4,709 research outputs found

    Computational methods for biofabrication in tissue engineering and regenerative medicine - a literature review

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    This literature review rigorously examines the growing scientific interest in computational methods for Tissue Engineering and Regenerative Medicine biofabrication, a leading-edge area in biomedical innovation, emphasizing the need for accurate, multi-stage, and multi-component biofabrication process models. The paper presents a comprehensive bibliometric and contextual analysis, followed by a literature review, to shed light on the vast potential of computational methods in this domain. It reveals that most existing methods focus on single biofabrication process stages and components, and there is a significant gap in approaches that utilize accurate models encompassing both biological and technological aspects. This analysis underscores the indispensable role of these methods in understanding and effectively manipulating complex biological systems and the necessity for developing computational methods that span multiple stages and components. The review concludes that such comprehensive computational methods are essential for developing innovative and efficient Tissue Engineering and Regenerative Medicine biofabrication solutions, driving forward advancements in this dynamic and evolving field

    Systematic mapping of software engineering management with an agile approach

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    El enfoque ágil ha generado una amplia variedad de estrategias para administrar con éxito diversos proyectos de software en todo el mundo. Además, podemos asegurar que los proyectos de software se han beneficiado de los métodos ágiles ya conocidos. En este sentido, este artículo busca demostrar cómo se aplica el enfoque ágil en las áreas de la gestión en la ingeniería del Software. Para ello, este estudio realiza un mapeo sistemático para identificar las principales tendencias en la gestión de la ingeniería de software con un enfoque ágil. Se han identificado un total de 1137 artículos, de los cuales 165 son relevantes para los fines de este estudio, estos indican que la entrega temprana de valor, un principio clave de la agilidad, sigue siendo la principal tendencia para el uso de métodos ágiles. Sin embargo, también existen fuertes tendencias enfocadas en puntos clave de la gestión en ingeniería de software, como optimizar la gestión de calidad, optimizar la especificación de requisitos, optimizar la gestión de riesgos y mejorar la comunicación y coordinación del equipo, estos resultados permitirán generar nuevas líneas de investigación para cada punto clave de la gestión en la ingeniería del software impactado por el enfoque ágil.The agile approach has generated a wide variety of strategies to successfully manage various software projects worldwide. In addition, we can ensure that software projects have benefited from the already known agile methods. In this sense, this article seeks to demonstrate how the agile approach is applied in Software engineering management areas. To do this, this study performs a systematic mapping to identify the main trends in software engineering management with an agile approach. A total of 1137 articles have identified, of which 165 are relevant for the purposes of this study, these indicate that early value delivery, a key principle of agility, continues to be the main trend for the use of agile methods. However, there are also strong trends focused on key points of management in software engineering, such as optimize quality management, optimize requirements specification, optimize risk management, and improve team communication and coordination, these results will allow generating new lines of research for each key point of management in software engineering impacted by the agile approach

    Distributed Ledger Technology (DLT) Applications in Payment, Clearing, and Settlement Systems:A Study of Blockchain-Based Payment Barriers and Potential Solutions, and DLT Application in Central Bank Payment System Functions

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    Payment, clearing, and settlement systems are essential components of the financial markets and exert considerable influence on the overall economy. While there have been considerable technological advancements in payment systems, the conventional systems still depend on centralized architecture, with inherent limitations and risks. The emergence of Distributed ledger technology (DLT) is being regarded as a potential solution to transform payment and settlement processes and address certain challenges posed by the centralized architecture of traditional payment systems (Bank for International Settlements, 2017). While proof-of-concept projects have demonstrated the technical feasibility of DLT, significant barriers still hinder its adoption and implementation. The overarching objective of this thesis is to contribute to the developing area of DLT application in payment, clearing and settlement systems, which is still in its initial stages of applications development and lacks a substantial body of scholarly literature and empirical research. This is achieved by identifying the socio-technical barriers to adoption and diffusion of blockchain-based payment systems and the solutions proposed to address them. Furthermore, the thesis examines and classifies various applications of DLT in central bank payment system functions, offering valuable insights into the motivations, DLT platforms used, and consensus algorithms for applicable use cases. To achieve these objectives, the methodology employed involved a systematic literature review (SLR) of academic literature on blockchain-based payment systems. Furthermore, we utilized a thematic analysis approach to examine data collected from various sources regarding the use of DLT applications in central bank payment system functions, such as central bank white papers, industry reports, and policy documents. The study's findings on blockchain-based payment systems barriers and proposed solutions; challenge the prevailing emphasis on technological and regulatory barriers in the literature and industry discourse regarding the adoption and implementation of blockchain-based payment systems. It highlights the importance of considering the broader socio-technical context and identifying barriers across all five dimensions of the social technical framework, including technological, infrastructural, user practices/market, regulatory, and cultural dimensions. Furthermore, the research identified seven DLT applications in central bank payment system functions. These are grouped into three overarching themes: central banks' operational responsibilities in payment and settlement systems, issuance of central bank digital money, and regulatory oversight/supervisory functions, along with other ancillary functions. Each of these applications has unique motivations or value proposition, which is the underlying reason for utilizing in that particular use case

    UMSL Bulletin 2023-2024

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    The 2023-2024 Bulletin and Course Catalog for the University of Missouri St. Louis.https://irl.umsl.edu/bulletin/1088/thumbnail.jp

    Multidisciplinary perspectives on Artificial Intelligence and the law

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    This open access book presents an interdisciplinary, multi-authored, edited collection of chapters on Artificial Intelligence (‘AI’) and the Law. AI technology has come to play a central role in the modern data economy. Through a combination of increased computing power, the growing availability of data and the advancement of algorithms, AI has now become an umbrella term for some of the most transformational technological breakthroughs of this age. The importance of AI stems from both the opportunities that it offers and the challenges that it entails. While AI applications hold the promise of economic growth and efficiency gains, they also create significant risks and uncertainty. The potential and perils of AI have thus come to dominate modern discussions of technology and ethics – and although AI was initially allowed to largely develop without guidelines or rules, few would deny that the law is set to play a fundamental role in shaping the future of AI. As the debate over AI is far from over, the need for rigorous analysis has never been greater. This book thus brings together contributors from different fields and backgrounds to explore how the law might provide answers to some of the most pressing questions raised by AI. An outcome of the Católica Research Centre for the Future of Law and its interdisciplinary working group on Law and Artificial Intelligence, it includes contributions by leading scholars in the fields of technology, ethics and the law.info:eu-repo/semantics/publishedVersio

    UMSL Bulletin 2022-2023

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    The 2022-2023 Bulletin and Course Catalog for the University of Missouri St. Louis.https://irl.umsl.edu/bulletin/1087/thumbnail.jp

    Digital Innovations for a Circular Plastic Economy in Africa

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    Plastic pollution is one of the biggest challenges of the twenty-first century that requires innovative and varied solutions. Focusing on sub-Saharan Africa, this book brings together interdisciplinary, multi-sectoral and multi-stakeholder perspectives exploring challenges and opportunities for utilising digital innovations to manage and accelerate the transition to a circular plastic economy (CPE). This book is organised into three sections bringing together discussion of environmental conditions, operational dimensions and country case studies of digital transformation towards the circular plastic economy. It explores the environment for digitisation in the circular economy, bringing together perspectives from practitioners in academia, innovation, policy, civil society and government agencies. The book also highlights specific country case studies in relation to the development and implementation of different innovative ideas to drive the circular plastic economy across the three sub-Saharan African regions. Finally, the book interrogates the policy dimensions and practitioner perspectives towards a digitally enabled circular plastic economy. Written for a wide range of readers across academia, policy and practice, including researchers, students, small and medium enterprises (SMEs), digital entrepreneurs, non-governmental organisations (NGOs) and multilateral agencies, policymakers and public officials, this book offers unique insights into complex, multilayered issues relating to the production and management of plastic waste and highlights how digital innovations can drive the transition to the circular plastic economy in Africa. The Open Access version of this book, available at https://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license

    Connecting the Dots in Trustworthy Artificial Intelligence: From AI Principles, Ethics, and Key Requirements to Responsible AI Systems and Regulation

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    Trustworthy Artificial Intelligence (AI) is based on seven technical requirements sustained over three main pillars that should be met throughout the system's entire life cycle: it should be (1) lawful, (2) ethical, and (3) robust, both from a technical and a social perspective. However, attaining truly trustworthy AI concerns a wider vision that comprises the trustworthiness of all processes and actors that are part of the system's life cycle, and considers previous aspects from different lenses. A more holistic vision contemplates four essential axes: the global principles for ethical use and development of AI-based systems, a philosophical take on AI ethics, a risk-based approach to AI regulation, and the mentioned pillars and requirements. The seven requirements (human agency and oversight; robustness and safety; privacy and data governance; transparency; diversity, non-discrimination and fairness; societal and environmental wellbeing; and accountability) are analyzed from a triple perspective: What each requirement for trustworthy AI is, Why it is needed, and How each requirement can be implemented in practice. On the other hand, a practical approach to implement trustworthy AI systems allows defining the concept of responsibility of AI-based systems facing the law, through a given auditing process. Therefore, a responsible AI system is the resulting notion we introduce in this work, and a concept of utmost necessity that can be realized through auditing processes, subject to the challenges posed by the use of regulatory sandboxes. Our multidisciplinary vision of trustworthy AI culminates in a debate on the diverging views published lately about the future of AI. Our reflections in this matter conclude that regulation is a key for reaching a consensus among these views, and that trustworthy and responsible AI systems will be crucial for the present and future of our society.Comment: 30 pages, 5 figures, under second revie

    Software Design Change Artifacts Generation through Software Architectural Change Detection and Categorisation

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    Software is solely designed, implemented, tested, and inspected by expert people, unlike other engineering projects where they are mostly implemented by workers (non-experts) after designing by engineers. Researchers and practitioners have linked software bugs, security holes, problematic integration of changes, complex-to-understand codebase, unwarranted mental pressure, and so on in software development and maintenance to inconsistent and complex design and a lack of ways to easily understand what is going on and what to plan in a software system. The unavailability of proper information and insights needed by the development teams to make good decisions makes these challenges worse. Therefore, software design documents and other insightful information extraction are essential to reduce the above mentioned anomalies. Moreover, architectural design artifacts extraction is required to create the developer’s profile to be available to the market for many crucial scenarios. To that end, architectural change detection, categorization, and change description generation are crucial because they are the primary artifacts to trace other software artifacts. However, it is not feasible for humans to analyze all the changes for a single release for detecting change and impact because it is time-consuming, laborious, costly, and inconsistent. In this thesis, we conduct six studies considering the mentioned challenges to automate the architectural change information extraction and document generation that could potentially assist the development and maintenance teams. In particular, (1) we detect architectural changes using lightweight techniques leveraging textual and codebase properties, (2) categorize them considering intelligent perspectives, and (3) generate design change documents by exploiting precise contexts of components’ relations and change purposes which were previously unexplored. Our experiment using 4000+ architectural change samples and 200+ design change documents suggests that our proposed approaches are promising in accuracy and scalability to deploy frequently. Our proposed change detection approach can detect up to 100% of the architectural change instances (and is very scalable). On the other hand, our proposed change classifier’s F1 score is 70%, which is promising given the challenges. Finally, our proposed system can produce descriptive design change artifacts with 75% significance. Since most of our studies are foundational, our approaches and prepared datasets can be used as baselines for advancing research in design change information extraction and documentation
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