Bioinformatics Applications Based On Machine Learning

The great advances in information technology (IT) have implications for many sectors, such as bioinformatics, and has considerably increased their possibilities. This book presents a collection of 11 original research papers, all of them related to the application of IT-related techniques within the bioinformatics sector: from new applications created from the adaptation and application of existing techniques to the creation of new methodologies to solve existing problems

Computational Optimizations for Machine Learning

The present book contains the 10 articles finally accepted for publication in the Special Issue “Computational Optimizations for Machine Learning” of the MDPI journal Mathematics, which cover a wide range of topics connected to the theory and applications of machine learning, neural networks and artificial intelligence. These topics include, among others, various types of machine learning classes, such as supervised, unsupervised and reinforcement learning, deep neural networks, convolutional neural networks, GANs, decision trees, linear regression, SVM, K-means clustering, Q-learning, temporal difference, deep adversarial networks and more. It is hoped that the book will be interesting and useful to those developing mathematical algorithms and applications in the domain of artificial intelligence and machine learning as well as for those having the appropriate mathematical background and willing to become familiar with recent advances of machine learning computational optimization mathematics, which has nowadays permeated into almost all sectors of human life and activity

Computational Methods for the Analysis of Genomic Data and Biological Processes

In recent decades, new technologies have made remarkable progress in helping to understand biological systems. Rapid advances in genomic profiling techniques such as microarrays or high-performance sequencing have brought new opportunities and challenges in the fields of computational biology and bioinformatics. Such genetic sequencing techniques allow large amounts of data to be produced, whose analysis and cross-integration could provide a complete view of organisms. As a result, it is necessary to develop new techniques and algorithms that carry out an analysis of these data with reliability and efficiency. This Special Issue collected the latest advances in the field of computational methods for the analysis of gene expression data, and, in particular, the modeling of biological processes. Here we present eleven works selected to be published in this Special Issue due to their interest, quality, and originality

Shortest Route at Dynamic Location with Node Combination-Dijkstra Algorithm

Abstract— Online transportation has become a basic requirement of the general public in support of all activities to go to work, school or vacation to the sights. Public transportation services compete to provide the best service so that consumers feel comfortable using the services offered, so that all activities are noticed, one of them is the search for the shortest route in picking the buyer or delivering to the destination. Node Combination method can minimize memory usage and this methode is more optimal when compared to A* and Ant Colony in the shortest route search like Dijkstra algorithm, but can’t store the history node that has been passed. Therefore, using node combination algorithm is very good in searching the shortest distance is not the shortest route. This paper is structured to modify the node combination algorithm to solve the problem of finding the shortest route at the dynamic location obtained from the transport fleet by displaying the nodes that have the shortest distance and will be implemented in the geographic information system in the form of map to facilitate the use of the system. Keywords— Shortest Path, Algorithm Dijkstra, Node Combination, Dynamic Location (key words

Solución rápida y automática de parámetros hipocentrales para eventos sísmicos, mediante el empleo de técnicas de aprendizaje de máquina

La generación de alertas tempranas para sismos es de gran utilidad, en particular para la ciudad de Bogotá-Colombia, dada su importancia social y económica para el país. Con base en la información de la estación sismológica de El Rosal, la cual es una estación de banda ancha y tres componentes, localizada muy cerca de la ciudad, perteneciente al Servicio Geológico Colombiano (SGC) se desarrolló un modelo de regresión basado en máquinas de vectores de soporte (SVM), con un kernel polinomial normalizado, usando como datos de entrada algunas características de la porción inicial de la onda P empleadas en trabajos anteriores tales como la amplitud máxima, los coeficientes de regresión lineal de los mismos, los parámetros de ajuste logarítmico de la envolvente y los valores propios de la relación de las tres componentes del sismograma. El modelo fue entrenado y evaluado aplicando correlación cruzada, permitiendo llevar a cabo el cálculo de la magnitud y la localización de un evento sísmico con una longitud de señal de tan solo cinco segundos. Con el modelo propuesto se logró la determinación de la magnitud local con una precisión de 0.19 unidades de magnitud, la distancia epicentral con una precisión de alrededor de 11 kilómetros, la profundidad hipocentral con una precisión de aproximadamente 40 kilómetros y el azimut de llegada con una precisión de 45°. Las precisiones obtenidas en magnitud y distancia epicentral son mejores que las encontradas en trabajos anteriores, donde se emplean gran número de eventos para la determinación del modelo y en los demás parámetros hipocentrales son del mismo orden. Este trabajo de investigación realiza un aporte considerable en la generación de alertas tempranas para sismos, no solamente para el país sino para cualquier otro lugar donde se deseen implementar los modelos aquí propuestos y es un excelente punto de partida para investigaciones futuras.Abstract. Earthquake early warning alerts generation is very useful, especially for the city of Bogotá-Colombia, given the social and economic importance of this city for the country. Based on the information from the seismological station “El Rosal”, which is a broadband and three components station, located very near the city that belongs to the Servicio Geológico Colombiano (SGC) a Support Vector Machine Regression (SVMR) model was developed, using a Normalized Polynomial Kernel, using as input some characteristics of the initial portion of the P wave used in earlier works such as the maximum amplitude, the linear regression coefficients of such amplitudes, the logarithmic adjustment parameters of the envelope of the waveform and the eigenvalues of the relationship between the three seismogram components of each band. The model was trained and evaluated by applying a cross-correlation strategy, allowing to calculate the magnitude and location of a seismic event with only five seconds of signal. With the proposed model it was possible to estimate local magnitude with an accuracy of 0.19 units of magnitude, epicentral distance with an accuracy of about 11 km, the hipocentral depth with a precision of approximately 40 km and the arrival back-azimut with a precision of 45°. Accuracies obtained in magnitude and epicentral distance are better that those found in earlier works, where a large number of events were used for model determination, and the other hipocentral parameters precisions obtained here are of the same order. This research work makes a considerable contribution in the generation of seismic early warning alerts, not only for the country but for any other place where proposed models here can be applied and is a very good starting point for future research.Doctorad