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Taha Toros Arşivi, Dosya No: 112-Lokantalarİstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN/0033

Factor XIII Val34Leu polymorphism in patients with cardiac syndrome X

Background: The aim of the study was to examine the frequency of factor XIII polymorphism among patients with cardiac syndrome X (CSX).Methods: This study was designed as a cross-sectional and observational study. Forty-eight female patients with CSX and 36 controls matched by age, gender, diabetes, and hypertension were studied. CSX was defined as typical chest pain during rest or effort, abnormal test result for exercise ECG, and presence of angiographically normal epicardial coronary arteries after ruling out inducible spasm. Factor XIII gene polymorphism was investigated by using CVD Strip Assay (ViennaLab Diagnostic GmbH) commercial kit.Results: The frequency of factor XIII (Val/Leu + Leu/Leu) mutation was significantly higher in patients with CSX (43%) than in controls (19%) (p = 0.02). Frequency of the Leu allele was significantly higher in the patient group (23.5% vs. 11.1%, p = 0.04). Factor XIII (Val/Leu + Leu/Leu) mutation (p = 0.01, OR = 3.42; 95% CI 1.22–9.58) and smoking (p = 0.04, OR = 3.33, 95% CI 1.05–10.58) were identified as independent predictors of the disease in multivariate regression analysis.Conclusions: This study indicates that there is an evidence for association between factor XIII Val34Leu polymorphism and CSX

Quantitative assessment of left atrial functions by speckle tracking echocardiography in hypertensive patients with and without retinopathy

Purpose:The association between hypertensive retinopathy and left atrial(LA) impairment is unknown. Accordingly, it was aimed to investigate the possiblerelationship between hypertensive retinopathy and LA phasic functions by means oftwo-dimensional speckle-tracking echocardiography (2D-STE).Methods:A total of 124 hypertensive patients and 27 control subjects were includedin the study. LA reservoir strain (LAS-S), LA conduit strain (LAS-E), and LA boosterstrain (LAS-A) parameters were used to evaluate LA myocardial functions.Results:Hypertensive patients (with and without retinopathy) displayed an obviousreduction in the LA reservoir strain (LAS-S),and LA conduit strain (LAS-E). Moreover,further impairment in LA reservoir and conduit strain was found in patients withhypertensive retinopathy than in the isolated hypertensive patients. There were nosignificant differences in LA booster strain (LAS-A) among the three groups. ImpairedLAS-S(OR: 0.764, CI: 0.657–0.888, andp< 0.001), LAS-E(OR: 0.754, CI: 0.634–0.897,andp=0.001), and hypertension (HT) duration (OR: 2.345, CI: 1.568–3.507, andp< 0.001) were shown to be independent predictors of hypertensive retinopathy.Conclusion:Impaired LA reservoir and conduit strain may be used to predict hyper-tensive patients at higher risk of developing hypertensive retinopathy, and to deter-mine which patients should be followed more closely for hypertensive retinopath

Çeliklere gaz altı kaynağının uygulanması

ÖZETGaz altı kaynağında kaynak akım şiddeti, kaynak gerilimi, kaynak pozisyonu, koruyucu gaz cinsi ve kaynak ilerleme hızı dikiş geometrisine önemli etkiler yapmaktadır. Bu parametrelerin dikiş boyutuyla olan ilişkisinin ortaya çıkarılması endüstriyel uygulayıcılar için önemlidir. Birleştirilecek parça boyutuna göre paso sayısının tespit edilmesi ve her paso çekilirken kaynak parametrelerinin bilinmesi kaynak tasarımcısının işini çok kolaylaştırır.Bu çalışmada St-52 malzemeye SG2 teli kullanılarak küt alın kaynağı ve levha üzeri dikiş çekilmiştir. Bu uygulamalarda farklı akım, gerilim ve kaynak ilerleme hızı parametreleri seçilmiştir. Daha sonra bu dikişlerin genişlik, taşan yükseklik, nüfuziyet derinliği ve yüzey temas açısı değerleri ölçülerek bu parametre değişimlerinin dikiş geometrisine etkileri incelenmiştir. ABSTRACT In the Gas Metal Arc Welding, the welding current intensity, current voltage, the position of the current, the shelding gas type and welding speed function important effects to the feeler metal shape. Revealing the relation between the parameters and feeler metal shape length is important for Industrial Welder . Examining the pass number according to the part’s length which will be united and knowing the welding parameters while every pass is occuring make the Welding Designer’s work easy.In this study, with using SG2 wire to the St-52, the square-groove weld and fillet weld on panel is made. In these applications, different current, intensity, and welding speed parameters are chosen. Then, as measuring feeler metal width, overfloewed height, the depth of effectiveness and the plane contact angle’s numbers, these paramaters’ variations effects to the feeler metal are examined

Alfa pirinç saçların sürtünme karıştırma kaynak özellikleri

ÖZETALFA PİRİNÇ SACLARIN SÜRTÜNME KARIŞTIRMA KAYNAK ÖZELLİKLERİSürtünme karıştırma kaynağı geleneksel ergitme kaynak yöntemleri ile birleştirilmesi zor olan yüksek alaşımlı alüminyum malzemelerin kaynağı için 1991 yılında merkezi İngiltere’de bulunan Kaynak Enstitüsü (TWI, UK) tarafından keşfedilen bir katı hal birleştirme yöntemidir. Yöntem, alın alına sabitlenmiş iki levhaya yüksek devirde dönen omuzlu bir pimin daldırılması ve kaynak yapılmak istenen uzunluk boyunca belirli bir hızda ilerletilmesinden ibarettir. Bu çalışmada MS 63(CuZn63) levhalar üç farklı takım dönme hızında(1040,1500,2080 dev/dak.), dört farklı takım ilerleme hızında (30,45,75,113 mm/dak.) ve 2 farklı uç geometrisine (konik dişli ve konik dişsiz) sahip takım kullanılarak birleştirilmiştir. Tüm kaynaklarda takıma yaklaşık 2° ‘lik eğim açısı verilmiştir. SKK tekniği ile birleştirilen MS 63(Cu63Zn37) levhaların, mekanik özelliklerini belirlemek amacıyla çekme, eğme, mikro sertlik ve Erichesen çökertme testleri yapılmıştır. Mikroyapı karakterizasyonu çalışmalarında optik mikroskop, SEM ve EDS analiz tekniklerinden yararlanılmıştır. Kaynak bölgesinde muhtemel oluşabilecek fazların belirlenmesi amacıyla XRD karakterizasyonu yapılmıştır.Deneysel çalışmalar sonucunda yapılan radyografik inceleme de iç yapıda hatasız kaynak dikişleri elde edildiği görülmüştür. Makroyapı incelemesinde MS 63(CuZn63) levhaların alın alına başarılı bir şekilde birleştirilebildiği ve bunun sonucunda mikroyapıda ana metal, termomekanik olarak etkilenen bölge(TMEB), ısı tesiri altındaki bölge (ITAB) ve karışım bölgesi olmak üzere dört bölge oluştuğu tespit edilmiştir. Her iki takım ilede yapılan birleştirmelerde artan takım dönme hızında bağlı olarak mukavemet değerlerinde artış olduğu ve artan takım ilerleme hızına bağlı olarak karışım bölgesinde tane incelmesi meydana geldiği belirlenmiştir. Takım aşınma miktarı, mukavemet ve % uzama değerleri gözönüne alındığında en yüksek verimin konik dişsiz takım ile 1040/113 paremetresinde elde edilmiştir.ABSTRACTFRICTION STIR WELDING PROPERTIES OF ALPHA BRASS PLATESFriction stir welding (FSW) is a welding method which has been invented to join high alloyed aluminium alloys which are difficult to weld with conventional fusion welding methods. This conventional method is a solid state joining process; which has been discovered at the Welding Institute located that in the center of England (TWI, UK) in 1991. This method basically depends on a rotating tool with a pin and shoulder which is submerges and moves all along the joint zone of two fixed work pieces.Within this research MS 63 (CuZn63) plates were welded with three different rotating speeds (1040, 1500, 2080 rev/min), with different travel speeds (30, 45, 75, 113 mm/min) and two different tool geometries (with and without conical screw). The tilt angle for all welds was maintained at approximately 2˚. The Bending, tensile, micro hardness and Erichsen cupping tests were applied to evaluate the mechanical properties of the friction stir welded of MS 63 (CuZn37) plates. SEM&EDS and optical microscope analysis techniques used for microstructure characterization. XRD characterization test was applied to determine the phases which occured at the welding zone. Radiographic testing of experimental studies showed that no indication observed at the welded seams. Macrostructure exeminations showed that MS 63 (CuZn63) plates were butt welded successfully and four different sections have been occured as based metal, thermo-mechanically affected zone (TMEB), heat affected zone (HAZ) and friction zone in microstructure. Both joints which performed by two different types of tools showed that increasing rotation speed improved the tensile properties and increasing rotation speed caused finer grain structure at friction zone. The amount of tool wear, strength and percentage elongation rates comparison showed that highest efficiency had been obtained with 1040/113 parameters and tool without conical screw

Deep Learning Techniques for Low-Field MRI

Delft University of Technology (TU Delft), Leiden University Medical Center (LUMC), Pennsylvania State University (PSU) and Mbarara University of Science and Technology (MUST) have an ongoing collaboration to create an affordable, portable and simplified version of the magnetic resonance imaging (MRI) scan for the CURE children’s hospital to diagnose children with hydrocephalus (water on the brain). As opposed to the conventional MRI scan, the low-field MRI prototype uses permanent magnets to create a magnetic field in the order of Milliteslas (mT). A downside of the low-field MRI application is the difficulty with spatial encoding due to small variations in the strength of magnetic field. This is a major problem for image reconstruction. The purpose of this research was to implement a deep learning (DL) network to overcome two of the major bottlenecks in image reconstruction for low-field MRI. These are the lack of real measured data for DL purposes, and the signal model associated with the low-field MRI. For DL purposes we generated synthetic data and acquired measured data. Each dataset consists of samples and each sample consist of an image and the corresponding signal. Due to technical limitations the measured dataset is small, 53 samples. To partially circumvent the problem, the data set was augmented to a total of 1908 samples. In addition, we used Transfer learning, which is a powerful method that applies knowledge gained from one problem to a different but related problem. We present three image reconstruction techniques, Model I, II, and III, based on convolutional and feedforward neural networks, which take MR signal data as input and directly and quickly outputs an image. We demonstrated that DL generates high quality images using synthetic data. In addition, we showed that Model III needs less training to reconstructs good quality images compared to Models I and III, respectively. Finally, Models I and III were unsuccessfully applied to real measured data. However, this study shows that neural networks are able to find a mapping between signal and image, therefore this idea can be extended to work on real measured data.Applied Mathematic

Efficacy of peloidotherapy in patients with subacromial impingement syndrome

Çalışmamızın temel amacı subakromiyal sıkışma sendromunda evde uygulanan ve hastanede uygulanan peloidoterapinin etkinliği araştırmaktır. Tek taraflı omzunda subakromiyal sıkışma sendromu tanısı almış olan 73 kadın hasta çalışmaya alındı. Hastalar tedavi grubu (n=42) ve kontrol grubu (n=31) olmak üzere iki farklı gruba ayrıldı. Tedavi grubundaki hastalara peloid tedavisi deriye direk temas olacak şekilde peloidoterapi ünitesinde uygulandı. Kontrol grubundaki hastalar ise peloidi evde kendi imkanlarıyla uyguladı. Her iki grup rutin medikal tedavilerine ve ev egzersiz programlarına devam ettiler. Değerlendirilmelerde hastaların omuz fonksiyonlarını değerlendirmek için DASH-T (Kol,omuz ve el yaralanması anketi) skorları, ağrı için VAS(Visuel Ağrı Skalası) ve genel durumları için sağlık değerlendirme anketi HAQ(Sağlık Değerlendirme Anketi) kullanıldı. Çalışma grubunda DASH ve HAQ skorları bakımından tedavi sonrasında tedavi öncesine göre anlamlı farklılık görülmemiştir (p>0.05). Yaptığımız çalışmada çalışma grubundaki peloidoterapi uygulamalarında kontrol grubundaki peloidoterapi uygulamalarına göre ağrı parametrelerinde daha olumlu sonuçlar elde edilmiştir. İleride yapılacak vaka sayısının arttırıldığı çalışmalara ihtiyaç vardır.The main purpose of our study is to investigate the efficacy of peloidotherapy applied at home in subacromial impingement syndrome and applied at the hospital. 73 female patients who were diagnosed with subacromial impingement syndrome were enrolled on one-sided shoulder. The patients were divided into two different groups, the treatment group (n = 42) and the control group (n = 31). Peloid therapy was performed in the Peloid therapy unit to direct contact with the skin in patients with treatment group. The patients in the control group applied the Peloid therapy at home with their own facilities. Both groups continued their routine medical treatment and home exercise programs. In the evaluation, DASH-T (Disabilities of the Arm, Shoulder and Hand) scores were used to assess the patient's shoulder functions..VAS (Visual Analogue Scale) was used for pain and health Assessment Questionnaire HAQ (Health Assessment Questionnaire) was used for general conditions.In the study group, in terms of DASH and HAQ scores, there was no significant difference after treatment (P > 0.05).In the study of Peloidotherapy in the study group, more positive results were obtained in pain parameters according to peloidotherapy applications in the control group. Studies are needed to increase the number of cases in the future