Wideband phantoms of different body tissues for heterogeneous models in body area networks

[EN] One of the key issues about wireless technologies is their interaction with the human body. The so-called internet of things will comprise many devices that will transmit either around or through the human body. These devices must be tested either in their working medium, when possible, or in the most realistic one. For this purpose, tissue-like phantoms are the best alternative to carry out realistic analyses of the performance of body area networks. In addition, they are the conventional way to certify the compliance of commercial standards by these devices. However, the number of phantoms that work in large bandwidths is limited in literature. This work aims at presenting chemical solutions that will be useful to prepare a variety of wideband tissue phantoms. Besides, the colon was mimicked in two ways, the healthy tissue and the malignant one, taking into account studies that relate changes on the relative permittivity with cancer. They were designed on the basis of acetonitrile in aqueous solutions as described in a previous work. Thus, many scenarios could be developed such as multilayers which imitate parts of the heterogeneous body.Research supported by the Programa de Ayudas de Investigación y Desarrollo (PAID-01-16) from Universitat Politècnica de València, by the Ministerio de Economía y Competitividad, Spain (TEC2014-60258-C2-1- R) and by the European FEDER Funds.Castelló-Palacios, S.; Garcia-Pardo, C.; Fornés Leal, A.; Cardona Marcet, N.; Vallés Lluch, A. (2018). Wideband phantoms of different body tissues for heterogeneous models in body area networks. IEEE. 3032-3035. https://doi.org/10.1109/EMBC.2017.8037496S3032303

Initial UWB in-body channel characterization using a novel multilayer phantom measurement setup

[EN] Wireless Body Area Networks (WBANs) are a promising technology for medical purposes. Currently the WBAN are classified into: implanted (in-), surface (on-) or outside (off-) body communications regarding the location of the devices with reference to the human body. The Ultra Wide-Band (UWB) frequency band is growing as a band of interest for implanted communications because of its high data rate and low power consumption among other benefits. Software simulations, in-vivo measurements and experimental phantom measurements are common methods to properly characterize the propagation channel. Nevertheless, up to now, experimental phantoms measurements presented in the literature show some inconveniences, i.e., the accuracy of the phantoms compared with the real human tissues or the testbed used for the measurements. This paper aims at overcoming these issues using accurate phantoms designed for the purpose of implanted communications in the UWB frequency band. In addition, a multilayer phantom container was developed. This container has capacity for two different phantoms, emulating a heterogeneous propagation medium for in-body measurements. Moreover, a novel setup was built for in-body phantom measurements. As a result, an experimental path loss model is presented from the measurements obtained with phantoms. Besides, software simulations mimicking the experimental setup are performed in order to validate the previous results obtainedThis work was supported by the European Union's H2020:MSCA:ITN program for the "Wireless In-body Environment Communication-WiBEC" project under the grant agreement no. 675353. this work was also funded by the Programa de Ayudas de Investigación y Desarrollo 8PAID-01-16) from Univeristat Politècnica de València and by the Ministerio de Economía y Competitividad, Spain (TEC2014-60258-C2-1-R), by the European FEDER funds.Pérez-Simbor, S.; Barbi, M.; Garcia-Pardo, C.; Castelló-Palacios, S.; Cardona Marcet, N. (2018). Initial UWB in-body channel characterization using a novel multilayer phantom measurement setup. IEEE. 384-389. https://doi.org/10.1109/WCNCW.2018.8369011S38438

Ultrawideband Technology for Medical In-Body Sensor Networks: An Overview of the Human Body as a Propagation Medium, Phantoms, and Approaches for Propagation Analysis

[EN] An in-body sensor network is that in which at least one of the sensors is located inside the human body. Such wireless in-body sensors are used mainly in medical applications, collecting and monitoring important parameters for health and disease treatment. IEEE Standard 802.15.6-2012 for wireless body area networks (WBANs) considers in-body communications in the Medical Implant Communications Service (MICS) band. Nevertheless, high-data-rate communications are not feasible at the MICS band because of its narrow occupied bandwidth. In this framework, ultrawideband (UWB) systems have emerged as a potential solution for in-body highdata-rate communications because of their miniaturization capabilities and low power consumption.This work was supported by the Programa de Ayudas de Investigación y Desarrollo (PAID-01-16) at the Universitat Politècnica de València, Spain; by the Ministerio de Economía y Competitividad, Spain (TEC2014-60258-C2-1-R); and by the European FEDER funds. It was also funded by the European Union’s H2020:MSCA:ITN program for the Wireless In-Body Environ-ment Communication–WiBEC project under grant 675353.Garcia-Pardo, C.; Andreu-Estellés, C.; Fornés Leal, A.; Castelló-Palacios, S.; Pérez-Simbor, S.; Barbi, M.; Vallés Lluch, A.... (2018). Ultrawideband Technology for Medical In-Body Sensor Networks: An Overview of the Human Body as a Propagation Medium, Phantoms, and Approaches for Propagation Analysis. IEEE Antennas and Propagation Magazine. 60(3):19-33. https://doi.org/10.1109/MAP.2018.2818458S193360

Tailor-Made Tissue Phantoms Based on Acetonitrile Solutions for Microwave Applications up to 18 GHz

(c) 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.Tissue-equivalent phantoms play a key role in the development of new wireless communication devices that are tested on such phantoms prior to their commercialization. However, existing phantoms cover a small number of tissues and do not reproduce them accurately within wide frequency bands. This paper aims at enlarging the number of mimicked tissues as well as their working frequency band. Thus, a variety of potential compounds are scanned according to their relative permittivity from 0.5 to 18 GHz. Next, a combination of these compounds is characterized so the relation between their dielectric properties and composition is provided. Finally, taking advantage of the previous analysis, tailor-made phantoms are developed for different human tissues up to 18 GHz and particularized for the main current body area network (BAN) operating bands. The tailor-made phantoms presented here exhibit such a high accuracy as would allow researchers and manufacturers to test microwave devices at high frequencies for large bandwidths as well as the use of heterogeneous phantoms in the near future. The key to these phantoms lies in the incorporation of acetonitrile to aqueous solutions. Such compounds have a suitable behavior to achieve the relative permittivity values of body tissues within the studied frequency band.This work was supported by the Ministerio de Economia y Competitividad, Spain (TEC2014-60258-C2-1-R) and by the European FEDER Funds.Castelló-Palacios, S.; García Pardo, C.; Fornés Leal, A.; Cardona Marcet, N.; Vallés Lluch, A. (2016). Tailor-Made Tissue Phantoms Based on Acetonitrile Solutions for Microwave Applications up to 18 GHz. IEEE Transactions on Microwave Theory and Techniques. 64(11):3987-3994. https://doi.org/10.1109/TMTT.2016.2608890S39873994641

UWB Path Loss Models for Ingestible Devices

[EN] Currently, some medical devices such as the Wireless Capsule Endoscopy (WCE) are used for data transmission from inside to outside the body. Nevertheless, for certain applications such as WCE, the data rates offered by current medical frequency bands can result insufficient. Ultra Wideband (UWB) frequency band has become an interesting solution for this. However, to date, there is not a formal channel path loss model for the UWB frequency band in the gastrointestinal (GI) scenario due to the huge differences between the proposed studies. There are three main methodologies to characterize the propagation channel, software simulations and experimental measurements either in phantom or in in vivo animals. Previous works do not compare all the methodologies or present some disagreements with the literature. In this paper, a dedicated study of the path loss using the three methodologies aforementioned (simulations, phantoms and in vivo measurements) and a comparison with previous researches in the literature is performed. Moreover, numerical values for a path loss model which agrees with the three methodologies and the literature are proposed. This paper aims at being the starting point for a formal path loss model in the UWB frequency band for WBANs in the GI scenarioThis work was supported in part by the European Union's H2020-MSCA-ITN Program for the "Wireless In-body Environment Communication" Project under Grant 675353, in part by the Programa de Ayudas de Investigacion y Desarrollo (PAID-01-16) from Universitat Politecnica de Valencia, and in part by the Ministerio de Economia y Competitividad, Spain under Grant TEC2014-60258-C2-1-R through the European FEDER Funds.Pérez-Simbor, S.; Andreu-Estellés, C.; Garcia-Pardo, C.; Frasson, M.; Cardona Marcet, N. (2019). UWB Path Loss Models for Ingestible Devices. IEEE Transactions on Antennas and Propagation. 67(8):5025-5034. https://doi.org/10.1109/TAP.2019.2891717S5025503467

Experimental Study of Ultra-Wideband Radio Propagation for Wireless Body Area Networks

東京電機大学201

Caracterización del canal radio en entornos especiales

En el presente proyecto se estudia el canal radio en dos casos especiales de Redes Inalámbricas de Área Personal (WPAN). El primero de los casos es la transmisión durante un incendio indoor. El objetivo es caracterizar el canal en la banda UWB (Banda Ultra-Ancha, por sus siglas en inglés) para averiguar si se producen pérdidas adicionales a las de espacio libre debidas al fuego, y con ello conocer en una primera aproximación si la implantación de nuevos sistemas para mejorar la seguridad de los bomberos es factible. El segundo caso a estudiar es la transmisión en Redes de Área Corporal (BAN), en concreto en un medio sintético que simula dieléctricamente un músculo humano. Se caracterizará el canal en las bandas UWB (3.1 a 10.6 GHz) e ISM (Industrial, Científica y Médica, por sus siglas en inglés, entorno a 2.4 GHz), y se obtendrán datos que podrían ser de ayuda de cara al diseño de futuros dispositivos en BAN.Fornés Leal, A. (2014). Caracterización del canal radio en entornos especiales. http://hdl.handle.net/10251/46612.Archivo delegad

Diseño de antenas UWB directivas y tamaño compacto para aplicaciones médicas operando en el entorno corporal

[ES] El objetivo de este TFM es diseñar antenas directivas y de tamaño compacto que faciliten la penetración de las ondas electromagnética en el interior del cuerpo humano para aplicaciones médicas. Se explorará la posibilidad de emplear pequeñas hélices diseñadas operando a frecuencias por encima de 3 GHz. Las hélices presentan buena directividad y buen ancho de banda, por lo que son candidatas perfectas para este tipo de aplicaciones. Con el objetivo de facilitar la penetración en el cuerpo de las ondas emitidas por la antena, la antena se sumergirá en un fluido, o se empleará algún gel de transición de alta permitividad que minimice las reflexiones que se producen en la piel. Se realizarán simulaciones de la antena y del escenario corporal empleando el software de simulación electromagnética CST, y se realizará un estudio de diferentes geles y fluidos de transición que colocados entre la antena y la piel permitan aumentar la profundidad de penetración de la ondas.[EN] The objective of this project is to design directive and compact size antennas that facilitate the penetration of electromagnetic waves inside the human body for medical applications. The possibility of using small helixes operating at frequencies above 3 GHz will be explored. The helixes have good directivity and good bandwidth, so they are perfect candidates for this type of applications. In order to facilitate the penetration into the body of the waves emitted by the antenna, the antenna will be submerged in a fluid, or a high-permittivity transitional gel will be used to minimize the reflections that occur in the skin. Simulations of the antenna and the body scenario will be performed using the CST electromagnetic simulation software, and a study will be made with different gels and transition fluids placed between the antenna and the skin, to increase the penetration depth of the waves.Palomar Cosín, N. (2019). Diseño de antenas UWB directivas y tamaño compacto para aplicaciones médicas operando en el entorno corporal. http://hdl.handle.net/10251/124628TFG

Antenna Development for Radio Frequency Hyperthermia Applications

This thesis deals with the design steps, development and validation of an applicator for radio frequency hyperthermia cancer therapy. An applicator design to enhance targeted energy coupling is a key enabler for preferential temperature increments in tumour regions. A single-element, near-field approach requires a miniaturised solution, that addresses ergonomic needs and is tolerant to patient anatomy. The antenna war-field rriodality and the high-dielectric patient loading introduce significant analytical and computational resource challenges. The antenna input impedance has to be sufficiently insensitive to in-band resonant cletuning and the fields in the tissue can he targeted to selected areas in the patient. An introduction to the medical and biological background of hyperthermia is presented. The design requirements of antennas for medical and in particular for hyperthermia applications are highlighted. Starting from a conventional circular patch, the antenna evolved into a compact circular patch with a concentric annular ring and slotted groundplane, operating at the 434 MHz Industrial Scientific and Medical frequency band. Feed point location is optimized for an energy deposition pattern aligned with the antenna centre. The applicator is assessed with other published approaches and clinically used loop, dipole and square patch antennas. The antennas are evaluated for the unloaded condition and when loaded with a tri-layer body tissue numerical model. This model comprises skin, fat and transverse fiber of muscle of variable thicknesses to account for different body locations and patient. anatomy. A waterbolus containing de-ionized water is added at the skin interface for superficial tissue cooling aud antelina matching. The proposed applicator achieves a penetration depth that supersedes other approaches while remaining compact and an ergonomic fit to tumour areas on the body. To consider the inner and peripheral complex shapes of human bodies, the full human body numerical model developed by Remcom is used. This model was segmented from 1 mm step computed tomography (CT) and magnetic resonance imaging (MRI) cross-sections through and adult male and it comprises twenty-three tissue types with thermal and frequency-dependent dielectric properties. The applicator performance is evaluated at three anatomical body areas of the model to assess its suitability for treatment of tumours at different locations. These three anatomical regions present different aperture coupling and tissue composition. \u27Different conformal waterbolus and air gap thickness values are evaluated. The models used in this work are validated with measurements performed in a phantom containing a lossy liquid with dielectric properties representative of homogeneous human body tissue. The dosimetric assessment system (DASY) is used to evaluaxe the specific absorption rate (SAR) generated for the antenna into the liquid. The measurement setup with the antenna, phantom and liquid are simulated. Simulated and measured results in terrms of specific absorption rate and return loss are evaluated

Experimental Assessment of Time Reversal for In-Body to In-Body UWB Communications

[EN] The standard of in-body communications is limited to the use of narrowband systems. These systems are far from the high data rate connections achieved by other wireless telecommunication services today in force. The UWB frequency band has been proposed as a possible candidate for future in-body networks. However, the attenuation of body tissues at gigahertz frequencies could be a serious drawback. Experimental measurements for channel modeling are not easy to carry out, while the use of humans is practically forbidden. Sophisticated simulation tools could provide inaccurate results since they are not able to reproduce all the in-body channel conditions. Chemical solutions known as phantoms could provide a fair approximation of body tissues¿ behavior. In this work, the Time Reversal technique is assessed to increase the channel performance of in-body communications. For this task, a large volume of experimental measurements is performed at the low part of UWB spectrum (3.1-5.1 GHz) by using a highly accurate phantom-based measurement setup. This experimental setup emulates an in-body to in-body scenario, where all the nodes are implanted inside the body. Moreover, the in-body channel characteristics such as the path loss, the correlation in transmission and reception, and the reciprocity of the channel are assessed and discussed.This work was supported by the Programa de Ayudas de Investigacion y Desarrollo (PAID-01-16) from Universitat Politecnica de Valencia and by the Ministerio de Economia y Competitividad, Spain (TEC2014-60258-C2-1-R), by the European FEDER funds.Andreu-Estellés, C.; Garcia-Pardo, C.; Castelló-Palacios, S.; Cardona Marcet, N. (2018). Experimental Assessment of Time Reversal for In-Body to In-Body UWB Communications. Wireless Communications and Mobile Computing (Online). (8927107):1-12. https://doi.org/10.1155/2018/8927107S1128927107Fireman, Z. (2003). Diagnosing small bowel Crohn’s disease with wireless capsule endoscopy. Gut, 52(3), 390-392. doi:10.1136/gut.52.3.390Burri, H., & Senouf, D. (2009). Remote monitoring and follow-up of pacemakers and implantable cardioverter defibrillators. Europace, 11(6), 701-709. doi:10.1093/europace/eup110Scanlon, W. G., Burns, B., & Evans, N. E. (2000). Radiowave propagation from a tissue-implanted source at 418 MHz and 916.5 MHz. IEEE Transactions on Biomedical Engineering, 47(4), 527-534. doi:10.1109/10.828152Chavez-Santiago, R., Garcia-Pardo, C., Fornes-Leal, A., Valles-Lluch, A., Vermeeren, G., Joseph, W., … Cardona, N. (2015). Experimental Path Loss Models for In-Body Communications within 2.36-2.5 GHz. IEEE Journal of Biomedical and Health Informatics, 1-1. doi:10.1109/jbhi.2015.2418757Khaleghi, A., Chávez-Santiago, R., & Balasingham, I. (2010). Ultra-wideband pulse-based data communications for medical implants. IET Communications, 4(15), 1889. doi:10.1049/iet-com.2009.0692Khaleghi, A., Chávez-Santiago, R., & Balasingham, I. (2011). Ultra-wideband statistical propagation channel model for implant sensors in the human chest. IET Microwaves, Antennas & Propagation, 5(15), 1805. doi:10.1049/iet-map.2010.0537Kurup, D., Scarpello, M., Vermeeren, G., Joseph, W., Dhaenens, K., Axisa, F., … Vanfleteren, J. (2011). In-body path loss models for implants in heterogeneous human tissues using implantable slot dipole conformal flexible antennas. EURASIP Journal on Wireless Communications and Networking, 2011(1). doi:10.1186/1687-1499-2011-51Floor, P. A., Chavez-Santiago, R., Brovoll, S., Aardal, O., Bergsland, J., Grymyr, O.-J. H. N., … Balasingham, I. (2015). In-Body to On-Body Ultrawideband Propagation Model Derived From Measurements in Living Animals. IEEE Journal of Biomedical and Health Informatics, 19(3), 938-948. doi:10.1109/jbhi.2015.2417805Shimizu, Y., Anzai, D., Chavez-Santiago, R., Floor, P. A., Balasingham, I., & Wang, J. (2017). Performance Evaluation of an Ultra-Wideband Transmit Diversity in a Living Animal Experiment. IEEE Transactions on Microwave Theory and Techniques, 65(7), 2596-2606. doi:10.1109/tmtt.2017.2669039Anzai, D., Katsu, K., Chavez-Santiago, R., Wang, Q., Plettemeier, D., Wang, J., & Balasingham, I. (2014). Experimental Evaluation of Implant UWB-IR Transmission With Living Animal for Body Area Networks. IEEE Transactions on Microwave Theory and Techniques, 62(1), 183-192. doi:10.1109/tmtt.2013.2291542Chou, C.-K., Chen, G.-W., Guy, A. W., & Luk, K. H. (1984). Formulas for preparing phantom muscle tissue at various radiofrequencies. Bioelectromagnetics, 5(4), 435-441. doi:10.1002/bem.2250050408Cheung, A. Y., & Koopman, D. W. (1976). Experimental Development of Simulated Biomaterials for Dosimetry Studies of Hazardous Microwave Radiation (Short Papers). IEEE Transactions on Microwave Theory and Techniques, 24(10), 669-673. doi:10.1109/tmtt.1976.1128936YAMAMOTO, H., ZHOU, J., & KOBAYASHI, T. (2008). Ultra Wideband Electromagnetic Phantoms for Antennas and Propagation Studies. IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences, E91-A(11), 3173-3182. doi:10.1093/ietfec/e91-a.11.3173Lazebnik, M., Madsen, E. L., Frank, G. R., & Hagness, S. C. (2005). Tissue-mimicking phantom materials for narrowband and ultrawideband microwave applications. Physics in Medicine and Biology, 50(18), 4245-4258. doi:10.1088/0031-9155/50/18/001Yilmaz, T., Foster, R., & Hao, Y. (2014). Broadband Tissue Mimicking Phantoms and a Patch Resonator for Evaluating Noninvasive Monitoring of Blood Glucose Levels. IEEE Transactions on Antennas and Propagation, 62(6), 3064-3075. doi:10.1109/tap.2014.2313139Gezici, S., Zhi Tian, Giannakis, G. B., Kobayashi, H., Molisch, A. F., Poor, H. V., & Sahinoglu, Z. (2005). Localization via ultra-wideband radios: a look at positioning aspects for future sensor networks. IEEE Signal Processing Magazine, 22(4), 70-84. doi:10.1109/msp.2005.1458289Marinova, M., Thielens, A., Tanghe, E., Vallozzi, L., Vermeeren, G., Joseph, W., … Martens, L. (2015). Diversity Performance of Off-Body MB-OFDM UWB-MIMO. IEEE Transactions on Antennas and Propagation, 63(7), 3187-3197. doi:10.1109/tap.2015.2422353SHI, J., ANZAI, D., & WANG, J. (2012). Channel Modeling and Performance Analysis of Diversity Reception for Implant UWB Wireless Link. IEICE Transactions on Communications, E95.B(10), 3197-3205. doi:10.1587/transcom.e95.b.3197Pajusco, P., & Pagani, P. (2009). On the Use of Uniform Circular Arrays for Characterizing UWB Time Reversal. IEEE Transactions on Antennas and Propagation, 57(1), 102-109. doi:10.1109/tap.2008.2009715Chavez-Santiago, R., Sayrafian-Pour, K., Khaleghi, A., Takizawa, K., Wang, J., Balasingham, I., & Li, H.-B. (2013). Propagation models for IEEE 802.15.6 standardization of implant communication in body area networks. IEEE Communications Magazine, 51(8), 80-87. doi:10.1109/mcom.2013.6576343Andreu, C., Castello-Palacios, S., Garcia-Pardo, C., Fornes-Leal, A., Valles-Lluch, A., & Cardona, N. (2016). Spatial In-Body Channel Characterization Using an Accurate UWB Phantom. IEEE Transactions on Microwave Theory and Techniques, 64(11), 3995-4002. doi:10.1109/tmtt.2016.2609409Pahlavan, K., & Levesque, A. H. (2005). Wireless Information Networks. doi:10.1002/0471738646Qiu, R. C., Zhou, C., Guo, N., & Zhang, J. Q. (2006). Time Reversal With MISO for Ultrawideband Communications: Experimental Results. IEEE Antennas and Wireless Propagation Letters, 5, 269-273. doi:10.1109/lawp.2006.875888Ando, H., Takizawa, K., Yoshida, T., Matsushita, K., Hirata, M., & Suzuki, T. (2016). Wireless Multichannel Neural Recording With a 128-Mbps UWB Transmitter for an Implantable Brain-Machine Interfaces. IEEE Transactions on Biomedical Circuits and Systems, 10(6), 1068-1078. doi:10.1109/tbcas.2016.251452