La iglesia de San Miguel en Caltojar. El Románico en transición

The church of San Miguel in Caltojar belongs to a large group of Romanesque architecture sited in the province of Soria. Simple in form and scale, only the sculpture of its southern main door has been approached by those few researchers engaged in its study. However, this building owns a sequence with two original building phases, dated to the late 12th and early 13th centuries, and numerous later modifications, standing out the vaults of the naves introduced in the modern period, not in the medieval one as it had been hitherto thought.La iglesia de San Miguel en Caltojar forma parte del amplio conjunto de arquitectura románica que puebla la provincia de Soria. De forma y escala sencillas, únicamente la decoración de su portada meridional ha llamado la atención de los escasos investigadores que se han ocupado de ella. Sin embargo, este edificio encierra una secuencia con dos fases originales de obra, atribuibles a finales del siglo XII e inicios del XIII, y un número importante de modificaciones posteriores, entre las cuales destacan las cubiertas abovedadas de las naves introducidas en época moderna, y no en época medieval como se había propuesto hasta hoy

Trends on epidemiological, virological, and clinical features among newly diagnosed HIV-1 persons in Northwest Spain over the last 10 years

[Abstract] To describe temporal trend and characteristics of newly HIV-diagnosed patients in a medical care area in Northwest Spain over the last 10 years. All newly diagnosed patients for HIV-infection from 2004 to 2013 at a reference medical care area in Northwest of Spain were identified. Epidemiological, virological, immunological, and clinical data, as well as HIV genotype and drug resistance information were recorded. A total of 565 newly HIV-diagnosed patients were identified. The number of new cases increased in the last 5 years (66 cases/year). Overall, 53.1% had a median CD4 counts < 350 cells/µl and 33.6% had an AIDS defining criteria. Non-B variants were found in 34.4% of patients being subtype F (25.8%) the most common non-B subtype. The rate of transmitted drug resistance (TDR) over the study period was 3.7%, but a decreased to 2.6% was observed in the last 5 years. The most prevalent TDR mutations were: T215 revertants (1.5%), K219QENR (1.2%), for NRTIs; K103N (1.9%), for NNRTIs; L90M (0.3%), for PIs. Overall, 73.2% of patients started antiretroviral treatment and 9.9% of patients died during follow-up. The number of newly HIV diagnosed patients increased since year 2009. There is a high prevalence of late diagnosis (53%) and 33% had an AIDS defining criteria. Interestingly, the most prevalent non-B subtype in our population was F (25.8%). These findings support the need to facilitate the access for HIV testing to reduce the rate of late HIV diagnosis, improve the clinical outcome and prevent HIV transmission.Instituto de Salud Carlos III; CP08/00214Instituto de Salud Carlos III; PI10/02166Instituto de Salud Carlos III; CM13/00328Instituto de Salud Carlos III; PI13/0226

Acute inflammatory response of patients with Pseudomonas aeruginosa infections: a prospective study

The severity of Pseudomonas aeruginosa (PA) infection may be determined by the interaction with the host immune system. We designed a prospective study to assess the relationship between the inflammatory response and the clinical presentation and outcome of PA infection. We also investigated whether there are differences in the inflammatory response depending on the resistance profile of PA. Interleukin-6 (IL-6), IL-10, procalcitonin (PCT), and C-reactive protein (CRP) were measured. Sixty-nine infection episodes were recorded; 40 caused by non-multidrug-resistant (non-MDR) strains [29 (73%) respiratory; 8 (20%) bacteremia], 12 by MDR non-extensively drug-resistant (MDR-non-XDR) [9 (75%) respiratory; 3 (25%) bacteremia], and 17 by XDR strains [9 (53%) respiratory; 7 (41%) bacteremia]. All inflammatory parameters were significantly higher in patients who developed acute organ dysfunction and bacteremia. PCT levels were higher in patients with early mortality [p = 0.050]. Inflammatory biomarkers were higher in patients with XDR than in those with non-MDR PA [IL-6 430 (67-951) vs. 77 (34-216), p = 0.02; IL-10 3.3 (1.5-16.3) vs. 1.3 (0-3.9), p = 0.02; and PCT 1.1 (0.6-5.2) vs. 0.3 (0.1-1.0), p = 0.008]. The intensity of inflammatory response was associated with the severity of PA infection, particularly if bacteremia occurred. Only PCT was documented useful to predict the outcome. XDR infections presented a higher inflammatory response; related in part to the larger number of bloodstream infections in this group

Seroprevalence of HCV and HIV infections by year of birth in Spain: impact of US CDC and USPSTF recommendations for HCV and HIV testing

Instituto de Salud Carlos III; CP08/00214Instituto de Salud Carlos III; PI10/02166Instituto de Salud Carlos III; PI13/02266Instituto de Salud Carlos III; CM13/0032

Any impact of blips and low-level viraemia episodes among HIV-infected patients with sustained virological suppression on ART?

[Abstract] Objectives. The objective of this study was to evaluate the prevalence of blips and risk of virological failure (VF) among HIV-infected patients with sustained virological suppression (HIV-RNA <50 copies/mL) on ART. Methods. Newly diagnosed (2004–13) HIV-infected patients with sustained virological suppression on ART (minimum follow-up of 3 months) were identified. Risk of VF was evaluated according to different plasma HIV-RNA quantification values based on the limits of quantification/detection of current commercial assays (20 copies/mL). Kaplan–Meier and Cox proportional hazards models were used to compare the cumulative incidence of VF. Results. A total of 565 newly diagnosed HIV-infected patients were identified: 453 started ART and 354 achieved virological suppression. Prevalence of blips (isolated HIV-RNA ranging from 50 to 200 copies/mL) and VF (HIV-RNA ≥50 copies/mL) was 22.7% and 8.8%, respectively (mean follow-up of 42 months). Multivariate analysis identified differences between HIV-RNA values as an independent predictor of VF (P = 0.008); risk of VF was higher for patients with blips [HR 2.500 (95% CI 0.524–11.926)] and for those with at least three consecutive detected, but not quantified, HIV-RNA determinations (HIV-RNA 200 copies/mL [33.7% at 24 and 60 months versus <5% for other HIV-RNA values; HR 6.943 (0.728–66.261), P = 0.092]. Conclusions. Blips are frequent (22.7%) among HIV-infected patients with sustained virological suppression on ART. HIV patients with blips and at least three consecutive detected, but not quantified, HIV-RNA determinations (<20 copies/mL) had a higher risk of VF. These findings highlight the relevance of maintaining HIV-RNA levels below the limits of quantification of current assays (<20 copies/mL).Instituto de Salud Carlos III; CPII14/00014Instituto de Salud Carlos III; PI10/02166Instituto de Salud Carlos III; PI13/0226

Estilos de aprendizaje y las habilidades metacognitivas infantiles

El objetivo del proyecto es establecer la relación existente entre los estilos de aprendizaje y las habilidades metacognitivas infantiles de los niños de nivel inicial, lo que permitirá generar estrategias metacognitivas que favorezcan un aprendizaje significativo. Para desarrollar el tema se documentó toda la información referente a los estilos de aprendizaje, metacognición, educación inicial, aprendizaje, psicología infantil donde los principales exponentes son: (Egido, 1999), (Ministerio de Educación, 2014), (Kolb, 1996), (Flavell, 1976) y (Gardner, 1984). Ello permitió determinar que la metacognición es un campo fascinante; analizarlo dependerá del docente motivar y orientar al niño para que logre entender e identificarse con los procesos de enseñanza aprendizaje

Jóvenes salesianos cambiando el mundo

Dar a conocer la experiencia en las misiones como jóvenes salesianas, las distintas realidades de otras personas, con el objetivo de analizar y dar a conocer nuestro aporte para intentar cambiar el mundo, motivando a que los jóvenes se apoyen unos a otros con sentido de pertenencia y amor a los demás. Esto se manifiesta en tres espacios diferentes, cada uno con una metodología distinta, los espacios fueron creados por y para los jóvenes con el único objetivo de originar un lugar en donde nos podamos abrir, ser auténticos, pero, sobre todo, aprender unos de otros. Estos espacios son: El Movimiento Juvenil Salesiano Colmena, el Oratorio María Auxiliadora de Cuenca y la Experiencia Anual de Misiones en Semana Santa. En las jornadas que se comparten, se puede observar las distintas realidades en las que viven y que a lo mejor muchas personas en la actualidad no las conocen debido a que vivimos en una especie de burbuja que de alguna manera nos oculta la realidad en la que vive el mundo, pero los jóvenes la podemos cambiar con pequeñas acciones, que, aunque suene raro, por más pequeña que sea la acción que se realiza, deja una marca más grande en el corazón de la persona que la recibe

Jóvenes salesianos cambiando el mundo

Dar a conocer la experiencia en las misiones como jóvenes salesianas, las distintas realidades de otras personas, con el objetivo de analizar y dar a conocer nuestro aporte para intentar cambiar el mundo, motivando a que los jóvenes se apoyen unos a otros con sentido de pertenencia y amor a los demás. Esto se manifiesta en tres espacios diferentes, cada uno con una metodología distinta, los espacios fueron creados por y para los jóvenes con el único objetivo de originar un lugar en donde nos podamos abrir, ser auténticos, pero, sobre todo, aprender unos de otros. Estos espacios son: El Movimiento Juvenil Salesiano Colmena, el Oratorio María Auxiliadora de Cuenca y la Experiencia Anual de Misiones en Semana Santa. En las jornadas que se comparten, se puede observar las distintas realidades en las que viven y que a lo mejor muchas personas en la actualidad no las conocen debido a que vivimos en una especie de burbuja que de alguna manera nos oculta la realidad en la que vive el mundo, pero los jóvenes la podemos cambiar con pequeñas acciones, que, aunque suene raro, por más pequeña que sea la acción que se realiza, deja una marca más grande en el corazón de la persona que la recibe

Molecular characterization of HIV-1 infection in Northwest Spain (2009–2013): investigation of the subtype F outbreak

[Abstract] Background. HIV-1 subtype B is the predominant one in European regions several, while other subtypes and recombinants are also circulating with high prevalence. A sub-epidemic of subtype F with specific characteristics and low response to treatment has been recently identified in Galicia. In this study we investigated the characteristics of the HIV-1 subtype F sub-epidemic in A Coruña and Santiago de Compostela in Northwest Spain. Methods. 420 newly HIV-1 diagnosed patients during 2009–2013 were enrolled in this study. HIV-1 subtyping was carried out using automated subtyping tools and phylogenetic analysis. Molecular epidemiology investigation of subtypes B and F was performed by means of phylogenetic analysis using fast maximum likelihood. Phylodynamic analysis was performed using Bayesian method as implemented in BEAST v1.8. Results. Subtype B found to be the predominant (61.2% and 70.4%) followed by subtype F (25.6% and 12.0%) in both areas (A Coruña and Santiago de Compostela, respectively). The latter found to mainly spread among men having sex with men (MSM). The vast majority of subtype F lineages from both areas clustered monophyletically, while subtype B sequences clustered in several tree branches. The exponential growth of subtype F sub-epidemic dated back in 2008 by means of phylodynamic analysis. Most of new infections during 2009–2013 occurred within the subtype F transmission cluster. Conclusions. Subtype F circulates at high prevalence in A Coruña and Santiago de Compostela in Northwest Spain, suggesting that the HIV-1 epidemic in this region has distinct characteristics to the rest of Spain. Subtype F has being spreading among MSM and is currently the most actively spreading network. The single cluster spread of this local sub-epidemic might provide an explanation for the distinct characteristics and the low response to antiretroviral treatment

Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia

Grip strength deficit is a measure of pain-induced functional disability in rheumatic disease. We tested whether this parameter and tactile allodynia, the standard pain measure in preclinical studies, show parallels in their response to analgesics and basic mechanisms. Mice with periarticular injections of complete Freund's adjuvant (CFA) in the ankles showed periarticular immune infiltration and synovial membrane alterations, together with pronounced grip strength deficits and tactile allodynia measured with von Frey hairs. However, inflammation-induced tactile allodynia lasted longer than grip strength alterations, and therefore did not drive the functional deficits. Oral administration of the opioid drugs oxycodone (1–8 mg/kg) and tramadol (10–80 mg/kg) induced a better recovery of grip strength than acetaminophen (40–320 mg/kg) or the nonsteroidal antiinflammatory drugs ibuprofen (10–80 mg/kg) or celecoxib (40–160 mg/kg); these results are consistent with their analgesic efficacy in humans. Functional impairment was generally a more sensitive indicator of drug-induced analgesia than tactile allodynia, as drug doses that attenuated grip strength deficits showed little or no effect on von Frey thresholds. Finally, ruthenium red (a nonselective TRP antagonist) or the in vivo ablation of TRPV1-expressing neurons with resiniferatoxin abolished tactile allodynia without altering grip strength deficits, indicating that the neurobiology of tactile allodynia and grip strength deficits differ. In conclusion, grip strength deficits are due to a distinct type of pain that reflects an important aspect of the human pain experience, and therefore merits further exploration in preclinical studies to improve the translation of new analgesics from bench to bedside.This study was partially supported by the Spanish Ministry of Economy and Competitiveness (MINECO, grant SAF2013-47481P), the Junta de Andalucía (grant CTS 109), and funding from Esteve and the European Regional Development Fund (FEDER)