Objectives: To investigate effect of acne treatment on quality of life in patients with acne vulgaris.Materials and methods: The study was prospective and conducted in a university hospital, enrolling the previously untreated patients with acne vulgaris. Before treatment, dermatology life quality index (DLQI) was applied to all participants of both study and control group. After 3rd and 6th months of treatment administration, DLQI tool was applied to patients in the study group, and scores were compared.Results: The acne severity of patients in the study group was 17 (27.9%), 34 (55.7%) and 10 (16.4%) for mild, moderate and severe form, respectively. Mean scoring for DLQI in the study group and the control group was 8.74±5.07 and 2.21±2.44, respectively (p=0.0005). In the study, significant difference were observed in life quality scores between severe acne and mild acne patients, and between severe acne and moderate acne patients (p=0.003 and p=0.011, respectively), but not between mild and moderate acne patients (p=0.937). Effect of gender in acne vulgaris on quality of life was not significantly different (p=0.336). At stage of treatment at the end of 3rd and 6th month, improvements on quality of life was observed significant for overall and all classification of acne severity (mild, moderate and severe; p<0.001, p<0.001 and p<0.001, respectively).Conclusions: We concluded that acne vulgaris was one of the major skin diseases inversely affecting quality of life in patients and we observed that quality of life improved with treatment in patients
