16,876 research outputs found
A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2017. Supplementary information accompanies this paper at doi:10.1038/s41598-017-01971-2.The question of how cell division orientation is determined is fundamentally important for understanding tissue and organ shape in both healthy or disease conditions. Here we provide evidence for cell contact-dependent orientation of planar cell division in the mammalian embryonic skin. We propose a model where the core planar polarity proteins Celsr1 and Frizzled-6 (Fz6) communicate the long axis orientation of interphase basal cells to neighbouring basal mitoses so that they align their horizontal division plane along the same axis. The underlying mechanism requires a direct, cell surface, planar polarised cue, which we posit depends upon variant post-translational forms of Celsr1 protein coupled to Fz6. Our hypothesis has parallels with contact-mediated division orientation in early C. elegans embryos suggesting functional conservation between the adhesion-GPCRs Celsr1 and Latrophilin-1. We propose that linking planar cell division plane with interphase neighbour long axis geometry reinforces axial bias in skin spreading around the mouse embryo body.Peer reviewe
Mechanism for bipolar resistive switching in transition metal oxides
We introduce a model that accounts for the bipolar resistive switching
phenomenom observed in transition metal oxides. It qualitatively describes the
electric field-enhanced migration of oxygen vacancies at the nano-scale. The
numerical study of the model predicts that strong electric fields develop in
the highly resistive dielectric-electrode interfaces, leading to a spatially
inhomogeneous oxygen vacancies distribution and a concomitant resistive
switching effect. The theoretical results qualitatively reproduce non-trivial
resistance hysteresis experiments that we also report, providing key validation
to our model.Comment: Accepted for publication in Physical Review B, 6 twocolumn pages, 5
figure
DART: Distribution Aware Retinal Transform for Event-based Cameras
We introduce a generic visual descriptor, termed as distribution aware
retinal transform (DART), that encodes the structural context using log-polar
grids for event cameras. The DART descriptor is applied to four different
problems, namely object classification, tracking, detection and feature
matching: (1) The DART features are directly employed as local descriptors in a
bag-of-features classification framework and testing is carried out on four
standard event-based object datasets (N-MNIST, MNIST-DVS, CIFAR10-DVS,
NCaltech-101). (2) Extending the classification system, tracking is
demonstrated using two key novelties: (i) For overcoming the low-sample problem
for the one-shot learning of a binary classifier, statistical bootstrapping is
leveraged with online learning; (ii) To achieve tracker robustness, the scale
and rotation equivariance property of the DART descriptors is exploited for the
one-shot learning. (3) To solve the long-term object tracking problem, an
object detector is designed using the principle of cluster majority voting. The
detection scheme is then combined with the tracker to result in a high
intersection-over-union score with augmented ground truth annotations on the
publicly available event camera dataset. (4) Finally, the event context encoded
by DART greatly simplifies the feature correspondence problem, especially for
spatio-temporal slices far apart in time, which has not been explicitly tackled
in the event-based vision domain.Comment: 12 pages, revision submitted to TPAMI in Nov 201
A model of ant route navigation driven by scene familiarity
In this paper we propose a model of visually guided route navigation in ants that captures the known properties of real behaviour whilst retaining mechanistic simplicity and thus biological plausibility. For an ant, the coupling of movement and viewing direction means that a familiar view specifies a familiar direction of movement. Since the views experienced along a habitual route will be more familiar, route navigation can be re-cast as a search for familiar views. This search can be performed with a simple scanning routine, a behaviour that ants have been observed to perform. We test this proposed route navigation strategy in simulation, by learning a series of routes through visually cluttered environments consisting of objects that are only distinguishable as silhouettes against the sky. In the first instance we determine view familiarity by exhaustive comparison with the set of views experienced during training. In further experiments we train an artificial neural network to perform familiarity discrimination using the training views. Our results indicate that, not only is the approach successful, but also that the routes that are learnt show many of the characteristics of the routes of desert ants. As such, we believe the model represents the only detailed and complete model of insect route guidance to date. What is more, the model provides a general demonstration that visually guided routes can be produced with parsimonious mechanisms that do not specify when or what to learn, nor separate routes into sequences of waypoints
Weakly-supervised appraisal analysis
This article is concerned with the computational treatment of Appraisal, a Systemic Functional Linguistic theory of the types of language employed to communicate opinion in English. The theory considers aspects such as Attitude (how writers communicate their point of view), Engagement (how writers align themselves with respect to the opinions of others) and Graduation (how writers amplify or diminish their attitudes and engagements). To analyse text according to the theory we employ a weakly-supervised approach to text classification, which involves comparing the similarity of words with prototypical examples of classes. We evaluate the method's performance using a collection of book reviews annotated according to the Appraisal theory
Magnetic Cycles in a Convective Dynamo Simulation of a Young Solar-type Star
Young solar-type stars rotate rapidly and many are magnetically active; some
undergo magnetic cycles similar to the 22-year solar activity cycle. We conduct
simulations of dynamo action in rapidly rotating suns with the 3D MHD anelastic
spherical harmonic (ASH) code to explore dynamo action achieved in the
convective envelope of a solar-type star rotating at 5 times the current solar
rotation rate. Striking global-scale magnetic wreaths appear in the midst of
the turbulent convection zone and show rich time-dependence. The dynamo
exhibits cyclic activity and undergoes quasi-periodic polarity reversals where
both the global-scale poloidal and toroidal fields change in sense on a roughly
1500 day time scale. These magnetic activity patterns emerge spontaneously from
the turbulent flow and are more organized temporally and spatially than those
realized in our previous simulations of the solar dynamo. We assess in detail
the competing processes of magnetic field creation and destruction within our
simulations that contribute to the global-scale reversals. We find that the
mean toroidal fields are built primarily through an -effect, while the
mean poloidal fields are built by turbulent correlations which are not
necessarily well represented by a simple -effect. During a reversal the
magnetic wreaths propagate towards the polar regions, and this appears to arise
from a poleward propagating dynamo wave. The primary response in the convective
flows involves the axisymmetric differential rotation which shows variations
associated with the poleward propagating magnetic wreaths. In the Sun, similar
patterns are observed in the poleward branch of the torsional oscillations, and
these may represent poleward propagating magnetic fields deep below the solar
surface. [abridged]Comment: 20 pages, 14 figures, emulateapj format; accepted for publication in
ApJ. Expanded and published version of sections 5-6 from
http://arxiv.org/abs/0906.240
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