Systematizing FAIR research data management in biomedical research projects: a data life cycle approach

Biomedical researchers are facing data management challenges brought by a new generation of data driven by the advent of translational medicine research. These challenges are further complicated by the recent calls for data re-use and long-term stewardship spearheaded by the FAIR principles initiative. As a result, there is an increasingly wide-spread recognition that advancing biomedical science is becoming dependent on the application of data science to manage and utilize highly diverse and complex data in ways that give it context, meaning, and longevity beyond its initial purpose. However, current methods and practices in biomedical informatics remain to adopt a traditional linear view of the informatics process (collect, store and analyse); focusing primarily on the challenges in data integration and analysis, which are challenges only pertaining to a part of the overall life cycle of research data. The aim of this research is to facilitate the adoption and integration of data management practices into the research life cycle of biomedical projects, thus improving their capabilities into solving data management-related challenges that they face throughout the course of their research work. To achieve this aim, this thesis takes a data life cycle approach to define and develop a systematic methodology and framework towards the systematization of FAIR data management in biomedical research projects. The overarching contribution of this research is the provision of a data-state life cycle model for research data management in Biomedical Translational Research Projects. This model provides insight into the dynamics between 1) the purpose of a research-driven data use case, 2) the data requirements that renders data in a state fit for purpose, 3) the data management functions that prepare and act upon data and 4) the resulting state of data that is _t to serve the use case. This insight led to the development of a FAIR data management framework, which is another contribution of this thesis. This framework provides data managers the groundwork, including the data models, resources and capabilities, needed to build a FAIR data management environment to manage data during the operational stages of a biomedical research project. An exemplary implementation of this architecture (PlatformTM) was developed and validated by real-world research datasets produced by collaborative research programs funded by the Innovative Medicine Initiative (IMI) BioVacSafe 1 , eTRIKS 2 and FAIRplus 3.Open Acces

Indo-U.S. FTA - Prospects for Audiovisual Services

Many WTO (World Trade Organization) member countries, including India, are defensive about opening up of the audiovisual sector in the Doha Round due to reasons of cultural sensitivity. On the other hand, the United States is pushing for liberalizing trade in this sector both in the WTO and in its bilateral FTAs (Free Trade Agreements). With the slow progress of the Doha Round, India and the United States are exploring the possibilities of entering into FTAs with like-minded trading partners. In this context, the present paper discusses the prospects of liberalizing audiovisual services under a possible Indo-U.S. FTA. The study found that India and the United States have significant trade complementarities in this sector which can be further enhanced under an FTA. It identifies areas such as co-production of films, digital content creation and broadband infrastructure in which companies from India and the United States can enter into mutually beneficial collaborations. It argues that India should enter into a media cooperation agreement with the U.S. to facilitate the inflow of technical know, finance and best management practices. It discusses regulatory and other reforms which would not only improve the productivity and global competitiveness of the Indian audiovisual sector but also enable it to gain from the FTA.Indo-U.S. FTA, GATS, bilateral agreements, audiovisual, Services

Indo-U.S. FTA: Prospects for Audiovisual Services

Many WTO (World Trade Organization) member countries, including India, are defensive about opening up of the audiovisual sector in the Doha Round due to reasons of cultural sensitivity. On the other hand, the United States is pushing for liberalizing trade in this sector - both in the WTO and in its bilateral FTAs (Free Trade Agreements). With the slow progress of the Doha Round, India and the United States are exploring the possibilities of entering into FTAs with like-minded trading partners. In this context, the present paper discusses the prospects of liberalizing audiovisual services under a possible Indo-U.S. FTA. The study found that India and the United States have significant trade complementarities in this sector which can be further enhanced under an FTA. It identifies areas such as co-production of films, digital content creation and broadband infrastructure in which companies from India and the United States can enter into mutually beneficial collaborations. It argues that India should enter into a media cooperation agreement with the U.S. to facilitate the inflow of technical know, finance and best management practices. It discusses regulatory and other reforms which would not only improve the productivity and global competitiveness of the Indian audiovisual sector but also enable it to gain from the FTA.Indo-U.S. FTA, GATS, bilateral agreements, audiovisual, services

Social Search with Missing Data: Which Ranking Algorithm?

Online social networking tools are extremely popular, but can miss potential discoveries latent in the social 'fabric'. Matchmaking services which can do naive profile matching with old database technology are too brittle in the absence of key data, and even modern ontological markup, though powerful, can be onerous at data-input time. In this paper, we present a system called BuddyFinder which can automatically identify buddies who can best match a user's search requirements specified in a term-based query, even in the absence of stored user-profiles. We deploy and compare five statistical measures, namely, our own CORDER, mutual information (MI), phi-squared, improved MI and Z score, and two TF/IDF based baseline methods to find online users who best match the search requirements based on 'inferred profiles' of these users in the form of scavenged web pages. These measures identify statistically significant relationships between online users and a term-based query. Our user evaluation on two groups of users shows that BuddyFinder can find users highly relevant to search queries, and that CORDER achieved the best average ranking correlations among all seven algorithms and improved the performance of both baseline methods

Becoming Artifacts: Medieval Seals, Passports and the Future of Digital Identity

What does a digital identity token have to do with medieval seals? Is the history of passports of any use for enabling the discovery of Internet users\u27 identity when crossing virtual domain boundaries during their digital browsing and transactions? The agility of the Internet architecture and its simplicity of use have been the engines of its growth and success with the users worldwide. As it turns out, there lies also its crux. In effect, Internet industry participants have argued that the critical problem business is faced with on the Internet is the absence of an identity layer from the core protocols of its logical infrastructure. As a result, the cyberspace parallels a global territory without any identification mechanism that is reliable, consistent and interoperable across domains. This dissertation is an investigation of the steps being taken by Internet stakeholders in order to resolve its identity problems, through the lenses of historical instances where similar challenges were tackled by social actors. Social science research addressing the Internet identity issues is barely nascent. Research on identification systems in general is either characterized by a paucity of historical perspective, or scantily references digital technology and online identification processes. This research is designed to bridge that gap. The general question at its core is: How do social actors, events or processes enable the historical emergence of authoritative identity credentials for the public at large? This work is guided by that line of inquiry through three broad historical case studies: first, the medieval experience with seals used as identity tokens in the signing of deeds that resulted in transfers of rights, particularly estate rights; second, comes the modern, national state with its claim to the right to know all individuals on its territory through credentials such as the passport or the national identity card; and finally, viewed from the United States, the case of ongoing efforts to build an online digital identity infrastructure. Following a process-tracing approach to historical case study, this inquiry presents enlightening connections between the three identity frameworks while further characterizing each. We understand how the medieval doctrines of the Trinity and the Eucharist developed by schoolmen within the Church accommodated seals as markers of identity, and we understand how the modern state seized on the term `nationality\u27 - which emerged as late as in the 19th century - to make it into a legal fiction that was critical for its identification project. Furthermore, this investigation brings analytical insights which enable us to locate the dynamics driving the emergence of those identity systems. An ordering of the contributing factors in sequential categories is proposed in a sociohistorical approach to explain the causal mechanisms at work across these large phenomena. Finally this research also proposes historically informed projections of scenarios as possible pathways to the realization of authoritative digital identity. But that is the beginning of yet another story of identity

ENHANCING PRIVACY IN MULTI-AGENT SYSTEMS

La pérdida de privacidad se está convirtiendo en uno de los mayores problemas en el mundo de la informática. De hecho, la mayoría de los usuarios de Internet (que hoy en día alcanzan la cantidad de 2 billones de usuarios en todo el mundo) están preocupados por su privacidad. Estas preocupaciones también se trasladan a las nuevas ramas de la informática que están emergiendo en los ultimos años. En concreto, en esta tesis nos centramos en la privacidad en los Sistemas Multiagente. En estos sistemas, varios agentes (que pueden ser inteligentes y/o autónomos) interactúan para resolver problemas. Estos agentes suelen encapsular información personal de los usuarios a los que representan (nombres, preferencias, tarjetas de crédito, roles, etc.). Además, estos agentes suelen intercambiar dicha información cuando interactúan entre ellos. Todo esto puede resultar en pérdida de privacidad para los usuarios, y por tanto, provocar que los usuarios se muestren adversos a utilizar estas tecnologías. En esta tesis nos centramos en evitar la colección y el procesado de información personal en Sistemas Multiagente. Para evitar la colección de información, proponemos un modelo para que un agente sea capaz de decidir qué atributos (de la información personal que tiene sobre el usuario al que representa) revelar a otros agentes. Además, proporcionamos una infraestructura de agentes segura, para que una vez que un agente decide revelar un atributo a otro, sólo este último sea capaz de tener acceso a ese atributo, evitando que terceras partes puedan acceder a dicho atributo. Para evitar el procesado de información personal proponemos un modelo de gestión de las identidades de los agentes. Este modelo permite a los agentes la utilización de diferentes identidades para reducir el riesgo del procesado de información. Además, también describimos en esta tesis la implementación de dicho modelo en una plataforma de agentes.Such Aparicio, JM. (2011). ENHANCING PRIVACY IN MULTI-AGENT SYSTEMS [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/13023Palanci

PROFILING - CONCEPTS AND APPLICATIONS

Profiling is an approach to put a label or a set of labels on a subject, considering the characteristics of this subject. The New Oxford American Dictionary defines profiling as: “recording and analysis of a person’s psychological and behavioral characteristics, so as to assess or predict his/her capabilities in a certain sphere or to assist in identifying a particular subgroup of people”. This research extends this definition towards things demonstrating that many methods used for profiling of people may be applied for a different type of subjects, namely things. The goal of this research concerns proposing methods for discovery of profiles of users and things with application of Data Science methods. The profiles are utilized in vertical and 2 horizontal scenarios and concern such domains as smart grid and telecommunication (vertical scenarios), and support provided both for the needs of authorization and personalization (horizontal usage).:The thesis consists of eight chapters including an introduction and a summary. First chapter describes motivation for work that was carried out for the last 8 years together with discussion on its importance both for research and business practice. The motivation for this work is much broader and emerges also from business importance of profiling and personalization. The introduction summarizes major research directions, provides research questions, goals and supplementary objectives addressed in the thesis. Research methodology is also described, showing impact of methodological aspects on the work undertaken. Chapter 2 provides introduction to the notion of profiling. The definition of profiling is introduced. Here, also a relation of a user profile to an identity is discussed. The papers included in this chapter show not only how broadly a profile may be understood, but also how a profile may be constructed considering different data sources. Profiling methods are introduced in Chapter 3. This chapter refers to the notion of a profile developed using the BFI-44 personality test and outcomes of a survey related to color preferences of people with a specific personality. Moreover, insights into profiling of relations between people are provided, with a focus on quality of a relation emerging from contacts between two entities. Chapters from 4 to 7 present different scenarios that benefit from application of profiling methods. Chapter 4 starts with introducing the notion of a public utility company that in the thesis is discussed using examples from smart grid and telecommunication. Then, in chapter 4 follows a description of research results regarding profiling for the smart grid, focusing on a profile of a prosumer and forecasting demand and production of the electric energy in the smart grid what can be influenced e.g. by weather or profiles of appliances. Chapter 5 presents application of profiling techniques in the field of telecommunication. Besides presenting profiling methods based on telecommunication data, in particular on Call Detail Records, also scenarios and issues related to privacy and trust are addressed. Chapter 6 and Chapter 7 target at horizontal applications of profiling that may be of benefit for multiple domains. Chapter 6 concerns profiling for authentication using un-typical data sources such as Call Detail Records or data from a mobile phone describing the user behavior. Besides proposing methods, also limitations are discussed. In addition, as a side research effect a methodology for evaluation of authentication methods is proposed. Chapter 7 concerns personalization and consists of two diverse parts. Firstly, behavioral profiles to change interface and behavior of the system are proposed and applied. The performance of solutions personalizing content either locally or on the server is studied. Then, profiles of customers of shopping centers are created based on paths identified using Call Detail Records. The analysis demonstrates that the data that is collected for one purpose, may significantly influence other business scenarios. Chapter 8 summarizes the research results achieved by the author of this document. It presents contribution over state of the art as well as some insights into the future work planned

EU Borders and Their Controls: Preventing unwanted movement of people in Europe? CEPS Essay No. 6, 14 November 2013

his Essay attempts to take a step back from the tragic event in the first week of October 2013, when a boat capsized off the Italian island of Lampedusa and some 300 persons drowned seeking safe harbour. It sets out to examine the issue of EU border controls from the perspectives of the technologies, new and old, building on a variety of scholarly disciplines to understand what is happening to border controls on the movement of persons in the EU and why the results are so deadly. The Essay opens with an overview of what actually happens at the EU’s external borders. It then moves on to assess the old and new set of border control technologies that are deployed at the EU external borders, and how new technologies such as those based on automated controls and biometrics, are transforming the classical principles of European border controls. It then covers the reasons why people are refused admission at the EU’s external borders and the extent to which new border and surveillance technologies would assist in the effective controls in light of EU border law. Conclusions are finally offered on the articulation between the facts of EU border controls on persons and the claims and proposals for new technologies that are emerging from the EU institutions

Security risk assessment in cloud computing domains

Cyber security is one of the primary concerns persistent across any computing platform. While addressing the apprehensions about security risks, an infinite amount of resources cannot be invested in mitigation measures since organizations operate under budgetary constraints. Therefore the task of performing security risk assessment is imperative to designing optimal mitigation measures, as it provides insight about the strengths and weaknesses of different assets affiliated to a computing platform. The objective of the research presented in this dissertation is to improve upon existing risk assessment frameworks and guidelines associated to different key assets of Cloud computing domains - infrastructure, applications, and users. The dissertation presents various informal approaches of performing security risk assessment which will help to identify the security risks confronted by the aforementioned assets, and utilize the results to carry out the required cost-benefit tradeoff analyses. This will be beneficial to organizations by aiding them in better comprehending the security risks their assets are exposed to and thereafter secure them by designing cost-optimal mitigation measures --Abstract, page iv