Educação para as relações étnico-raciais, destinado a implementação das leis 10.639 e 11.645 no currículo escolar.

O curso de Extensão “Educação para as Relações Étnico-Raciais, destinado à implementação das Leis 10.639/03 e 11.645/08 no currículo escolar” fomenta a formação de professores da rede pública e particular de ensino de Foz do Iguaçu e região, no ensino da História e Cultura Afro-brasileira, africana e indígena. O intuito é colaborar com o desenvolvimento de práticas pedagógicas sensíveis e fundamentadas no reconhecimento e valorização do conhecimento da diversidade étnico-racial, com a finalidade de valorizar e reconhecer Histórias e culturas até então negligenciadas e negadas historicamente pela sociedade brasileira. O fundamento metodológico teóricoconceitual adotado propõe que as/os docentes, no seu âmbito escolar e a partir das discussões dos encontros, realizem ações que considerem as trocas de saberes para uma educação que reconheça e valorize as Relações Étnico-Raciais. O curso teve sua primeira versão em 2013, a partir de demandas de docentes da escola pública engajados na discussão para a implementação da legislação que respeite a diversidade cultural. Dessa forma, identificamos que o curso está sendo fundamental ao atuar na desnaturalização do preconceito racial, racismo e discriminação racial no ambiente escolar

Identification of drought-responsive genes in roots of upland rice (Oryza sativa L)

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BALB/c Mice Infected with Antimony Treatment Refractory Isolate of Leishmania braziliensis Present Severe Lesions due to IL-4 Production

Leishmaniasis is a neglected disease that affects more than 12 million people worldwide. In Brazil, the cutaneous disease is more prevalent with about 28,000 new cases reported each year, and L. braziliensis is the main causative agent. The interesting data about the infection with this parasite is the wide variety of clinical manifestations that ranges from single ulcerated lesions to mucocutaneous and disseminated disease. However, experimental models to study the infection with this parasite are difficult to develop due to high resistance of most mouse strains to the infection, and the mechanisms underlying the distinct manifestations remain poorly understood. Here, the authors use a mouse experimental model of infection with different L. braziliensis isolates, known to induce diseases with distinct severity in the human hosts, to elucidate immune mechanisms that may be involved in the different manifestations. They showed that distinct parasite isolates may modulate host response, and increased IL-4 production and Arg I expression was related to more severe disease, resulting in longer length of disease with larger lesions and reduced parasite clearance. These findings may be useful in the identification of immunological targets to control L. braziliensis infection and potential clinical markers of disease progression

Evaluation of the genotoxic and antigenotoxic potential of Melissa officinalis in mice

Melissa officinalis (L.) (Lamiaceae), a plant known as the lemon balm, is native to the east Mediterranean region and west Asia. Also found in tropical countries, such as Brazil, where it is popularly known as “erva-cidreira” or “melissa”, it is widely used in aqueous- or alcoholic-extract form in the treatment of various disorders. The aim was to investigate in vivo its antigenotoxicity and antimutagenicity, as well as its genotoxic/mutagenic potential through comet and micronucleus assaying. CF-1 male mice were treated with ethanolic (Mo-EE) (250 or 500 mg/kg) or aqueous (Mo-AE) (100 mg/kg) solutions of an M. officinalis extract for 2 weeks, prior to treatment with saline or Methyl methanesulfonate (MMS) doses by intraperitoneal injection. Irrespective of the doses, no genotoxic or mutagenic effects were observed in blood and bone-marrow samples. Although Mo-EE exerted an antigenotoxic effect on the blood cells of mice treated with the alkylating agent (MMS) in all the doses, this was not so with Mo-AE. Micronucleus testing revealed the protector effect of Mo-EE, but only when administered at the highest dose. The implication that an ethanolic extract of M. officinalis has antigenotoxic/antimutagenic properties is an indication of its medicinal relevance