Toward a Taxonomy and Computational Models of Abnormalities in Images

The human visual system can spot an abnormal image, and reason about what makes it strange. This task has not received enough attention in computer vision. In this paper we study various types of atypicalities in images in a more comprehensive way than has been done before. We propose a new dataset of abnormal images showing a wide range of atypicalities. We design human subject experiments to discover a coarse taxonomy of the reasons for abnormality. Our experiments reveal three major categories of abnormality: object-centric, scene-centric, and contextual. Based on this taxonomy, we propose a comprehensive computational model that can predict all different types of abnormality in images and outperform prior arts in abnormality recognition.Comment: To appear in the Thirtieth AAAI Conference on Artificial Intelligence (AAAI 2016

Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML)

The t(8;21)(q22;q22) is a frequently occurring aberration in acute myeloid leukemia (AML) (18-20%) and usually correlate with French-America-British (FAB) M2 subtype. Several studies showed that patients carrying this abnormality demonstrated good response to standard chemotherapy but also have a high incidence of disease relapse. Trisomy 4 is a rare and specific chromosomal abnormality occurring in AML M2 or M4 of the FAB subtypes. We report a case of a 33-year-old female with an apparently clinical and hematologic diagnosis of acute promyelocytic leukemia (APL) in whom cytogenetic analysis revealed an abnormal karyotype with trisomy 4, in addition to t(8;21). Trisomy 4 and t(8;21) in a patient with AML is rare. The significance of t(8;21) with trisomy 4 in AML are unclear but patients bearing this abnormality are associated with a poor prognosis

The Painful Long Head of the Biceps Brachii: Nonoperative Treatment Approaches

Pain associated with the long head of the biceps (LHB) brachii seems to be increasingly recognized in the past 4 to 5 years. The LHB has long been considered a troublesome pain generator in the shoulder. Abnormality involving the LHB brachii has long been an area of debate, with Codman in 1934 even questioning the specificity of the diagnosis of biceps tendinitis. Biceps tendon abnormality is often associated with rotator cuff impingement. Shoulder pain originating from the biceps tendon can be debilitating, causing a severe decrease in shoulder function. As a result of the frequent clinical presentation of biceps pain, there is currently a great deal of interest regarding the diagnosis, treatment, and prevention of biceps abnormality. This article describes a classification system of LHB pain and discusses nonoperative treatment concepts and techniques for the painful LHB

Madness in Southern China : illness as metaphor in Su Tong\u27s The tale of the siskins and Madwoman on the bridge

In Su Tong’s novels, the term madness is more than a medical term and it carries metaphorical meanings. In The Tale of the Siskins and “Madwoman on the Bridge,” Su Tong uses madness as a metaphor to challenge the dichotomy between normality and abnormality, and draws an analogy between mental hospitals and contemporary society. Unlike Yu Hua’s 余華 (1960-) novels, which intertwine sanguinary violence with madness, Su Tong depicts madness mainly to unveil the absurdity of the Mahogany Street. This paper analyses the use of patients’ illnesses in mental hospitals as metaphors in these two stories. In “Madwoman on the Bridge,” Su Tong displaces the role of doctors and madmen. In The Tale of the Siskins, Su Tong dismantles the clear-cut distinction between normality and abnormality. By reversing the two signifying concepts of normality and abnormality, Su Tong leads us to re-assess a variety of conventions, customs and acts we deem reasonable and legitimate in contemporary society

Systems modeling of white matter microstructural abnormalities in Alzheimer's disease

INTRODUCTION: Microstructural abnormalities in white matter (WM) are often reported in Alzheimer's disease (AD). However, it is unclear which brain regions have the strongest WM changes in presymptomatic AD and what biological processes underlie WM abnormality during disease progression. METHODS: We developed a systems biology framework to integrate matched diffusion tensor imaging (DTI), genetic and transcriptomic data to investigate regional vulnerability to AD and identify genetic risk factors and gene subnetworks underlying WM abnormality in AD. RESULTS: We quantified regional WM abnormality and identified most vulnerable brain regions. A SNP rs2203712 in CELF1 was most significantly associated with several DTI-derived features in the hippocampus, the top ranked brain region. An immune response gene subnetwork in the blood was most correlated with DTI features across all the brain regions. DISCUSSION: Incorporation of image analysis with gene network analysis enhances our understanding of disease progression and facilitates identification of novel therapeutic strategies for AD