Prevalence of obstructive coronary artery disease and prognosis in patients with stable symptoms and a zero-coronary calcium score

© The Author 2017. Published by Oxford University Press on behalf of the European Society of Cardiology.Aims: CT calcium scoring (CTCS) and CT cardiac angiography (CTCA) are widely used in patients with stable chest pain to exclude significant coronary artery disease (CAD). We aimed to resolve uncertainty about the prevalence of obstructive coronary artery disease and long-term outcomes in patients with a zero-calcium score (ZCS). Methods and results: Consecutive patients with stable cardiac symptoms referred for CTCS or CTCS and CTCA from chest pain clinics to a tertiary cardiothoracic centre were prospectively enrolled. In those with a ZCS, the prevalence of obstructive CAD on CTCA was determined. A follow-up for all-cause mortality was obtained from the NHS tracer service. A total of 3914 patients underwent CTCS of whom 2730 (69.7%) also had a CTCA. Half of the patients were men (50.3%) with a mean age of 56.9 years. Among patients who had both procedures, a ZCS was present in 52.2%, with a negative predictive value of 99.5% for excluding ≥70% stenosis on CTCA. During a mean follow-up of 5.2 years, the annual event rate was 0.3% for those with ZCS compared with 1.2% for CS ≥1. The presence of non-calcified atheroma on CTCA in patients with ZCS did not affect the prognostic value (P = 0.98). Conclusion: In patients with stable symptoms and a ZCS, obstructive CAD is rare, and prognosis over the long-term is excellent, regardless of whether non-calcified atheroma is identified. A ZCS could reliably be used as a 'gatekeeper' in this patient cohort, obviating the need for further more expensive tests.Peer reviewedFinal Published versio

Steady States of a Microwave Irradiated Quantum Hall Gas

We consider effects of a long-wavelength disorder potential on the Zero Conductance State (ZCS) of the microwave-irradiated 2D electron gas. Assuming a uniform Hall conductivity, we construct a Lyapunov functional and derive stability conditions on the domain structure of the photo-generated fields. We solve the resulting equations for a general one-dimensional and certain two-dimensional disorder potentials, and find non-zero conductances, photo-voltages, and circulating dissipative currents. In contrast, weak white noise disorder does not destroy the ZCS, but induces mesoscopic current fluctuations.Comment: 4 pages, 2 colour figure

Topological string entanglement

We investigate how topological entanglement of Chern-Simons theory is captured in a string theoretic realization. Our explorations are motivated by a desire to understand how quantum entanglement of low energy open string degrees of freedom is encoded in string theory (beyond the oft discussed classical gravity limit). Concretely, we realize the Chern-Simons theory as the worldvolume dynamics of topological D-branes in the topological A-model string theory on a Calabi-Yau target. Via the open/closed topological string duality one can map this theory onto a pure closed topological A-model string on a different target space, one which is related to the original Calabi-Yau geometry by a geometric/conifold transition. We demonstrate how to uplift the replica construction of Chern-Simons theory directly onto the closed string and show that it provides a meaningful definition of reduced density matrices in topological string theory. Furthermore, we argue that the replica construction commutes with the geometric transition, thereby providing an explicit closed string dual for computing reduced states, and Renyi and von Neumann entropies thereof. While most of our analysis is carried out for Chern-Simons on S^3, the emergent picture is rather general. Specifically, we argue that quantum entanglement on the open string side is mapped onto quantum entanglement on the closed string side and briefly comment on the implications of our result for physical holographic theories where entanglement has been argued to be crucial ingredient for the emergence of classical geometry.Comment: 48 pages + appendices, many tikz fgures. v2: added clarification

Complex resonance frequencies of a finite, circular radiating duct with an infinite flange

Radiation by solid or fluid bodies can be characterized by resonance modes. They are complex, as well as resonance frequencies, because of the energy loss due to radiation. For ducts, they can be computed from the knowledge of the radiation impedance matrix. For the case of a flanged duct of finite length radiating on one side in an infinite medium, the expression of this matrix was given by Zorumski, using a decomposition in duct modes. In order to calculate the resonance frequencies, the formulation used in Zorumski's theory must be modified as it is not valid for complex frequencies. The analytical development of the Green's function in free space used by Zorumski depends on the integrals of Bessel functions which become divergent for complex frequencies. This paper proposes first a development of the Green's function which is valid for all frequencies. Results are applied to the calculation of the complex resonance frequencies of a flanged duct, by using a formulation of the internal pressure based upon cascade impedance matrices. Several series of resonance modes are found, each series being shown to be related to a dominant duct mode. Influence of higher order duct modes and the results for several fluid densities is presented and discussed

A zero-current-switching based three-phase PWM inverter having resonant circuits on AC-side

The authors present a zero-current-switching (ZCS)-based three-phase PWM (pulse-width-modulated) inverter having small resonant circuits on the AC side, whose resonant frequency is 50 kHz. The ZCS inverter can greatly reduce the switching losses and electromagnetic noise. The principle of ZCS operation, the design of the resonant circuits, and the control sequence are described from theoretical and practical points of view. Experimental results obtained from a ZCS PWM inverter driving an induction motor of 2.2 kW are shown to verify the practicability of this device </p

Spin-phonon coupling in antiferromagnetic chromium spinels

The temperature dependence of eigenfrequencies and intensities of the IR active modes has been investigated for the antiferromagnetic chromium spinel compounds CdCr2O4, ZnCr2O4, ZnCr2S4, ZnCr2Se4, and HgCr2S4 by IR spectroscopy for temperatures from 5 K to 300 K. At the transition into the magnetically ordered phases, and driven by spin-phonon coupling, most compounds reveal significant splittings of the phonon modes. This is true for geometrically frustrated CdCr2O4, and ZnCr2O4, for bond frustrated ZnCr2S4 and for ZnCr2Se4, which also is bond frustrated, but dominated by ferromagnetic exchange. The pattern of splitting is different for the different compounds and crucially depends on the nature of frustration and of the resulting spin order. HgCr2S4, which is almost ferromagnetic, exhibits no splitting of the eigenfrequencies, but shows significant shifts due to ferromagnetic spin fluctuations.Comment: 15 pages, 6 figure

On universal decoherence under gravity: a perspective through the Equivalence Principle

In Nature Phys. 11, 668 (2015) (Ref. [1]), a composite particle prepared in a pure initial quantum state and propagated in a uniform gravitational field is shown to undergo a decoherence process at a rate determined by the gravitational acceleration. By assuming Einstein's Equivalence Principle to be valid, we demonstrate, first in a Lorentz frame with accelerating detectors, and then directly in the Lab frame with uniform gravity, that the dephasing between the different internal states arise not from gravity but rather from differences in their rest mass, and the mass dependence of the de Broglie wave's dispersion relation. We provide an alternative view to the situation considered by Ref. [1], where we propose that gravity plays a kinematic role in the loss of fringe visibility by giving the detector a transverse velocity relative to the particle beam; visibility can be easily recovered by giving the screen an appropriate uniform velocity. We finally propose that dephasing due to gravity may in fact take place for certain modifications to the gravitational potential where the Equivalence Principle is violated.Comment: 5 pages, 3 figure