Medical imaging analysis with artificial neural networks

Given that neural networks have been widely reported in the research community of medical imaging, we provide a focused literature survey on recent neural network developments in computer-aided diagnosis, medical image segmentation and edge detection towards visual content analysis, and medical image registration for its pre-processing and post-processing, with the aims of increasing awareness of how neural networks can be applied to these areas and to provide a foundation for further research and practical development. Representative techniques and algorithms are explained in detail to provide inspiring examples illustrating: (i) how a known neural network with fixed structure and training procedure could be applied to resolve a medical imaging problem; (ii) how medical images could be analysed, processed, and characterised by neural networks; and (iii) how neural networks could be expanded further to resolve problems relevant to medical imaging. In the concluding section, a highlight of comparisons among many neural network applications is included to provide a global view on computational intelligence with neural networks in medical imaging

Human Action Recognition and Monitoring in Ambient Assisted Living Environments

Population ageing is set to become one of the most significant challenges of the 21st century, with implications for almost all sectors of society. Especially in developed countries, governments should immediately implement policies and solutions to facilitate the needs of an increasingly older population. Ambient Intelligence (AmI) and in particular the area of Ambient Assisted Living (AAL) offer a feasible response, allowing the creation of human-centric smart environments that are sensitive and responsive to the needs and behaviours of the user. In such a scenario, understand what a human being is doing, if and how he/she is interacting with specific objects, or whether abnormal situations are occurring is critical. This thesis is focused on two related research areas of AAL: the development of innovative vision-based techniques for human action recognition and the remote monitoring of users behaviour in smart environments. The former topic is addressed through different approaches based on data extracted from RGB-D sensors. A first algorithm exploiting skeleton joints orientations is proposed. This approach is extended through a multi-modal strategy that includes the RGB channel to define a number of temporal images, capable of describing the time evolution of actions. Finally, the concept of template co-updating concerning action recognition is introduced. Indeed, exploiting different data categories (e.g., skeleton and RGB information) improve the effectiveness of template updating through co-updating techniques. The action recognition algorithms have been evaluated on CAD-60 and CAD-120, achieving results comparable with the state-of-the-art. Moreover, due to the lack of datasets including skeleton joints orientations, a new benchmark named Office Activity Dataset has been internally acquired and released. Regarding the second topic addressed, the goal is to provide a detailed implementation strategy concerning a generic Internet of Things monitoring platform that could be used for checking users' behaviour in AmI/AAL contexts

Towards Incremental Parsing of Natural Language using Recursive Neural Networks

In this paper we develop novel algorithmic ideas for building a natural language parser grounded upon the hypothesis of incrementality. Although widely accepted and experimentally supported under a cognitive perspective as a model of the human parser, the incrementality assumption has never been exploited for building automatic parsers of unconstrained real texts. The essentials of the hypothesis are that words are processed in a left-to-right fashion, and the syntactic structure is kept totally connected at each step. Our proposal relies on a machine learning technique for predicting the correctness of partial syntactic structures that are built during the parsing process. A recursive neural network architecture is employed for computing predictions after a training phase on examples drawn from a corpus of parsed sentences, the Penn Treebank. Our results indicate the viability of the approach andlay out the premises for a novel generation of algorithms for natural language processing which more closely model human parsing. These algorithms may prove very useful in the development of eÆcient parsers

Deep Incremental Learning for Object Recognition

In recent years, deep learning techniques received great attention in the field of information technology. These techniques proved to be particularly useful and effective in domains like natural language processing, speech recognition and computer vision. In several real world applications deep learning approaches improved the state-of-the-art. In the field of machine learning, deep learning was a real revolution and a number of effective techniques have been proposed for both supervised and unsupervised learning and for representation learning. This thesis focuses on deep learning for object recognition, and in particular, it addresses incremental learning techniques. With incremental learning we denote approaches able to create an initial model from a small training set and to improve the model as new data are available. Using temporal coherent sequences proved to be useful for incremental learning since temporal coherence also allows to operate in unsupervised manners. A critical point of incremental learning is called forgetting which is the risk to forget previously learned patterns as new data are presented. In the first chapters of this work we introduce the basic theory on neural networks, Convolutional Neural Networks and incremental learning. CNN is today one of the most effective approaches for supervised object recognition; it is well accepted by the scientific community and largely used by ICT big players like Google and Facebook: relevant applications are Facebook face recognition and Google image search. The scientific community has several (large) datasets (e.g., ImageNet) for the development and evaluation of object recognition approaches. However very few temporally coherent datasets are available to study incremental approaches. For this reason we decided to collect a new dataset named TCD4R (Temporal Coherent Dataset For Robotics)

Sketch2Pose : estimating a 3D character pose from a bitmap sketch

Artists frequently capture character poses via raster sketches, then use these drawings as a reference while posing a 3D character in a specialized 3D software --- a time-consuming process, requiring specialized 3D training and mental effort. We tackle this challenge by proposing the first system for automatically inferring a 3D character pose from a single bitmap sketch, producing poses consistent with viewer expectations. Algorithmically interpreting bitmap sketches is challenging, as they contain significantly distorted proportions and foreshortening. We address this by predicting three key elements of a drawing, necessary to disambiguate the drawn poses: 2D bone tangents, self-contacts, and bone foreshortening. These elements are then leveraged in an optimization inferring the 3D character pose consistent with the artist's intent. Our optimization balances cues derived from artistic literature and perception research to compensate for distorted character proportions. We demonstrate a gallery of results on sketches of numerous styles. We validate our method via numerical evaluations, user studies, and comparisons to manually posed characters and previous work

Visualizing and Predicting the Effects of Rheumatoid Arthritis on Hands

This dissertation was inspired by difficult decisions patients of chronic diseases have to make about about treatment options in light of uncertainty. We look at rheumatoid arthritis (RA), a chronic, autoimmune disease that primarily affects the synovial joints of the hands and causes pain and deformities. In this work, we focus on several parts of a computer-based decision tool that patients can interact with using gestures, ask questions about the disease, and visualize possible futures. We propose a hand gesture based interaction method that is easily setup in a doctor\u27s office and can be trained using a custom set of gestures that are least painful. Our system is versatile and can be used for operations like simple selections to navigating a 3D world. We propose a point distribution model (PDM) that is capable of modeling hand deformities that occur due to RA and a generalized fitting method for use on radiographs of hands. Using our shape model, we show novel visualization of disease progression. Using expertly staged radiographs, we propose a novel distance metric learning and embedding technique that can be used to automatically stage an unlabeled radiograph. Given a large set of expertly labeled radiographs, our data-driven approach can be used to extract different modes of deformation specific to a disease

Deep Learning for Sensor-based Human Activity Recognition: Overview, Challenges and Opportunities

The vast proliferation of sensor devices and Internet of Things enables the applications of sensor-based activity recognition. However, there exist substantial challenges that could influence the performance of the recognition system in practical scenarios. Recently, as deep learning has demonstrated its effectiveness in many areas, plenty of deep methods have been investigated to address the challenges in activity recognition. In this study, we present a survey of the state-of-the-art deep learning methods for sensor-based human activity recognition. We first introduce the multi-modality of the sensory data and provide information for public datasets that can be used for evaluation in different challenge tasks. We then propose a new taxonomy to structure the deep methods by challenges. Challenges and challenge-related deep methods are summarized and analyzed to form an overview of the current research progress. At the end of this work, we discuss the open issues and provide some insights for future directions

Automated Distinct Bone Segmentation from Computed Tomography Images using Deep Learning

Large-scale CT scans are frequently performed for forensic and diagnostic purposes, to plan and direct surgical procedures, and to track the development of bone-related diseases. This often involves radiologists who have to annotate bones manually or in a semi-automatic way, which is a time consuming task. Their annotation workload can be reduced by automated segmentation and detection of individual bones. This automation of distinct bone segmentation not only has the potential to accelerate current workflows but also opens up new possibilities for processing and presenting medical data for planning, navigation, and education. In this thesis, we explored the use of deep learning for automating the segmentation of all individual bones within an upper-body CT scan. To do so, we had to find a network architec- ture that provides a good trade-off between the problem’s high computational demands and the results’ accuracy. After finding a baseline method and having enlarged the dataset, we set out to eliminate the most prevalent types of error. To do so, we introduced an novel method called binary-prediction-enhanced multi-class (BEM) inference, separating the task into two: Distin- guishing bone from non-bone is conducted separately from identifying the individual bones. Both predictions are then merged, which leads to superior results. Another type of error is tack- led by our developed architecture, the Sneaky-Net, which receives additional inputs with larger fields of view but at a smaller resolution. We can thus sneak more extensive areas of the input into the network while keeping the growth of additional pixels in check. Overall, we present a deep-learning-based method that reliably segments most of the over one hundred distinct bones present in upper-body CT scans in an end-to-end trained matter quickly enough to be used in interactive software. Our algorithm has been included in our groups virtual reality medical image visualisation software SpectoVR with the plan to be used as one of the puzzle piece in surgical planning and navigation, as well as in the education of future doctors