Predicting substance use behavior among South African adolescents: The role of leisure experiences across time

Using seven waves of data, collected twice a year from the 8th through the 11th grades in a low-resource community in Cape Town, South Africa, we aimed to describe the developmental trends in three specific leisure experiences (leisure boredom, new leisure interests, and healthy leisure) and substance use (cigarettes, alcohol, and marijuana) behaviors and to investigate the ways in which changes in leisure experiences predict changes in substance use behaviors over time. Results indicated that adolescents’ substance use increased significantly across adolescence, but that leisure experiences remained fairly stable over time. We also found that adolescent leisure experiences predicted baseline substance use and that changes in leisure experiences predicted changes in substance use behaviors over time, with leisure boredom emerging as the most consistent and strongest predictor of alcohol, cigarette, and marijuana use. Implications for interventions that target time use and leisure experiences are discussed.Web of Scienc

Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype–phenotype correlation

Purpose: Neurofibromatosis type 1 (NF1) is characterized by a highly variable clinical presentation, but almost all NF1-affected adults present with cutaneous and/or subcutaneous neurofibromas. Exceptions are individuals heterozygous for the NF1 in-frame deletion, c.2970_2972del (p.Met992del), associated with a mild phenotype without any externally visible tumors. Methods: A total of 135 individuals from 103 unrelated families, all carrying the constitutional NF1 p.Met992del pathogenic variant and clinically assessed using the same standardized phenotypic checklist form, were included in this study. Results: None of the individuals had externally visible plexiform or histopathologically confirmed cutaneous or subcutaneous neurofibromas. We did not identify any complications, such as symptomatic optic pathway gliomas (OPGs) or symptomatic spinal neurofibromas; however, 4.8% of individuals had nonoptic brain tumors, mostly low-grade and asymptomatic, and 38.8% had cognitive impairment/learning disabilities. In an individual with the NF1 constitutional c.2970_2972del and three astrocytomas, we provided proof that all were NF1-associated tumors given loss of heterozygosity at three intragenic NF1 microsatellite markers and c.2970_297

Health impact assessment in Australia and New Zealand: an exploration of methodological concerns

This paper explores methodological issues raised by recent attempts to promote the use of health impact assessment (HIA) in Australia and New Zealand. The experiences from both countries are used to highlight important aspects of the debate about the relevance of HIA in appraising both policies and projects particularly in the three broad areas: inclusivity, legitimacy, and method. Many countries are attempting to develop HIA for use in policy development without due consideration of either important methodological issues or the workforce development and capacity-building necessary for its successful implementation.<br /

What about theory? : The consequences on a widened perspective of social theory

One of the leading debates in social sciences concerns research design. However, in comparative politics, the predominant way conducting research misses out crucial aspects that are central to social theory. This article shows how method and empirical research are highly dependent on the definition of theory. Arguing that theory should not only give an explanation of the social phenomena in question but should also show how this relationship is constructed, this article outlines the consequence of such a perspective, namely that the collection of data should reflect both macro and micro perspectives and the analyses of data should be carried out using mixed methods. In conclusion, such an integrated framework is the most appropriate way to give valuable theoretical feedback, either by examination and revision of already established theories or by a contribution to the construction of new theory in the social sciences. It is important, though, that such a framework is applied in a systematized way

Survival and quality of life of octogenarians who underwent mechanical valve replacement at a younger age

Purpose. Mechanical valve replacement is associated with complications, however, there is little information on the quality of life (QOL) of octogenarians who had undergone mechanical valve replacement at a relatively younger age. We examined survival, valve-related events, and the QOL of octogenarians who had undergone mechanical valve replacement. Methods. A total of 56 octogenarians who underwent mechanical valve replacement between 1969 and 1997 (age at the time of surgery, 65.6 ± 6.7 years), completed a questionnaire on survival, valve-related events, and QOL (basic activities of daily living, instrumental activities of daily living, mental health). Results. The mean follow-up was 12.4 ± 6.6 years, and the cumulative follow-up period was 642.4 patient-years. Six valve-related deaths (0.9%/patient-year) were registered during the follow-up. Furthermore, 11 valverelated events (1.8%/patient-year) were recorded. The mean age of the 21 survivors was 82.9 ± 1.8 years, and 19 of the survivors lived at home. Their QOL was excellent. Conclusion. The valve-related deaths and events in octogenarians who had previously undergone mechanical valve replacement at a younger age were within acceptable limits. The QOL was similar to that of octogenarians described in previous studies

Reducing Complexity in Qualitative Comparative Analysis (QCA): Remote and Proximate Factors and the Consolidation of Democracy

Comparative methods based on set theoretic relationships such as 'fuzzy set Qualitative Comparative Analysis' (fs/QCA) represent a useful tool for dealing with complex causal hypotheses in terms of necessary and sufficient conditions under the constraint of a medium-sized number of cases. However, real-world research situations might make the application of fs/QCA difficult in two respects - namely, the complexity of the results and the phenomenon of limited diversity. We suggest a two-step approach as one possibility to mitigate these problems. After introducing the difference between remote and proximate factors, the application of a two-step fs/QCA approach is demonstrated analyzing the causes of the consolidation of democracy. We find that different paths lead to consolidation, but all are characterized by a fit of the institutional mix chosen to the societal context in terms of power dispersion. Hence, we demonstrate that the application of fs/QCA in a two-step manner helps to formulate and test equifinal and conjunctural hypotheses in medium-size N comparative analyses, and thus to contribute to an enhanced understanding of social phenomena