Multi-modal brain tumor segmentation via conditional synthesis with Fourier domain adaptation

Accurate brain tumor segmentation is critical for diagnosis and treatment planning, whereby multi-modal magnetic resonance imaging (MRI) is typically used for analysis. However, obtaining all required sequences and expertly labeled data for training is challenging and can result in decreased quality of segmentation models developed through automated algorithms. In this work, we examine the possibility of employing a conditional generative adversarial network (GAN) approach for synthesizing multi-modal images to train deep learning-based neural networks aimed at high-grade glioma (HGG) segmentation. The proposed GAN is conditioned on auxiliary brain tissue and tumor segmentation masks, allowing us to attain better accuracy and control of tissue appearance during synthesis. To reduce the domain shift between synthetic and real MR images, we additionally adapt the low-frequency Fourier space components of synthetic data, reflecting the style of the image, to those of real data. We demonstrate the impact of Fourier domain adaptation (FDA) on the training of 3D segmentation networks and attain significant improvements in both the segmentation performance and prediction confidence. Similar outcomes are seen when such data is used as a training augmentation alongside the available real images. In fact, experiments on the BraTS2020 dataset reveal that models trained solely with synthetic data exhibit an improvement of up to 4% in Dice score when using FDA, while training with both real and FDA-processed synthetic data through augmentation results in an improvement of up to 5% in Dice compared to using real data alone. This study highlights the importance of considering image frequency in generative approaches for medical image synthesis and offers a promising approach to address data scarcity in medical imaging segmentation.</p

Image based cardiac acceleration map using statistical shape and 3D+t myocardial tracking models; in-vitro study on heart phantom

International audienceIt has been demonstrated that the acceleration signal has potential to monitor heart function and adaptively optimize Cardiac Resynchronization Therapy (CRT) systems. In this paper, we propose a non-invasive method for computing myocardial acceleration from 3D echocardiographic sequences. Displacement of the myocardium was estimated using a two-step approach: (1) 3D automatic segmentation of the myocardium at end-diastole using 3D Active Shape Models (ASM); (2) propagation of this segmentation along the sequence using non-rigid 3D+t image registration (temporal diffeomorphic free-form-deformation, TDFFD). Acceleration was obtained locally at each point of the myocardium from local displacement. The framework has been tested on images from a realistic physical heart phantom (DHP-01, Shelley Medical Imaging Technologies, London, ON, CA) in which the displacement of some control regions was known. Good correlation has been demonstrated between the estimated displacement function from the algorithms and the phantom setup. Due to the limited temporal resolution, the acceleration signals are sparse and highly noisy. The study suggests a non-invasive technique to measure the cardiac acceleration that may be used to improve the monitoring of cardiac mechanics and optimization of CRT

3D Convolutional Neural Networks for Tumor Segmentation using Long-range 2D Context

We present an efficient deep learning approach for the challenging task of tumor segmentation in multisequence MR images. In recent years, Convolutional Neural Networks (CNN) have achieved state-of-the-art performances in a large variety of recognition tasks in medical imaging. Because of the considerable computational cost of CNNs, large volumes such as MRI are typically processed by subvolumes, for instance slices (axial, coronal, sagittal) or small 3D patches. In this paper we introduce a CNN-based model which efficiently combines the advantages of the short-range 3D context and the long-range 2D context. To overcome the limitations of specific choices of neural network architectures, we also propose to merge outputs of several cascaded 2D-3D models by a voxelwise voting strategy. Furthermore, we propose a network architecture in which the different MR sequences are processed by separate subnetworks in order to be more robust to the problem of missing MR sequences. Finally, a simple and efficient algorithm for training large CNN models is introduced. We evaluate our method on the public benchmark of the BRATS 2017 challenge on the task of multiclass segmentation of malignant brain tumors. Our method achieves good performances and produces accurate segmentations with median Dice scores of 0.918 (whole tumor), 0.883 (tumor core) and 0.854 (enhancing core). Our approach can be naturally applied to various tasks involving segmentation of lesions or organs.Comment: Submitted to the journal Computerized Medical Imaging and Graphic

Co-Fusion: Real-time Segmentation, Tracking and Fusion of Multiple Objects

In this paper we introduce Co-Fusion, a dense SLAM system that takes a live stream of RGB-D images as input and segments the scene into different objects (using either motion or semantic cues) while simultaneously tracking and reconstructing their 3D shape in real time. We use a multiple model fitting approach where each object can move independently from the background and still be effectively tracked and its shape fused over time using only the information from pixels associated with that object label. Previous attempts to deal with dynamic scenes have typically considered moving regions as outliers, and consequently do not model their shape or track their motion over time. In contrast, we enable the robot to maintain 3D models for each of the segmented objects and to improve them over time through fusion. As a result, our system can enable a robot to maintain a scene description at the object level which has the potential to allow interactions with its working environment; even in the case of dynamic scenes.Comment: International Conference on Robotics and Automation (ICRA) 2017, http://visual.cs.ucl.ac.uk/pubs/cofusion, https://github.com/martinruenz/co-fusio

Object segmentation from low depth of field images and video sequences

This thesis addresses the problem of autonomous object segmentation. To do so the proposed segementation method uses some prior information, namely that the image to be segmented will have a low depth of field and that the object of interest will be more in focus than the background. To differentiate the object from the background scene, a multiscale wavelet based assessment is proposed. The focus assessment is used to generate a focus intensity map, and a sparse fields level set implementation of active contours is used to segment the object of interest. The initial contour is generated using a grid based technique. The method is extended to segment low depth of field video sequences with each successive initialisation for the active contours generated from the binary dilation of the previous frame's segmentation. Experimental results show good segmentations can be achieved with a variety of different images, video sequences, and objects, with no user interaction or input. The method is applied to two different areas. In the first the segmentations are used to automatically generate trimaps for use with matting algorithms. In the second, the method is used as part of a shape from silhouettes 3D object reconstruction system, replacing the need for a constrained background when generating silhouettes. In addition, not using a thresholding to perform the silhouette segmentation allows for objects with dark components or areas to be segmented accurately. Some examples of 3D models generated using silhouettes are shown

Robust Temporally Coherent Laplacian Protrusion Segmentation of 3D Articulated Bodies

In motion analysis and understanding it is important to be able to fit a suitable model or structure to the temporal series of observed data, in order to describe motion patterns in a compact way, and to discriminate between them. In an unsupervised context, i.e., no prior model of the moving object(s) is available, such a structure has to be learned from the data in a bottom-up fashion. In recent times, volumetric approaches in which the motion is captured from a number of cameras and a voxel-set representation of the body is built from the camera views, have gained ground due to attractive features such as inherent view-invariance and robustness to occlusions. Automatic, unsupervised segmentation of moving bodies along entire sequences, in a temporally-coherent and robust way, has the potential to provide a means of constructing a bottom-up model of the moving body, and track motion cues that may be later exploited for motion classification. Spectral methods such as locally linear embedding (LLE) can be useful in this context, as they preserve "protrusions", i.e., high-curvature regions of the 3D volume, of articulated shapes, while improving their separation in a lower dimensional space, making them in this way easier to cluster. In this paper we therefore propose a spectral approach to unsupervised and temporally-coherent body-protrusion segmentation along time sequences. Volumetric shapes are clustered in an embedding space, clusters are propagated in time to ensure coherence, and merged or split to accommodate changes in the body's topology. Experiments on both synthetic and real sequences of dense voxel-set data are shown. This supports the ability of the proposed method to cluster body-parts consistently over time in a totally unsupervised fashion, its robustness to sampling density and shape quality, and its potential for bottom-up model constructionComment: 31 pages, 26 figure

Learning from Synthetic Humans

Estimating human pose, shape, and motion from images and videos are fundamental challenges with many applications. Recent advances in 2D human pose estimation use large amounts of manually-labeled training data for learning convolutional neural networks (CNNs). Such data is time consuming to acquire and difficult to extend. Moreover, manual labeling of 3D pose, depth and motion is impractical. In this work we present SURREAL (Synthetic hUmans foR REAL tasks): a new large-scale dataset with synthetically-generated but realistic images of people rendered from 3D sequences of human motion capture data. We generate more than 6 million frames together with ground truth pose, depth maps, and segmentation masks. We show that CNNs trained on our synthetic dataset allow for accurate human depth estimation and human part segmentation in real RGB images. Our results and the new dataset open up new possibilities for advancing person analysis using cheap and large-scale synthetic data.Comment: Appears in: 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR 2017). 9 page