Question Drawer

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Interview of Caroline Wistar

Caroline Wistar was the La Salle Art Museum curator since 1976. The La Salle Art Museum is located in the basement of the Olney building at the main campus of La Salle

IMPLEMENTASI PROGRAM PUSAT PELATIHAN PERTANIAN PERDESAAN SWADAYA (P4S) SEBAGAI USAH MENSEJAHTERAKAN MASYARAKAT DI DESA SUNGAI AGUNG KECAMATAN TAPUNG KABUPATEN KAMPAR

Penelitian ini dilatar belakangi oleh permasalahan masyarakat masih banyak yang belum mendapatkan kesejahteraan yang layak untuk keberlangsungan hidupnya. Untuk itu, peneliti terfokus pada Implementasi Program Pusat Pelatihan Pertanian Perdesaan Swadaya (P4S) Sebagai Usaha Mensejahterakan Masyarakat Di Desa Sungai Agung Kecamatan Tapung Kabupaten Kampar. Adapun yang menjadi rumusan masalah dalam penelitian ini adalah bagaimana Implementasi Program Pusat Pelatihan Pertanian Perdesaan Swadaya (P4S) Sebagai Usaha Mensejahterakan Masyarakat di Desa Sungai Agung Kecamatan Tapung Kabupaten Kampar. Metode pengumpulan data adalah prosedur yang sistematik dan standar untuk memperoleh data yang diperlukan. Secara umum metode pengumpulan data dalam penelitian ini menggunakana teknik wawancara, observasi dan dokumentasi. Sedangkan teknik analisa data penulis menggunkan metode analisis deskriptif kualitatif. Hasil penelitian menunjukkan bahwa dengan adanya Program Pusat Pelatihan Pertanian Perdesaan Swadaya (P4S) Sebagai Usaha Mensejahterakan Masyarakat di Desa Sungai Agung Kecamatan Tapung Kabupaten Kampar dapat mensejahterahkan masyarakat seperti : Meningkatnya keterampilan masyarakat, Bertambahnya pengetahuan masyarakat dibidang peternakan, Meningkatnya kesejahteraan masyarakat dibidang ekonomi dan Terciptanya lapangan pekerjaan. Katakunci : Implementasi, Pusat Pelatihan Pertanian Perdesaan Swadaya (P4S

Satb1 overexpression drives tumor-promoting activities in cancer-associated dendritic cells

Special AT-rich sequence-binding protein 1 (Satb1) governs genome-wide transcriptional programs. Using a conditional knockout mouse, we find that Satb1 is required for normal differentiation of conventional dendritic cells (DCs). Furthermore, Satb1 governs the differentiation of inflammatory DCs by regulating major histocompatibility complex class II (MHC II) expression through Notch1 signaling. Mechanistically, Satb1 binds to the Notch1 promoter, activating Notch expression and driving RBPJ occupancy of the H2-Ab1 promoter, which activates MHC II transcription. However, tumor-driven, unremitting expression of Satb1 in activated Zbtb46(+) inflammatory DCs that infiltrate ovarian tumors results in an immunosuppressive phenotype characterized by increased secretion of tumor-promoting Galectin-1 and IL-6. In vivo silencing of Satb1 in tumor-associated DCs reverses their tumorigenic activity and boosts protective immunity. Therefore, dynamic fluctuations in Satb1 expression govern the generation and immunostimulatory activity of steady-state and inflammatory DCs, but continuous Satb1 overexpression in differentiated DCs converts them into tolerogenic/pro-inflammatory cells that contribute to malignant progression.Fil: Tesone, Amelia J.. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados UnidosFil: Rutkowski, Melanie R.. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados UnidosFil: Brencicova, Eva. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados UnidosFil: Svoronos, Nikolaos. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados UnidosFil: Perales Puchal, Alfredo. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados UnidosFil: Stephen, Tom L.. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados UnidosFil: Allegrezza, Michael J.. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados UnidosFil: Payne, Kyle K.. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados UnidosFil: Nguyen, Jenny M.. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados UnidosFil: Wickramasinghe, Jayamanna. The Wistar Institute. Center for Systems and Computational Biology; Estados UnidosFil: Tchou, Julia. University of Pennsylvania; Estados UnidosFil: Borowsky, Mark E.. Christiana Care Health System. Helen F. Graham Cancer Center; Estados UnidosFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Kossenkov, Andrew V.. The Wistar Institute. Center for Systems and Computational Biology; Estados UnidosFil: Conejo Garcia, José R.. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados Unido

Functional Feeding Groups of Aquatic Macroinvertebrates on Natural and Artificial Leaves in Forested Stream Habitats in the Sebago Lake Land Reserve

We investigated preferential insect colonization of natural versus artificial leaves in forested streams to determine the impact of invertebrate-substrate associations on macroinvertebrate community composition and ecosystem nutrient cycling. We created 10 onion bags filled with natural maple leaves and 10 filled with artificial maple leaves, and placed 5 of each in two forested streams, one larger and one smaller, in the Sebago Lake Land Reserve in Standish, Maine. We identified the aquatic macroinvertebrates found on these samples after approximately one month to order-level and used Maine DEP biomonitoring data and functional feeding group taxonomies to classify macroinvertebrates by functional feeding groups. There was a greater difference in Simpson diversity values between habitats than between substrate types and a substantially greater difference in functional feeding group composition between habitats than between substrate types. The patterns in functional feeding group abundance across habitats (specifically the decline in shredder proportions from the smaller stream to the larger stream) match the patterns of the river continuum concept. This indicates an unexpectedly high degree of small-scale ecosystem heterogeneity, with wide potential implications for ecosystem-level macroinvertebrate community structure and nutrient cycling

Acquistions from the Pincus Fund

Recent acquisitions from the Marjorie and Irwin Nat Pincus Fund, Fall 1995https://digitalcommons.lasalle.edu/exhibition_catalogues/1075/thumbnail.jp

Low-carbohydrate diets affect energy balance and fuel homeostasis differentially in lean and obese rats

In parallel with increased prevalence of overweight people in affluent societies are individuals trying to lose weight, often using low-carbohydrate diets. Nevertheless, long-term metabolic consequences of those diets, usually high in (saturated) fat, remain unclear. Therefore, we investigated long-term effects of high-fat diets with different carbohydrate/protein ratios on energy balance and fuel homeostasis in obese (fa/fa) Zucker and lean Wistar rats. Animals were fed high-carbohydrate (HC), high-fat (HsF), or low-carbohydrate, high-fat, high-protein (LC-HsF-HP) diets for 60 days. Both lines fed the LC-HsF-HP diet displayed reduced energy intake compared with those fed the HsF diet (Zucker, -3.7%) or the HC diet (Wistar rats, -12.4%). This was not associated with lower weight gain relative to HC fed rats, because of increased food efficiencies in each line fed HsF and particularly LC-HsF-HP food. Zucker rats were less glucose tolerant than Wistar rats. Lowest glucose tolerances were found in HsF and particularly in LC-HsF-HP-fed animals irrespective of line, but this paralleled reduced plasma adiponectin levels, elevated plasma resistin levels, higher retroperitoneal fat masses, and reduced insulin sensitivity (indexed by insulin-induced hypoglycemia) only in Wistar rats. In Zucker rats, however, improved insulin responses during glucose tolerance testing and tendency toward increased insulin sensitivities were observed with HsF or LC-HsF-HP feeding relative to HC feeding. Thus, despite adverse consequences of LC-HsF diets on blood glucose homeostasis, principal differences exist in the underlying hormonal regulatory mechanisms, which could have benefits for B-cell functioning and insulin action in the obese state but not in the lean state.

Glutamatergic transmission in the central nucleus of the amygdala is selectively altered in Marchigian Sardinian alcohol-preferring rats: Alcohol and CRF effects

The CRF system of the central nucleus of the amygdala (CeA) is important for the processing of anxiety, stress, and effects of acute and chronic ethanol. We previously reported that ethanol decreases evoked glutamate transmission in the CeA of Sprague Dawley rats and that ethanol dependence alters glutamate release in the CeA. Here, we examined the effects of ethanol, CRF and a CRF1 receptor antagonist on spontaneous and evoked glutamatergic transmission in CeA neurons from Wistar and Marchigian Sardinian Preferring (msP) rats, a rodent line genetically selected for excessive alcohol drinking and characterized by heightened activity of the CRF1 system. Basal spontaneous and evoked glutamate transmission in CeA neurons from msP rats was increased compared to Wistar rats. Ethanol had divergent effects, either increasing or decreasing spontaneous glutamate release in the CeA of Wistar rats. This bidirectional effect was retained in msP rats, but the magnitude of the ethanol-induced increase in glutamate release was significantly smaller. The inhibitory effect of ethanol on evoked glutamatergic transmission was similar in both strains. CRF also either increased or decreased spontaneous glutamate release in CeA neurons of Wistar rats, however, in msP rats CRF only increased glutamate release. The inhibitory effect of CRF on evoked glutamatergic transmission was also lost in neurons from msP rats. A CRF1 antagonist produced only minor effects on spontaneous glutamate transmission, which were consistent across strains, and no effects on evoked glutamate transmission. These results demonstrate that the genetically altered CRF system of msP rats results in alterations in spontaneous and stimulated glutamate signaling in the CeA that may contribute to both the anxiety and drinking behavioral phenotypes

Albrecht Durer\u27s Life of the Virgin

Selections from the permanent collection, Winter 2002-2003https://digitalcommons.lasalle.edu/exhibition_catalogues/1098/thumbnail.jp

Japanese Prints: 20th Century

Twentieth century Japanese prints, October 9 - Nvember 29 1992https://digitalcommons.lasalle.edu/exhibition_catalogues/1068/thumbnail.jp