"Dreams and Deeds" and other Dualities: Nielsen and the Two-Movement Sympony

It is well known that Nielsen’s two-movement Fifth Symphony is strongly dualistic in character. The composer himself commented that ‘A title such as “Dreams and Deeds” [Drøm og Daad] could maybe sum up the inner picture I had in front of my eyes when composing’. But it is by no means clear at what level that duality and others he mentioned are actually embodied in the work, or where it stands in relation to other two-movement symphonies composed before and after. Building on an essay by David Fanning in Carl Nielsen Studies 4, the present article fi rst considers these questions in the light of the model for symphonism proposed by the Russian scholar Mark Aranovsky. The Fifth Symphony and those two-movement symphonies found to contain the most fundamental and polarised dualities are then variously related to religious and philosophical traditions that stress dualism – from Zoroastrianism, through Yin and Yang, to Sufism, touching in passing on the philosophy of the mind and on Jung. The aim is to gain a richer and clearer picture of the uniqueness of Nielsen’s Fifth in relation both to symphonic tradition and to the history of ideas

Akimov and Shostakovich’s Hamlet: a Soviet ‘Shakesperiment’

When in 1932 the young theatre artist Nikolay Akimov made his directing debut with Hamlet, nobody expected to witness one of the biggest scandals of Russian/Soviet theatrical history. Akimov’s production for the Vakhtangov Theatre in Moscow had every element of the famously controversial style of Vsevolod Meyerhold (Russia’s Bertolt Brecht), including an apparently irreverent score by the equally young Dmitry Shostakovich. Yet even Meyerhold criticised the show severely. With Ophelia portrayed as a drunken prostitute, and Hamlet as a short, fat comedian, it is hardly surprising that critical opinion should have been sharply divided, agreeing only that Shostakovich’s music was the best thing about the production. Over the years Western views – without the benefit of access to materials in Moscow’s theatre archives – have become rigid and reductionist. As a case study for Soviet appropriation of Shakespeare, this paper suggests an understanding of Akimov’s intentions more grounded in documentary evidence, not least in relation to the socio-political and cultural climate of the time and to Shostakovich’s music, which, paradoxically, may have been too skilful for the good of the production.Lorsqu’en 1932 le jeune artiste Nikolaï Akimov fit ses débuts comme metteur en scène en montant Hamlet de Shakespeare, personne ne s’attendait à l’un des plus grands scandales de l’histoire du théâtre russe/soviétique. La mise en scène d’Akimov au théâtre de Vakhtangov de Moscou avait tous les éléments typiques des œuvres de Vsevolod Meyerhold (le « Bertolt Brecht russe »), y compris une musique de scène excentrique et apparemment hors sujet du jeune Dimitri Chostakovitch. Pourtant, même Meyerhold critiqua sévèrement cette « Shakespérience » d’Akimov. En réinterprétant Ophélie en prostituée et Hamlet en bon vivant, la mise en scène d’Akimov suscita des réactions partagées de la part des critiques. Cependant la musique de Chostakovitch fit l’unanimité. Sans bénéficier d’accès aux documents d’archives, les études occidentales de cette mise-en-scène sont souvent réductionnistes et rigides. Dans cette communication, en m’appuyant sur les sources primaires et les matériaux des archives et en se tenant compte du contexte politico-culturel de pays soviétique, je cherche à mieux comprendre les intentions artistiques d’Akimov pour son Hamlet et à souligner les points de convergences et de divergences avec la musique de scène de Chostakovitch. Enfin la question se pose de savoir si une musique de scène, dont la fonction est d’accompagner un spectacle, peut le desservir par sa qualité même

'Hamlet' in the Stalin Era and Beyond: Stage and Score/ Les mises en scène et mises en musique d’Hamlet à l’ère stalinienne et après

Hamlet has long been an inseparable part of Russian national identity. Staging Hamlet in Russia during the Stalin era, however, presented particular problems connected with the ideological framework imposed on the arts and culture as well as with Stalin’s own negative perceived view of the tragedy. The two major productions of Hamlet in Russia during this period were those directed by Nikolai Akimov (1932) and Sergei Radlov (1938). Thorough re-examination of these productions, as undertaken in the central chapters of this dissertation, reveals much previously unknown detail about their conception, realisation, reception and afterlife. It highlights the importance of the role of music composed for them by Dmitry Shostakovich and Sergei Prokofiev, respectively, and it suggests a complex interaction of individual and institutional agendas. This work has been made possible by numerous visits to Russian archives, which contain invaluable documents such as production books and stenographic reports of discussions, previously unreferenced in Western scholarship. These central chapters are preceded by a historical overview of Hamlet in Russia and of music and Shakespeare in general. They are followed by a survey of major adaptations of Hamlet in the late-Stalin era and beyond, concentrating on those with significant musical contributions. The outcome is a richer and more complex account of the familiar image of Hamlet as a mirror of Russian/Soviet society

What Did Hamlet (Not) Do to Offend Stalin?

Soon after its arrival in a Russia in 1748, Hamlet and its chief protagonist became inseparable parts of Russian national identity, prompting such remarks as William Morris’s: “Hamlet should have been a Russian, not a Dane”. However, at the outbreak of the Second World War, the play seems to have disappeared for more than a decade from the major stages of Moscow and Leningrad. Thus was born the ‘myth’ of Stalin and Hamlet. Today virtually every mention of Hamlet in the Stalin era refers to the dictator’s hatred for this tragedy and his supposed banning of it from all Soviet stages. Notwithstanding the efforts of theatre directors such as Sergei Radlov with his heroic production of Hamlet in 1938, there is no doubt that Hamlet was problematic in the context of the paradigm of Socialist Realism. And it was certainly not the most suitable play for a war-stricken country. Moreover, from Stalin’s own pejorative reference to ‘an indecisive Hamlet’ in connection with Eisenstein’s ill-fated depiction of Ivan the Terrible (Part II), it is evident that for the dictator the character of Hamlet had negative connotations. The chequered history of Hamlet in the Soviet Union from the outbreak of the War to the death of Stalin in 1953 and the flood of new productions almost immediately after this date, together with the myth of Stalin’s ‘ban’, deserve more nuanced and broadly contextualised study than they have received to date, based on concrete historical facts, memoirs and official documents.Peu après son arrivée en Russie en 1748, Hamlet (et son personnage principal) devient inséparable de l’identité nationale russe, au point de faire dire à William Morris : « Hamlet aurait dû être russe, pas danois ». Pourtant, lorsque éclate la Seconde Guerre Mondiale, la pièce semble avoir disparu depuis plus d’une décennie des scènes principales à Moscou et à Leningrad. Ainsi est né le « mythe » de Staline et Shakespeare. La grande majorité des études consacrées à Hamlet pendant l’ère stalinienne mentionnent la haine du dictateur à l’égard de cette tragédie et l’interdiction de sa représentation qu’il aurait imposée sur toutes les scènes soviétiques. Malgré les efforts (parfois héroïques) de metteurs en scène comme Sergueï Radlov en 1938, Hamlet pose indubitablement problème par rapport au paradigme du Réalisme socialiste. En outre, ce n’est sans doute pas la pièce la plus adéquate pour un pays en guerre. Enfin, la référence péjorative de Staline à « l’indécision » de Hamlet à propos de l’infortunée représentation d’Ivan le Terrible par Eisenstein (IIe partie) montre clairement que le personnage de Hamlet avait des connotations négatives pour le dictateur. L’histoire en dents de scie de la réception de Hamlet en Union Soviétique du début de la guerre à la mort de Staline en 1953 (suivie immédiatement d’un déluge de nouvelles mises en scène), ainsi que le mythe de son « interdiction » par Staline, doivent recevoir un traitement plus nuancé que celui qui leur est habituellement réservé, fondé sur l’étude de faits historiques concrets, de mémoires et de documents officiels

A new modification of the chiron ACS assay for total prostate-specific antigen achieves equimolar response characteristics and improves the detection of prostate cancer

Nonequimolar-response assays for prostate-specific antigen (PSA) are criticized for overestimating total PSA in some men without prostate cancer (PCA), and underestimating total PSA in some men with PCA. We recently studied three nonequimolar-response PSA assays that had undergone modifications. While two of the studied assays achieved equimolar-response characteristics with improved areas under receiver operating characteristic (ROC) curves (AUC), the modification of the Chiron ACS PSA assay (ACS PSA2, Chiron) failed to achieve this. Recently, the ACS assay underwent another modification (ACS PSA, Bayer), which we investigated. Sera from 305 men (155 without and 150 with PCA, PSA greater than or equal to2 and less than or equal to30 mug/l, TandemE) were measured using both modifications of the ACS assay and equimolar-response reference methods (TandemR free and Tandem E, Hybritech). Molar response relative to the reference method and clinical performance (comparison of AUCs) between the previous and new ACS assay modifications were studied. The new modification of the ACS assay (ACS PSA, Bayer) achieved equimolar-response characteristics but reported lower values (average 10%) than the Tandem E assay. Compared to the previous modification (ACS PSA2, Chiron), a 3% improvement in AUC (p=0.01) was found. Using results of the redesigned equimolar-response assay (ACS PSA, Bayer), we calculated that 6 of 155 men without PCA in this sample set could be spared unnecessary biopsy compared with the previous nonequimolar-response assay (ACS PSA2, Chiron) without missing additional PCA (90% sensitivity). These data provide additional evidence for clinical advantages of equimolar-response over nonequimolar-response PSA assay formats

International Laboratory Comparison of Influenza Microneutralization Assays for A(H1N1) pdm09, A(H3N2), and A(H5N1) Influenza Viruses by CONSISE

The microneutralization assay is commonly used to detect antibodies to influenza virus, and multiple protocols are used worldwide. These protocols differ in the incubation time of the assay as well as in the order of specific steps, and even within protocols there are often further adjustments in individual laboratories. The impact these protocol variations have on influenza serology data is unclear. Thus, a laboratory comparison of the 2-day enzyme-linked immunosorbent assay (ELISA) and 3-day hemagglutination (HA) microneutralization (MN) protocols, using A(H1N1)pdm09, A(H3N2), and A(H5N1) viruses, was performed by the CONSISE Laboratory Working Group. Individual laboratories performed both assay protocols, on multiple occasions, using different serum panels. Thirteen laboratories from around the world participated. Within each laboratory, serum sample titers for the different assay protocols were compared between assays to determine the sensitivity of each assay and were compared between replicates to assess the reproducibility of each protocol for each laboratory. There was good correlation of the results obtained using the two assay protocols in most laboratories, indicating that these assays may be interchangeable for detecting antibodies to the influenza A viruses included in this study. Importantly, participating laboratories have aligned their methodologies to the CONSISE consensus 2-day ELISA and 3-day HA MN assay protocols to enable better correlation of these assays in the future

The rodent uterotrophic assay: Critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay

The major protocol features of the immature rat uterotrophic assay have been evaluated using a range of reference chemicals. The protocol variables considered include the selection of the test species and route of chemical administration, the age of the test animals, the maintenance diet used, and the specificity of the assay for estrogens. It is concluded that three daily oral administrations of test chemicals to 21- to 22-day-old rats, followed by determination of absolute uterus weights on the fourth day, provide a sensitive and toxicologically relevant in vivo estrogenicity assay. Rats are favored over mice for reasons of toxicological practice, but the choice of test species is probably not a critical protocol variable, as evidenced by the similar sensitivity of rats and mice to the uterotrophic activity of methoxychlor. Vaginal opening is shown to be a useful, but nondefinitive, adjunct to the uterotrophic assay. The ability of test chemicals to reduce or abolish the uterotrophic response of estradiol is suggested to provide a useful extension of the uterotrophic assay for the purpose of detecting antiestrogens. The results of a series of studies on the environmental estrogen nonyl phenol (NP), and its linear isomer n -nonyl phenol, confirm that branching of the aliphatic side chain is important for activity. 17beta-Desoxyestradiol is shown to be of similar activity to estradiol in the uterotrophic assay and is suggested to represent the "parent" estrogen of NP. Benzoylation of NP and 17-desoxyestradiol did not affect their uterotrophic activity, in contrast to the enhancing effect of benzoylation on estradiol. Selected chemicals shown to be active in the immature rat uterotrophic assay were also evaluated in an in vitro yeast human estrogen receptor transactivation assay. Most of the chemicals gave similar qualitative responses to those seen in the uterotrophic assay, and the detection of the estrogen methoxychlor by the yeast assay evidenced a degree of intrinsic metabolic competence. However, the assay had a reduced ability (compared to rodents) to hydrolyze the benzoate ester of estradiol, and the estrogenic benzoate derivative of NP was not active in the yeast assay. These last results indicate that current metabolic deficiencies of in vitro estrogenicity assays will limit the value of negative data for the immediate future. The results described illustrate the intrinsic complexity of evaluating chemicals for estrogenic activities and confirm the need for rigorous attention to experimental design and criteria for assessing estrogenic activity

Comparison of established and emerging biodosimetry assays

Rapid biodosimetry tools are required to assist with triage in the case of a large-scale radiation incident. Here, we aimed to determine the dose-assessment accuracy of the well-established dicentric chromosome assay (DCA) and cytokinesis-block micronucleus assay (CBMN) in comparison to the emerging γ-H2AX foci and gene expression assays for triage mode biodosimetry and radiation injury assessment. Coded blood samples exposed to 10 X-ray doses (240 kVp, 1 Gy/min) of up to 6.4 Gy were sent to participants for dose estimation. Report times were documented for each laboratory and assay. The mean absolute difference (MAD) of estimated doses relative to the true doses was calculated. We also merged doses into binary dose categories of clinical relevance and examined accuracy, sensitivity and specificity of the assays. Dose estimates were reported by the first laboratories within 0.3-0.4 days of receipt of samples for the γ-H2AX and gene expression assays compared to 2.4 and 4 days for the DCA and CBMN assays, respectively. Irrespective of the assay we found a 2.5-4-fold variation of interlaboratory accuracy per assay and lowest MAD values for the DCA assay (0.16 Gy) followed by CBMN (0.34 Gy), gene expression (0.34 Gy) and γ-H2AX (0.45 Gy) foci assay. Binary categories of dose estimates could be discriminated with equal efficiency for all assays, but at doses ≥1.5 Gy a 10% decrease in efficiency was observed for the foci assay, which was still comparable to the CBMN assay. In conclusion, the DCA has been confirmed as the gold standard biodosimetry method, but in situations where speed and throughput are more important than ultimate accuracy, the emerging rapid molecular assays have the potential to become useful triage tools

Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP)

Background: Pro-gastrin releasing peptide ( ProGRP) concentrations in blood play an important role in the diagnosis and treatment of patients with small cell lung cancer (SCLC). The automated quantitative ARCHITECT (R) ProGRP assay was developed to aid in the differential diagnosis and in the management of SCLC. The purpose of this study was to evaluate the analytical performance of this chemiluminescent microparticle immunoassay at multiple sites. Methods: ARCHITECT ProGRP measures ProGRP using a two-step sandwich using monoclonal anti-ProGRP antibodies coated on paramagnetic microparticles and labeled with acridinium. Analytical performance of the assay was evaluated at four sites: Abbott Japan, Denka Seiken, the Johns Hopkins University, and the University of Munich. Results: Total precision (%CV) for nine analyte concentrations was between 2.2 and 5.7. The analytical sensitivity of the assay was between 0.20 pg/mL and 0.88 pg/mL. The functional sensitivity at 20% CV was between 0.66 pg/mL and 1.73 pg/mL. The assay was linear up to 50,000 pg/mL using a 1:10 autodilution protocol. The calibration curve was stable for 30 days. Comparison with the Fujirebio microtiter plate enzyme-linked immunosorbent assay (EIA) ProGRP assay gave a slope of 0.93 and a correlation coefficient (r) of 0.99. Conclusions: These results demonstrate that the ARCHITECT ProGRP assay has excellent sensitivity, precision, and correlation to a reference method. This assay provides a convenient automated method for ProGRP measurement in serum and plasma in hospitals and clinical laboratories. Clin Chem Lab Med 2009;47:1557-63