Multifractality without fine-tuning in a Floquet quasiperiodic chain

Periodically driven, or Floquet, disordered quantum systems have generated many unexpected discoveries of late, such as the anomalous Floquet Anderson insulator and the discrete time crystal. Here, we report the emergence of an entire band of multifractal wavefunctions in a periodically driven chain of non-interacting particles subject to spatially quasiperiodic disorder. Remarkably, this multifractality is robust in that it does not require any fine-tuning of the model parameters, which sets it apart from the known multifractality of $critical$ wavefunctions. The multifractality arises as the periodic drive hybridises the localised and delocalised sectors of the undriven spectrum. We account for this phenomenon in a simple random matrix based theory. Finally, we discuss dynamical signatures of the multifractal states, which should betray their presence in cold atom experiments. Such a simple yet robust realisation of multifractality could advance this so far elusive phenomenon towards applications, such as the proposed disorder-induced enhancement of a superfluid transition.Comment: 22 pages, 13 figures, SciPost submissio

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. The novel associations nearly double the number of genome-wide hits reported for SSc thus far. We define 95% credible sets of less than 5 likely causal variants in 12 loci. Additionally, we identify specific SSc subtype-associated signals. Functional analysis of high-priority variants shows the potential function of SSc signals, with the identification of 43 robust target genes through HiChIP. Our results point towards molecular pathways potentially involved in vasculopathy and fibrosis, two main hallmarks in SSc, and highlight the spectrum of critical cell types for the disease. This work supports a better understanding of the genetic basis of SSc and provides directions for future functional experiments

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. The novel associations nearly double the number of genome-wide hits reported for SSc thus far. We define 95% credible sets of less than 5 likely causal variants in 12 loci. Additionally, we identify specific SSc subtype-associated signals. Functional analysis of high-priority variants shows the potential function of SSc signals, with the identification of 43 robust target genes through HiChIP. Our results point towards molecular pathways potentially involved in vasculopathy and fibrosis, two main hallmarks in SSc, and highlight the spectrum of critical cell types for the disease. This work supports a better understanding of the genetic basis of SSc and provides directions for future functional experiments

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. The novel associations nearly double the number of genome-wide hits reported for SSc thus far. We define 95% credible sets of less than 5 likely causal variants in 12 loci. Additionally, we identify specific SSc subtype-associated signals. Functional analysis of high-priority variants shows the potential function of SSc signals, with the identification of 43 robust target genes through HiChIP. Our results point towards molecular pathways potentially involved in vasculopathy and fibrosis, two main hallmarks in SSc, and highlight the spectrum of critical cell types for the disease. This work supports a better understanding of the genetic basis of SSc and provides directions for future functional experiments.</p

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. The novel associations nearly double the number of genome-wide hits reported for SSc thus far. We define 95% credible sets of less than 5 likely causal variants in 12 loci. Additionally, we identify specific SSc subtype-associated signals. Functional analysis of high-priority variants shows the potential function of SSc signals, with the identification of 43 robust target genes through HiChIP. Our results point towards molecular pathways potentially involved in vasculopathy and fibrosis, two main hallmarks in SSc, and highlight the spectrum of critical cell types for the disease. This work supports a better understanding of the genetic basis of SSc and provides directions for future functional experiments.</p

Limits on the gravity wave contribution to microwave anisotropies

We present limits on the fraction of large angle microwave anisotropies which could come from tensor perturbations. We use the COBE results as well as smaller scale CMB observations, measurements of galaxy correlations, abundances of galaxy clusters, and Lyman alpha absorption cloud statistics. Our aim is to provide conservative limits on the tensor-to-scalar ratio for standard inflationary models. For power-law inflation, for example, we find T/S<0.52 at 95% confidence, with a similar constraint for phi^p potentials. However, for models with tensor amplitude unrelated to the scalar spectral index it is still currently possible to have T/S>1.Comment: 23 pages, 7 figures, accepted for publication in Phys. Rev. D. Calculations extended to blue spectral index, Fig. 6 added, discussion of results expande

Convergence of the critical attractor of dissipative maps: Log-periodic oscillations, fractality and nonextensivity

For a family of logistic-like maps, we investigate the rate of convergence to the critical attractor when an ensemble of initial conditions is uniformly spread over the entire phase space. We found that the phase space volume occupied by the ensemble W(t) depicts a power-law decay with log-periodic oscillations reflecting the multifractal character of the critical attractor. We explore the parametric dependence of the power-law exponent and the amplitude of the log-periodic oscillations with the attractor's fractal dimension governed by the inflexion of the map near its extremal point. Further, we investigate the temporal evolution of W(t) for the circle map whose critical attractor is dense. In this case, we found W(t) to exhibit a rich pattern with a slow logarithmic decay of the lower bounds. These results are discussed in the context of nonextensive Tsallis entropies.Comment: 8 pages and 8 fig

Storywalking as transnational method:from Juteopolis to Sugaropolis

This chapter sets out to formalise a design framework which emerged during the development of Generation ZX(X), which I argue could provide an exciting methodology for re-presenting transnational histories for new audiences. Generation ZX(X) was a hybrid multi-media event which explored how video games can engage with different types of historical data: oral herstories, lived experience, collective memory and audio-video archives. It explored the hidden figures of the video games industry: the women who assembled the ZX Spectrum computers in the Timex factory in Dundee, and the ramifications that this labour had for the city’s development as one of UK’s leading games development and education centres. This design framework is called storywalking and combines walking as an aesthetic, critical, and dramaturgical practice of reading and performing an environment, with designing complex, sensory and story-rich environments for a moving, meaning-making body. Storywalking invites a critical engagement with the site and its remembered and lived past, enlivening the archive and transforming oral histories, lived experience and collective memory into gameplay. The direct use of the framework in the context of charged sites and living memory gestures towards its potential applications in cultural heritage contexts, exploring heritage sites and their transnational stories. This potential is now being explored in ongoing research tracing memories of sugar and transnational histories in Greenock, which will be outlined in this chapter

Universal scaling at non-thermal fixed points of a two-component Bose gas

Quasi-stationary far-from-equilibrium critical states of a two-component Bose gas are studied in two spatial dimensions. After the system has undergone an initial dynamical instability it approaches a non-thermal fixed point. At this critical point the structure of the gas is characterised by ensembles of (quasi-)topological defects such as vortices, skyrmions and solitons which give rise to universal power-law behaviour of momentum correlation functions. The resulting power-law spectra can be interpreted in terms of strong-wave-turbulence cascades driven by particle transport into long-wave-length excitations. Scaling exponents are determined on both sides of the miscible-immiscible transition controlled by the ratio of the intra-species to inter-species couplings. Making use of quantum turbulence methods, we explain the specific values of the exponents from the presence of transient (quasi-)topological defects.Comment: 13 pages, 12 figure