Videopoesía, artivismo y defensa de los derechos medioambientales en la formación docente

This Arts-Based Educational Research has been developed from 2018 to 2022 at the Faculty of Educational Studies of the University of A Coruña. Participation has involved senior students in Early Childhood Education and Primary Education Degrees, as well as students in Master’s Degree in Research and Innovation in Specific Didactics for Infant and Primary Education and Master´s Degree in Compulsory Secondary Teachers, Upper Secondary Education Teachers specializing in Visual Arts. The main objective has been to work on environmental activism in teacher training in defence of ecojustice. To this end, the various problems arising from climate change and natural exploitation have been considered, as well as the challenges of the 2030 Agenda and its implications for education. To carry out this research we make use of a methodology typical of the arts (Arts-Based Educational Research). In this case, the artistic creation and the obtaining of visual data take place through video art and, more specifically, the video poem.Esta Investigación Educativa Basada en las Artes se ha desarrollado desde 2018 a 2022 en la Facultad de Ciencias de la Educación de la Universidad de A Coruña. Su participación ha implicado al profesorado en formación de los grados de Educación Infantil y Educación Primaria, así como al alumnado del Máster de Investigación e Innovación en Didácticas Específicas y del Máster en Profesorado de ESO y BACH de la especialidad de Artes Plásticas y Visuales. El objetivo principal ha sido trabajar el activismo medioambiental en la formación docente en defensa de la ecojusticia. Para ello, se han tenido en cuenta las diversas problemáticas derivadas del cambio climático y la explotación natural, así como los retos de la Agenda 2030 y sus implicaciones para la educación. Para desarrollar nuestra investigación, empleamos la metodología propia de las artes (Arts-Based Educational Research). En este caso, la creación artística y de obtención de datos visuales tiene lugar a través del videoarte y, más concretamente, del videopoema

Videopoetry, Artivism and Defense of Environmental Rights in Teacher Training

[Resumen] Esta Investigación Educativa Basada en las Artes se ha desarrollado desde 2018 a 2022 en la Facultad de Ciencias de la Educación de la Universidad de A Coruña. Su participación ha implicado al profesorado en formación de los grados de Educación Infantil y Educación Primaria, así como al alumnado del Máster de Investigación e Innovación en Didácticas Específicas y del Máster en Profesorado de ESO y BACH de la especialidad de Artes Plásticas y Visuales. El objetivo principal ha sido trabajar el activismo medioambiental en la formación docente en defensa de la ecojusticia. Para ello, se han tenido en cuenta las diversas problemáticas derivadas del cambio climático y la explotación natural, así como los retos de la Agenda 2030 y sus implicaciones para la educación. Para desarrollar nuestra investigación, empleamos la metodología propia de las artes (Arts-Based Educational Research). En este caso, la creación artística y de obtención de datos visuales tiene lugar a través del videoarte y, más concretamente, del videopoema.[Abstract] This Arts-Based Educational Research has been developed from 2018 to 2022 at the Faculty of Educational Studies of the University of A Coruña. Participation has involved senior students in Early Childhood Education and Primary Education Degrees, as well as students in Master’s Degree in Research and Innovation in Specific Didactics for Infant and Primary Education and Master ́s Degree in Compulsory Secondary Teachers, Upper Secondary Education Teachers specializing in Visual Arts. The main objective has been to work on environmental activism in teacher training in defence of ecojustice. To this end, the various problems arising from climate change and natural exploitation have been considered, as well as the challenges of the 2030 Agenda and its implications for education. To carry out this research we make use of a methodology typical of the arts (Arts-Based Educational Research). In this case, the artistic creation and the obtaining of visual data take place through video art and, more specifically, the video poem

Lupinus angustifolius Protein Hydrolysates Reduce Abdominal Adiposity and Ameliorate Metabolic Associated Fatty Liver Disease (MAFLD) in Western Diet Fed-ApoE−/− Mice

Metabolic-associated fatty liver disease (MAFLD) is the most important cause of liver disease worldwide. It is characterized by the accumulation of fat in the liver and is closely associated with abdominal obesity. In addition, oxidative stress and inflammation are significant features involved in MAFLD. Recently, our group demonstrated that lupin protein hydrolysates (LPHs) had lipid lowering, antioxidant, and anti-inflammatory effects. Sixty male mice fed with a Western diet were intragastrically treated with LPHs (or vehicle) for 12 weeks. Liver and adipose tissue lipid accumulation and hepatic inflammatory and oxidant status were evaluated. A significant decrease in steatosis was observed in LPHs-treated mice, which presented a decreased gene expression of CD36 and LDL-R, crucial markers in MAFLD. In addition, LPHs increased the hepatic total antioxidant capacity and reduced the hepatic inflammatory status. Moreover, LPHs-treated mice showed a significant reduction in abdominal adiposity. This is the first study to show that the supplementation with LPHs markedly ameliorates the generation of the steatotic liver caused by the intake of a Western diet and reduces abdominal obesity in ApoE−/− mice. Future clinical trials should shed light on the effects of LPHs on MAFLD.Ministerio de Economía y Competitividad [AGL2012-40247-C02-01 and AGL2012-40247-C02-02]Andalusian Government Ministry of Health [PC-0111-2016-0111]PAIDI Program from the Andalusian Government [CTS160]Spanish Ministerio de Educación, Cultura y Deporte [FPU16/02339] and [FPU13/01210]The National Net RETICEF for Aging Studies (RD12/0043/0012 from the Instituto de Salud Carlos III, Spanish Ministerio de Ciencia e Innovación)European Social Fund and Spanish Ministerio de Empleo y Seguridad Social [EJ-086]Andalusian Government Ministry of Health [PI-0136-2019]VI Program of Inner Initiative for Research and Transfer of University of Seville (VI PPIT-US

Safety and Efficacy of a Beverage Containing Lupine Protein Hydrolysates on the Immune, Oxidative and Lipid Status in Healthy Subjects: An Intervention Study (the Lupine-1 Trial)

Scope: We have previously demonstrated the anti-inflammatory and antioxidant properties of in vitro administered Lupinus angustifolius protein hydrolysates (LPHs) on human peripheral blood mononuclear cells (PBMCs). This study aims to evaluate the safety and efficacy of a beverage containing LPHs (LPHb) on the immune, oxidative and metabolic status of healthy subjects. Methods and Results: In this open-label intervention, 33 participants daily ingest a LPHb containing 1 g LPHs for 28 days. Biochemical parameters are assayed in fasting peripheral blood and urine samples before, during (14 days) and after LPHb ingestion. Participants’ health status and the immune and antioxidant responses of PBMCs are also evaluated throughout the trial. The LPHb ingestion is safe and effective in both increasing the anti-/pro-inflammatory response of PBMCs and improving the cellular anti-oxidant capacity. LPHb also reduces the low-density lipoprotein-cholesterol (LDL-C)/high-density lipoprotein-cholesterol (HDL-C) atherogenic index. LPHb effect is particularly beneficial on decreasing not only the LDL-C/HDL-C index but also serum total cholesterol levels in the male cohort that shows the highest baseline levels of well-known cardiovascular risk factors. Conclusion: This is the first study to show the pleiotropic actions of a lupine bioactive peptides-based functional food on key steps of atherosclerosis including inflammation, oxidative stress, and cholesterol metabolism.Ministerio de Economía y Competitividad AGL2012-40247-C02-01, AGL2012-40247- C02-02Junta de Andalucía PC-0111-2016- 0111, CTS160Ministerio de Ciencia e Innovación RD06/0013/0001, RD12/0043/001

Impacto en la mortalidad tras la implantación de una red de atención al infarto agudo de miocardio con elevación del segmento ST: Estudio IPHENAMIC

[Abstract] Introduction and objectives: Little is known about the impact of networks for ST-segment elevation myocardial infarction (STEMI) care on the population. The objective of this study was to determine whether the PROGALIAM (Programa Gallego de Atención al Infarto Agudo de Miocardio) improved survival in northern Galicia. Methods: We collected all events coded as STEMI between 2001 and 2013. A total of 6783 patients were identified and divided into 2 groups: pre-PROGALIAM (2001-2005), with 2878 patients, and PROGALIAM (2006-2013), with 3905 patients. Results: In the pre-PROGALIAM period, 5-year adjusted mortality was higher both in the total population (HR, 1.22, 95%CI, 1.14-1.29; P <.001) and in each area (A Coruña: HR, 1.12; 95%CI, 1.02-1.23; P=.02; Lugo: HR, 1.34; 95%CI, 1.2-1.49; P <.001 and Ferrol: HR, 1.23; 95%CI, 1.1-1.4; P=.001). Before PROGALIAM, 5-year adjusted mortality was higher in the areas of Lugo (HR, 1.25; 95%CI, 1.05-1.49; P=.02) and Ferrol (HR, 1.32; 95%CI, 1.13-1.55; P=.001) than in A Coruña. These differences disappeared after the creation of the STEMI network (Lugo vs A Coruña: HR, 0.88; 95%CI, 0.72-1.06; P=.18, Ferrol vs A Coruña: HR, 1.04; 95%CI, 0.89-1.22; P=.58. Conclusions: For patients with STEMI, the creation of PROGALIAM in northern Galicia decreased mortality and increased equity in terms of survival both overall and in each of the areas where it was implemented. This study was registered at ClinicalTrials.gov (Identifier: NCT02501070).[Resumen] Introducción y objetivos. Se sabe muy poco del impacto que las redes de atención del infarto agudo de miocardio con elevación del segmento ST (IAMCEST) tienen en la población. El objetivo de este estudio es averiguar si el PROGALIAM (Programa Gallego de Atención al Infarto Agudo de Miocardio) mejoró la supervivencia en la zona norte de Galicia. Métodos. Se recogieron todos los eventos codificados como IAMCEST entre 2001 y 2013. Se identificó a 6.783 pacientes, divididos en 2 grupos: pre-PROGALIAM (2001-2005), 2.878 pacientes, y PROGALIAM (2006-2013), 3.905 pacientes. Resultados. En la etapa pre-PROGALIAM, la mortalidad ajustada a 5 años fue superior tanto en la población total (HR = 1,22; IC95%, 1,14-1,29; p < 0,001), como en cada una de las áreas (A Coruña, HR = 1,12; IC95%, 1,02-1,23; p = 0,02; Lugo, HR = 1,34; IC95%, 1,2-1,49; p < 0,001, y Ferrol, HR = 1,23; IC95%, 1,1-1,4; p = 0,001). Antes del PROGALIAM, la mortalidad a 5 años en las áreas de Lugo (HR = 0,8; IC95%, 0,67-0,95; p = 0,02) y Ferrol (HR = 0,75; IC95%, 0,64-0,88; p = 0,001) era superior que en A Coruña. Estas diferencias desaparecieron tras el desarrollo de la red (Lugo comparado con A Coruña, HR = 0,88; IC95%, 0,72-1,06; p = 0,18; Ferrol comparado con A Coruña, HR = 1,04; IC95%, 0,89-1,22; p = 0,58. Conclusiones. El desarrollo del PROGALIAM en el área norte de Galicia disminuyó la mortalidad e incrementó la equidad de los pacientes con IAMCEST tanto en general como en cada una de las áreas donde se implantó. Estudio registrado en ClinicalTrials.gov (Identificador: NCT02501070)

Outcomes of COVID-19 Patients Admitted to the Intermediate Respiratory Care Unit: Non-Invasive Respiratory Therapy in a Sequential Protocol

The intermediate respiratory care units (IRCUs) have a pivotal role managing escalation and de-escalation between the general wards and the intensive care units (ICUs). Since the COVID-19 pandemic began, the early detection of patients that could improve on non-invasive respiratory therapies (NRTs) in IRCUs without invasive approaches is crucial to ensure proper medical management and optimize limiting ICU resources. The aim of this study was to assess factors associated with survival, ICU admission and intubation likelihood in COVID-19 patients admitted to IRCUs. Observational retrospective study in consecutive patients admitted to the IRCU of a tertiary hospital from March 2020 to April 2021. Inclusion criteria: hypoxemic respiratory failure (SpO(2) = 25 rpm with FiO(2) > 50% supplementary oxygen) due to acute COVID-19 infection. Demographic, comorbidities, clinical and analytical data, and medical and NRT data were collected at IRCU admission. Multivariate logistic regression models assessed factors associated with survival, ICU admission, and intubation. From 679 patients, 79 patients (12%) had an order to not do intubation. From the remaining 600 (88%), 81% survived, 41% needed ICU admission and 37% required intubation. In the IRCU, 51% required non-invasive ventilation (NIV group) and 49% did not (non-NIV group). Older age and lack of corticosteroid treatment were associated with higher mortality and intubation risk in the scheme, which could be more beneficial in severe forms. Initial NIV does not always mean worse outcomes

Ausonia y Carrefour: #LaCienciaespoderosa

[ES] El cáncer es un conjunto de enfermedades caracterizadas por el desarrollo de células anormales que se dividen sin control y tienen la capacidad de infiltrarse y destruir el tejido corporal. Con motivo del día mundial del cáncer de mama, el 19 de octubre de 2021, Ausonia, junto con la fundación Solidaridad Carrefour y la Asociación Española Contra el Cáncer (AECC) lanzaron una campaña, bajo el hashtag #LaCienciaEsPodeROSA, destinada a recaudar fondos para la financiación de proyectos de investigación contra esta enfermedad. La campaña fue de carácter interactivo buscando la participación del público mediante el hashtag en redes sociales y obtuvo unos resultados elevados en cuanto a notoriedad y alcance.[EN] Cancer is a group of illnesses characterized by the development of abnormal cells which divide themselves without control and that have the capability to infiltrate and destroy the body tissue. Because of world Breast Cancer Day, on 19th of October of 2021, Ausonia, in collaboration with Fundación Solidaridad Carrefour and Asociación Española Contra el Cáncer (AECC) launched a campaign, with the hashtag #LaCienciaEsPodeROSA, that was destined to reach funds to fund research projects against this illness. The campaign had an interactive character searching the participation of the public by the use of the hashtag in social media and reached very high results in terms of visibility and reach.S

Anxiolytic-like effects of Lupinus angustifolious protein hydrolysates in alzheimer model mice

Alzheimer’s disease (AD), which is characterized by a devastating and progressive loss of memory, is the principal neurodegenerative disease in the elderly population worldwide. As a consequence, AD patients present neuropsychiatric symptoms, such as anxiety, causing sleeping difficulty, irritability, agitation, or aggressiveness. Previous studies have demonstrated that a high-fat diet, in addition to exacerbating AD, aggravates anxiety. We have demonstrated that Lupinus angustifolius protein hydrolysates (LPHs) have anti-inflammatory and antioxidant effects, key factors for AD and anxiety. Thus, this study aimed to evaluate the potential effects of LPHs on spatial memory and anxiety of a preclinical model of AD. ApoE−/− mice fed with a western diet were intragastrically treated with LPHs (or a vehicle) for 14 weeks. Spatial memory and anxiety were then assessed through the Morris water maze and elevated plus maze, respectively. The results did not show significant differences in spatial memory between groups. However, a significant increase (p < 0.05) in time in open arms, center time, the number of crossings, and a reduction of anxiety behavior were observed in LPH-treated mice. This is the first study showing that an LPH treatment causes anxiolytic effects, pointing to LPHs as a potential component of future nutritional therapies.Ministerio de Economía y Competitividad AGL2012-40247-C02-01Ministerio de Economía y Competitividad AGL2012-40247-C02-02Ministerio de Salud del Gobierno Andaluz PC-0111-2016-0111Gobierno Andaluz CTS160Ministerio de Educación, Cultura y Deporte FPU16/02339Ministerio de Educación, Cultura y Deporte FPU13/01210Universidad de Sevilla VI PPIT-U

Bioactive Peptides from Lupin (Lupinus angustifolius) Prevent the Early Stages of Atherosclerosis in Western Diet-Fed ApoE-/- Mice

11 Páginas.-- 5 Figuras.-- 2 TablasWe have previously reported the in vitro hypocholesterolemic, anti-inflammatory, and antioxidant effects of Alcalase-generated lupin protein hydrolysate (LPH). Given that lipoprotein deposition, oxidative stress, and inflammation are the main components of atherogenesis, we characterized the LPH composition, in silico identified LPH-peptides with activities related to atherosclerosis, and evaluated the in vivo LPH effects on atherosclerosis risk factors in a mouse model of atherosclerosis. After 15 min of Alcalase hydrolysis, peptides smaller than 8 kDa were obtained, and 259 peptides out of 278 peptides found showed biological activities related to atherosclerosis risk factors. Furthermore, LPH administration for 12 weeks reduced the plasma lipids, as well as the cardiovascular and atherogenic risk indexes. LPH also increased the total antioxidant capacity, decreased endothelial permeability, inflammatory response, and atherogenic markers. Therefore, this study describes for the first time that LPH prevents the early stages of atherosclerosis.Ministerio de Economía y Competitividad, Gobierno de España [AGL2012-40247-C02-01 and AGL2012-40247-C02-02], Consejería de Salud, Junta de Andalucía [PC-0111-2016-0111 and PEMP-0085-2020], and the Programa PAIDI from the Junta de Andalucía [CTS160]. G.S.-S. was supported by Formación Profesorado Universitario grants from the Ministerio de Educación, Cultura y Deporte, Gobierno de España [FPU16/02339]. I.C.-C. was supported by a postdoctoral fellowship from the Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía [DOC_00587/2020]. N.Á.-S. was supported by a fellowship from the Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF) [RD12/0043/0012 from the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Gobierno de España]. B.R.-O. was supported by a grant from the Programa de Empleo Juvenil of Ministerio de Empleo y Seguridad Social, Gobierno de España [EJ-086]. A.I.Á.-L. was funded by the Consejería de Salud, Junta de Andalucía [PI-0136-2019]. I.B. was supported by the VI Plan Propio de Investigación y Transferencia of Universidad de Sevilla [VI PPIT-US].Peer reviewe

A Lupin (Lupinus angustifolius) Protein Hydrolysate Exerts Anxiolytic-Like Effects in Western Diet-Fed ApoE−/− Mice

16 Páginas.-- 6 Figuras.-- 3 TablasAnxiety is the most prevalent psychiatric disorder worldwide, causing a substantial economic burden due to the associated healthcare costs. Given that commercial anxiolytic treatments may cause important side effects and have medical restrictions for prescription and high costs, the search for new natural and safer treatments is gaining attention. Since lupin protein hydrolysate (LPH) has been shown to be safe and exert anti-inflammatory and antioxidant effects, key risk factors for the anxiety process and memory impairment, we evaluated in this study the potential effects of LPH on anxiety and spatial memory in a Western diet (WD)-induced anxiety model in ApoE-/- mice. We showed that 20.86% of the 278 identified LPH peptides have biological activity related to anxiolytic/analgesic effects; the principal motifs found were the following: VPL, PGP, YL, and GQ. Moreover, 14 weeks of intragastrical LPH treatment (100 mg/kg) restored the WD-induced anxiety effects, reestablishing the anxiety levels observed in the standard diet (SD)-fed mice since they spent less time in the anxiety zones of the elevated plus maze (EPM). Furthermore, a significant increase in the number of head dips was recorded in LPH-treated mice, which indicates a greater exploration capacity and less fear due to lower levels of anxiety. Interestingly, the LPH group showed similar thigmotaxis, a well-established indicator of animal anxiety and fear, to the SD group, counteracting the WD effect. This is the first study to show that LPH treatment has anxiolytic effects, pointing to LPH as a potential component of future nutritional therapies in patients with anxiety.This research was funded by the Spanish Government, Ministerio de Economía y Competitividad (AGL2012-40247-C02-01, and AGL2012-40247-C02-02), the Andalusian Government Ministry of Health (PC-0111-2016-0111, and PEMP-0085-2020) and the PAIDI Program from the Andalusian Government (CTS160). G.S.-S. was supported by a FPU grant from the Spanish Ministerio de Educación, Cultura y Deporte (FPU16/02339). E.P.-E. and I.B. were supported by the VI Program of Inner Initiative for Research and Transfer of University of Seville (VI PPIT-US). I.C.-C. was supported by the VI Program of Inner Initiative for Research and Transfer of the University of Seville (VIPPIT-2020-II.4) and by a postdoctoral fellowship from the Andalusian Government Ministry of Economy, Knowledge, Business, and University (DOC_00587/2020). N.A.-S. was supported by a fellowship from the National Net RETICEF for Aging Studies (RD12/0043/0012 from the Instituto de Salud Carlos III, Spanish Ministerio de Ciencia e Innovación). A.I.Á.-L. was funded by Andalusian Government Ministry of Health (PI-0136-2019).Peer reviewe