasında fark izlenmedi (p0,036). Cinsiyetin akne vulgarisin hastalarında yaşam kalitesi üzerine etkisi izlenmedi (p0,336). Tedavinin 3. ve 6. aylarında çalışma grubunda yaşam kalitesi tüm olgu ve her bir akne derecesi (hafif, orta ve ileri derece) için tekrar değerlendirildi (sırası ile; p<0,001, p<0,001, p<0,001 ve p<0,001). Sonuç: Sonuç olarak, çalışmamızda akne vulgarisin yaşam kalitesini ciddi anlamda etkileyen bir majör deri hastalıklarından biri olduğu, fakat tedavi ile yaşam kalitesinin düzeldiği sonucuna ulaştık

Efficacy of iloprost and montelukast combination on spinal cord ischemia/reperfusion injury in a rat model

Ankarali, Handan Camdeviren/0000-0002-3613-0523; Cicek, Omer Faruk/0000-0002-4675-3273; Kaya, Ertugrul/0000-0003-0081-682XWOS: 000318773400001PubMed: 23557242Background: The thoracic or thoracoabdominal aortic aneurysm surgery may cause spinal cord ischemia because of aortic cross-clamping and may result in severe postoperative complications caused by spinal cord injury. Ischemia/reperfusion injury may directly or indirectly be responsible for these complications. In this study we sought to determine whether combination of iloprost and montelukast can reduce the ischemia/reperfusion injury of spinal cord in a rat model. Methods: Medulla spinalis tissue concentrations of interleukin-6 (IL-6), myeloperoxidase (MPO) and heat shock protein 70 (HSP-70) were determined in 3 groups of Spraque Dawley rats: control group (operation with cross clamping and intraperitoneal administration of 0.9% saline, n = 7), sham group (operation without cross clamping, n = 7), and study group (operation with cross-clamping and intraperitoneal administration of iloprost (25 ng/kg) and montelukast (1 mg/kg), n = 7). The abdominal aorta was clamped for 45 minutes, with a proximal (just below the left renal artery) and a distal (just above the aortic bifurcation) clip in control and study groups. Hindlimb motor functions were evaluated at 6, 12, 24, and 48 hours using the Motor Deficit Index score. All rats were sacrificed 48 hours after the procedure and spinal cord tissue levels of myeloperoxidase, interleukin-6, and heat shock protein (HSP-70) were evaluated as markers of oxidative stress and inflammation. Histopathological analyses of spinal cord were also performed. Results: The tissue level of HSP-70 was found to be similar among the 3 groups, however, MPO was highest and IL-6 receptor level was lowest in the control group (p = 0.007 and p = 0.005; respectively). In histopathological examination, there was no significant difference among the groups with respect to the neuronal cell degeneration, edema, or inflammation, but vascular congestion was found to be significantly more prominent in the control group than in the sham or in the study group (p = 0.05). Motor deficit index scores at 24 and 48 hours after ischemia were significantly lower in the study group than in the control group. Conclusion: This study suggests that combined use of iloprost and montelukast may reduce ischemic damage in transient spinal cord ischemia and may provide better neurological outcome

Relation of Angiographic Thrombus Burden with Severity of Coronary Artery Disease in Patients with ST Segment Elevation Myocardial Infarction

Durakoglugil, Emre/0000-0001-5268-4262; Cetin, Mustafa/0000-0001-6342-436X; duman, hakan/0000-0002-1441-7320WOS: 000365240100001PubMed: 26573108Background: We planned to investigate the relationship of thrombus burden with SYNTAX score in patients with ST elevation myocardial infarction (STEMI). Material/Methods: We retrospectively enrolled 780 patients who underwent PPCI in our clinic due to STEMI. Clinical, laboratory, and demographic properties of the patients were recorded. Angiographic coronary thrombus burden was classified using thrombolysis in myocardial infarction (TIMI) thrombus grades. Results: Patients with high thrombus burden were older, with higher diabetes prevalence longer pain to balloon time, higher leukocyte count, higher admission troponin, and admission CK-MB concentrations. SYNTAX score was higher and myocardial perfusion grades were lower in patients with high thrombus burden. Multivariate logistic regression analysis revealed SYNTAX score as the strongest predictor of thrombus burden. ROC analysis demonstrated a sensitivity of 75.5%, specificity of 61.2%, and cut-off value of >14 (area under the curve (AUC): 0.702; 95% confidence interval [CI]: 0.773-0.874; P<0.001) for high thrombus burden. Conclusions: SYNTAX score may have additional value in predicting higher thrombus burden besides being a marker of coronary artery disease severity and complexity