Courts Have Gone Overboard in Applying the Maritime Drug Law Enforcement Act

The Maritime Drug Law Enforcement Act (MDLEA), enacted through Congress’s power to “define and punish . . . Felonies Committed on the high Seas,” prosecutes individuals for drug trafficking “on board” vessels. Individuals often raise jurisdictional defenses in U.S. courts when prosecuted under MDLEA, and scholarship in the area argues about whether the Constitution permits MDLEA to reach drug traffickers who are on the high seas. Recently, courts have begun using MDLEA to prosecute foreign nationals located in a foreign nation who are not on board a vessel as conspirators. However, no court has fully examined Congress’s authority to enact a statute with this reach or engaged in a comprehensive statutory interpretation of MDLEA’s conspiracy provision. This Note examines MDLEA from two perspectives. First, it examines whether Congress has constitutional authority to enact a law prosecuting drug trafficking by a foreign national on land in a foreign nation to determine the validity of such law. Because the Constitution grants Congress the power to punish crimes on the high seas, this inquiry depends on whether conspiracy can effectively extend an individual’s conduct from land to the high seas. Second, this Note considers the statutory language of MDLEA to determine whether the law enables the prosecution of a foreign national located in a foreign nation as a conspirator.This Note argues that the text of the statute limits the substantive offense by using the jurisdictional language of “on board a covered vessel,” and so MDLEA remains a valid exercise of Congress’s Article I authority under the Felonies Clause

Ground Software Maintenance Facility (GSMF) user's manual. Appendices NASA-CR-178806 NAS 1.26:178806 Rept-41849-G159-026-App HC A05/MF A01

Procedures are presented that allow the user to assemble tasks, link, compile, backup the system, generate/establish/print display pages, cancel tasks in memory, and to TET an assembly task without having to enter the commands every time. A list of acronyms is provided. Software identification, payload checkout unit operating system services, data base generation, and MITRA operating procedures are also discussed

Perturbative corrections to semileptonic b decay distributions

We compute O(alpha_s) and O(alpha_s^n beta_0^{n-1}) (BLM) corrections to the five structure functions relevant for b->q l nu decays and apply the results to the moments of a few distributions of phenomenological importance. We present compact analytic one-loop formulae for the structure functions, with proper subtraction of the soft divergence.Comment: 23 pages, LaTex. A number of textual changes are added for clarity, a missing definition is provide

Ground Software Maintenance Facility (GSMF) user's manual

Instructions for the Ground Software Maintenance Facility (GSMF) system user is provided to operate the GSMF in all modes. The GSMF provides the resources for the Automatic Test Equipment (ATE) computer program maintenance (GCOS and GOAL). Applicable reference documents are listed. An operational overview and descriptions of the modes in terms of operator interface, options, equipment, material utilization, and operational procedures are contained. Test restart procedures are described. The GSMF documentation tree is presented including the user manual

NOVEL TECHNIQUES FOR IN VIVO CHARACTERIZATION OF SHORT PEPTIDES AND PROTEINS IN MEMBRANE PERMEABILIZATION AND SIGNAL TRANSDUCTION

My scientific interest is focused on the field of cellular electrical activity, ranging from the study of intracellular enzymatic processes to the characterization of new generation of drugs. For this purpose I also used the most powerful techniques of investigation, including patch-clamp technique, fluorescence imaging, and surface plasmon resonance (SPR) spectroscopy. Moreover, to shed light on complex molecular mechanisms, unconventional strategies were employed, requiring sometimes the realization of specific devices not commercially available. In particular my PhD thesis includes two different scientific projects: the biophysical characterization of antimicrobial peptides and the modulation of visual phototransduction in vertebrate cones. In the first project, the patch-clamp technique was employed to study the pore forming properties of synthetic cecropin-melittin hybrid peptide (CM15), alamethicin F50/5 and its synthetic analog [L-Glu(OMe)7,18,19] under strict physiological conditions. These short peptides selectively permeabilize the bacteria plasma membrane leading to their lyses and death: they are therefore a source of antibacterial molecules, and inspiration for novel and more selective drugs. I pursued this study by recording the ion current through the channels formed by these peptides, once inserted in the membrane of photoreceptor rod outer segment membrane (OS) isolated from frog retinae. The peptides were applied to (and removed from) the extracellular OS side in ~50 ms with a computer-controlled microperfusion system, so that the ion channel characteristics (as its selectivity, blockade and gating) and the dynamics of pore formation could be precisely assessed. On the basis of the electrophysiological recordings obtained, it was demonstrated that, different than alamethicins, CM15 produced voltage-independent membrane permeabilisation, repetitive peptide application caused a progressive permeabilisation increase, and no single-channel events were detected at low peptide concentrations. Collectively, these results indicate that CM15 form pores according to a toroidal model. Moreover, in order to understand the divalent-cation dependency of [L-Glu(OMe)7,18,19] binding to the lipid bilayer at the molecular level, the electrophysiological experiments were paralleled with experiments employing SPR spectroscopy. Results indicate the presence of Ca2+ in the external solution increases the probability of formation of smaller and more stable [L-Glu(OMe)7,18,19] pores. The second project of this thesis concerns the investigation of the physiological role of the neuronal calcium sensor zGCAP3 in the photrasduction cascade. This study was pursued through the simulation of an over expression and a knock-down of this protein, by delivering it, or its monoclonal antibody, into zebrafish cone cytosol, while recording their photoresponses with the patch-clamp technique. The intracellular protein delivery was attained via the patch pipette, by ejecting the proteins out of a tube inserted into the pipette lumen. A microperfusion system was employed to apply the desired exogenous molecules with a precise timing. However, the long tapered shape of the pipette shank make it very difficult to perfuse efficiently the cell with this strategy. For this reason a pressure polishing setup was assembled to enlarge the patch pipette shank, through the calibrated combination of heat and air pressure. This allowed to insert quartz or plastic tubes in the pipette lumen very close to its tip. In order to obtain a substantial and specific silencing of the zGCAP3s in zebrafish cones, surface plasmon resonance experiments were performed to allow the selection of a monoclonal antibody with strong affinity for zGCAP3 and low cross interaction with other components of the phototransduction cascade. Results showed that the perfusion with GCAP3 did not altered significantly the light response, while he anti-zGCAP3 incorporation in the cytosol caused the progressive photoresponse fall, followed by the progressive fall of saturating flash response amplitude, probably due to the progressive GC inhibition. The unexpected lack of an effect of zGCAP3 incorporation in the cone cytosol, suggests that the endogenous number of zGCAP3 is saturating, i.e. their number is equal or above the number of their target molecules (guanylate cyclase), therefore any further increase of zGAP3 in the cytosol is uneffective

Occupational Therapy for Adults with Intellectual and Developmental Disabilities

This capstone was completed at Cleveland State University as a point of outreach to various organizations in Northeast Ohio to determine the gaps in services for adults with intellectual and developmental disabilities. Occupational therapy services within this population have been promoted to various organizations.https://engagedscholarship.csuohio.edu/ot_capstone_posters/1022/thumbnail.jp

Towards a physiological role for cytochrome P450 aromatase in ejaculated human sperm

n/

The therapist in the room : towards an understanding of the therapist\u27s personhood in therapeutic practice : a project based upon an independent investigation

This theoretical study explores the phenomenon of the therapist\u27s personhood during consultation in relation to her professional demeanor, role, and responsibilities. This study examines the idea and treatment of this personhood through psychodynamic and relational perspectives. By comparing and contrasting the different models of the therapist via these two theories, the study is grounded in the history and evolution of ideas about the therapist, and elucidates how these ideas have changed over time. The study also explores the importance of broadening discussion and study of the therapist\u27s personhood for trainees and beginning practitioners, and concludes with recommendations for increased attention to this complex issue from mental health professions

Breaking the paradigm : new approaches to pricing accounting services

https://egrove.olemiss.edu/aicpa_guides/1440/thumbnail.jp