Integrins Are the Necessary Links to Hypertrophic Growth in Cardiomyocytes

To compensate for hemodynamic overload of the heart, an event which stretches the myocardium, growth and survival signaling are activated in cardiac muscle cells (cardiomyocytes). Integrins serve as the signaling receptors of cardiomyocytes responsible for mechanotransduction toward intracellular signaling. The main integrin heterodimers on the cardiomyocyte surface are α5β1 and αvβ3, and elimination of either β1 or β3 integrins impedes pressure-induced hypertrophic signaling and leads to increased mortality. The growth signaling pathways downstream of β1 and β3 integrins are well characterized. However, new integrin pathways responsible for inhibiting apoptosis induced by hemodynamic overload are emerging. β1 and β3 integrins activate differential survival signaling, yet both integrins initiate survival signaling downstream of ubiquitination and the kinase pathway including phosphoinositol-3-kinase (PI3K)/Akt. Further characterization of these integrin-signaling mechanisms may lead to drug targets to prevent decompensation to heart failure

Condensed heterotricycles: synthesis of pyrazolo[3,4-c]qumoline derivatives

Pyrazol[3,4-c]quinoline 4a is obtained from 4-(2-riitrophenyl)pyrazole-3-carboxylate (3a) by reduction followed by thermal cyclization. 4a undergoes aminoalkylation uniquely at N(3) to form 4b-d, as shown by I3C NMR. Pyrazoles 3a and 3c are methylated at N(2) to 6a and 6b respectively which are re-ductively cyclized to pyrazoloquinolones 7a and 7b. The later are transformed into amino derivatives 8b-d and 8g,h via chloro compounds 8a and 8f. The.amino alkoxypyrazoloquinoline (8e) is obtained from 8a or the lactam 7a. Cyclic hydroxamic acids 7c and 7d are prepared from the nitropyrazoles 6a and 6b by using NaBH4 and Pd - C. A second synthesis of die pyrazolo[3,4-c]quinoline ring system consists of heating mercaptoacid (8) with methyl or phenyl hydrazine when 10a or 10b is obtained. Attempts to convert the pyrazole carboxylate 13a into an isomeric pyrazoloisoquinoline system 12 via the isocyan-ate 13d resulted only in the formation of bis-urea 14

Variable stars in the globular cluster NGC 7492. New discoveries and physical parameters determination

We have performed a photometric V, R, I CCD time-series analysis with a baseline of ~8 years of the outer-halo globular cluster NGC 7492 with the aim of searching for new variables and using these (and the previously known variables) to determine the physical parameters of interest for the cluster (e.g. metallicity, absolute magnitude of the horizontal branch, distance, etc.). We use difference image analysis (DIA) to extract precise light curves in the relatively crowded star field, especially towards the densely populated central region. Several approaches are used for variability detection that recover the known variables and lead to new discoveries. We determine the physical parameters of the only RR0 star using light curve Fourier decomposition analysis. We find one new long period variable and two SX Phe stars in the blue straggler region. We also present one candidate SX Phe star which requires follow-up observations. Assuming that the SX Phe stars are cluster members and using the period-luminosity relation for these stars, we estimate their distances as ~25.2+-1.8 and 26.8+-1.8 kpc, and identify their possible modes of oscillation. We refine the periods of the two RR Lyrae stars in our field of view. We find that the RR1 star V2 is undergoing a period change and possibly exhibits the Blazhko effect. Fourier decomposition of the light curve of the RR0 star V1 allows us to estimate the metallicity [Fe/H]_ZW-1.68+-0.10 or [Fe/H]_UVES-1.64+-0.13, log-luminosity ~1.76+-0.02, absolute magnitude ~0.38+-0.04 mag, and true distance modulus of ~16.93+-0.04 mag, which is equivalent to a distance of ~24.3+-0.5 kpc. All of these values are consistent with previous estimates in the literature.Comment: 12 pages, 13 figures, 6 tables, accepted for publication in A&

Constraining the parameters of globular cluster NGC 1904 from its variable star population

We present the analysis of 11 nights of V and I time-series observations of the globular cluster NGC 1904 (M 79). Using this we searched for variable stars in this cluster and attempted to refine the periods of known variables, making use of a time baseline spanning almost 8 years. We use our data to derive the metallicity and distance of NGC 1904. We used difference imaging to reduce our data to obtain high-precision light curves of variable stars. We then estimated the cluster parameters by performing a Fourier decomposition of the light curves of RR Lyrae stars for which a good period estimate was possible. We also derive an estimate for the age of the cluster by fitting theoretical isochrones to our colour-magnitude diagram (CMD). Out of 13 stars previously classified as variables, we confirm that 10 are bona fide variables. We cannot detect variability in one other within the precision of our data, while there are two which are saturated in our data frames, but we do not find sufficient evidence in the literature to confirm their variability. We also detect a new RR Lyrae variable, giving a total number of confirmed variable stars in NGC 1904 of 11. Using the Fourier parameters, we find a cluster metallicity [Fe/H]_ZW=-1.63 +- 0.14, or [Fe/H]_UVES=-1.57 \pm 0.18, and a distance of 13.3 +- 0.4 kpc (using RR0 variables) or 12.9 kpc (using the one RR1 variable in our sample for which Fourier decomposition was possible).Comment: 14 pages, 11 figures, accepted for publication in A&

The unusually large population of Blazhko variables in the globular cluster NGC 5024 (M53)

We report the discovery of amplitude and phase modulations typical of the Blazhko effect in 22 RRc and 9 RRab type RR Lyrae stars in NGC 5024 (M53). This brings the confirmed Blazhko variables in this cluster to 23 RRc and 11 RRab, that represent 66% and 37% of the total population of RRc and RRab stars in the cluster respectively, making NGC 5024 the globular cluster with the largest presently known population of Blazhko RRc stars. We place a lower limit on the overall incidence rate of the Blazhko effect among the RR Lyrae population in this cluster of 52%. New data have allowed us to refine the pulsation periods. The limitations imposed by the time span and sampling of our data prevents reliable estimations of the modulation periods. The amplitudes of the modulations range between 0.02 and 0.39 mag. The RRab and RRc are neatly separated in the CMD, and the RRc Blazhko variables are on averge redder than their stable couterparts; these two facts may support the hypothesis that the HB evolution in this cluster is towards the red and that the Blazhko modulations in the RRc stars are connected with the pulsation mode switch.Comment: ACCEPTED IN MNRAS 14 pages, 9 figures and 6 table

Penerapan Model Pembelajaran Atraktif Berbasis Multiple Intelligences Tentang Pemantulan Cahaya pada Cermin

Penelitian ini bertujuan untuk mengetahui efektivitas penerapan model pembelajaran atraktif berbasis multiple intelligences dalam meremediasi miskonsepsi siswa tentang pemantulan cahaya pada cermin. Pada penelitian ini digunakan bentuk pre-eksperimental design dengan rancangan one group pretest-post test design. Alat pengumpulan data berupa tes pilihan ganda dengan reasoning. Hasil validitas sebesar 4,08 dan reliabilitas 0,537. Siswa dibagi menjadi lima kelompok kecerdasan, yaitu kelompok linguistic intelligence, mathematical-logical intelligence, visual-spatial intelligence, bodily-khinestetic intelligence, dan musical intelligence. Siswa membahas konsep fisika sesuai kelompok kecerdasannya dalam bentuk pembuatan pantun-puisi, teka-teki silang, menggambar kreatif, drama, dan mengarang lirik lagu. Efektivitas penerapan model pembelajaran multiple intelligences menggunakan persamaan effect size. Ditemukan bahwa skor effect size masing-masing kelompok berkategori tinggi sebesar 5,76; 3,76; 4,60; 1,70; dan 1,34. Penerapan model pembelajaran atraktif berbasis multiple intelligences efektif dalam meremediasi miskonsepsi siswa. Penelitian ini diharapkan dapat digunakan pada materi fisika dan sekolah lainnya