Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

Knowledge management, innovation and big data: Implications for sustainability, policy making and competitiveness

This Special Issue of Sustainability devoted to the topic of “Knowledge Management, Innovation and Big Data: Implications for Sustainability, Policy Making and Competitiveness” attracted exponential attention of scholars, practitioners, and policy-makers from all over the world. Locating themselves at the expanding cross-section of the uses of sophisticated information and communication technology (ICT) and insights from social science and engineering, all papers included in this Special Issue contribute to the opening of new avenues of research in the field of innovation, knowledge management, and big data. By triggering a lively debate on diverse challenges that companies are exposed to today, this Special Issue offers an in-depth, informative, well-structured, comparative insight into the most salient developments shaping the corresponding fields of research and policymaking

Information Access in a Multilingual World: Transitioning from Research to Real-World Applications

Multilingual Information Access (MLIA) is at a turning point wherein substantial real-world applications are being introduced after fifteen years of research into cross-language information retrieval, question answering, statistical machine translation and named entity recognition. Previous workshops on this topic have focused on research and small- scale applications. The focus of this workshop was on technology transfer from research to applications and on what future research needs to be done which facilitates MLIA in an increasingly connected multilingual world

Symbol Emergence in Robotics: A Survey

Humans can learn the use of language through physical interaction with their environment and semiotic communication with other people. It is very important to obtain a computational understanding of how humans can form a symbol system and obtain semiotic skills through their autonomous mental development. Recently, many studies have been conducted on the construction of robotic systems and machine-learning methods that can learn the use of language through embodied multimodal interaction with their environment and other systems. Understanding human social interactions and developing a robot that can smoothly communicate with human users in the long term, requires an understanding of the dynamics of symbol systems and is crucially important. The embodied cognition and social interaction of participants gradually change a symbol system in a constructive manner. In this paper, we introduce a field of research called symbol emergence in robotics (SER). SER is a constructive approach towards an emergent symbol system. The emergent symbol system is socially self-organized through both semiotic communications and physical interactions with autonomous cognitive developmental agents, i.e., humans and developmental robots. Specifically, we describe some state-of-art research topics concerning SER, e.g., multimodal categorization, word discovery, and a double articulation analysis, that enable a robot to obtain words and their embodied meanings from raw sensory--motor information, including visual information, haptic information, auditory information, and acoustic speech signals, in a totally unsupervised manner. Finally, we suggest future directions of research in SER.Comment: submitted to Advanced Robotic