7,995 research outputs found
A simulation study of two major events in the heliosphere during the present sunspot cycle
The two major disturbances in the heliosphere during the present sunspot cycle, the event of June to August, 1982, and the event of April to June, 1978, are simulated by the method developed by Hakamada and Akasofu (1982). Specifically, an attempt was made to simulate the effects of six major flares from three active regions in June and July, 1982, and April and May, 1978. A comparison of the results with the solar wind observations at Pioneer 12 (approximately 0.8 au), ISEE-3 (approximately 1 au), Pioneer 11 (approximately 7 to 13 au) and Pioneer 10 (approximately 16 to 28 au) suggests that some major flares occurred behind the disk of the sun during the two periods. The method provides qualitatively some information as to how such a series of intense solar flares can greatly disturb both the inner and outer heliospheres. A long lasting effect on cosmic rays is discussed in conjunction with the disturbed heliosphere
Failure of the Standard Coupled-Channels Method in Describing the Inelastic Reaction Data: On the Use of a New Shape for the Coupling Potential
We present the failure of the standard coupled-channels method in explaining
the inelastic scattering together with other observables such as elastic
scattering, excitation function and fusion data. We use both microscopic
double-folding and phenomenological deep potentials with shallow imaginary
components. We argue that the solution of the problems for the inelastic
scattering data is not related to the central nuclear potential, but to the
coupling potential between excited states. We present that these problems can
be addressed in a systematic way by using a different shape for the coupling
potential instead of the usual one based on Taylor expansion.Comment: 10 pages, 4 figures, 1 table, Latex:RevTex4 published in J. Phys. G:
Nucl. Part. Phy
Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder
Background
The 39,XY*O mouse, which lacks the orthologues of the ADHD and autism candidate genes STS (steroid sulphatase) and ASMT (acetylserotonin O-methyltransferase), exhibits behavioural phenotypes relevant to developmental disorders. The neurobiology underlying these phenotypes is unclear, although there is evidence for serotonergic abnormalities in the striatum and hippocampus.
Methods
Using microarray and quantitative gene expression analyses, and gas chromatography–mass spectrometry, we compared brain gene expression and steroid biochemistry in wildtype (40,XY) and 39,XY*O adult mice to identify non-obvious genetic and endocrine candidates for between-group differences in behaviour and neurochemistry. We also tested whether acute STS inhibition by COUMATE in wildtype (40,XY) adult male mice recapitulated any significant gene expression or biochemical findings from the genetic comparison. Data were analysed by unpaired t-test or Mann Whitney U-test depending on normality, with a single factor of KARYOTYPE.
Results
Microarray analysis indicated seven robust gene expression differences between the two groups (Vmn2r86, Sfi1, Pisd-ps1, Tagap1, C1qc, Metap1d, Erdr1); Erdr1 and C1qc expression was significantly reduced in the 39,XY*O striatum and hippocampus, whilst the expression of Dhcr7 (encoding 7-dehydrocholesterol reductase, a modulator of serotonin system development), was only reduced in the 39,XY*O hippocampus. None of the confirmed gene expression changes could be recapitulated by COUMATE administration. We detected ten free, and two sulphated steroids in 40,XY and 39,XY*O brain; surprisingly, the concentrations of all of these were equivalent between groups.
Conclusions
Our data demonstrate that the mutation in 39,XY*O mice: i) directly disrupts expression of the adjacent Erdr1 gene, ii) induces a remarkably limited suite of downstream gene expression changes developmentally, with several of relevance to associated neurobehavioural phenotypes and iii) does not elicit large changes in brain steroid biochemistry. It is possible that individuals with STS/ASMT deficiency exhibit a similarly specific pattern of gene expression changes to the 39,XY*O mouse, and that these contribute towards their abnormal neurobiology. Future work may focus on whether complement pathway function, mitochondrial metabolism and cholesterol biosynthesis pathways are perturbed in such subjects
Development of measurement techniques for studying propeller erosion damage in severe wake fields
Preliminary propeller erosion tests have been conducted at the Naval Surface Warfare Center Carderock Division 24 inch variable pressure water tunnel (VPWT), shown in Figure 1, to establish testing procedures for evaluating various coatings to minimize cavitation erosion damage to marine propellers. A severe wake field was produced using a two dimensional, thick foil ahead of a downstream driven propeller model. This approach was derived from similar tests conducted by Miller [11]. Conventional cavitation viewing was performed with cameras viewing through the tunnel side window. Images were acquired using high speed (up to 6000 fps) and high resolution (2K x 2K) cameras. In addition, a waterproof camera was mounted inside the foil looking directly downstream at the suction face of the blade. Two propellers were tested, a 16 inch (0.406 m) diameter propeller 5388 and a 12 inch (0.305 m) diameter propeller 4119 [8]. The foil wake field was measured with LDV surveys. Accelerometers were mounted in the water tunnel test section to measure acoustic emissions of cavitation activity. Cavitation erosion was observed at the tip of the 16 inch diameter propeller due to excessive tip vortex, and complicated vortex collapse. Moderate erosion was also observed at the inner radii, where leading edge sheet cavitation collapsed. Scanning techniques for quantifying propeller erosion damage were evaluated. These studies will transition to the 36-inch VPWT where a number of geosym propellers of different materials and coating will be assessed in a similar wake field.http://deepblue.lib.umich.edu/bitstream/2027.42/84210/1/CAV2009-final156.pd
Fermionic Determinant of the Massive Schwinger Model
A representation for the fermionic determinant of the massive Schwinger
model, or , is obtained that makes a clean separation between the
Schwinger model and its massive counterpart. From this it is shown that the
index theorem for follows from gauge invariance, that the Schwinger
model's contribution to the determinant is canceled in the weak field limit,
and that the determinant vanishes when the field strength is sufficiently
strong to form a zero-energy bound state
QED in strong, finite-flux magnetic fields
Lower bounds are placed on the fermionic determinants of Euclidean quantum
electrodynamics in two and four dimensions in the presence of a smooth,
finite-flux, static, unidirectional magnetic field , where
or , and is a point in the xy-plane.Comment: 10 pages, postscript (in uuencoded compressed tar file
Constraints on Galaxy Bias, Matter Density, and Primordial Non--Gausianity from the PSCz Galaxy Redshift Survey
We compute the bispectrum for the \IRAS PSCz catalog and find that the galaxy
distribution displays the characteristic signature of gravity. Assuming
Gaussian initial conditions, we obtain galaxy biasing parameters
and , with no sign of
scale-dependent bias for h/Mpc. These results impose stringent
constraints on non-Gaussian initial conditions. For dimensional scaling models
with statistics, we find N>49, which implies a constraint on
primordial skewness .Comment: 4 pages, 3 embedded figures, uses revtex style file, minor changes to
reflect published versio
The Ministry of Works and the Development of Souvenir Guides from 1955
The first formal guidebooks for historic sites placed in state guardianship in the United Kingdom appeared in 1917. There was an expansion of the series in the 1930s and 1950s. However, from the late 1950s the Ministry of Works, and later the Ministry of Public Buildings and Works, started to produce an additional series of illustrated souvenir guides. One distinct group covered Royal Palaces: the Tower of London, Hampton Court Palace, Queen Victoria's residence of Osborne House on the Isle of Wight, and Holyroodhouse in Edin-burgh. This was followed by guides for archaeological sites such as Stone-henge and Avebury, the Neolithic flint mines at Grime's Graves, the Roman villa at Lullingstone, and Hadrian's Wall. In 1961, a series of guides, with covers designed by Kyffin Williams, was produced for the English castles constructed in North Wales. These illustrated guides, some with colour, prepared the way for the fully designed guides now produced by English Heritage, Cadw, and Historic Environment Scotland
Absence of correlation between built-in electric dipole moment and quantum Stark effect in InAs/GaAs self-assembled quantum dots
We report significant deviations from the usual quadratic dependence of the
ground state interband transition energy on applied electric fields in
InAs/GaAs self-assembled quantum dots. In particular, we show that conventional
second-order perturbation theory fails to correctly describe the Stark shift
for electric field below kV/cm in high dots. Eight-band calculations demonstrate this effect is predominantly due to
the three-dimensional strain field distribution which for various dot shapes
and stoichiometric compositions drastically affects the hole ground state. Our
conclusions are supported by two independent experiments.Comment: 4 pages, 4 figure
Improving the mass determination of Galactic Cepheids
We have selected a sample of Galactic Cepheids for which accurate estimates
of radii, distances, and photometric parameters are available. The comparison
between their pulsation masses, based on new Period-Mass-Radius (PMR)
relations, and their evolutionary masses, based on both optical and NIR
Color-Magnitude (CM) diagrams, suggests that pulsation masses are on average of
the order of 10% smaller than the evolutionary masses. Current pulsation masses
show, at fixed radius, a strongly reduced dispersion when compared with values
published in literature.The increased precision in the pulsation masses is due
to the fact that our predicted PMR relations based on nonlinear, convective
Cepheid models present smaller standard deviations than PMR relations based on
linear models. At the same time, the empirical radii of our Cepheid sample are
typically accurate at the 5% level. Our evolutionary mass determinations are
based on stellar models constructed by neglecting the effect of mass-loss
during the He burning phase. Therefore, the difference between pulsation and
evolutionary masses could be intrinsic and does not necessarily imply a problem
with either evolutionary and/or nonlinear pulsation models. The marginal
evidence of a trend in the difference between evolutionary and pulsation masses
when moving from short to long-period Cepheids is also briefly discussed. The
main finding of our investigation is that the long-standing Cepheid mass
discrepancy seems now resolved at the 10% level either if account for canonical
or mild convective core overshooting evolutionary models.Comment: 14 pages, 4 postscript figures, accepted for publication on ApJ
Letter
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