Effects of Isotretinoin Treatment on Levels of Hormones Involved in the Etiopathogenesis of Acne

Objective: This study was performed to measure the effect of isotretinoin treatment on hormonal responses and insulin resistance in acne patients. Material and Methods: A total of 30 acne vulgaris patients and 30 control group volunteers were examined between February 2015 and June 2015. Firstly, the basal insulin resistance and endocrine hormone levels were measured in both groups. A daily dose of 120-150 mg/kg oral isotretinoin was administered to the patient group for three months. Following this, insulin resistance and endocrine hormone levels were re-evaluated in both groups. Results: Age, waist circumference, and body mass index were similar between the patient and control groups. Liver transaminase, low-density lipoprotein (LDL), adrenocorticotropic hormone, cortisol, 17-hydroxyprogesterone, and total testosterone levels were different in the patient group compared to the control group (p<0.05). The levels of dehydroepiandrosterone sulfate (DHEA-S), liver transaminase, LDL, and triglycerides increased after three months of isotretinoin administration (p<0.05). The changes in blood triglyceride levels were correlated with the changes in insulin growth factor-1, DHEA-S, total testosterone, progesterone, LDL, and estradiol levels (p<0.05). Conclusion: Isotretinoin might not affect pituitary gland hormones, adrenal hormones, and insulin resistance significantly. Increased blood triglyceride levels may be expected in patients whose testosterone and progesterone hormone levels are high

Prevalence and Awareness of Hypertension in Seven Distinct Geographic Regions of Turkey: The SEMT HT Study

Objective: This study aimed to assess the prevalence, the level of awareness, and the factors that increase hypertension in Turkey. Material and Methods: A cross-sectional survey with a multi-stage probability sampling was conducted. A total of 9604 people were screened; of them, 9316 had a complete clinical examination. The ages, genders, personal and family histories of hypertension, diabetes, coronary artery diseases were recorded. Their systolic and diastolic blood pressures (BP), heights, weights, waist, and hip circumferences were measured. Hypertension was defined as taking medication for hypertension or BP >= 140/90 mmHg. Results: According to the JNC-7 criteria, 22.1% of the population had prehypertension, 36.5% had hypertension (15.3% stage 1 and 21.2% stage 2 hypertension), and 41.4% were normal population. Of the population, 30% had an awareness of hypertension. The prevalence of hypertension was higher in Mediterranean, Central Anatolia, and Black Sea Regions and lower in South-East Anatolia, Aegean Regions, while it was similar in Marmara and East Anatolia Regions when compared to the general population of Turkey. Though rural life, advancing age, increasing body mass index, and waist to height ratio >0.5 were the factors responsible for an increased prevalence of hypertension, smoking was found to decrease the prevalence. Conclusion: The data of the SEMT hypertension study indicated that more than onethird of the adult population was hypertensive in Turkey. Furthermore, only one-third of the hypertensive adult population showed awareness of their hypertension

Characteristics of patients with hypertension in a population with type 2 diabetes mellitus. Results from the Turkish Nationwide SurvEy of Glycemic and Other Metabolic Parameters of Patients with Diabetes Mellitus (TEMD Hypertension Study)

Background: The present survey aimed to find out the demographical and clinical characteristics of patients with hypertension in a population with type 2 diabetes mellitus (T2DM) in Turkey

The acromegaly registry of ten different centers in Turkey

Objectives: To describe biochemical and clinical features, and therapeutic outcomes of acromegaly patients in Turkey