Fötal malformasyonların antenatal tanısında amniyotik sıvı AFP düzeyinin yeri

TEZ84Tez (Uzmanlık) -- Çukurova Üniversitesi, Adana, 1981.Kaynakça (s. 31-38) var.38 s. : res. ; 31 cm.

Ovarian Autografting in Rabbits: Hormonal and Morphological Evaluations

Giriş: 10 adet erişkin dişi tavşanda otograft öncesi ve sonrası ovaryumda oluşan fonksiyonel ve histolojik değişiklikler değerlendirildi. Materyal ve Metod: Preoperatif (otografttan bir ay önce) ve postoperatif (otograftan iki ay sonra) östradiol (E2) ve progesteron (P) seviyeleri ölçüldü, akabinde histolojik değerlendirmeler ışık mikroskobuyla yapıldı. Bir ay sonra, tavşanlarda ovaryum otograftı yapıldı. Sonuçlar: Ovaryum dokularının %80'inde transplante ovaryum örnekleri gözlendi. Preoperatif ve postoperatif P değerleri bazaldan geç periyoda doğru artış gösterdi ve farklar istatistiksel olarak anlamlıdır. Bazaldan geç periyoda doğru preoperatif ve postoperatif E2 değerleri arasında istatistiksel olarak anlamlı bir fark yoktur. Her üç zaman periyodunda da preoperatif P değerleri postoperatif P değerlerinden istatiktiksel olarak anlamlı şekilde yüksektir. Preoperatif E2 değeri postoperatif E2 değerine göre yüksektir fakat bu fark istatistiksel olarak anlamlı değildir. Tartışma: Eğer otograft işlemleri mikrocerrahi yöntemleri kullanılarak gerçekleştirilirse, postoperatif periyottaki ovaryum otograftları preoperatif periyotta olduğu gibi hormonal fonksiyon ve morfoloji gösterirler.Purpose: The functional and histological changes in the ovarian tissue of 10 female mature rabbits were evaluated before and after ovarian autografting. Material and Methods: Preoperative (one month before the autograft) and postoperative (two months after the autograft) estradiol ( E2) and progesterone ( P) levels were measured, and histological evaluations were performed by light microscope. One month later, ovarian autografting was performed on the rabbits. Results: Ovarian tissue was observed in 80% of the transplanted ovarian samples. Both preoperative and postoperative P values increased from the basal to the late period and the differences were statistically significant. There was no significant difference between preoperative and postoperative E2 values from the basal to the late period. Preoperative P values were statistically significantly higher than postoperative P values in all three time periods. Preoperative E2 values were also higher than postoperative E2 values, but the differences were not statistically significant. Conclusion: If autografting is performed by employing microsurgical techniques, ovarian autografts will have similar postoperative hormonal function and morphology as in preoperative period

Effect of Hysteroscopic Surgery Before Frozen Embryo Transfer on Patients with Previous Implantation Failure

Aim: The aim of this study was to evaluate the benefit of hysteroscopy (HS) before single frozen-thawed embryo transfer (sFET) on patients with previous implantation failure. Material and Methods: A total of 1352 infertile women with a previous implantation failure who underwent their first sFET treatment between January 2015 and December 2017 were included in this study. The patients were classified into two main groups in which HS was omitted (Group 1), and who underwent HS (Group 2). Furthermore, Group 2 was classified into two subgroups as patients without any intrauterine pathology (Group 2a), and those with intrauterine pathology (Group 2b). sFET was performed on all patients within 50 days of hysteroscopy. The major outcome measure was the clinical pregnancy rate. Results: The mean number of mature oocytes and fertilization rates were similar between groups. The clinical pregnancy rate was found to be 33.3% (n=70) in Group 1. Comparatively this rate was statistically significantly higher in patients in Group 2. The clinical pregnancy rate was 44.2% (n=378) in Group 2a, and 44.4% (n=127) in Group 2b (p=0.014). There was a significant difference between Group 1 and Group 2a (OR: 1.58, 95% CI: 1.15-2.17, p=0.004), and also Group 2b (OR: 1.59, 95% CI: 1.10-2.31, p=0.013). However, no significant difference was observed between Group 2a and Group 2b (p=0.896). Conclusion: Our findings demonstrate that HS surgery increases the probability of pregnancy rate at least by 1.58 times in patients having previous implantation failure when the hysteroscopic procedure is followed by sFET