Effect of Helicobacter pylori infection on deep vein thrombosis seen in patients with Behçet's disease

Objective: To investigate the role of homocysteine metabolism due to Helicobacter pylori infection on the development of deep vein thrombosis (DVT) in patients with Behcet's disease (BD). Design: Prospective clinical study. Setting: Teaching hospital. Subject: Fifty-five patients with BD divided into groups, with DVT and without DVT, 19 healthy individuals and 18 patients with coronary artery disease (CAD) were enrolled into the study. Interventions: Plasma homocysteine and Hp seropositivity were determined. Results: There was significant Hp positivity in all groups (p>0.05). Homocysteine levels were not significantly different for each group except patients with CAD (p>0.05). Conclusion: There was no difference for frequency of Hp infection in all groups. We conclude that Hp does not influence DVT seen in BD via homocysteine metabolism, but the methinnin-loading test would be appropriate for enlighting patients whose fasting plasma homocysteine levels are found to be normal. East African Medical Journal Vol. 83(1) 2006: 49-5

Frontal sinüs boyutlarının yaş ve cinsiyet ile ilişkisinin değerlendirilmesi

Amaç: Adli araştırmaların önemli bir parçası bireyin kimliklendirilmesidir. Frontal sinüs, kişisel tanımlama, yaş tahmini ve cinsiyet tayini için değerli özelliklere sahiptir. Bu çalışmada amaç konik ışınlı bilgisayarlı tomografi (KIBT) görüntülerinde frontal sinüs boyutlarını değerlendirerek, bu boyutların yaş ile ilişkisini ve cinsiyet tayinindeki önemini belirlemektir.Gereç ve Yöntemler: Yaşları 20 ile 85 arasında değişen toplam 178 birey (105 Kadın, 73 Erkek) retrospektif olarak incelendi. KIBT görüntülerinde her sinüs için sağ ve sol taraf olmak üzere genişlik, yükseklik ve anteroposterior derinlik ve maksimum toplam genişlik ölçümleri yapıldı. Çalışmaya dahil olan bireyler yaşa göre 5 alt gruba ayrıldı ve her ölçüm parametresi de alt gruplar arasında karşılaştırıldı. Toplanan verilerin istatistiksel analizi Statistical Package for the Social Sciences (SPSS) 23.0 programı kullanılarak yapıldı.Bulgular: Sağ ve sol frontal sinüs genişliği, anteroposterior derinlik ve maksimum toplam genişlik özellikleri açısından erkekler kadınlardan istatistiksel olarak önemli derecede yüksek ortalamalara sahipken (p<0.01), sinüs yüksekliği açısından istatistiksel olarak önemli bir fark belirlenmedi. Değerlendirilen tüm parametreler için yaş grupları arasında istatistiksel olarak önemli bir fark gözlenmedi. Yapılan diskriminant analizi sonucu cinsiyet tahmininde doğruluk oranı % 71.3 olarak hesaplandı.Sonuç: Bu çalışmada KIBT görüntülerinde ölçülen frontal sinüs boyutlarının yaş grupları arasında önemli farklılık göstermediği belirlendi. Bununla birlikte frontal sinüsün cinsiyet tayininde dimorfik özellikte olduğu fakat tek başına cinsiyet belirlemede yeterli olmadığı ve ilave parametrelerle doğruluğunun artırılacağı düşünüldü.ANAHTAR KELİMELER Adli bilimler, Cinsiyet tespiti analizi, Frontal sinus, Konik ışınlı bilgisayarlı tomograf

The Impact of Septal Deviation on Intranasal Schirmer Test Values

Objective:Intranasal Schirmer test serves as an objective measurement for evaluation of nasal secretion and humidity. This study aimed to evaluate the effect of septal deviation on nasal secretion and humidity by measuring the intranasal Schirmer test values in patients who had septal deviation and compare it to the values of our healthy volunteers.Methods:The study included 52 patients with nasal septum deviation and 52 volunteers without any rhinologic complaints or deviated nasal septum. Intranasal Schirmer test was performed to all patients and volunteers for both nasal cavities.Results:The intranasal Schirmer test values of the convex (deviated) side were lower than that of the concave (non-deviated) side (20.71 and 23.35 respectively); although this difference was not statistically significant (p=0.054,). After excluding the four patients with equal Schirmer test results on both sides, 70% (34/48) of our patients had lower intranasal Schirmer test values on the deviated side. There was no statistically significant difference between the Schirmer test values of the patients with septal deviation and the volunteers without septal deviation (p>0.05).Conclusion:The Schirmer test values of the deviated sides were less than the values of the contralateral side in majority of our patients. This finding supports the negative effect of nasal septum deviation on nasal humidification, although the difference did not reach statistical significance

Transcanal Endoscopic Type 1 Cartilage Tympanoplasty in Children

Objective:Transcanal endoscopic type 1 tympanoplasty is a minimally invasive procedure that enables better visualization of deep and narrow spaces compared to conventional microscopic methods. In our study, we aimed to evaluate air-bone gap difference, graft success, and hearing gain according to the perforation size and location in pediatric patients who underwent transcanal endoscopic type 1 cartilage tympanoplasty.Methods:Fifty pediatric patients who underwent transcanal endoscopic type 1 cartilage tympanoplasty for chronic otitis media were included in the study. Tragal cartilage grafts were used in all patients. Air conduction pure tone audiometry hearing results (500, 1000, 2000, and 4000 Hz), mean air-bone gap levels, operating times, postoperative gap closure, and graft success rates were evaluated.Results:Mean operating time was 43.34±8.56 minutes. Overall graft success was 94% (47/50). Mean hearing levels at all frequencies (500, 1000, 2000, and 4000 Hz) were found to have significantly improved after the operation (p<0.001). Mean preoperative air conduction pure tone threshold and mean air–bone gap had statistically significantly improved by the 6th postoperative month (p<0.001).Conclusion:Transcanal endoscopic type 1 cartilage tympanoplasty was found to be a minimally traumatic, easy and safe method with a low complication rate. In pediatric patients, this method allows for high rates of anatomic and functional recovery with optimal surgery time regardless of the location and the size of the perforation

In a real-life setting, direct-acting antivirals to people who inject drugs with chronic hepatitis c in Turkey

Background: People who inject drugs (PWID) should be treated in order to eliminate hepatitis C virus in the world. The aim of this study was to compare direct-acting antivirals treatment of hepatitis C virus for PWID and non-PWID in a real-life setting. Methods: We performed a prospective, non-randomized, observational multicenter cohort study in 37 centers. All patients treated with direct-acting antivirals between April 1, 2017, and February 28, 2019, were included. In total, 2713 patients were included in the study among which 250 were PWID and 2463 were non-PWID. Besides patient characteristics, treatment response, follow-up, and side effects of treatment were also analyzed. Results: Genotype 1a and 3 were more prevalent in PWID-infected patients (20.4% vs 9.9% and 46.8% vs 5.3%). The number of naïve patients was higher in PWID (90.7% vs 60.0%), while the number of patients with cirrhosis was higher in non-PWID (14.1% vs 3.7%). The loss of follow-up was higher in PWID (29.6% vs 13.6%). There was no difference in the sustained virologic response at 12 weeks after treatment (98.3% vs 98.4%), but the end of treatment response was lower in PWID (96.2% vs 99.0%). In addition, the rate of treatment completion was lower in PWID (74% vs 94.4%). Conclusion: Direct-acting antivirals were safe and effective in PWID. Primary measures should be taken to prevent the loss of follow-up and poor adherence in PWID patients in order to achieve World Health Organization’s objective of eliminating viral hepatitis

PISA 2006 Uluslararası Öğrenci Değerlendirme Programı'nda insan kaynakları ve fiziksel kaynakların öğrencilerin fen okuryazarlığına olan etkisinin kültürlerarası karşılaştırılması.

This study investigates the students’ characteristics and school characteristics and their influences on scientific literacy skills of 15-year-old students across Turkey, Canada, and Sweden, through the use of data from Organisation for Economic Co-operation and Development’s (OECD’s) Programme for International Student Assessment (PISA) 2006. The purpose of this study is to gain a more complete understanding of the effect of human and physical resource allocations and their interaction on students’ scientific literacy skills using Hierarchical Linear Modeling (HLM) techniques. By PISA 2006 results, in terms of scientific literacy, Canada is a high performing country whereas Turkey is far below the average and Sweden has a rank in the average. For modeling scientific literacy, student-level characteristics determined by student questionnaire, and school-level characteristics determined by school questionnaire were used. Results of the present study indicated that there were significant between-school differences in scientific literacy skills of students for all three countries. Turkey had the highest between-school variance and it was more than half of the total variance whereas in Canada and Sweden they were far lower. School type and size were common school factors affecting students’ scientific literacy skills in Canada and Sweden; however, in Turkey school admittance policies, educational resources, science promotional activities, and teacher qualities were school characteristics which have impact on scientific literacy. Enjoyment of learning science, self-efficacy in science, general value given to science, awareness of environmental issues, responsibility for sustainable development, and confidence in use of information technologies were common student factors affecting development of scientific literacy skills in the three countries. Finally, in all three countries cross-level interactions of student and school characteristics for developing scientific literacy skills were observed.Ph.D. - Doctoral Progra

Kavramsal değişim yaklaşımına dayalı öğretimin hal değişiklikleriyle kavram yanılgılarının giderilmesine etkisi.

In this study, a comparison of the effectiveness of conceptual change oriented instruction with traditionally designed chemistry instruction and an investigation of the effect of gender difference were made on ninth grade students̕ understanding of phases and phase changes concepts. In addition, the effects of these instructional methods on students̕ attitudes toward chemistry as a school subject were compared. In this study 56 ninth grade students from two classes of a chemistry course instructed by the same teacher from Ankara Atatürk Anatolian Lycee in 2003-2004 educational year̕s first semester took part. The classes were randomly assigned as control and experimental groups. The experimental group was instructed by conceptual change oriented method with conceptual change texts supported by demonstration, whereas the control group was instructed by traditionally designed method over a period of three weeks. Both groups were administered to Phases and Phase Changes Achievement Test as pretest and posttest in order to assess students̕ understanding of phases and phase changes concepts. Additionally, Science Process Skills Test was given before the treatment to measure students̕ science process skills and Attitude Scale toward Chemistry as a School Subject was given after the treatment to determine their attitudes. The hypotheses were tested using analysis of covariance (ANCOVA), paired samples t-test, and analysis of variance (ANOVA). Results of this study indicated that conceptual change oriented instruction caused a significantly better understanding of phases and phase changes concepts; that males had fewer alternative conceptions than females on phases and phase changes; and that science process skills were strong predictors of understanding in phases and phase changes concepts. On the other hand, no significant difference between conceptual change orientedM.S. - Master of Scienc