Deregulated expression of aurora kinases is not a prognostic biomarker in papillary thyroid cancer patients.

Abstract A number of reports indicated that Aurora-A or Aurora-B overexpression represented a negative prognostic factor in several human malignancies. In thyroid cancer tissues a deregulated expression of Aurora kinases has been also demonstrated, butno information regarding its possible prognostic role in differentiated thyroid cancer is available. Here, weevaluated Aurora-A and Aurora-B mRNA expression and its prognostic relevance in a series of 87 papillary thyroid cancers (PTC), with a median follow-up of 63 months. The analysis of Aurora-A and Aurora-B mRNA levels in PTC tissues, compared to normal matched tissues, revealed that their expression was either up-or down-regulatedin the majority of cancer tissues. In particular, Aurora-A and Aurora-B mRNA levels were altered, respectively, in 55 (63.2%) and 79 (90.8%) out of the 87 PTC analyzed. A significant positive correlation between Aurora-A and Aurora-B mRNAswas observed (p=0.001). The expression of both Aurora genes was not affected by the BRAF(V600E) mutation. Univariate, multivariate and Kaplan-Mayer analyses documented the lack of association between Aurora-A or Aurora-B expression and clinicopathological parameterssuch as gender, age, tumor size, histology, TNM stage, lymph node metastasis and BRAF status as well asdisease recurrences or disease-free interval. Only Aurora-B mRNA was significantly higher in T(3-4) tissues, with respect to T(1-2) PTC tissues. The data reported here demonstrate that the expression of Aurora kinases is deregulated in the majority of PTC tissues, likely contributing to PTC progression. However, differently from other human solid cancers, detection of Aurora-A or Aurora-B mRNAs is not a prognostic biomarker inPTC patients

On the solar wind control of cusp aurora during northward IMF

[1] The location of cusp aurora during northward interplanetary magnetic field (IMF) conditions and the solar wind control of that location are explored. The cusp aurora is imaged by the Imager for Magnetopause-to-Aurora Global Exploration\u27s (IMAGE) Far Ultraviolet Instrument (FUV). Predicted locations of the cusp aurora were computed by assuming anti-parallel reconnection between the observed IMF orientation and the 1996 Tsyganenko model magnetopause magnetic field. While the majority of anti-parallel reconnection sites tailward of the cusp, when mapped to the ionosphere, coincide with the observed cusp aurora, the anti-parallel merging hypothesis cannot explain certain aspects of the observations, including its location dependence with IMF + By

Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition.

The protein kinase Aurora-A is a major regulator of the cell cycle that orchestrates mitotic entry and is required for the assembly of a functional mitotic spindle. Overexpression of Aurora-A has been strongly linked with oncogenesis and this has led to considerable efforts at therapeutic targeting of the kinase activity of this protein. However, the exact mechanism by which Aurora-A promotes oncogenesis remains unclear. Here, we show that Aurora-A modulates the repair of DNA double-strand breaks (DSBs). Aurora-A expression inhibits RAD51 recruitment to DNA DSBs, decreases DSB repair by homologous recombination and sensitizes cancer cells to PARP inhibition. This impairment of RAD51 function requires inhibition of CHK1 by Polo-like kinase 1 (PLK1). These results identify a novel function of Aurora-A in modulating the response to DNA DSB that likely contributes to carcinogenesis and suggest a novel therapeutic approach to the treatment of cancers overexpressing this protein

where angels fear to tread : Tracing the Journey of the Female Poet in Aurora Leigh

Through Aurora Leigh, Elizabeth Barrett Browning explores the role of female poets as agents of social change in the Victorian society. During the Victorian period, the role of women was largely confined to the domestic setting. While women were allowed to write, female writers were limited to the realm of novels, which was perceived by the Victorian society to be the less distinguished genre. In writing Aurora Leigh, Barrett Browning challenged this gender stereotype by producing a novel-poem that unites the feminine voice with masculine authority and superiority. Like Barrett Browning, Aurora Leigh, in her fictional role as a writer, also challenges the same stereotypes. She seeks to redefine poetry, which is the domain of man. In rejecting Romney’s initial marriage proposal, Aurora Leigh also rebels against the stereotypical gender roles. At the same time, in doing so, she inadvertently rejects Romney’s plan for social change that involves only the physical aspect. Instead, in pursuing her career as a poet, Aurora Leigh finds herself in a position to bring about social change on a level that transcends the physical. By telling the story of Marian Erle, Aurora Leigh has the power to change the plight of women in the Victorian society. Finally, being women themselves, both Barrett Browning and Aurora Leigh can speak up for the Victorian women even more effectively

Combined EISCAT radar and optical multispectral and tomographic observations of black aurora

Black auroras are recognized as spatially well-defined regions within a uniform diffuse auroral background where the optical emission is significantly reduced. Black auroras typically appear post-magnetic midnight and during the substorm recovery phase, but not exclusively so. We report on the first combined multimonochromatic optical imaging, bistatic white-light TV recordings and incoherent scatter radar observations of black aurora by EISCAT of the phenomenon. From the relatively larger reduction in luminosity at 4278 Å than at 8446 Å we show that nonsheared black auroras are most probably not caused by downward directed electrical fields at low altitude. From the observations, we determine this by relating the height and intensity of the black aurora to precipitating particle energy within the surrounding background diffuse aurora. The observations are more consistent with an energy selective loss cone. Hence the mechanism causing black aurora is most probably active in the magnetosphere rather than close to Earth

The Northern Lights

This activity requires students to plot the location and boundaries of a typical auroral oval in the Arctic region. They will see its geographic extent and determine its relationship to familiar continents and countries. As they perform this activity, they will learn how aurora are described by scientists and by other students, the geographic locations of aurora based on satellite data, how aurora appear in the sky at different geographic latitudes, and the height of aurora above the ground. This is one of series of activities that will help students understand how the Northern Lights work, what causes them, and how to observe them. Educational levels: Middle school

Rana aurora

Number of Pages: 4Integrative BiologyGeological Science

Aurora Leadership Institutes: Assisting future leaders to maximise their leadership skills and potential

Paper presented at Oceans of Opportunities: Library and Information Association of New Zealand Aotearoa 2003 Conference, 7 – 10 October 2003 Napier, New ZealandThis paper provides background information on the Aurora Leadership Institutes and the Aurora Foundation. The latter part of the paper focuses on the looming leadership crisis in the library profession in New Zealand and overseas and identifies several strategies that require implementation to ensure that the crisis is averted