Data Mining to Uncover Heterogeneous Water Use Behaviors From Smart Meter Data

Knowledge on the determinants and patterns of water demand for different consumers supports the design of customized demand management strategies. Smart meters coupled with big data analytics tools create a unique opportunity to support such strategies. Yet, at present, the information content of smart meter data is not fully mined and usually needs to be complemented with water fixture inventory and survey data to achieve detailed customer segmentation based on end use water usage. In this paper, we developed a data‐driven approach that extracts information on heterogeneous water end use routines, main end use components, and temporal characteristics, only via data mining existing smart meter readings at the scale of individual households. We tested our approach on data from 327 households in Australia, each monitored with smart meters logging water use readings every 5 s. As part of the approach, we first disaggregated the household‐level water use time series into different end uses via Autoflow. We then adapted a customer segmentation based on eigenbehavior analysis to discriminate among heterogeneous water end use routines and identify clusters of consumers presenting similar routines. Results revealed three main water end use profile clusters, each characterized by a primary end use: shower, clothes washing, and irrigation. Time‐of‐use and intensity‐of‐use differences exist within each class, as well as different characteristics of regularity and periodicity over time. Our customer segmentation analysis approach provides utilities with a concise snapshot of recurrent water use routines from smart meter data and can be used to support customized demand management strategies.TU Berlin, Open-Access-Mittel - 201

Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy.

The success of immunotherapy has led to a myriad of clinical trials accompanied by efforts to gain mechanistic insight and identify predictive signatures for personalization. However, many immune monitoring technologies face investigator bias, missing unanticipated cellular responses in limited clinical material. We present here a mass cytometry (CyTOF) workflow for standardized, systems-level biomarker discovery in immunotherapy trials. To broadly enumerate immune cell identity and activity, we established and extensively assessed a reference panel of 33 antibodies to cover major cell subsets, simultaneously quantifying activation and immune checkpoint molecules in a single assay. This assay enumerates ≥98% of peripheral immune cells with ≥4 positively identifying antigens. Robustness and reproducibility are demonstrated on multiple samples types, across two research centers and by orthogonal measurements. Using automated analysis, we identify stratifying immune signatures in bone marrow transplantation-associated graft-versus-host disease. Together, this validated workflow ensures comprehensive immunophenotypic analysis and data comparability and will accelerate biomarker discovery

Acoustic Space Learning for Sound Source Separation and Localization on Binaural Manifolds

In this paper we address the problems of modeling the acoustic space generated by a full-spectrum sound source and of using the learned model for the localization and separation of multiple sources that simultaneously emit sparse-spectrum sounds. We lay theoretical and methodological grounds in order to introduce the binaural manifold paradigm. We perform an in-depth study of the latent low-dimensional structure of the high-dimensional interaural spectral data, based on a corpus recorded with a human-like audiomotor robot head. A non-linear dimensionality reduction technique is used to show that these data lie on a two-dimensional (2D) smooth manifold parameterized by the motor states of the listener, or equivalently, the sound source directions. We propose a probabilistic piecewise affine mapping model (PPAM) specifically designed to deal with high-dimensional data exhibiting an intrinsic piecewise linear structure. We derive a closed-form expectation-maximization (EM) procedure for estimating the model parameters, followed by Bayes inversion for obtaining the full posterior density function of a sound source direction. We extend this solution to deal with missing data and redundancy in real world spectrograms, and hence for 2D localization of natural sound sources such as speech. We further generalize the model to the challenging case of multiple sound sources and we propose a variational EM framework. The associated algorithm, referred to as variational EM for source separation and localization (VESSL) yields a Bayesian estimation of the 2D locations and time-frequency masks of all the sources. Comparisons of the proposed approach with several existing methods reveal that the combination of acoustic-space learning with Bayesian inference enables our method to outperform state-of-the-art methods.Comment: 19 pages, 9 figures, 3 table

Dimensionality Reduction and Subspace Clustering in Mixed Reality for Condition Monitoring of High-Dimensional Production Data

Visual analytics are becoming more and more important in the light of big data and related scenarios. Along this trend, the field of immersive analytics has been variously furthered as it is able to provide sophisticated visual data analytics on one hand, while preserving user-friendliness on the other. Furthermore, recent hardware developments like smart glasses, as well as achievements in virtual-reality applications, have fanned immersive analytic solutions. Notably, such solutions can be very effective when they are applied to high-dimensional data sets. Taking this advantage into account, the work at hand applies immersive analytics to a high-dimensional production data set in order to improve the digital support of daily work tasks. More specifically, a mixed-reality implementation is presented that shall support manufactures as well as data scientists to comprehensively analyze machine data. As a particular goal, the prototype shall simplify the analysis of manufacturing data through the usage of dimensionality reduction effects. Therefore, five aspects are mainly reported in this paper. First, it is shown how dimensionality reduction effects can be represented by clusters. Second, it is presented how the resulting information loss of the reduction is addressed. Third, the graphical interface of the developed prototype is illustrated as it provides a (1) correlation coefficient graph, a (2) plot for the information loss, and a (3) 3D particle system. In addition, an implemented voice recognition feature of the prototype is shown, which was considered as being promising to select or deselect data variables users are interested in when analyzing the data. Fourth, based on a machine learning library, it is shown how the prototype reduces computational resources by the use of smart glasses. The main idea is based on a recommendation approach as well as the use of subspace clustering. Fifth, results from a practical setting are presented, in which the prototype was shown to domain experts. The latter reported that such a tool is actually helpful to analyze machine data on a daily basis. Moreover, it was reported that such system can be used to educate machine operators more properly. As a general outcome of this work, the presented approach may constitute a helpful solution for the industry as well as other domains like medicine

Machine learning for crystal identification and discovery

As computers get faster, researchers -- not hardware or algorithms -- become the bottleneck in scientific discovery. Computational study of colloidal self-assembly is one area that is keenly affected: even after computers generate massive amounts of raw data, performing an exhaustive search to determine what (if any) ordered structures occur in a large parameter space of many simulations can be excruciating. We demonstrate how machine learning can be applied to discover interesting areas of parameter space in colloidal self assembly. We create numerical fingerprints -- inspired by bond orientational order diagrams -- of structures found in self-assembly studies and use these descriptors to both find interesting regions in a phase diagram and identify characteristic local environments in simulations in an automated manner for simple and complex crystal structures. Utilizing these methods allows analysis methods to keep up with the data generation ability of modern high-throughput computing environments.Comment: Fixed typo, added missing acknowledgment, added supplementary informatio