Detection of Epileptic Seizures on EEG Signals Using ANFIS Classifier, Autoencoders and Fuzzy Entropies

Epileptic seizures are one of the most crucial neurological disorders, and their early diagnosis will help the clinicians to provide accurate treatment for the patients. The electroencephalogram (EEG) signals are widely used for epileptic seizures detection, which provides specialists with substantial information about the functioning of the brain. In this paper, a novel diagnostic procedure using fuzzy theory and deep learning techniques is introduced. The proposed method is evaluated on the Bonn University dataset with six classification combinations and also on the Freiburg dataset. The tunable- Q wavelet transform (TQWT) is employed to decompose the EEG signals into different sub-bands. In the feature extraction step, 13 different fuzzy entropies are calculated from different sub-bands of TQWT, and their computational complexities are calculated to help researchers choose the best set for various tasks. In the following, an autoencoder (AE) with six layers is employed for dimensionality reduction. Finally, the standard adaptive neuro-fuzzy inference system (ANFIS), and also its variants with grasshopper optimization algorithm (ANFIS-GOA), particle swarm optimization (ANFIS-PSO), and breeding swarm optimization (ANFIS-BS) methods are used for classification. Using our proposed method, ANFIS-BS method has obtained an accuracy of 99.7

Real-Time Localization of Epileptogenic Foci EEG Signals: An FPGA-Based Implementation

The epileptogenic focus is a brain area that may be surgically removed to control of epileptic seizures. Locating it is an essential and crucial step prior to the surgical treatment. However, given the difficulty of determining the localization of this brain region responsible of the initial seizure discharge, many works have proposed machine learning methods for the automatic classification of focal and non-focal electroencephalographic (EEG) signals. These works use automatic classification as an analysis tool for helping neurosurgeons to identify focal areas off-line, out of surgery, during the processing of the huge amount of information collected during several days of patient monitoring. In turn, this paper proposes an automatic classification procedure capable of assisting neurosurgeons online, during the resective epilepsy surgery, to refine the localization of the epileptogenic area to be resected, if they have doubts. This goal requires a real-time implementation with as low a computational cost as possible. For that reason, this work proposes both a feature set and a classifier model that minimizes the computational load while preserving the classification accuracy at 95.5%, a level similar to previous works. In addition, the classification procedure has been implemented on a FPGA device to determine its resource needs and throughput. Thus, it can be concluded that such a device can embed the whole classification process, from accepting raw signals to the delivery of the classification results in a cost-effective Xilinx Spartan-6 FPGA device. This real-time implementation begins providing results after a 5 s latency, and later, can deliver floating-point classification results at 3.5 Hz rate, using overlapped time-windows

Determinant of Covariance Matrix Model Coupled with AdaBoost Classification Algorithm for EEG Seizure Detection

Experts usually inspect electroencephalogram (EEG) recordings page-by-page in order to identify epileptic seizures, which leads to heavy workloads and is time consuming. However, the efficient extraction and effective selection of informative EEG features is crucial in assisting clinicians to diagnose epilepsy accurately. In this paper, a determinant of covariance matrix (Cov–Det) model is suggested for reducing EEG dimensionality. First, EEG signals are segmented into intervals using a sliding window technique. Then, Cov–Det is applied to each interval. To construct a features vector, a set of statistical features are extracted from each interval. To eliminate redundant features, the Kolmogorov–Smirnov (KST) and Mann–Whitney U (MWUT) tests are integrated, the extracted features ranked based on KST and MWUT metrics, and arithmetic operators are adopted to construe the most pertinent classified features for each pair in the EEG signal group. The selected features are then fed into the proposed AdaBoost Back-Propagation neural network (AB_BP_NN) to effectively classify EEG signals into seizure and free seizure segments. Finally, the AB_BP_NN is compared with several classical machine learning techniques; the results demonstrate that the proposed mode of AB_BP_NN provides insignificant false positive rates, simpler design, and robustness in classifying epileptic signals. Two datasets, the Bern–Barcelona and Bonn datasets, are used for performance evaluation. The proposed technique achieved an average accuracy of 100% and 98.86%, respectively, for the Bern–Barcelona and Bonn datasets, which is considered a noteworthy improvement compared to the current state-of-the-art methods

Developing artificial intelligence models for classification of brain disorder diseases based on statistical techniques

The Abstract is currently unavailable, due to the thesis being under Embargo

An enhanced stress indices in signal processing based on advanced mmatthew correlation coefficient (MCCA) and multimodal function using EEG signal

Stress is a response to various environmental, psychological, and social factors, resulting in strain and pressure on individuals. Categorizing stress levels is a common practise, often using low, medium, and high stress categories. However, the limitation of only three stress levels is a significant drawback of the existing approach. This study aims to address this limitation and proposes an improved method for EEG feature extraction and stress level categorization. The main contribution of this work lies in the enhanced stress level categorization, which expands from three to six levels using the newly established fractional scale based on the quantities' scale influenced by MCCA and multimodal equation performance. The concept of standard deviation (STD) helps in categorizing stress levels by dividing the scale of quantities, leading to an improvement in the process. The lack of performance in the Matthew Correlation Coefficient (MCC) equation is observed in relation to accuracy values. Also, multimodal is rarely discussed in terms of parameters. Therefore, the MCCA and multimodal function provide the advantage of significantly enhancing accuracy as a part of the study's contribution. This study introduces the concept of an Advanced Matthew Correlation Coefficient (MCCA) and applies the six-sigma framework to enhance accuracy in stress level categorization. The research focuses on expanding the stress levels from three to six, utilizing a new scale of fractional stress levels influenced by MCCA and multimodal equation performance. Furthermore, the study applies signal pre-processing techniques to filter and segregate the EEG signal into Delta, Theta, Alpha, and Beta frequency bands. Subsequently, feature extraction is conducted, resulting in twenty-one statistical and non-statistical features. These features are employed in both the MCCA and multimodal function analysis. The study employs the Support Vector Machine (SVM), Random Forest (RF), and k-Nearest Neighbour (k-NN) classifiers for stress level validation. After conducting experiments and performance evaluations, RF demonstrates the highest average accuracy of 85%–10% in 10-Fold and K-Fold techniques, outperforming SVM and k-NN. In conclusion, this study presents an improved approach to stress level categorization and EEG feature extraction. The proposed Advanced Matthew Correlation Coefficient (MCCA) and six-sigma framework contribute to achieving higher accuracy, surpassing the limitations of the existing three-level categorization. The results indicate the superiority of the Random Forest classifier over SVM and k-NN. This research has implications for various applications and fields, providing a more effective equation to accurately categorize stress levels with a potential accuracy exceeding 95%

The enhancement on stress levels based on physiological signal and self-stress assessment

The prolonged stress needs to be determined and controlled before it harms the physical and mental conditions. This research used questionnaire and physiological approaches in determine stress. EEG signal is an electrophysiological signal to analyze the signal features. The standard features used are peak-to-peak values, mean, standard deviation and root means square (RMS). The unique features in this research are Matthew Correlation Coefficient Advanced (MCCA) and multimodal capabilities in the area of frequency and time-frequency analysis are proposed. In the frequency domain, Power Spectral Density (PSD) techniques were applied while Short Time Fourier Transform (STFT) and Continuous Wavelet Transform (CWT) were utilized to extract seven features based on time-frequency domain. Various methods applied from previous works are still limited by the stress indices. The merged works between quantities score and physiological measurements were enhanced the stress level from three-levels to six stress levels based on music application will be the second contribution. To validate the proposed method and enhance performance between electroencephalogram (EEG) signals and stress score, support vector machine (SVM), random forest (RF), K- nearest neighbor (KNN) classifier is needed. From the finding, RF gained the best performance average accuracy 85% ±10% in Ten-fold and K-fold techniques compared with SVM and KNN

Seizure Detection, Seizure Prediction, and Closed-Loop Warning Systems in Epilepsy

Nearly one-third of patients with epilepsy continue to have seizures despite optimal medication management. Systems employed to detect seizures may have the potential to improve outcomes in these patients by allowing more tailored therapies and might, additionally, have a role in accident and SUDEP prevention. Automated seizure detection and prediction require algorithms which employ feature computation and subsequent classification. Over the last few decades, methods have been developed to detect seizures utilizing scalp and intracranial EEG, electrocardiography, accelerometry and motion sensors, electrodermal activity, and audio/video captures. To date, it is unclear which combination of detection technologies yields the best results, and approaches may ultimately need to be individualized. This review presents an overview of seizure detection and related prediction methods and discusses their potential uses in closed-loop warning systems in epilepsy

Developing new techniques to analyse and classify EEG signals

A massive amount of biomedical time series data such as Electroencephalograph (EEG), electrocardiography (ECG), Electromyography (EMG) signals are recorded daily to monitor human performance and diagnose different brain diseases. Effectively and accurately analysing these biomedical records is considered a challenge for researchers. Developing new techniques to analyse and classify these signals can help manage, inspect and diagnose these signals. In this thesis novel methods are proposed for EEG signals classification and analysis based on complex networks, a statistical model and spectral graph wavelet transform. Different complex networks attributes were employed and studied in this thesis to investigate the main relationship between behaviours of EEG signals and changes in networks attributes. Three types of EEG signals were investigated and analysed; sleep stages, epileptic and anaesthesia. The obtained results demonstrated the effectiveness of the proposed methods for analysing these three EEG signals types. The methods developed were applied to score sleep stages EEG signals, and to analyse epileptic, as well as anaesthesia EEG signals. The outcomes of the project will help support experts in the relevant medical fields and decrease the cost of diagnosing brain diseases

A Multi-Tier Distributed fog-based Architecture for Early Prediction of Epileptic Seizures

Epilepsy is the fourth most common neurological problem. With 50 million people living with epilepsy worldwide, about one in 26 people will continue experiencing recurring seizures during their lifetime. Epileptic seizures are characterized by uncontrollable movements and can cause loss of awareness. Despite the optimal use of antiepileptic medications, seizures are still difficult to control due to their sudden and unpredictable nature. Such seizures can put the lives of patients and others at risk. For example, seizure attacks while patients are driving could affect their ability to control a vehicle and could result in injuries to the patients as well as others. Notifying patients before the onset of seizures can enable them to avoid risks and minimize accidents, thus, save their lives. Early and accurate prediction of seizures can play a significant role in improving patients’ quality of life and helping doctors to administer medications through providing a historical overview of patient's condition over time. The individual variability and the dynamic disparity in differentiating between the pre-ictal phase (a period before the onset of the seizure) and other seizures phases make the early prediction of seizures a challenging task. Although several research projects have focused on developing a reliable seizure prediction model, numerous challenges still exist and need to be addressed. Most of the existing approaches are not suitable for real-time settings, which requires bio-signals collection and analysis in real-time. Various methods were developed based on the analysis of EEG signals without considering the notification latency and computational cost to support monitoring of multiple patients. Limited approaches were designed based on the analysis of ECG signals. ECG signals can be collected using consumer wearable devices and are suitable for light-weight real-time analysis. Moreover, existing prediction methods were developed based on the analysis of seizure state and ignored the investigation of pre-ictal state. The analysis of the pre-ictal state is essential in the prediction of seizures at an early stage. Therefore, there is a crucial need to design a novel computing model for early prediction of epileptic seizures. This model would greatly assist in improving the patients' quality of lives. This work proposes a multi-tier architecture for early prediction of seizures based on the analysis of two vital signs, namely, Electrocardiography (ECG) and Electroencephalogram (EEG) signals. The proposed architecture comprises of three tiers: (1) sensing at the first tier, (2) lightweight analysis based on ECG signals at the second tier, and (3) deep analysis based on EEG signals at the third tier. The proposed architecture is developed to leverage the potential of fog computing technology at the second tier for a real-time signal analytics and ubiquitous response. The proposed architecture can enable the early prediction of epileptic seizures, reduce the notification latency, and minimize the energy consumption on real-time data transmissions. Moreover, the proposed architecture is designed to allow for both lightweight and extensive analytics, thus make accurate and reliable decisions. The proposed lightweight model is formulated using the analysis of ECG signals to detect the pre-ictal state. The lightweight model utilizes the Least Squares Support Vector Machines (LS-SVM) classifier, while the proposed extensive analytics model analyzes EEG signals and utilizes Deep Belief Network (DBN) to provide an accurate classification of the patient’s state. The performance of the proposed architecture is evaluated in terms of latency minimization and energy consumption in comparison with the cloud. Moreover, the performance of the proposed prediction models is evaluated using three datasets. Various performance metrics were used to investigate the prediction model performance, including: accuracy, sensitivity, specificity, and F1-Measure. The results illustrate the merits of the proposed architecture and show significant improvement in the early prediction of seizures in terms of accuracy, sensitivity, and specificity

Automated Deep Neural Network Approach for Detection of Epileptic Seizures

In this thesis, I focus on exploiting electroencephalography (EEG) signals for early seizure diagnosis in patients. This process is based on a powerful deep learning algorithm for times series data called Long Short-Term Memory (LSTM) network. Since manual and visual inspection (detection) of epileptic seizure through the electroencephalography (EEG) signal by expert neurologists is time-consuming, work-intensive and error-prone and it might take a couple hours for experts to analyze a single patient record and to do recognition when immediate action is needed to be taken. This thesis proposes a reliable automatic seizure/non-seizure classification method that could facilitate the identification process of characteristic epileptic patterns, such as pre-ictal spikes, seizures and determination of seizure frequency, seizure type, etc. In order to recognize epileptic seizure accurately, the proposed model exploits the temporal dependencies in the EEG data. Experiments on clinical data present that this method achieves a high seizure prediction accuracy and maintains reliable performance. This thesis also finds the most efficient lengths of EEG recording for highest accuracies of different classification in the automated seizure detection realm. It could help non-experts to predict the seizure more comprehensively and bring awareness to patients and caregivers of upcoming seizures, enhancing the daily lives of patients against unpredictable occurrence of seizures.Master of Science in Applied Computer Scienc