331 research outputs found
Open electronics for medical devices: State-of-art and unique advantages
A wide range of medical devices have significant electronic components. Compared to open-source medical software, open (and open-source) electronic hardware has been less published in peer-reviewed literature. In this review, we explore the developments, significance, and advantages of using open platform electronic hardware for medical devices. Open hardware electronics platforms offer not just shorter development times, reduced costs, and customization; they also offer a key potential advantage which current commercial medical devices lack—seamless data sharing for machine learning and artificial intelligence. We explore how various electronic platforms such as microcontrollers, single board computers, field programmable gate arrays, development boards, and integrated circuits have been used by researchers to design medical devices. Researchers interested in designing low cost, customizable, and innovative medical devices can find references to various easily available electronic components as well as design methodologies to integrate those components for a successful design
Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring
Photoplethysmography (PPG) is a low-cost, noninvasive optical technique that uses change in light transmission with changes in blood volume within tissue to provide information for cardiovascular health and fitness. As remote health and wearable medical devices become more prevalent, PPG devices are being developed as part of wearable systems to monitor parameters such as heart rate (HR) that do not require complex analysis of the PPG waveform. However, complex analyses of the PPG waveform yield valuable clinical information, such as: blood pressure, respiratory information, sympathetic nervous system activity, and heart rate variability. Systems aiming to derive such complex parameters do not always account for realistic sources of noise, as testing is performed within controlled parameter spaces. A wearable monitoring tool to be used beyond fitness and heart rate must account for noise sources originating from individual patient variations (e.g., skin tone, obesity, age, and gender), physiology (e.g., respiration, venous pulsation, body site of measurement, and body temperature), and external perturbations of the device itself (e.g., motion artifact, ambient light, and applied pressure to the skin). Here, we present a comprehensive review of the literature that aims to summarize these noise sources for future PPG device development for use in health monitoring
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Methods and systems for extracting venous pulsation and respiratory information from photoplethysmographs
A system and method for separating a venous component and an arterial component from a red signal and an infrared signal of a PPG sensor is provided. The method uses the second order statistics of venous and arterial signals to separate the venous andarterial signals. After reliable separation of the venous and thearterial component signals,the component signals can be used for different purposes. In a preferred embodiment, the respiratory signal, pattern, and rate are extracted from the separated venous component and a reliable ?ratio of ratios? is extracted for SpO, using only the arterial component of the PPG signals. The disclosed embodiments enable real-time continuous monitoring of respiration pattern/rate and site-independentarterial oxygen saturation.Board of Regents, University of Texas Syste
Hemodynamic monitor for rapid, cost-effective assessment of peripheral vascular function
Worldwide, at least 200 million people are affected by peripheral vascular diseases (PVDs), including peripheral arterial disease (PAD), chronic venous insufficiency (CVI) and deep vein thrombosis (DVT). These diseases have considerable socioeconomic impacts due to their high prevalence, cost of investigation, treatment and their effects on quality of life. PVDs are often undiagnosed with up to 60% of patients with PVD remaining asymptomatic. Early diagnosis is essential for effective treatment and reducing socioeconomic costs, particularly in patients with diabetes where early endovascular treatment can prevent lower extremity amputation. However, available diagnostic methods simply do not meet the needs of clinicians. For example, duplex ultrasound or plethysmography are time-consuming methods, costly and require access to highly trained clinicians. Due to the cost and time requirements of such methods, they are often reserved for symptomatic patients. On the other hand, the Ankle Brachial Index (ABI) test is cheap but has poor sensitivity for those patients with diabetes and the elderly, both growing high-risk populations. There is an urgent need for new diagnostic tools to enable earlier intervention. Researchers at the MARCS Institute have developed a novel hemodynamic monitor platform named HeMo, specifically for the assessment of peripheral blood flow in the leg. This development aimed to provide a fast and low-cost diagnosis of both peripheral arterial disease and chronic venous insufficiency. This work first provides a comprehensive literature review of the existing non-invasive diagnostic devices developed since 1677 to highlight the need of development of a new blood monitoring tool. Second, it presents the simplified circuit of the HeMo device and provides series of pilot experiments with HeMo demonstrating its potential for diagnosis of both peripheral arterial disease and chronic venous insufficiency. Third, it presents a quantitative characterisation of the electrical behaviour of the electro-resistive band sensors with the development of an expansion/contraction simulator rig and using spectral analysis. The characterisation of the electro-resistive band was essential to understand the nonlinear electrical behaviour of such sensors and would be of interest for other users and uses of the electro-resistive band sensors. However, in another perspective this sinusoidal linear stretching movement and the presented method shows an example for the application of the presented rig, highlighting that the same technique could be used for characterisation of similar stretchable sensors. Fourth, it shows data from a healthy population, assessing the performance of HeMo compared to light reflection rheography (LRR sensor-VasoScreen 5000) for the assessment of venous function. Fifth, it presents human study data where the performance of HeMo is compared to photoplethysmography (PPG sensor-VasoScreen 5000) for the evaluation of the arterial function. Overall, the presented work here, steps toward development of the final version of a novel hemodynamic monitoring device, and its validation
Multidimensional embedded MEMS motion detectors for wearable mechanocardiography and 4D medical imaging
Background: Cardiovascular diseases are the number one cause of death. Of these deaths, almost 80% are due to coronary artery disease (CAD) and cerebrovascular disease. Multidimensional microelectromechanical systems (MEMS) sensors allow measuring the mechanical movement of the heart muscle offering an entirely new and innovative solution to evaluate cardiac rhythm and function. Recent advances in miniaturized motion sensors present an exciting opportunity to study novel device-driven and functional motion detection systems in the areas of both cardiac monitoring and biomedical imaging, for example, in computed tomography (CT) and positron emission tomography (PET).
Methods: This Ph.D. work describes a new cardiac motion detection paradigm and measurement technology based on multimodal measuring tools — by tracking the heart’s kinetic activity using micro-sized MEMS sensors — and novel computational approaches — by deploying signal processing and machine learning techniques—for detecting cardiac pathological disorders. In particular, this study focuses on the capability of joint gyrocardiography (GCG) and seismocardiography (SCG) techniques that constitute the mechanocardiography (MCG) concept representing the mechanical characteristics of the cardiac precordial surface vibrations.
Results: Experimental analyses showed that integrating multisource sensory data resulted in precise estimation of heart rate with an accuracy of 99% (healthy, n=29), detection of heart arrhythmia (n=435) with an accuracy of 95-97%, ischemic disease indication with approximately 75% accuracy (n=22), as well as significantly improved quality of four-dimensional (4D) cardiac PET images by eliminating motion related inaccuracies using MEMS dual gating approach. Tissue Doppler imaging (TDI) analysis of GCG (healthy, n=9) showed promising results for measuring the cardiac timing intervals and myocardial deformation changes.
Conclusion: The findings of this study demonstrate clinical potential of MEMS motion sensors in cardiology that may facilitate in time diagnosis of cardiac abnormalities. Multidimensional MCG can effectively contribute to detecting atrial fibrillation (AFib), myocardial infarction (MI), and CAD. Additionally, MEMS motion sensing improves the reliability and quality of cardiac PET imaging.Moniulotteisten sulautettujen MEMS-liiketunnistimien käyttö sydänkardiografiassa sekä lääketieteellisessä 4D-kuvantamisessa
Tausta: Sydän- ja verisuonitaudit ovat yleisin kuolinsyy. Näistä kuolemantapauksista lähes 80% johtuu sepelvaltimotaudista (CAD) ja aivoverenkierron häiriöistä. Moniulotteiset mikroelektromekaaniset järjestelmät (MEMS) mahdollistavat sydänlihaksen mekaanisen liikkeen mittaamisen, mikä puolestaan tarjoaa täysin uudenlaisen ja innovatiivisen ratkaisun sydämen rytmin ja toiminnan arvioimiseksi. Viimeaikaiset teknologiset edistysaskeleet mahdollistavat uusien pienikokoisten liiketunnistusjärjestelmien käyttämisen sydämen toiminnan tutkimuksessa sekä lääketieteellisen kuvantamisen, kuten esimerkiksi tietokonetomografian (CT) ja positroniemissiotomografian (PET), tarkkuuden parantamisessa.
Menetelmät: Tämä väitöskirjatyö esittelee uuden sydämen kineettisen toiminnan mittaustekniikan, joka pohjautuu MEMS-anturien käyttöön. Uudet laskennalliset lähestymistavat, jotka perustuvat signaalinkäsittelyyn ja koneoppimiseen, mahdollistavat sydämen patologisten häiriöiden havaitsemisen MEMS-antureista saatavista signaaleista. Tässä tutkimuksessa keskitytään erityisesti mekanokardiografiaan (MCG), joihin kuuluvat gyrokardiografia (GCG) ja seismokardiografia (SCG). Näiden tekniikoiden avulla voidaan mitata kardiorespiratorisen järjestelmän mekaanisia ominaisuuksia.
Tulokset: Kokeelliset analyysit osoittivat, että integroimalla usean sensorin dataa voidaan mitata syketiheyttä 99% (terveillä n=29) tarkkuudella, havaita sydämen rytmihäiriöt (n=435) 95-97%, tarkkuudella, sekä havaita iskeeminen sairaus noin 75% tarkkuudella (n=22). Lisäksi MEMS-kaksoistahdistuksen avulla voidaan parantaa sydämen 4D PET-kuvan laatua, kun liikeepätarkkuudet voidaan eliminoida paremmin. Doppler-kuvantamisessa (TDI, Tissue Doppler Imaging) GCG-analyysi (terveillä, n=9) osoitti lupaavia tuloksia sydänsykkeen ajoituksen ja intervallien sekä sydänlihasmuutosten mittaamisessa.
Päätelmä: Tämän tutkimuksen tulokset osoittavat, että kardiologisilla MEMS-liikeantureilla on kliinistä potentiaalia sydämen toiminnallisten poikkeavuuksien diagnostisoinnissa. Moniuloitteinen MCG voi edistää eteisvärinän (AFib), sydäninfarktin (MI) ja CAD:n havaitsemista. Lisäksi MEMS-liiketunnistus parantaa sydämen PET-kuvantamisen luotettavuutta ja laatua
Contact and remote breathing rate monitoring techniques: a review
ABSTRACT: Breathing rate monitoring is a must for hospitalized patients with the current coronavirus disease 2019 (COVID-19). We review in this paper recent implementations of breathing monitoring techniques, where both contact and remote approaches are presented. It is known that with non-contact monitoring, the patient is not tied to an instrument, which improves patients’ comfort and enhances the accuracy of extracted breathing activity, since the distress generated by a contact device is avoided. Remote breathing monitoring allows screening people infected with COVID-19 by detecting abnormal respiratory patterns. However, non-contact methods show some disadvantages such as the higher set-up complexity compared to contact ones. On the other hand, many reported contact methods are mainly implemented using discrete components. While, numerous integrated solutions have been reported for non-contact techniques, such as continuous wave (CW) Doppler radar and ultrawideband (UWB) pulsed radar. These radar chips are discussed and their measured performances are summarized and compared
Internet of medical things – integrated, ultrasound-based respiration monitoring system for incubators
The study's aim was to develop a non-contact, ultrasound (US) based respiration rate
and respiratory signal monitor suitable for babies in incubators. Respiration rate
indicates average number of breaths per minute and is higher in young children than
adults. It is an important indicator of health deterioration in critically ill patients. The
current incubators do not have an integrated respiration monitor due to complexities in
its adaptation. Monitoring respiratory signal assists in diagnosing respiration rated
problems such as central Apnoea that can affect infants. US sensors are suitable for
integration into incubators as US is a harmless and cost-effective technology.
US beam is focused on the chest or abdomen. Chest or abdomen movements, caused
by respiration process, result in variations in their distance to the US transceiver located
at a distance of about 0.5 m. These variations are recorded by measuring the time of
flight from transmitting the signal and its reflection from the monitored surface.
Measurement of this delay over a time interval enables a respiration signal to be
produced from which respiration rate and pauses in breathing are determined.
To assess the accuracy of the developed device, a platform with a moving surface was
devised. The magnitude and frequency of its surface movement were accurately
controlled by its signal generator. The US sensor was mounted above this surface at a
distance of 0.5 m. This US signal was wirelessly transmitted to a microprocessor board
to digitise. The recorded signal that simulated a respiratory signal was subsequently
stored and displayed on a computer or an LCD screen. The results showed that US could
be used to measure respiration rate accurately. To cater for possible movement of the
infant in the incubator, four US sensors were adapted. These monitored the movements
from different angles. An algorithm to interpret the output from the four US sensors
was devised and evaluated. The algorithm interpreted which US sensor best detected
the chest movements.
An IoMT system was devised that incorporated NodeMcu to capture signals from the
US sensor. The detected data were transmitted to the ThingSpeak channel and
processed in real-time by ThingSpeak’s add-on Matlab© feature. The data were
processed on the cloud and then the results were displayed in real-time on a computer
screen. The respiration rate and respiration signal could be observed remotely on
portable devices e.g. mobile phones and tablets. These features allow caretakers to have
access to the data at any time and be alerted to respiratory complications.
A method to interpret the recorded US signals to determine respiration patterns, e.g.
intermittent pauses, were implemented by utilising Matlab© and ThingSpeak Server.
The method successfully detected respiratory pauses by identifying lack of chest
movements. The approach can be useful in diagnosing central apnoea. In central apnoea,
respiratory pauses are accompanied by cessation of chest or abdominal movements. The
devised system will require clinical trials and integration into an incubator by
conforming to the medical devices directives. The study demonstrated the integration
of IoMT-US for measuring respiration rate and respiratory signal. The US produced
respiration rate readings compared well with the actual signal generator's settings of the
platform that simulated chest movements
Wearable devices and IoT applications for symptom detection, infection tracking, and diffusion containment of the COVID-19 pandemic: a survey
Until a safe and effective vaccine to fight the SARS-CoV-2 virus is developed and available for the global population, preventive measures, such as wearable tracking and monitoring systems supported by Internet of Things (IoT) infrastructures, are valuable tools for containing the pandemic. In this review paper we analyze innovative wearable systems for limiting the virus spread, early detection of the first symptoms of the coronavirus disease COVID-19 infection, and remote monitoring of the health conditions of infected patients during the quarantine. The attention is focused on systems allowing quick user screening through ready-to-use hardware and software components. Such sensor-based systems monitor the principal vital signs, detect symptoms related to COVID-19 early, and alert patients and medical staff. Novel wearable devices for complying with social distancing rules and limiting interpersonal contagion (such as smart masks) are investigated and analyzed. In addition, an overview of implantable devices for monitoring the effects of COVID-19 on the cardiovascular system is presented. Then we report an overview of tracing strategies and technologies for containing the COVID-19 pandemic based on IoT technologies, wearable devices, and cloud computing. In detail, we demonstrate the potential of radio frequency based signal technology, including Bluetooth Low Energy (BLE), Wi-Fi, and radio frequency identification (RFID), often combined with Apps and cloud technology. Finally, critical analysis and comparisons of the different discussed solutions are presented, highlighting their potential and providing new insights for developing innovative tools for facing future pandemics
Smart Sensors for Healthcare and Medical Applications
This book focuses on new sensing technologies, measurement techniques, and their applications in medicine and healthcare. Specifically, the book briefly describes the potential of smart sensors in the aforementioned applications, collecting 24 articles selected and published in the Special Issue “Smart Sensors for Healthcare and Medical Applications”. We proposed this topic, being aware of the pivotal role that smart sensors can play in the improvement of healthcare services in both acute and chronic conditions as well as in prevention for a healthy life and active aging. The articles selected in this book cover a variety of topics related to the design, validation, and application of smart sensors to healthcare
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